Esophageal angiolipoma is a rare disease with unspecific clinical manifestations.This paper reported a case of esophageal angiolipoma confirmed by upper gastrointestinal endoscopy and summarized the clinical manifestations,endoscopic and pathological features,treatment and prognosis of the patients by reviewing the relevant literature,aiming to provide references for clinical diagnosis and treatment of this disease in the future.
Humans ; Angiolipoma/pathology* ; Prognosis

Angiolipomas are composed of mature adipose tissue and blood vessels. Spinal angiolipomas are rare benign tumors with a good prognosis, and most symptoms are due to progressive compression of the spinal cord and root. The treatment of choice is total resection without any additional therapy. We report a case of an epidural angiolipoma on the lumbar spine in a 69-year-old man with weakness of the lower extremities. Lumbar magnetic resonance images revealed a well-enhanced epidural mass. He underwent laminectomy, and the tumor was completely removed. Pathologic examination confirmed the tumor was an angiolipoma. The patient’s symptoms gradually improved postoperatively.
Adipose Tissue ; Aged ; Angiolipoma* ; Blood Vessels ; Humans ; Laminectomy ; Lower Extremity ; Prognosis ; Spinal Cord ; Spine*

We report on an unusual case with infiltrating extradural spinal angiolipoma. Most spinal angiolipomas involve the thoracic spine and infiltrating ones are also located mainly at the thoracic levels rather than lumbar lesion. In particular, there are few cases of lumbar extradural infiltrating type spinal angiolipoma. One case is that of a 52-year-old female with infiltrating extradural spinal angiolipoma involving lumbar 4 (L4) vertebra, who underwent a L4-5 laminectomy and surgical removal of the tumor. We achieved satisfactory results with surgical treatment of the patient. Spinal angiolipoma has a benign course with a good postoperative outcome.
Angiolipoma* ; Female ; Humans ; Laminectomy ; Middle Aged ; Spine*

We report the case in a 72-year-old man who presented with a right inguinal mass and with a one month history that was initially interpreted as an inguinal hernia. Ultrasonography (US) and computed tomography (CT) demonstrated a right inguinal mass, including myxoid and fat component, extending from the right spermatic cord to the right inguinal subcutaneous layer. Mass excision was performed, and the diagnosis turned out to be angiomyxolipoma. Angiomyxolipoma is a rare tumor and the preoperative diagnosis of this disease is very difficult. However, angiomyxolipoma of the spermatic cord should be considered in the differential diagnosis in patients with an irreducible inguinal mass. Imaging diagnosis, such as US and CT may help to make a preoperative diagnosis.
Aged ; Angiolipoma/pathology/*radiography/*ultrasonography ; Hernia, Inguinal/ultrasonography ; Humans ; Male ; Myxoma/pathology/*radiography/*ultrasonography ; Spermatic Cord/*pathology/radiography/ultrasonography ; *Tomography, X-Ray Computed ; *Ultrasonography, Doppler

OBJECTIVE: To describe the MRI findings in ten patients of spinal epidural angiolipoma for differentiated diagnosis presurgery. MATERIALS AND METHODS: Ten surgically proved cases of spinal epidural angiolipomas were retrospectively reviewed, and the lesion was classified according to the MR findings. RESULTS: Ten tumors were located in the superior (n = 4), middle (n = 2), or inferior (n = 4) thoracic level. The mass, with the spindle shape, was located in the posterior epidural space and extended parallel to the long axis of the spine. All lesions contained a fat and vascular element. The vascular content, correlating with the presence of hypointense regions on T1-weighted imaging (T1WI) and hyperintense signals on T2-weighted imaging, had marked enhancement. However, there were no flow void signs on MR images. All tumors were divided into two types based on the MR features. In type 1 (n = 3), the mass was predominantly composed of lipomatous tissue (> 50%) and contained only a few small angiomatous regions, which had a trabeculated or mottled appear. In type 2 (n = 7), the mass, however, was predominantly composed of vascular components (> 50%), which presented as large foci in the center of the mass. CONCLUSION: Most spinal epidural angiolipomas exhibit hyperintensity on T1WI while the hypointense region on the noncontrast T1WI indicates to be vascular, which manifests an obvious enhancement with gadolinium administration.
Adult ; Aged ; Angiolipoma/*diagnosis/surgery ; Diagnosis, Differential ; Epidural Neoplasms/*diagnosis/surgery ; Female ; Follow-Up Studies ; Humans ; Laminectomy/methods ; Magnetic Resonance Imaging/*methods ; Male ; Middle Aged ; Retrospective Studies ; Thoracic Vertebrae ; Young Adult

Spinal angiolipomas are rare lesions usually found in the epidural space of the thoracic spine. The infiltrating type of spinal angiolipomas is extremely rare. This report presents the case and reviews the related literature. A 58-year-old man was presented with a 7-month history of progressive weakness and sensory change of lower extremities. Magnetic resonance images showed a well-enhanced mass infiltrating the vertebral foramen at the T4-5 level. Resection of the tumor was performed. Histological study revealed the tumor as an angiolipoma. The patient was relieved from symptoms after tumor resection.
Angiolipoma ; Epidural Space ; Humans ; Lower Extremity ; Magnetic Resonance Spectroscopy ; Middle Aged ; Spine

BACKGROUND: Stromal cells (SCs) of hemangioblastomas (HBs) have been regarded as true neoplastic components, but their ontogeny remains unclear. Convincing evidence suggests that embryonic mesenchymal cells may be the cells of origin of HBs. The aim of the present study was to investigate the immunophenotypic characteristics of neoplastic SCs using a set of markers against endothelial cells (ECs), vascular smooth muscle cells (vSMCs), mesenchymal stromal cells (MSCs), and pericytes. METHODS: Intracranial HBs (n=46), angiolipoma (n=9), and pyogenic granuloma (n=11) were retrieved and the immunophenotypic profile of SCs was determined by immune stainings. RESULTS: The MIB-1 labeling index was significantly higher in SCs compared to that of ECs and vSMCs, regardless of the type of lesion. The neoplastic SCs of HBs consistently expressed both MSC and pericyte markers, but did not express markers of ECs and vSMCs. Double immunofluorescent staining demonstrated that the neoplastic SCs of HBs expressing MSC or pericyte markers directly abutted onto the ECs of capillaries/venules. CONCLUSIONS: The results suggest that the neoplastic SCs of HBs share the immunophenotypic profile and distribution with those of pericyte-derived MSCs. Thus, HBs might originate from a distinctive population of pericyte-derived MSCs in the central nervous system.
Angiolipoma ; Central Nervous System ; Endothelial Cells ; Granuloma, Pyogenic ; Hemangioblastoma ; Mesenchymal Stromal Cells ; Muscle, Smooth, Vascular ; Pericytes ; Phenotype ; Stromal Cells

PURPOSE: We wanted to retrospectively determine the accuracy of an ultrasonographic diagnosis of superficial soft tissue masses in the extremities by using the histologic results as the reference standard. MATERIALS AND METHODS: From January 2005 to June 2010, 154 patients with soft tissue masses in the extremities and who underwent ultrasonographic evaluation followed by biopsy or resection were retrospectively evaluated. The ultrasonographic and histologic diagnoses of the soft tissue masses were lipoma, ganglion cyst, hemangioma, neurogenic tumor, giant cell tumor of the tendon sheath, epidermoid cyst, fibroma, glomus tumor, Baker's cyst and neurofibromatosis. RESULTS: Out of 154 patients, 114 (74%) patients showed concordance between the histologic diagnosis and the ultrasonographic diagnosis, and the remaining 40 (26%) patients did not. The diagnostic accuracy of each soft tissue mass was 95% for lipoma, 83% for ganglion cyst, 75% for hemangioma, 72% for neurogenic tumor, 50% for giant cell tumor of the tendon sheath, 43% for epidermoid cyst, 33% for fibroma and 100% each for glomus tumor, fibromatosis and Baker's cyst. Aside from these tumors, there were also sarcoma, malignant melanoma, elastofibroma, Kimura disease and pilomatricoma. Among the cases that showed discordance between the histologic diagnosis and the ultrasonographic diagnosis, three of them were notable; pilomatricoma being misdiagnosed as dermatofibroma protuberans, angiolipoma being misdiagnosed as vascular leiomyoma and malignant fibrous histiocytoma being misdiagnosed as a malignant soft tissue mass. CONCLUSION: The accuracy of an ultrasonographic diagnosis for soft tissue masses in the extremities varies greatly according to each type of mass. Lipoma, ganglion cyst, hemangioma, glomus tumor, neurogenic tumor and Baker's cyst showed a relatively high rate of concordance between the ultrasonographic diagnosis and the histologic diagnosis, but epidermoid cyst and fibroma showed a relatively lower rate of concordance.
Angiolipoma ; Angiolymphoid Hyperplasia with Eosinophilia ; Angiomyoma ; Biopsy ; Epidermal Cyst ; Extremities ; Fibroma ; Ganglion Cysts ; Giant Cell Tumors ; Glomus Tumor ; Hemangioma ; Histiocytoma, Benign Fibrous ; Histiocytoma, Malignant Fibrous ; Humans ; Lipoma ; Melanoma ; Pilomatrixoma ; Popliteal Cyst ; Retrospective Studies ; Sarcoma ; Soft Tissue Neoplasms ; Tendons

The role of ultrasound (US) is limited in the pathologic diagnosis of soft tissue tumors. It is possible to predict the pathologic results of some common soft tissue tumors with typical US features. We report the US and pathologic findings of three angiolipomas, one nodular hidradenoma, and one benign myofibroblastic tumor, which are uncommon soft tissue tumors with characteristic US findings.
Acrospiroma ; Angiolipoma ; Myofibroblasts

Hobnail hemangioma is a benign vascular tumor that typically presents as a small, solitary lesion on the trunk or limbs of young or middle-aged persons. Characteristically,the tumor has a targetoid appearance where a violaceous papule is surrounded by an ecchymotic rim. Hobnail hemangioma is characterized by a biphasic growth pattern of the neoplastic vascular structures and prominent matchstick-like endothelial cells. Based on the positivity of the endothelial cells for monoclonal antibody D2-40, it has been proposed that this tumor displays lymphatic differentiation. Angiolipomas are benign subcutaneous tumors that consist of mature adipocytes and blood vessels. They are usually multiple and they typically occur in young adults with an obvious male predilection. We describe here a case of hobnail hemangioma that occurred together with angiolipoma in an 8-year-old girl, who had a violaceous papule encircled by a peripheral ecchymotic halo on the left heel.
Adipocytes ; Angiolipoma ; Antibodies, Monoclonal, Murine-Derived ; Blood Vessels ; Child ; Endothelial Cells ; Extremities ; Heel ; Hemangioma ; Humans ; Male ; Young Adult