Objective: To investigate the clinical, pathological and immunophenotypic features, molecular biology and prognosis of fibrin-associated large B-cell lymphoma (LBCL-FA) in various sites. Methods: Six cases of LBCL-FA diagnosed from April 2016 to November 2021 at the Beijing Friendship Hospital, Capital Medical University, Beijing, China and the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China were collected. The cases were divided into atrial myxoma and cyst-related groups. Clinical characteristics, pathological morphology, immunophenotype, Epstein Barr virus infection status, B-cell gene rearrangement and fluorescence in situ hybridization of MYC, bcl-2, bcl-6 were summarized. Results: The patients' mean age was 60 years. All of them were male. Three cases occurred in atrial myxoma background, while the others were in cyst-related background, including adrenal gland, abdominal cavity and subdura. All cases showed tumor cells located in pink fibrin clot. However, three cyst-related cases showed the cyst wall with obviously fibrosis and inflammatory cells. All cases tested were non germinal center B cell origin, positive for PD-L1, EBER and EBNA2, and were negative for MYC, bcl-2 and bcl-6 rearrangements, except one case with MYC, bcl-2 and bcl-6 amplification. All of the 5 cases showed monoclonal rearrangement of the Ig gene using PCR based analysis. The patients had detailed follow-ups of 9-120 months, were treated surgically without radiotherapy or chemotherapy, and had long-term disease-free survivals. Conclusions: LBCL-FA is a group of rare diseases occurring in various sites, with predilection in the context of atrial myxoma and cyst-related lesions. Cyst-related lesions with obvious chronic inflammatory background show more scarcity of lymphoid cells and obvious degeneration, which are easy to be missed or misdiagnosed. LBCL-FA overall has a good prognosis with the potential for cure by surgery alone and postoperative chemotherapy may not be necessary.
Humans ; Male ; Middle Aged ; Atrial Fibrillation ; Epstein-Barr Virus Infections ; Fibrin/genetics* ; Herpesvirus 4, Human/genetics* ; In Situ Hybridization, Fluorescence ; Lymphoma, Large B-Cell, Diffuse/pathology* ; Myxoma ; Proto-Oncogene Proteins c-bcl-2/genetics* ; Proto-Oncogene Proteins c-bcl-6/genetics*

Cardiac myxoma is often discovered as an incidental finding and presents with various subtle symptoms and signs. Electrocardiographic findings are mostly non-specific. Atrial flutter or conduction abnormalities are known to be rare. We report a case of large left atrial myxoma that was diagnosed by transthoracic echocardiography at a primary care clinic. An asymptomatic, 71-year-old woman presented with serial abnormal electrocardiogram changes during a routine consultation. A diagnosis of left atrial myxoma was obtained through transthoracic echocardiography. We report this case with a review of literature on cardiac myxoma associated with arrhythmia.
Aged ; Arrhythmias, Cardiac ; Atrial Fibrillation ; Atrial Flutter ; Diagnosis ; Echocardiography ; Electrocardiography* ; Female ; Humans ; Incidental Findings ; Myxoma* ; Primary Health Care

BACKGROUND: Robotic surgery is an alternative to minimally invasive surgery. The aim of this study was to report on current trends in robotic thoracic and cardiovascular surgical techniques in Korea. METHODS: Data from the National Evidence-based Healthcare Collaborating Agency (NECA) between January 2006 and June 2012 were used in this study, including a total of 932 cases of robotic surgeries reported to NECA. The annual trends in the case volume, indications for robotic surgery, and distribution by hospitals and surgeons were analyzed in this study. RESULTS: Of the 932 cases, 591 (63%) were thoracic operations and 340 (37%) were cardiac operations. The case number increased explosively in 2007 and 2008. However, the rate of increase regained a steady state after 2011. The main indications for robotic thoracic surgery were pulmonary disease (n=271, 46%), esophageal disease (n=199, 34%), and mediastinal disease (n=117, 20%). The main indications for robotic cardiac surgery were valvular heart disease (n=228, 67%), atrial septal defect (n=79, 23%), and cardiac myxoma (n=27, 8%). Robotic thoracic and cardiovascular surgeries were performed in 19 hospitals. Three large volume hospitals performed 94% of the case volume of robotic cardiac surgery and 74% of robotic thoracic surgery. Centralization of robotic operation was significantly (p<0.0001) more common in cardiac surgery than in thoracic surgery. A total of 39 surgeons performed robotic surgeries. However, only 27% of cardiac surgeons and 23% of thoracic surgeons performed more than 10 cases of robotic surgery. CONCLUSION: Trend analysis of robotic and cardiovascular operations demonstrated a gradual increase in the surgical volume in Korea. Meanwhile, centralization of surgical cases toward specific surgeons in specific hospitals was observed.
Adenosine-5'-(N-ethylcarboxamide) ; Delivery of Health Care ; Esophageal Diseases ; Heart Septal Defects, Atrial ; Heart Valve Diseases ; Korea* ; Lung Diseases ; Mediastinal Diseases ; Myxoma ; Robotics ; Surgical Procedures, Minimally Invasive ; Thoracic Surgery

This is a report of a biatrial cardiac myxoma in a young man with a 10-month history of exertional dyspnea and palpitation. The echocardiogram revealed biatrial myxoma prolapsing through the mitral and tricuspid valves during diastole. All cardiac chambers were enlarged and dysfunctional. The electrocardiogram revealed a rapid ventricular response with atrial flutter rhythm. The masses were resected and diagnosed as myxoma by a histological examination. The follow-up echocardiogram revealed significant improvement in ventricular function and reduction in the cardiac chambers' volume. There was no evidence of myxoma recurrence. The most probable cause of the patient's heart failure was considered to be tachycardia-induced cardiomyopathy.
Atrial Flutter ; Cardiomyopathies ; Diastole ; Dyspnea ; Echocardiography ; Electrocardiography ; Follow-Up Studies ; Heart Failure ; Humans ; Myxoma* ; Recurrence ; Tricuspid Valve ; Ventricular Function

BACKGROUND: We report our initial experiences of robot-assisted cardiac surgery using the da Vinci Surgical System. METHODS: Between February 2010 and March 2014, 50 consecutive patients underwent minimally invasive robot-assisted cardiac surgery. RESULTS: Robot-assisted cardiac surgery was employed in two cases of minimally invasive direct coronary artery bypass, 17 cases of mitral valve repair, 10 cases of cardiac myxoma removal, 20 cases of atrial septal defect repair, and one isolated CryoMaze procedure. Average cardiopulmonary bypass time and average aorta cross-clamping time were 194.8+/-48.6 minutes and 126.1+/-22.6 minutes in mitral valve repair operations and 132.0+/-32.0 minutes and 76.1+/-23.1 minutes in myxoma removal operations, respectively. During atrial septal defect closure operations, the average cardiopulmonary bypass time was 128.3+/-43.1 minutes. The median length of stay was between five and seven days. The only complication was that one patient needed reoperation to address bleeding. There were no hospital mortalities. CONCLUSION: Robot-assisted cardiac surgery is safe and effective for mitral valve repair, atrial septal defect closure, and cardiac myxoma removal surgery. Reducing operative time depends heavily on the experience of the entire robotic surgical team.
Aorta ; Cardiopulmonary Bypass ; Coronary Artery Bypass ; Heart Septal Defects, Atrial ; Hemorrhage ; Hospital Mortality ; Humans ; Length of Stay ; Mitral Valve ; Myxoma ; Operative Time ; Reoperation ; Robotics ; Surgical Procedures, Minimally Invasive ; Thoracic Surgery*

No abstract available.
Heart Septal Defects, Atrial* ; Mitral Valve Insufficiency* ; Myxoma*

No abstract available.
Heart Septal Defects, Atrial* ; Mitral Valve Stenosis* ; Myxoma*

Myxomas are the most common type of primary cardiac tumour with 86% occurring in the left atrium. Right atrial myxomas is far less common. Patients usually present with progressive dyspnoea, fever, weight loss, right-sided heart failure, or pulmonary embolisation. We report the case of a 55-year-old man who presented with progressive dyspnoea and signs of right heart failure secondary to a large right atrial myxoma, which was diagnosed with a bedside transthoracic echocardiogram. This was successfully removed surgically.
Atrial Myxoma ; Dyspnea ; Heart Failure ; Treatment Outcome

The primary tumor of the heart is rare and the myxoma is the most common primary cardiac tumor. Sudden death due to cardiac myxoma is mainly with atrial myxoma, tumor embolization, or obstruction of blood flow at the mitral or tricuspid valve. Thus it appears that histologically benign but potentially lethal. This report describes an unusual cause of sudden unexpected death and the autopsy findings for a 51-years-old woman with left atrial myxoma. She complained fatigue and weight loss during 1 year, without dyspnea or other systemic symptoms. On autopsy, the left atrium is slightly enlarged as ball-shaped. Opening it, a smooth surfaced pale, round and lobulated mass is found, attached on left atrial septum. On cut section, it is dark brown to dark red colored with gelatinous appearance, and shows focal interstitial fibrosis, calcification and hemorrhage. We present a case diagnosed at post-mortem of an left atrial myxoma without any informations of clinical symptoms. The cardiac myxoma must considered for cause of sudden death to cardiac problem.
Atrial Septum ; Autopsy ; Death, Sudden ; Dyspnea ; Fatigue ; Female ; Fibrosis ; Gelatin ; Heart ; Heart Atria ; Heart Neoplasms ; Hemorrhage ; Humans ; Myxoma ; Tricuspid Valve ; Weight Loss

A 76-year-old female present to the emergency department with dysarthria, dizziness, dyspnea. The patient had hypertension and atrial fibrillation. Brain MRI revealed right cerebellar infarction. Transthoracic echocardiography showed a large round mass in the left atrium. Transesophageal echocardiography showed large complex echogenic round mass lesion attached on left atrial side of interatrial septum. Coronary angiogram revealed round movable mass lesion in left atrium with feeding arteries originated from right coronary artery. She underwent removal of mass and Maze operation, and pathologic finding was compatible with myxoma.
Aged ; Arteries ; Atrial Fibrillation ; Brain ; Coronary Vessels ; Dizziness ; Dysarthria ; Dyspnea ; Echocardiography ; Echocardiography, Transesophageal ; Emergencies ; Female ; Heart ; Heart Atria ; Heart Murmurs ; Humans ; Hypertension ; Infarction ; Myxoma