1.Catalpa bignonioides extract improves exercise performance through regulation of growth and metabolism in skeletal muscles
Hoibin Jeong ; Dong-joo Lee ; Sung-Pil Kwon ; SeonJu Park ; Song-Rae Kim ; Seung Hyun Kim ; Jae-Il Park ; Deug-chan Lee ; Kyung-Min Choi ; WonWoo Lee ; Ji-Won Park ; Bohyun Yun ; Su-Hyeon Cho ; Kil-Nam Kim
Asian Pacific Journal of Tropical Biomedicine 2024;14(2):47-54
Objective: To evaluate the effects of Catalpa bignonioides fruit extract on the promotion of muscle growth and muscular capacity in vitro and in vivo. Methods: Cell viability was measured using the 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide assay. Cell proliferation was assessed using a 5-bromo-2’-deoxyuridine (BrdU) assay kit. Western blot analysis was performed to determine the protein expressions of related factors. The effects of Catalpa bignonioides extract were investigated in mice using the treadmill exhaustion test and whole-limb grip strength assay. Chemical composition analysis was performed using high-performance liquid chromatography (HPLC). Results: Catalpa bignonioides extract increased the proliferation of C2C12 mouse myoblasts by activating the Akt/mTOR signaling pathway. It also induced metabolic changes, increasing the number of mitochondria and glucose metabolism by phosphorylating adenosine monophosphate-activated protein kinase. In an in vivo study, the extract-treated mice showed improved motor abilities, such as muscular endurance and grip strength. Additionally, HPLC analysis showed that vanillic acid may be the main component of the Catalpa bignonioides extract that enhanced muscle strength. Conclusions: Catalpa bignonioides improves exercise performance through regulation of growth and metabolism in skeletal muscles, suggesting its potential as an effective natural agent for improving muscular strength.
2.Survey of Experts’ Opinions on the Diagnosis and Management of Pancreatic Cystic Neoplasms
Jeong Hee YOON ; In Rae CHO ; Won CHANG ; Bohyun KIM ; Siwon JANG ; Yeun-Yoon KIM ; Jeong Woo KIM ; Sang Hyub LEE ; Jeong Min LEE
Korean Journal of Radiology 2024;25(12):1047-1060
Objective:
To survey experts’ opinions in abdominal radiology (radiologists) and pancreas-specialized gastroenterology (pancreatologists) in South Korea regarding diagnosing and managing pancreatic cystic neoplasms (PCNs).
Materials and Methods:
Between August 25, 2023, and October 5, 2023, an online survey was conducted among members of the Korean Society of Abdominal Radiology and the Korean Pancreatobiliary Association via email invitation.
Results:
The responses from 100 radiologists and 41 pancreatologists were analyzed. Of the respondents, 55.3% (78/141) reported seeing more than 50 patients or reading more than 50 exams related to PCN each month. The most common and preferred diagnostic modality for PCN was contrast-enhanced computed tomography (CECT), favored by 87.8% (36/41) of pancreatologists. When discrepancies arose between CECT or magnetic resonance imaging (MRI) and endoscopic ultrasound, 31.2% (44/141) of the respondents opted for multidisciplinary team discussion, whereas 29.1% (41/141) chose short-term follow-up using CECT or MRI. A total of 88.7% (125/141) of the respondents adhered to the 2017 International Association of Pancreatology (IAP) guidelines in their practice. Among the radiologists, 51.0% (51/100) endorsed a cut-off value of 5 mm for enhancing mural nodules, and 22.0% (22/100) supported a 5 mm/2 yr growth rate in the IAP guidelines v.2017.Additionally, 73.0% (73/100) of radiologists favored discontinuing surveillance, whereas 41.5% (17/41) of pancreatologists disagreed with stopping surveillance.
Conclusion
The survey underscores the clinical burden PCN poses and identifies CECT as the foremost diagnostic tool.Variability was noted in the terminology, differential diagnosis, approaches for resolving discrepancies between imaging examinations, and opinions on surveillance discontinuation among the respondents as a whole, as well as between radiologists and pancreatologists. Although the 2017 IAP guidelines are primarily followed, there remains a level of dissatisfaction with risk stratification among radiologists. This highlights the need for more standardized diagnostic algorithms and improved consensus among specialists to address these challenges.
3.Survey of Experts’ Opinions on the Diagnosis and Management of Pancreatic Cystic Neoplasms
Jeong Hee YOON ; In Rae CHO ; Won CHANG ; Bohyun KIM ; Siwon JANG ; Yeun-Yoon KIM ; Jeong Woo KIM ; Sang Hyub LEE ; Jeong Min LEE
Korean Journal of Radiology 2024;25(12):1047-1060
Objective:
To survey experts’ opinions in abdominal radiology (radiologists) and pancreas-specialized gastroenterology (pancreatologists) in South Korea regarding diagnosing and managing pancreatic cystic neoplasms (PCNs).
Materials and Methods:
Between August 25, 2023, and October 5, 2023, an online survey was conducted among members of the Korean Society of Abdominal Radiology and the Korean Pancreatobiliary Association via email invitation.
Results:
The responses from 100 radiologists and 41 pancreatologists were analyzed. Of the respondents, 55.3% (78/141) reported seeing more than 50 patients or reading more than 50 exams related to PCN each month. The most common and preferred diagnostic modality for PCN was contrast-enhanced computed tomography (CECT), favored by 87.8% (36/41) of pancreatologists. When discrepancies arose between CECT or magnetic resonance imaging (MRI) and endoscopic ultrasound, 31.2% (44/141) of the respondents opted for multidisciplinary team discussion, whereas 29.1% (41/141) chose short-term follow-up using CECT or MRI. A total of 88.7% (125/141) of the respondents adhered to the 2017 International Association of Pancreatology (IAP) guidelines in their practice. Among the radiologists, 51.0% (51/100) endorsed a cut-off value of 5 mm for enhancing mural nodules, and 22.0% (22/100) supported a 5 mm/2 yr growth rate in the IAP guidelines v.2017.Additionally, 73.0% (73/100) of radiologists favored discontinuing surveillance, whereas 41.5% (17/41) of pancreatologists disagreed with stopping surveillance.
Conclusion
The survey underscores the clinical burden PCN poses and identifies CECT as the foremost diagnostic tool.Variability was noted in the terminology, differential diagnosis, approaches for resolving discrepancies between imaging examinations, and opinions on surveillance discontinuation among the respondents as a whole, as well as between radiologists and pancreatologists. Although the 2017 IAP guidelines are primarily followed, there remains a level of dissatisfaction with risk stratification among radiologists. This highlights the need for more standardized diagnostic algorithms and improved consensus among specialists to address these challenges.
4.Survey of Experts’ Opinions on the Diagnosis and Management of Pancreatic Cystic Neoplasms
Jeong Hee YOON ; In Rae CHO ; Won CHANG ; Bohyun KIM ; Siwon JANG ; Yeun-Yoon KIM ; Jeong Woo KIM ; Sang Hyub LEE ; Jeong Min LEE
Korean Journal of Radiology 2024;25(12):1047-1060
Objective:
To survey experts’ opinions in abdominal radiology (radiologists) and pancreas-specialized gastroenterology (pancreatologists) in South Korea regarding diagnosing and managing pancreatic cystic neoplasms (PCNs).
Materials and Methods:
Between August 25, 2023, and October 5, 2023, an online survey was conducted among members of the Korean Society of Abdominal Radiology and the Korean Pancreatobiliary Association via email invitation.
Results:
The responses from 100 radiologists and 41 pancreatologists were analyzed. Of the respondents, 55.3% (78/141) reported seeing more than 50 patients or reading more than 50 exams related to PCN each month. The most common and preferred diagnostic modality for PCN was contrast-enhanced computed tomography (CECT), favored by 87.8% (36/41) of pancreatologists. When discrepancies arose between CECT or magnetic resonance imaging (MRI) and endoscopic ultrasound, 31.2% (44/141) of the respondents opted for multidisciplinary team discussion, whereas 29.1% (41/141) chose short-term follow-up using CECT or MRI. A total of 88.7% (125/141) of the respondents adhered to the 2017 International Association of Pancreatology (IAP) guidelines in their practice. Among the radiologists, 51.0% (51/100) endorsed a cut-off value of 5 mm for enhancing mural nodules, and 22.0% (22/100) supported a 5 mm/2 yr growth rate in the IAP guidelines v.2017.Additionally, 73.0% (73/100) of radiologists favored discontinuing surveillance, whereas 41.5% (17/41) of pancreatologists disagreed with stopping surveillance.
Conclusion
The survey underscores the clinical burden PCN poses and identifies CECT as the foremost diagnostic tool.Variability was noted in the terminology, differential diagnosis, approaches for resolving discrepancies between imaging examinations, and opinions on surveillance discontinuation among the respondents as a whole, as well as between radiologists and pancreatologists. Although the 2017 IAP guidelines are primarily followed, there remains a level of dissatisfaction with risk stratification among radiologists. This highlights the need for more standardized diagnostic algorithms and improved consensus among specialists to address these challenges.
5.Practice guidelines for managing extrahepatic biliary tract cancers
Hyung Sun KIM ; Mee Joo KANG ; Jingu KANG ; Kyubo KIM ; Bohyun KIM ; Seong-Hun KIM ; Soo Jin KIM ; Yong-Il KIM ; Joo Young KIM ; Jin Sil KIM ; Haeryoung KIM ; Hyo Jung KIM ; Ji Hae NAHM ; Won Suk PARK ; Eunkyu PARK ; Joo Kyung PARK ; Jin Myung PARK ; Byeong Jun SONG ; Yong Chan SHIN ; Keun Soo AHN ; Sang Myung WOO ; Jeong Il YU ; Changhoon YOO ; Kyoungbun LEE ; Dong Ho LEE ; Myung Ah LEE ; Seung Eun LEE ; Ik Jae LEE ; Huisong LEE ; Jung Ho IM ; Kee-Taek JANG ; Hye Young JANG ; Sun-Young JUN ; Hong Jae CHON ; Min Kyu JUNG ; Yong Eun CHUNG ; Jae Uk CHONG ; Eunae CHO ; Eui Kyu CHIE ; Sae Byeol CHOI ; Seo-Yeon CHOI ; Seong Ji CHOI ; Joon Young CHOI ; Hye-Jeong CHOI ; Seung-Mo HONG ; Ji Hyung HONG ; Tae Ho HONG ; Shin Hye HWANG ; In Gyu HWANG ; Joon Seong PARK
Annals of Hepato-Biliary-Pancreatic Surgery 2024;28(2):161-202
Background:
s/Aims: Reported incidence of extrahepatic bile duct cancer is higher in Asians than in Western populations. Korea, in particular, is one of the countries with the highest incidence rates of extrahepatic bile duct cancer in the world. Although research and innovative therapeutic modalities for extrahepatic bile duct cancer are emerging, clinical guidelines are currently unavailable in Korea. The Korean Society of Hepato-Biliary-Pancreatic Surgery in collaboration with related societies (Korean Pancreatic and Biliary Surgery Society, Korean Society of Abdominal Radiology, Korean Society of Medical Oncology, Korean Society of Radiation Oncology, Korean Society of Pathologists, and Korean Society of Nuclear Medicine) decided to establish clinical guideline for extrahepatic bile duct cancer in June 2021.
Methods:
Contents of the guidelines were developed through subgroup meetings for each key question and a preliminary draft was finalized through a Clinical Guidelines Committee workshop.
Results:
In November 2021, the finalized draft was presented for public scrutiny during a formal hearing.
Conclusions
The extrahepatic guideline committee believed that this guideline could be helpful in the treatment of patients.
6.Differences in Medical Use and Patient Outcomes between Patients Admitted to the Integrated Nursing Care Ward and the General Ward
Journal of Korean Academy of Nursing Administration 2024;30(5):439-450
Purpose:
This study aimed to analyze the differences in medical care use and patient outcomes between patient groups in the general ward (GW) and integrated nursing care ward (INCW).
Methods:
Among all patients admitted from January 1 to December 31, 2020, 430 patients (total 860) were selected in the GW and INCW using propensity score matching. The differences in the two groups were analyzed using t-test and x 2 test. Multiple and logistic regression were used to investigate the effect of admission to the INCW or GW on medical use and patient outcomes.
Results:
The total medical expenses, urinary tract infection rate, and pneumonia rate of the two groups did not show significant differences; however, the length of stay for the INCW group was approximately 3 days longer and unplanned readmissions were 5.4% lower for the INCW group than that for the GW group. Multiple and logistic regression analysis showed similar results.
Conclusion
Patients in the INCW group had longer hospitalization days and lower rates of unplanned readmission than those in GW group. Additional studies related to longer hospital stays are needed, and measures should be taken to prevent social hospitalization.
7.Differences in Medical Use and Patient Outcomes between Patients Admitted to the Integrated Nursing Care Ward and the General Ward
Journal of Korean Academy of Nursing Administration 2024;30(5):439-450
Purpose:
This study aimed to analyze the differences in medical care use and patient outcomes between patient groups in the general ward (GW) and integrated nursing care ward (INCW).
Methods:
Among all patients admitted from January 1 to December 31, 2020, 430 patients (total 860) were selected in the GW and INCW using propensity score matching. The differences in the two groups were analyzed using t-test and x 2 test. Multiple and logistic regression were used to investigate the effect of admission to the INCW or GW on medical use and patient outcomes.
Results:
The total medical expenses, urinary tract infection rate, and pneumonia rate of the two groups did not show significant differences; however, the length of stay for the INCW group was approximately 3 days longer and unplanned readmissions were 5.4% lower for the INCW group than that for the GW group. Multiple and logistic regression analysis showed similar results.
Conclusion
Patients in the INCW group had longer hospitalization days and lower rates of unplanned readmission than those in GW group. Additional studies related to longer hospital stays are needed, and measures should be taken to prevent social hospitalization.
8.Differences in Medical Use and Patient Outcomes between Patients Admitted to the Integrated Nursing Care Ward and the General Ward
Journal of Korean Academy of Nursing Administration 2024;30(5):439-450
Purpose:
This study aimed to analyze the differences in medical care use and patient outcomes between patient groups in the general ward (GW) and integrated nursing care ward (INCW).
Methods:
Among all patients admitted from January 1 to December 31, 2020, 430 patients (total 860) were selected in the GW and INCW using propensity score matching. The differences in the two groups were analyzed using t-test and x 2 test. Multiple and logistic regression were used to investigate the effect of admission to the INCW or GW on medical use and patient outcomes.
Results:
The total medical expenses, urinary tract infection rate, and pneumonia rate of the two groups did not show significant differences; however, the length of stay for the INCW group was approximately 3 days longer and unplanned readmissions were 5.4% lower for the INCW group than that for the GW group. Multiple and logistic regression analysis showed similar results.
Conclusion
Patients in the INCW group had longer hospitalization days and lower rates of unplanned readmission than those in GW group. Additional studies related to longer hospital stays are needed, and measures should be taken to prevent social hospitalization.
9.Survey of Experts’ Opinions on the Diagnosis and Management of Pancreatic Cystic Neoplasms
Jeong Hee YOON ; In Rae CHO ; Won CHANG ; Bohyun KIM ; Siwon JANG ; Yeun-Yoon KIM ; Jeong Woo KIM ; Sang Hyub LEE ; Jeong Min LEE
Korean Journal of Radiology 2024;25(12):1047-1060
Objective:
To survey experts’ opinions in abdominal radiology (radiologists) and pancreas-specialized gastroenterology (pancreatologists) in South Korea regarding diagnosing and managing pancreatic cystic neoplasms (PCNs).
Materials and Methods:
Between August 25, 2023, and October 5, 2023, an online survey was conducted among members of the Korean Society of Abdominal Radiology and the Korean Pancreatobiliary Association via email invitation.
Results:
The responses from 100 radiologists and 41 pancreatologists were analyzed. Of the respondents, 55.3% (78/141) reported seeing more than 50 patients or reading more than 50 exams related to PCN each month. The most common and preferred diagnostic modality for PCN was contrast-enhanced computed tomography (CECT), favored by 87.8% (36/41) of pancreatologists. When discrepancies arose between CECT or magnetic resonance imaging (MRI) and endoscopic ultrasound, 31.2% (44/141) of the respondents opted for multidisciplinary team discussion, whereas 29.1% (41/141) chose short-term follow-up using CECT or MRI. A total of 88.7% (125/141) of the respondents adhered to the 2017 International Association of Pancreatology (IAP) guidelines in their practice. Among the radiologists, 51.0% (51/100) endorsed a cut-off value of 5 mm for enhancing mural nodules, and 22.0% (22/100) supported a 5 mm/2 yr growth rate in the IAP guidelines v.2017.Additionally, 73.0% (73/100) of radiologists favored discontinuing surveillance, whereas 41.5% (17/41) of pancreatologists disagreed with stopping surveillance.
Conclusion
The survey underscores the clinical burden PCN poses and identifies CECT as the foremost diagnostic tool.Variability was noted in the terminology, differential diagnosis, approaches for resolving discrepancies between imaging examinations, and opinions on surveillance discontinuation among the respondents as a whole, as well as between radiologists and pancreatologists. Although the 2017 IAP guidelines are primarily followed, there remains a level of dissatisfaction with risk stratification among radiologists. This highlights the need for more standardized diagnostic algorithms and improved consensus among specialists to address these challenges.
10.Differences in Medical Use and Patient Outcomes between Patients Admitted to the Integrated Nursing Care Ward and the General Ward
Journal of Korean Academy of Nursing Administration 2024;30(5):439-450
Purpose:
This study aimed to analyze the differences in medical care use and patient outcomes between patient groups in the general ward (GW) and integrated nursing care ward (INCW).
Methods:
Among all patients admitted from January 1 to December 31, 2020, 430 patients (total 860) were selected in the GW and INCW using propensity score matching. The differences in the two groups were analyzed using t-test and x 2 test. Multiple and logistic regression were used to investigate the effect of admission to the INCW or GW on medical use and patient outcomes.
Results:
The total medical expenses, urinary tract infection rate, and pneumonia rate of the two groups did not show significant differences; however, the length of stay for the INCW group was approximately 3 days longer and unplanned readmissions were 5.4% lower for the INCW group than that for the GW group. Multiple and logistic regression analysis showed similar results.
Conclusion
Patients in the INCW group had longer hospitalization days and lower rates of unplanned readmission than those in GW group. Additional studies related to longer hospital stays are needed, and measures should be taken to prevent social hospitalization.

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