1.The Effect of Lower Eyelid Blepharoplasty on Corneal Biomechanical Parameters
Seyed Mohsen RAFIZADEH ; Hesam HASHEMIAN ; Masoud KHORRAMI-NEJAD ; Ali HADI ; Ghazal GHOCHANI
Korean Journal of Ophthalmology 2025;39(1):31-40
Purpose:
To determine the effect of lower eyelid blepharoplasty (LEB) surgery on corneal biomechanical parameters before and 4 months after the procedure.
Methods:
In this prospective longitudinal study, corneal biomechanical parameters measured by Corneal Visualization Scheimpflug Technology device were evaluated before and 4 months after LEB surgery.
Results:
The study included 19 eyelids of the right eyes of 19 patients who underwent LEB, with a mean age of 49.0 ± 10.1 years (range, 37–72 years). Four months after the procedure, significant increases were observed in the first applanation time (p = 0.007), second applanation time (p < 0.001), highest concavity time (p = 0.004), intraocular pressure (p = 0.009), and biomechanical-compensated intraocular pressure (p = 0.007). In addition, the absolute value of highest concavity delta arc length and stress-strain index showed a significant decrease after the LEB (p = 0.021 and p = 0.037, respectively). Other corneal biomechanical parameters did not show significant differences following the LEB procedure (p < 0.05).
Conclusions
The resection and repositioning of the fat pockets in LEB lead to biomechanical changes of the cornea in the direction of increasing corneal stiffness.
2.Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis
Syedda AYESHA ; Masood Muhammad KARIM ; Maria ALI ; Abdul Hadi SHAHID ; Salman Naseem ADIL
The Korean Journal of Gastroenterology 2025;85(1):73-77
Microangiopathic hemolytic anemia (MAHA) is a rare subtype of hemolytic anemia characterized by elevated hemolytic markers and red blood cell destruction. Though uncommon, MAHA can occur as a complication of acute pancreatitis because of the associated inflammatory response. Patients with MAHA secondary to pancreatitis show favorable outcomes when treated with plasma exchange.This paper presents the case of a patient diagnosed with acute pancreatitis-induced hemolytic anemia and thrombocytopenia, who was managed successfully with plasma exchange, steroids, and rituximab. Clinicians should maintain a high index of suspicion in patients with acute pancreatitis who present with anemia, thrombocytopenia, and schistocytes on peripheral smears, even in the absence of end-organ injuries and with normal ADAMTS13 activity. The early initiation of plasmapheresis can be lifesaving. The timely introduction of rituximab in cases where plasma exchange and steroids are insufficient, despite the ADAMTS13 activity status, may lead to better outcomes.
3.The Effect of Lower Eyelid Blepharoplasty on Corneal Biomechanical Parameters
Seyed Mohsen RAFIZADEH ; Hesam HASHEMIAN ; Masoud KHORRAMI-NEJAD ; Ali HADI ; Ghazal GHOCHANI
Korean Journal of Ophthalmology 2025;39(1):31-40
Purpose:
To determine the effect of lower eyelid blepharoplasty (LEB) surgery on corneal biomechanical parameters before and 4 months after the procedure.
Methods:
In this prospective longitudinal study, corneal biomechanical parameters measured by Corneal Visualization Scheimpflug Technology device were evaluated before and 4 months after LEB surgery.
Results:
The study included 19 eyelids of the right eyes of 19 patients who underwent LEB, with a mean age of 49.0 ± 10.1 years (range, 37–72 years). Four months after the procedure, significant increases were observed in the first applanation time (p = 0.007), second applanation time (p < 0.001), highest concavity time (p = 0.004), intraocular pressure (p = 0.009), and biomechanical-compensated intraocular pressure (p = 0.007). In addition, the absolute value of highest concavity delta arc length and stress-strain index showed a significant decrease after the LEB (p = 0.021 and p = 0.037, respectively). Other corneal biomechanical parameters did not show significant differences following the LEB procedure (p < 0.05).
Conclusions
The resection and repositioning of the fat pockets in LEB lead to biomechanical changes of the cornea in the direction of increasing corneal stiffness.
4.Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis
Syedda AYESHA ; Masood Muhammad KARIM ; Maria ALI ; Abdul Hadi SHAHID ; Salman Naseem ADIL
The Korean Journal of Gastroenterology 2025;85(1):73-77
Microangiopathic hemolytic anemia (MAHA) is a rare subtype of hemolytic anemia characterized by elevated hemolytic markers and red blood cell destruction. Though uncommon, MAHA can occur as a complication of acute pancreatitis because of the associated inflammatory response. Patients with MAHA secondary to pancreatitis show favorable outcomes when treated with plasma exchange.This paper presents the case of a patient diagnosed with acute pancreatitis-induced hemolytic anemia and thrombocytopenia, who was managed successfully with plasma exchange, steroids, and rituximab. Clinicians should maintain a high index of suspicion in patients with acute pancreatitis who present with anemia, thrombocytopenia, and schistocytes on peripheral smears, even in the absence of end-organ injuries and with normal ADAMTS13 activity. The early initiation of plasmapheresis can be lifesaving. The timely introduction of rituximab in cases where plasma exchange and steroids are insufficient, despite the ADAMTS13 activity status, may lead to better outcomes.
5.The Effect of Lower Eyelid Blepharoplasty on Corneal Biomechanical Parameters
Seyed Mohsen RAFIZADEH ; Hesam HASHEMIAN ; Masoud KHORRAMI-NEJAD ; Ali HADI ; Ghazal GHOCHANI
Korean Journal of Ophthalmology 2025;39(1):31-40
Purpose:
To determine the effect of lower eyelid blepharoplasty (LEB) surgery on corneal biomechanical parameters before and 4 months after the procedure.
Methods:
In this prospective longitudinal study, corneal biomechanical parameters measured by Corneal Visualization Scheimpflug Technology device were evaluated before and 4 months after LEB surgery.
Results:
The study included 19 eyelids of the right eyes of 19 patients who underwent LEB, with a mean age of 49.0 ± 10.1 years (range, 37–72 years). Four months after the procedure, significant increases were observed in the first applanation time (p = 0.007), second applanation time (p < 0.001), highest concavity time (p = 0.004), intraocular pressure (p = 0.009), and biomechanical-compensated intraocular pressure (p = 0.007). In addition, the absolute value of highest concavity delta arc length and stress-strain index showed a significant decrease after the LEB (p = 0.021 and p = 0.037, respectively). Other corneal biomechanical parameters did not show significant differences following the LEB procedure (p < 0.05).
Conclusions
The resection and repositioning of the fat pockets in LEB lead to biomechanical changes of the cornea in the direction of increasing corneal stiffness.
6.Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis
Syedda AYESHA ; Masood Muhammad KARIM ; Maria ALI ; Abdul Hadi SHAHID ; Salman Naseem ADIL
The Korean Journal of Gastroenterology 2025;85(1):73-77
Microangiopathic hemolytic anemia (MAHA) is a rare subtype of hemolytic anemia characterized by elevated hemolytic markers and red blood cell destruction. Though uncommon, MAHA can occur as a complication of acute pancreatitis because of the associated inflammatory response. Patients with MAHA secondary to pancreatitis show favorable outcomes when treated with plasma exchange.This paper presents the case of a patient diagnosed with acute pancreatitis-induced hemolytic anemia and thrombocytopenia, who was managed successfully with plasma exchange, steroids, and rituximab. Clinicians should maintain a high index of suspicion in patients with acute pancreatitis who present with anemia, thrombocytopenia, and schistocytes on peripheral smears, even in the absence of end-organ injuries and with normal ADAMTS13 activity. The early initiation of plasmapheresis can be lifesaving. The timely introduction of rituximab in cases where plasma exchange and steroids are insufficient, despite the ADAMTS13 activity status, may lead to better outcomes.
7.The Effect of Lower Eyelid Blepharoplasty on Corneal Biomechanical Parameters
Seyed Mohsen RAFIZADEH ; Hesam HASHEMIAN ; Masoud KHORRAMI-NEJAD ; Ali HADI ; Ghazal GHOCHANI
Korean Journal of Ophthalmology 2025;39(1):31-40
Purpose:
To determine the effect of lower eyelid blepharoplasty (LEB) surgery on corneal biomechanical parameters before and 4 months after the procedure.
Methods:
In this prospective longitudinal study, corneal biomechanical parameters measured by Corneal Visualization Scheimpflug Technology device were evaluated before and 4 months after LEB surgery.
Results:
The study included 19 eyelids of the right eyes of 19 patients who underwent LEB, with a mean age of 49.0 ± 10.1 years (range, 37–72 years). Four months after the procedure, significant increases were observed in the first applanation time (p = 0.007), second applanation time (p < 0.001), highest concavity time (p = 0.004), intraocular pressure (p = 0.009), and biomechanical-compensated intraocular pressure (p = 0.007). In addition, the absolute value of highest concavity delta arc length and stress-strain index showed a significant decrease after the LEB (p = 0.021 and p = 0.037, respectively). Other corneal biomechanical parameters did not show significant differences following the LEB procedure (p < 0.05).
Conclusions
The resection and repositioning of the fat pockets in LEB lead to biomechanical changes of the cornea in the direction of increasing corneal stiffness.
8.Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis
Syedda AYESHA ; Masood Muhammad KARIM ; Maria ALI ; Abdul Hadi SHAHID ; Salman Naseem ADIL
The Korean Journal of Gastroenterology 2025;85(1):73-77
Microangiopathic hemolytic anemia (MAHA) is a rare subtype of hemolytic anemia characterized by elevated hemolytic markers and red blood cell destruction. Though uncommon, MAHA can occur as a complication of acute pancreatitis because of the associated inflammatory response. Patients with MAHA secondary to pancreatitis show favorable outcomes when treated with plasma exchange.This paper presents the case of a patient diagnosed with acute pancreatitis-induced hemolytic anemia and thrombocytopenia, who was managed successfully with plasma exchange, steroids, and rituximab. Clinicians should maintain a high index of suspicion in patients with acute pancreatitis who present with anemia, thrombocytopenia, and schistocytes on peripheral smears, even in the absence of end-organ injuries and with normal ADAMTS13 activity. The early initiation of plasmapheresis can be lifesaving. The timely introduction of rituximab in cases where plasma exchange and steroids are insufficient, despite the ADAMTS13 activity status, may lead to better outcomes.
9.The Effect of Lower Eyelid Blepharoplasty on Corneal Biomechanical Parameters
Seyed Mohsen RAFIZADEH ; Hesam HASHEMIAN ; Masoud KHORRAMI-NEJAD ; Ali HADI ; Ghazal GHOCHANI
Korean Journal of Ophthalmology 2025;39(1):31-40
Purpose:
To determine the effect of lower eyelid blepharoplasty (LEB) surgery on corneal biomechanical parameters before and 4 months after the procedure.
Methods:
In this prospective longitudinal study, corneal biomechanical parameters measured by Corneal Visualization Scheimpflug Technology device were evaluated before and 4 months after LEB surgery.
Results:
The study included 19 eyelids of the right eyes of 19 patients who underwent LEB, with a mean age of 49.0 ± 10.1 years (range, 37–72 years). Four months after the procedure, significant increases were observed in the first applanation time (p = 0.007), second applanation time (p < 0.001), highest concavity time (p = 0.004), intraocular pressure (p = 0.009), and biomechanical-compensated intraocular pressure (p = 0.007). In addition, the absolute value of highest concavity delta arc length and stress-strain index showed a significant decrease after the LEB (p = 0.021 and p = 0.037, respectively). Other corneal biomechanical parameters did not show significant differences following the LEB procedure (p < 0.05).
Conclusions
The resection and repositioning of the fat pockets in LEB lead to biomechanical changes of the cornea in the direction of increasing corneal stiffness.
10.Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis
Syedda AYESHA ; Masood Muhammad KARIM ; Maria ALI ; Abdul Hadi SHAHID ; Salman Naseem ADIL
The Korean Journal of Gastroenterology 2025;85(1):73-77
Microangiopathic hemolytic anemia (MAHA) is a rare subtype of hemolytic anemia characterized by elevated hemolytic markers and red blood cell destruction. Though uncommon, MAHA can occur as a complication of acute pancreatitis because of the associated inflammatory response. Patients with MAHA secondary to pancreatitis show favorable outcomes when treated with plasma exchange.This paper presents the case of a patient diagnosed with acute pancreatitis-induced hemolytic anemia and thrombocytopenia, who was managed successfully with plasma exchange, steroids, and rituximab. Clinicians should maintain a high index of suspicion in patients with acute pancreatitis who present with anemia, thrombocytopenia, and schistocytes on peripheral smears, even in the absence of end-organ injuries and with normal ADAMTS13 activity. The early initiation of plasmapheresis can be lifesaving. The timely introduction of rituximab in cases where plasma exchange and steroids are insufficient, despite the ADAMTS13 activity status, may lead to better outcomes.

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