Objective:To investigate the epidemic status of drinking-tea type endemic fluorosis (fluorosis for short) in Inner Mongolia Autonomous Region (Inner Mongolia for short), and to provide theoretical basis and basic data for formulation and evaluation of prevention and control measures.Methods:From May to October 2022, a cross-sectional survey was conducted in key areas (168 administrative villages in 6 leagues or cities) identified in the 2019 regional census with tea drinking habits, daily per capita intake of tea fluoride > 3.5 mg, and patients with skeletal fluorosis. The drinking condition of brick tea in 10 households of each administrative village was investigated, and the brick tea samples were collected to detect fluoride level. The prevalence of dental fluorosis in children aged 8 - 12 and skeletal fluorosis in adults aged 16 and older was investigated, and urine samples of patients with skeletal fluorosis were collected to detect urinary fluoride levels.Results:Totally 98.40% (1 657/1 684) of the households in the surveyed areas had a habit of drinking brick tea, with an annual per capita consumption of brick tea and a daily per capita intake of tea fluoride of 5.07 kg and 5.38 mg, respectively. The qualified rate of fluoride level in brick tea samples was 55.64% (922/1 657), the average fluoride level of all other brick tea varieties exceeded the national standard limit (300 mg/kg) except for black brick tea (291.08 mg/kg). Totally 2 747 children aged 8 to 12 were examined, with a detection rate of 13.91% (382/2 747) for dental fluorosis. The disease was mainly mild. There was no statistically significant difference in the detection rate of dental fluorosis among different age groups (χ 2 = 5.53, P = 0.238). Totally 71 708 adults aged 16 and older were examined, and the detection rate of skeletal fluorosis was 1.02% (734/71 708). Patients were mainly aged between 50 and 70 years old, and the condition in each age group was mainly mild. Totally 715 urine samples of skeletal fluorosis patients were collected and tested, and 55.24% (395/715) of the urine samples had fluoride levels higher than 1.6 mg/L. Conclusions:In Inner Mongolia, the proportion of high fluoride brick tea in endemic areas of drinking-tea type fluorosis is high. The detection rates of dental fluorosis in children and skeletal fluorosis in adults are relatively high. The prevention and control situation of drinking-tea type fluorosis is still serious.

Objective:In this study, the role of IL-17 in the pathogenesis of idiopathic myositis (IIM) was preliminarily investigated by detecting the expression of IL-17 in the muscle tissues of patients with idiopathic inflammatory myositis (IIM) and normal controls.Methods:Twenty-eight patients (20 in DM group with dermatomyositis and 8 in ASS group with anti-synthase syndrome) who were diagnosed with IIM after muscle biopsy and autoantibody detection in our hospital for the first time from October 2019 to August 2021 were included. Twelve cases with normal muscle tissue matched for age and sex were included as the control group. Western blot and immunohistochemical techniques were used to detect the expression level of IL-17 in muscle tissue, and enzyme-linked immunosorbent assay (ELISA) was used to detect serum IL-6. Mann-Whitney U rank sum test was used to compare the difference of IL-17 expression in muscle tissue between the two groups, and non-parametric test was used for comparison between multiple groups. Chi-square test and Spearman rank correlation analysis were used, and P<0.05 was considered statistically significant. Results:① The expression level of IL-17 in IIM muscle tissue[1.63(1.30, 2.05)pg/ml was higher than that in control group[1.00(0.96, 1.00)pg/ml, and the difference was statistically significant ( Z=-3.52, P<0.001). The difference be-tween DM[1.94(1.58, 2.14)pg/ml] and ASS[1.22(1.04,1.55)pg/ml was statistically significant ( Z=-3.20, P=0.001). ② Compared with healthy control group [4.08(3.01, 5.67)pg/ml, the expression of IL-6 in ⅡM serum[8.88(4.93, 13.64) was high ( Z=-3.01, P=0.003), which was positively correlated with the expression of IL-17 ( r=0.42, P=0.027). ③ The ex-pression of IL-17 in muscle tissue was higher in IIM associated with muscle weakness[1.91(1.56, 2.14) pg/ml vs 1.50(1.04, 2.00)pg/ml] ( Z=-1.38, P=0.020), dysphagia [2.06(1.99, 2.14)pg/ml vs 1.62(1.52, 2.04)pg/ml] ( Z=-2.74, P=0.010) and skin involvement[1.98(1.57, 2.14)pg/ml vs 1.04(0.86, 1.61)pg/ml] ( Z=-3.20, P<0.010), and the differences were statistically significant ( P<0.05). ④IL-17 was positively correlated with Myoact-total activity ( r=0.51, P=0.006), Myoact-muscle symptom ( r=0.45, P=0.016), erythrocyte sedimen tation ( r=0.48, P=0.020), and myoenzyme increase ( r=0.56, P=0.002). Conclusion:IL-17 and IL-6 are synergistically involved in the pathogenesis of IIM, suggesting that IL-17 is the therapeutic target of IIM.

Objective:To investigate the construction of containing CT imaging features Nomograms model of postoperative intraluminal thromus (ILT) formation in patients with aortic dissective aneurysm (ADA).Methods:One hundred and twenty patients with Stanford type B ADA treated with overlapping stent endoluminal repair and multilayer spiral CT (MSCT) examination in Affiliated Hospital of Jining Medical College from May 2020 to February 2022 were selected. The patients were divided into the modeling population (84 patients) and the validation population (36 patients) according to a 7∶3 ratio. The factors influencing postoperative ILT formation in ADA patients were analyzed by univariate and Logistic multifactor regression models, and the prediction model of postoperative ILT formation was constructed based on the influencing factors.Results:In the modeled population, the rate of ILT formation within 1 month after luminal repair with overlapping stents was 27.38%(23/84), including 5 cases in the aortic arch and 18 cases in the abdominal aorta. In the modeled population, the results of univariate analysis showed that the sex, age, body mass index(BMI), smoking, drinking, hypertension, hyperlipidemia, rupture diameter, rupture distance from left subclavicular artery, involvement of important branches, uneven thickening of aneurysm wall, low density on plain scan and operation timing between the ILT formation group and non-ILT formation group had no statistically significant ( P>0.05). The diabetes mellitus, irregular inner wall, calcified plaque, postoperative anticoagulant therapy, B-type brain natriuretic peptide (BNP), fibrinogen (Fib), D-dimer (D-D) and C-reactive protein (CRP) between the two groups had statistical differences: 43.48%(10/23) vs. 11.48%(7/61), 86.96%(20/23) vs. 57.38%(35/61), 91.30%(21/23) vs. 62.30%(38/61), 21.74%(5/23) vs. 57.38%(35/61), (523.60 ± 128.74) ng/L vs.(271.83 ± 109.65) ng/L, (3.82 ± 0.96) g/L vs. (2.85 ± 0.83) g/L, (601.37 ± 75.62) μg/L vs. (389.20 ± 68.79)μg/L, (0.63 ± 0.19) mg/L vs. (0.48 ± 0.15) mg/L, P<0.05. The results of Logistic multifactor regression analysis showed that diabetes mellitus, irregular inner wall, calcified plaque, postoperative anticoagulant therapy and BNP, Fib, D-D CRP levels were influential factors for postoperative ILT formation in Stanford type B ADA patients ( P<0.05). The C-index of the model was 0.903 and 0.894 for the modeled and validated populations, respectively, which had good discrimination and was good at predicting ILT formation after operation in Stanford type B ADA patients. The model had good clinical utility in predicting postoperative ILT formation in Stanford B ADA patients. Conclusions:The Nomograms model can help to screen and identify patients with high risk of ILT formation at an early clinical stage.

Objective:To investigate the safety and efficacy of FOLFOX (5-fluorouracil + calcium folinate + oxaliplatin) hepatic arterial infusion chemotherapy (FOLFOX-HAIC) combined with immune and targeted therapy as triple combination therapy for patients with single China Liver Cancer Staging (CNLC) Ⅰb hepatocellular carcinoma.Methods:A total of 20 patients with single CNLC Ⅰb hepatocellular carcinoma who received FOLFOX-HAIC combined with immune and targeted therapy as triple combination therapy in the First Affiliated Hospital of Guangxi Medical University from October 2021 to August 2022 were included. The clinical data of all patients was retrospectively analyzed. There were 18 males and 2 females, with the age of (55.1±9.9) years. Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 and Modified Response Evaluation Criteria in Solid Tumors (mRECIST) were used to evaluate the efficacy of FOLFOX-HAIC combined with immune and targeted therapy, and the clinical safety of triple combination therapy was evaluated by common terminology criteria for adverse events 4.0.Results:According to RECIST 1.1, objective response rate of 20 patients was 70.0% (14/20) and disease control rate was 100.0% (20/20) after 2 cycles of treatment (one cycle of FOLFOX-HAIC plus programmed death-1 antibody). According to mRECIST, objective response rate was 90.0% (18/20) and the disease control rate was 100.0% (20/20) after 2 cycles of treatment. Following the treatment, 12 patients (60.0%) received liver tumor resection, and all of them achieved R 0 resection, 2 patients (10.0%) received radiotherapy, 3 patients (15.0%) stopped drug treatment for surgery, 2 patients (10.0%) refused surgery, and 1 patient (5.0%) died of multiple organ failure caused by immune hepatitis. According to pathological results, 3 patients (25.0%, 3/12) achieved pathological complete response, and 4 patients (33.3%, 4/12) achieved major pathological response. In the safety evaluation, the overall incidence of adverse events was 100.0% (20/20). Seven patients (35.0%) had grade 3 adverse events and 1 patient (5.0%) died of multiple organ failure due to immune hepatitis (grade 5). Grade 1-3 adverse events could be relieved after symptomatic treatment. Conclusion:The triple combination therapy of FOLFOX-HAIC combined with immune and targeted therapy is safe and has high objective response rate and disease control rate, which could be a new strategy for the neoadjuvant treatment of hepatocellular carcinoma.

Objective:To study the effects of water fluoride and tea fluoride on the occurrence of dental fluorosis in children, and to provide a basis for scientific prevention and control of the disease.Methods:From April to September 2020, Baolongshan Town with qualified water fluoride but no habit of drinking brick tea, Xingyao Town with qualified water fluoride and habit of drinking brick tea, Baokang Town with exceeded water fluoride but no habit of drinking brick tea, and Wuliyasitai Town with exceeded water fluoride and habit of drinking brick tea were selected as survey sites in Inner Mongolia Autonomous Region based on historical monitoring data. In all Gacha (villages) of 4 towns, a survey was carried out on residents' drinking water, brick tea drinking habits and children's dental fluorosis detection, and the water fluoride, tea fluoride exceeding standard rates, daily per capita intake of brick tea fluoride and the detection rate of children's dental fluorosis were calculated. At the same time, multivariate logistic regression was used to analyze the influencing factors affecting the occurrence of dental fluorosis in children.Results:In 2020, a total of 165 water samples were collected in 4 towns of Inner Mongolia Autonomous Region, and the total water fluoride exceeding standard rate was 38.18% (63/165). A total of 320 tea samples were collected, the tea fluoride exceeding standard rates in Xingyao Town and Wuliyasitai Town were 96.38% (213/221) and 89.90% (89/99), respectively; the daily per capita intake of brick tea fluoride was 5.67 and 7.35 mg, respectively. A total of 1 652 children were examined for dental fluorosis, and 639 cases were detected, the detection rate was 38.68%. The detection rates of dental fluorosis in boys and girls were 37.18% (322/866) and 40.33% (317/786), respectively, with no significant difference between sexes (χ 2 = 1.72, P = 0.104); the detection rates of dental fluorosis in children aged 8 - 12 years were 43.93% (105/239), 40.50% (147/363), 46.57% (163/350), 30.56% (88/288) and 33.01% (136/412), respectively, with statistical significant difference among ages (χ 2 = 26.07, P < 0.001); the detection rates of dental fluorosis in children in Baolongshan, Baokang, Xingyao and Wuliyasitai towns were 0.68% (2/293), 14.09% (31/220), 24.79% (89/359) and 66.28% (517/780), respectively, with statistical significant differences among regions (χ 2 = 213.05, P < 0.001). Multivariate logistic regression analysis showed that when the fluoride content in water was 1.2 - < 2.0, 2.0 - < 2.5, and ≥2.5 mg/L, the risk of dental fluorosis in children was 3.93, 6.60, and 9.02 times of water fluoride content < 1.2 mg/L; when the daily per capita intakes of brick tea fluoride was 3.6 - 7.0 and > 7.0 mg, the risk of dental fluorosis in children was 2.94 and 3.90 times of daily per capita intakes of brick tea fluoride ≤3.5 mg; the risk of dental fluorosis in children aged 10 years was 1.81 times of children aged 8 years; the risk of dental fluorosis in children in Xingyao, Baokang, and Wuliyasitai towns was 22.35, 40.93, and 151.58 times of Baolongshan Town, respectively. Conclusions:The prevalence of dental fluorosis in children still exists in Inner Mongolia Autonomous Region, and the detection rate of dental fluorosis is high. High water fluoride and high tea fluoride are the main risk factors for dental fluorosis in children.

Objective:To investigate the distribution of fluoride content in water and dental fluorosis in children and skeletal fluorosis in adults in drinking water-borne endemic fluorosis areas of Inner Mongolia Autonomous Region.Methods:From April to November 2021, all natural villages in the drinking water-borne endemic fluorosis areas of Inner Mongolia Autonomous Region were investigated on the status quo of water improvement and water fluoride monitoring. At the same time, all children aged 8 - 12 and adults aged 18 and older were examined for dental fluorosis and skeletal fluorosis, respectively, and the detection rates were calculated.Results:There were 9 465 villages in drinking water-borne endemic fluorosis areas in Inner Mongolia Autonomous Region, among which 8 920 villages had completed the water improvement, with a water improvement rate of 94.24% (8 920/9 465); 8 664 villages had completed the water improvement with qualified water fluoride, and the qualified rate of water improvement was 97.13% (8 664/8 920). A total of 80 915 children aged 8 - 12 in the villages underwent dental fluorosis examination, and 4 868 children were diagnosed with dental fluorosis, with a detection rate of 6.02%. A total of 3 545 915 adults aged 18 and older in the villages were examined for skeletal fluorosis, and 3 567 adults were diagnosed with skeletal fluorosis, with a detection rate of 0.10%.Conclusion:The water improvement rate and qualified rate of water improvement in drinking water-borne endemic fluorosis areas in Inner Mongolia Autonomous Region are high, while both of the detection rates of dental fluorosis in children and skeletal fluorosis in adults are relatively low.

Objective:To study the prevalence of skeletal fluorosis in drinking-water-borne endemic fluorosis areas in Inner Mongolia Autonomous Region (Inner Mongolia), and to provide reference for further prevention and treatment of skeletal fluorosis at this stage.Methods:From March to October 2019, a survey of skeletal fluorosis was carried out in all diseased villages of the eight diseased leagues (cities) in Inner Mongolia, including Alxa, Bayannur, Baotou, Ordos, Hohhot, Hulunbeier, Ulanqab and Xilingol. Permanent residents aged 18 years and above in the diseased villeges were investigated. Face to face questionnaires were used to collect the basic data of age, sex, epidemiological history, etc. of all subjects, and clinical examination of skeletal fluorosis was carried out. Drinking water samples were collected from residents for fluoride content testing.Results:A total of 123 166 residents aged 18 years and above were investigated, 1 781 cases of skeletal fluorosis were detected, and the detection rate was 1.45%. The degree of skeletal fluorosis was mild, accounting for 72.26% (1 287/1 781); the others were moderate and severe, accounting for 20.38% (363/1 781) and 7.36% (131/1 781), respectively. There were statistically significant differences in the detection rates of skeletal fluorosis among people of different water fluoride content, age, gender and regions (χ 2 = 565.96, 671.32, 4.38, 17 283.80, P < 0.05). Among them, the detection rates of skeletal fluorosis in water fluoride content > 4.0 mg/L, ≥56 years old and female population were relatively high, which were 5.21% (49/941), 2.26% (1 428/63 188) and 1.52% (905/59 555), respectively. The detection rates of skeletal fluorosis in Xilingol League and Baotou City were significantly higher, 25.48% (745/2 924) and 24.32% (225/925), respectively. Conclusion:The situation of skeletal fluorosis in drinking-water-borne endemic fluorosis areas in Inner Mongolia has been effectively controlled, but there are still relatively many patients with skeletal fluorosis in some areas, and further targeted prevention and control work is needed.

Clinical data of 3 pregnant women with primary hyperparathyroidism admitted in Jinan Maternal and Child Health Hospital from 2013 to 2021 were retrospectively reviewed. Hyperparathyroidism was diagnosed during pregnancy in all 3 cases. The clinical manifestations were non-specific, such as nausea, vomiting, anorexia, and fatigue. Patients also had gallbladder stones (1 case), gallbladder polyps (1 case), and renal parenchyma changes (2 cases). The hypercalcemia crisis occurred in all 3 cases, the blood Ca 2+ levels were 4.11 mmol/L, 2.92-3.82 mmol/L and 3.49-4.10 mmol/L, respectively; and preeclampsia developed in 2 cases. Sudden death occurred in case 1 who did not receive effective treatment during pregnancy; blood calcium was well controlled during pregnancy in case 2, and her neonate had hypocalcemia with good prognosis; case 3 underwent surgical treatment in early pregnancy, and then had missed abortion. Pathological examination revealed parathyroid tumors in all 3 cases.

Objective:To investigate the correlation between state-trait anxiety levels and quality of life before and after orthognathic surgery in patients with dentofacial deformities, and explore the feasibility of using the state-trait anxiety inventory(STAI) to screen postoperative patients with low quality of life.Methods:Patients with dentofacial deformities who underwent orthognathic surgery in Peking University Stomatological Hospital from September 2019 to March 2021 were selected as the research objects. STAI [including state anxiety inventory(SAI) and trait anxiety inventory(TAI)] and orthognathic quality of life questionnaire(OQLQ) were used to investigate patients before surgery, 2 weeks after surgery, 3 months after surgery and 6 months after surgery. The total scores of SAI and TAI ranged from 20 to 80 points, with higher scores implying a higher level of state-trait anxiety. The OQLQ includes four dimensions: social function, facial aesthetics, oral function and aesthetic perception, with total scores ranging from 22 to 88, higher scores representing a lower life quality level. SPSS 26.0 software used for statistical analysis, the measurement data was expressed as Mean±SD. Repeated measures ANOVA and the Bonferroni method were used to compare the SAI, TAI and OQLQ scores in different periods. Pearson correlation analysis was used to explore the correlation between patients’ demographic characteristics (gender, age, diagnostic classification, education, number of social contacts) and state-trait anxiety level, and life quality level at different periods, as well as the correlation between the state-trait anxiety level and the life quality level over time. Receiver operator characteristic(ROC) curve analysis was used to explore the feasibility of using the preoperative STAI scale to screen postoperative patients with low quality of life.Results:A total of 96 patients were included in this study, including 26 males and 70 females, aged (26.0±5.8) years. The SAI, TAI, and OQLQ total scores decreased during three postoperative periods compared to preoperative period ( P<0.01), indicating that the patients’ postoperative state-trait anxiety level decreased and their life quality level improved after surgery. Pearson correlation analysis showed a negative correlation between the patient’s social contact number and their SAI and TAI scores at postoperative 2 weeks (SAI: r=-0.30, P=0.003; TAI: r=-0.35, P<0.001). SAI and TAI scores were positively correlated in different periods ( r=0.48-0.84, P<0.01). Preoperative SAI scores and TAI scores were correlated with preoperative social function, aesthetic perception, facial aesthetic scores and total OQLQ scores (SAI: r=0.39-0.52, P<0.01; TAI: r=0.32-0.51, P<0.01). Preoperative SAI scores were positively correlated with social function and aesthetic perception scores and total OQLQ scores at 2 weeks postoperatively and with aesthetic perception, social function at 6 months postoperatively ( r=0.20-0.52, P<0.05 or <0.01). Postoperative SAI scores were positively correlated with OQLQ scores in all dimensions and total scores except for oral function scores at 3 months postoperatively, which were not correlated with the same period ( r= 0.24-0.55, P<0.05 or <0.01). Preoperative TAI scores were positively correlated with social function scores at 2 weeks( r=0.36, P<0.001) and 3 months( r=0.21, P=0.041) postoperatively. Postoperative TAI scores were positively correlated with OQLQ scores in all dimensions and total scores except for oral function scores at 2 weeks postoperatively, which were not correlated with oral function scores at the same period ( r=0.21-0.58, P<0.05 or <0.01). ROC curve analysis showed that preoperative SAI scores >34.5 and >33.5 screened people with low life quality level at postoperative 3 months and 6 months, with an area under the curve (AUC) of 0.75 (95% CI: 0.62-0.87, P=0.001) and 0.71 (95% CI: 0.59-0.84, P=0.003), respectively. Preoperative TAI scores >43.5, >42.5 and >33.5 can screen patients with low quality of life at 2 weeks, 3 months and 6 months after surgery, with AUC of 0.64(95% CI: 0.52-0.75, P=0.046), 0.73(95% CI: 0.60-0.85, P=0.001)and 0.67(95% CI: 0.55-0.80, P=0.016)respectively. Conclusion:The preoperative and postoperative state-trait anxiety level of patients with dentofacial deformity is correlated with the overall level of quality of life, social function, aesthetic perception and facial aesthetics. The preoperative application of STAI scale can screen patients with low quality of life after orthognathic surgery.

Objective:To investigate the correlation between state-trait anxiety levels and quality of life before and after orthognathic surgery in patients with dentofacial deformities, and explore the feasibility of using the state-trait anxiety inventory(STAI) to screen postoperative patients with low quality of life.Methods:Patients with dentofacial deformities who underwent orthognathic surgery in Peking University Stomatological Hospital from September 2019 to March 2021 were selected as the research objects. STAI [including state anxiety inventory(SAI) and trait anxiety inventory(TAI)] and orthognathic quality of life questionnaire(OQLQ) were used to investigate patients before surgery, 2 weeks after surgery, 3 months after surgery and 6 months after surgery. The total scores of SAI and TAI ranged from 20 to 80 points, with higher scores implying a higher level of state-trait anxiety. The OQLQ includes four dimensions: social function, facial aesthetics, oral function and aesthetic perception, with total scores ranging from 22 to 88, higher scores representing a lower life quality level. SPSS 26.0 software used for statistical analysis, the measurement data was expressed as Mean±SD. Repeated measures ANOVA and the Bonferroni method were used to compare the SAI, TAI and OQLQ scores in different periods. Pearson correlation analysis was used to explore the correlation between patients’ demographic characteristics (gender, age, diagnostic classification, education, number of social contacts) and state-trait anxiety level, and life quality level at different periods, as well as the correlation between the state-trait anxiety level and the life quality level over time. Receiver operator characteristic(ROC) curve analysis was used to explore the feasibility of using the preoperative STAI scale to screen postoperative patients with low quality of life.Results:A total of 96 patients were included in this study, including 26 males and 70 females, aged (26.0±5.8) years. The SAI, TAI, and OQLQ total scores decreased during three postoperative periods compared to preoperative period ( P<0.01), indicating that the patients’ postoperative state-trait anxiety level decreased and their life quality level improved after surgery. Pearson correlation analysis showed a negative correlation between the patient’s social contact number and their SAI and TAI scores at postoperative 2 weeks (SAI: r=-0.30, P=0.003; TAI: r=-0.35, P<0.001). SAI and TAI scores were positively correlated in different periods ( r=0.48-0.84, P<0.01). Preoperative SAI scores and TAI scores were correlated with preoperative social function, aesthetic perception, facial aesthetic scores and total OQLQ scores (SAI: r=0.39-0.52, P<0.01; TAI: r=0.32-0.51, P<0.01). Preoperative SAI scores were positively correlated with social function and aesthetic perception scores and total OQLQ scores at 2 weeks postoperatively and with aesthetic perception, social function at 6 months postoperatively ( r=0.20-0.52, P<0.05 or <0.01). Postoperative SAI scores were positively correlated with OQLQ scores in all dimensions and total scores except for oral function scores at 3 months postoperatively, which were not correlated with the same period ( r= 0.24-0.55, P<0.05 or <0.01). Preoperative TAI scores were positively correlated with social function scores at 2 weeks( r=0.36, P<0.001) and 3 months( r=0.21, P=0.041) postoperatively. Postoperative TAI scores were positively correlated with OQLQ scores in all dimensions and total scores except for oral function scores at 2 weeks postoperatively, which were not correlated with oral function scores at the same period ( r=0.21-0.58, P<0.05 or <0.01). ROC curve analysis showed that preoperative SAI scores >34.5 and >33.5 screened people with low life quality level at postoperative 3 months and 6 months, with an area under the curve (AUC) of 0.75 (95% CI: 0.62-0.87, P=0.001) and 0.71 (95% CI: 0.59-0.84, P=0.003), respectively. Preoperative TAI scores >43.5, >42.5 and >33.5 can screen patients with low quality of life at 2 weeks, 3 months and 6 months after surgery, with AUC of 0.64(95% CI: 0.52-0.75, P=0.046), 0.73(95% CI: 0.60-0.85, P=0.001)and 0.67(95% CI: 0.55-0.80, P=0.016)respectively. Conclusion:The preoperative and postoperative state-trait anxiety level of patients with dentofacial deformity is correlated with the overall level of quality of life, social function, aesthetic perception and facial aesthetics. The preoperative application of STAI scale can screen patients with low quality of life after orthognathic surgery.