Objective To explore the impact of digital upgrading of public hospitals on operational efficiency,and to provide theoretical and practical guidance for the application of digital technology in the medical field.Methods The digital transformation of H hospital were collected through semi-structured interviews and field observations,and the exploratory single case study method was used for analysis and discussion.Results Digital upgrading significantly improved the operational efficiency of public hospitals by promoting information flow,strengthening hospital gover-nance and optimizing human resource allocation.Hospital culture,organizational structure and information literacy af-fected the effect of digital upgrading.Conclusion Digital upgrading has played a positive role in improving the opera-tional efficiency of public hospitals.In order to maximize its benefits,hospitals can strengthen the top-level design of digital construction,strengthen the cultivation of compound talents,pay attention to data governance and infor-mation security,promote departmental coordination and promote the iterative upgrading of digital reform.

Objective To explore the impact of digital upgrading of public hospitals on operational efficiency,and to provide theoretical and practical guidance for the application of digital technology in the medical field.Methods The digital transformation of H hospital were collected through semi-structured interviews and field observations,and the exploratory single case study method was used for analysis and discussion.Results Digital upgrading significantly improved the operational efficiency of public hospitals by promoting information flow,strengthening hospital gover-nance and optimizing human resource allocation.Hospital culture,organizational structure and information literacy af-fected the effect of digital upgrading.Conclusion Digital upgrading has played a positive role in improving the opera-tional efficiency of public hospitals.In order to maximize its benefits,hospitals can strengthen the top-level design of digital construction,strengthen the cultivation of compound talents,pay attention to data governance and infor-mation security,promote departmental coordination and promote the iterative upgrading of digital reform.

Objective To explore the impact of digital upgrading of public hospitals on operational efficiency,and to provide theoretical and practical guidance for the application of digital technology in the medical field.Methods The digital transformation of H hospital were collected through semi-structured interviews and field observations,and the exploratory single case study method was used for analysis and discussion.Results Digital upgrading significantly improved the operational efficiency of public hospitals by promoting information flow,strengthening hospital gover-nance and optimizing human resource allocation.Hospital culture,organizational structure and information literacy af-fected the effect of digital upgrading.Conclusion Digital upgrading has played a positive role in improving the opera-tional efficiency of public hospitals.In order to maximize its benefits,hospitals can strengthen the top-level design of digital construction,strengthen the cultivation of compound talents,pay attention to data governance and infor-mation security,promote departmental coordination and promote the iterative upgrading of digital reform.

Objective To explore the impact of digital upgrading of public hospitals on operational efficiency,and to provide theoretical and practical guidance for the application of digital technology in the medical field.Methods The digital transformation of H hospital were collected through semi-structured interviews and field observations,and the exploratory single case study method was used for analysis and discussion.Results Digital upgrading significantly improved the operational efficiency of public hospitals by promoting information flow,strengthening hospital gover-nance and optimizing human resource allocation.Hospital culture,organizational structure and information literacy af-fected the effect of digital upgrading.Conclusion Digital upgrading has played a positive role in improving the opera-tional efficiency of public hospitals.In order to maximize its benefits,hospitals can strengthen the top-level design of digital construction,strengthen the cultivation of compound talents,pay attention to data governance and infor-mation security,promote departmental coordination and promote the iterative upgrading of digital reform.

Objective To explore the impact of digital upgrading of public hospitals on operational efficiency,and to provide theoretical and practical guidance for the application of digital technology in the medical field.Methods The digital transformation of H hospital were collected through semi-structured interviews and field observations,and the exploratory single case study method was used for analysis and discussion.Results Digital upgrading significantly improved the operational efficiency of public hospitals by promoting information flow,strengthening hospital gover-nance and optimizing human resource allocation.Hospital culture,organizational structure and information literacy af-fected the effect of digital upgrading.Conclusion Digital upgrading has played a positive role in improving the opera-tional efficiency of public hospitals.In order to maximize its benefits,hospitals can strengthen the top-level design of digital construction,strengthen the cultivation of compound talents,pay attention to data governance and infor-mation security,promote departmental coordination and promote the iterative upgrading of digital reform.

Objective To explore the impact of digital upgrading of public hospitals on operational efficiency,and to provide theoretical and practical guidance for the application of digital technology in the medical field.Methods The digital transformation of H hospital were collected through semi-structured interviews and field observations,and the exploratory single case study method was used for analysis and discussion.Results Digital upgrading significantly improved the operational efficiency of public hospitals by promoting information flow,strengthening hospital gover-nance and optimizing human resource allocation.Hospital culture,organizational structure and information literacy af-fected the effect of digital upgrading.Conclusion Digital upgrading has played a positive role in improving the opera-tional efficiency of public hospitals.In order to maximize its benefits,hospitals can strengthen the top-level design of digital construction,strengthen the cultivation of compound talents,pay attention to data governance and infor-mation security,promote departmental coordination and promote the iterative upgrading of digital reform.

Objective To explore the impact of digital upgrading of public hospitals on operational efficiency,and to provide theoretical and practical guidance for the application of digital technology in the medical field.Methods The digital transformation of H hospital were collected through semi-structured interviews and field observations,and the exploratory single case study method was used for analysis and discussion.Results Digital upgrading significantly improved the operational efficiency of public hospitals by promoting information flow,strengthening hospital gover-nance and optimizing human resource allocation.Hospital culture,organizational structure and information literacy af-fected the effect of digital upgrading.Conclusion Digital upgrading has played a positive role in improving the opera-tional efficiency of public hospitals.In order to maximize its benefits,hospitals can strengthen the top-level design of digital construction,strengthen the cultivation of compound talents,pay attention to data governance and infor-mation security,promote departmental coordination and promote the iterative upgrading of digital reform.

Objective To explore the impact of digital upgrading of public hospitals on operational efficiency,and to provide theoretical and practical guidance for the application of digital technology in the medical field.Methods The digital transformation of H hospital were collected through semi-structured interviews and field observations,and the exploratory single case study method was used for analysis and discussion.Results Digital upgrading significantly improved the operational efficiency of public hospitals by promoting information flow,strengthening hospital gover-nance and optimizing human resource allocation.Hospital culture,organizational structure and information literacy af-fected the effect of digital upgrading.Conclusion Digital upgrading has played a positive role in improving the opera-tional efficiency of public hospitals.In order to maximize its benefits,hospitals can strengthen the top-level design of digital construction,strengthen the cultivation of compound talents,pay attention to data governance and infor-mation security,promote departmental coordination and promote the iterative upgrading of digital reform.

Objective     To explore the relationship between preoperative fasting plasma glucose (FPG) and postoperative pulmonary complications (PPCs) in type 2 diabetic patients undergoing elective thoracoscopic lung resection, and provide a reference for prediction and prevention of PPCs in the clinic. Methods     A retrospective analysis was performed on the type 2 diabetic patients who underwent elective thoracoscopic lung resection for the first time in our hospital from January 2017 to March 2021. According to the level of FPG one day before the operation, the patients were divided into three groups: a hypoglycemia group (<6.1 mmol/L), a medium level blood glucose group (≥6.1 mmol/L and <8.0 mmol/L) and a high blood glucose group (≥8.0 mmol/L). Besides, the patients were divided into a PPCs group and a non-PPCs group according to whether PPCs occurred. The risk factors for PPCs were analyzed by logistic regression analysis, and the predictive value of preoperative FPG level on PPCs was estimated by the area under the receiver operating characteristic curve (AUC). Results     A total of 130 patients were included, including 75 (57.7%) males and 55 (42.3%) females with an average age of 63.5±9.0 years. Logistic regression analysis showed that compared to non-PPCs patients, the level of preoperative FPG (P=0.023) and smoking history ratio (P=0.036) were higher and the operation time was longer (P=0.004) in the PPCs patients. High FPG level on preoperative day 1 and longer operation time were associated with PPCs risk. Besides, the preoperative FPG of 6.79 mmol/L was the threshold value to predict the occurrence of PPCs [AUC=0.653, 95%CI (0.559, 0.747), P=0.003]. Conclusion     There is a certain correlation between preoperative FPG level and postoperative PPCs, which may be used as an index to predict the occurrence of PPCs.

Objective:To evaluate the relationship between nuclear factor E2-related factor 2 (Nrf2) and ferroptosis during lung ischemia-reperfusion (I/R) in rats.Methods:Fifty-four healthy male Sprague-Dawley rats, weighing 220-250 g, were divided into 3 groups ( n=18 each) using a random number table method: sham operation group (Sham group), lung I/R group (IR group), and lung I/R+ Nrf2 agonist sulforaphane group (IR+ SFP group). Lung I/R model was developed by clamping the left pulmonary hilum for 60 min followed by 120 min of reperfusion.In IR+ SFP group, SFP 500 μg/kg was intraperitoneally injected at 3 days before lung ischemia once a day for 3 consecutive days, and the model was developed at 2 h after the end of administration.The rats were sacrificed at the end of reperfusion, and the bronchoalveolar lavage fluid (BALF) was collected to determine the protein concentration (using bicinchoninic acid method), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) concentrations (by enzyme-linked immunosorbent assay). The animals were then sacrificed, and lung tissue specimens were harvested for microscopic examination of the pathological changes (with a transmission electron microscope) and for determination of wet/dry weight (W/D) ratio, contents of iron, malondialdehyde (MDA) and glutathione (GSH) (by chemical colorimetric) and expression of nuclear Nrf2, glutathione peroxidase 4 (GPX4) and acyl-CoA synthetase long-chain family member 4 (ACSL4) (by Western blot). Results:Compared with Sham group, the concentrations of protein, IL-6 and TNF-α in BALF, W/D ratio, and contents of Fe 2+ and MDA were significantly increased, GSH content was decreased, GPX4 expression was down-regulated, the expression of nuclear Nrf2and ACSL4 was up-regulated ( P<0.05), and the mitochondrial morphology of type Ⅱalveolar epithelial cells showed the characteristic changes of ferroptosis, including the presence of smaller mitochondria and reduced cristae in IR group.Compared with IR group, the concentrations of protein, IL-6 and TNF-α in BALF, W/D ratio, and contents of Fe 2+ and MDA were significantly decreased, GSH content was increased, the expression of nuclear Nrf2 and GPX4 expression was up-regulated, ACSL4 expression was down-regulated ( P<0.05), and the pathological changes of lung tissues were significantly attenuated in IR+ SFP group. Conclusions:Nrf2 can inhibit ferroptosis during lung I/R and is involved in the endogenous protective mechanism in rats.