1.Antidiabetic and Beta Cell-Protection Activities of Purple Corn Anthocyanins.
Su Hee HONG ; Jee In HEO ; Jeong Hyeon KIM ; Sang Oh KWON ; Kyung Mok YEO ; Anna M BAKOWSKA-BARCZAK ; Paul KOLODZIEJCZYK ; Ok Hyun RYU ; Moon Ki CHOI ; Young Hee KANG ; Soon Sung LIM ; Hong Won SUH ; Sung Oh HUH ; Jae Yong LEE
Biomolecules & Therapeutics 2013;21(4):284-289
Antidiabetic and beta cell-protection activities of purple corn anthocyanins (PCA) were examined in pancreatic beta cell culture and db/db mice. Only PCA among several plant anthocyanins and polyphenols showed insulin secretion activity in culture of HIT-T15 cells. PCA had excellent antihyperglycemic activity (in terms of blood glucose level and OGTT) and HbA1c-decreasing activity when compared with glimepiride, a sulfonylurea in db/db mice. In addition, PCA showed efficient protection activity of pancreatic beta cell from cell death in HIT-T15 cell culture and db/db mice. The result showed that PCA had antidiabetic and beta cell-protection activities in pancreatic beta cell culture and db/db mice.
Animals
;
Anthocyanins*
;
Blood Glucose
;
Cell Culture Techniques
;
Cell Death
;
Insulin
;
Insulin-Secreting Cells
;
Mice
;
Passive Cutaneous Anaphylaxis
;
Plants
;
Polyphenols
;
Zea mays*
Result Analysis
Print
Save
E-mail