Objective To analyze the epidemiological characteristics and risk factors of common viruses in children with respiratory tract infection in Yangling District, and to provide scientific basis for clinical formulation of effective prevention and control strategies. Methods The study subjects were 502 children with respiratory tract infection in Yangling Demonstration Zone Hospital from February 2022 to February 2024. 10 kinds of common respiratory infection viruses such as respiratory syncytial virus, parainfluenza virus, human rhinovirus, influenza B virus, influenza A virus, human adenovirus, enterovirus, coronavirus, human metapneumovirus and human Boca virus were detected by multiple real-time fluorescent polymerase chain reaction (PCR). According to the results of viral nucleic acid detection, 502 children were divided into positive detection group and negative detection group. Univariate and logistic multivariate regression analyses were adopted to analyze the risk factors of respiratory virus infection in children. Results Among the 502 children with respiratory tract infection, 112 cases were positive for viral nucleic acid detection, with a positive rate of 22.31%. Among the 95 cases were with single virus infection with a positive rate of 18.92%, mainly respiratory syncytial virus and parainfluenza virus, and 17 cases were with mixed virus infection, with the positive rate of 3.39%, mainly respiratory syncytial virus+parainfluenza virus mixed infection. After logistic multivariate analysis, it was found that age≤1 year old, onset in autumn and winter, monthly family income≤5000 yuan, concomitant congenital heart disease, maternal atopic disease history, maternal gestational diabetes mellitus, malnutrition and anemia were independent risk factors for respiratory virus infection in children (P<0.05). Conclusion Respiratory virus infection in acute hospitalized children in Yangling District is mainly a single virus, and is affected by many factors such as age of children, onset season, family monthly income and so on. Clinically, it is necessary to actively screen the above indicators of children and take active preventive measures to reduce viral infection.

Objective To analyze the epidemiological characteristics and risk factors of common viruses in children with respiratory tract infection in Yangling District, and to provide scientific basis for clinical formulation of effective prevention and control strategies. Methods The study subjects were 502 children with respiratory tract infection in Yangling Demonstration Zone Hospital from February 2022 to February 2024. 10 kinds of common respiratory infection viruses such as respiratory syncytial virus, parainfluenza virus, human rhinovirus, influenza B virus, influenza A virus, human adenovirus, enterovirus, coronavirus, human metapneumovirus and human Boca virus were detected by multiple real-time fluorescent polymerase chain reaction (PCR). According to the results of viral nucleic acid detection, 502 children were divided into positive detection group and negative detection group. Univariate and logistic multivariate regression analyses were adopted to analyze the risk factors of respiratory virus infection in children. Results Among the 502 children with respiratory tract infection, 112 cases were positive for viral nucleic acid detection, with a positive rate of 22.31%. Among the 95 cases were with single virus infection with a positive rate of 18.92%, mainly respiratory syncytial virus and parainfluenza virus, and 17 cases were with mixed virus infection, with the positive rate of 3.39%, mainly respiratory syncytial virus+parainfluenza virus mixed infection. After logistic multivariate analysis, it was found that age≤1 year old, onset in autumn and winter, monthly family income≤5000 yuan, concomitant congenital heart disease, maternal atopic disease history, maternal gestational diabetes mellitus, malnutrition and anemia were independent risk factors for respiratory virus infection in children (P<0.05). Conclusion Respiratory virus infection in acute hospitalized children in Yangling District is mainly a single virus, and is affected by many factors such as age of children, onset season, family monthly income and so on. Clinically, it is necessary to actively screen the above indicators of children and take active preventive measures to reduce viral infection.

Objective To understand the epidemiological characteristics of hemorrhagic fever with renal syndrome (HFRS) in Shijiazhuang City,and to provide scientific evidence for finding available prevention and control measures against the disease.Methods Using data retrospective method,the monitoring data of HFRS in Shijiazhuang from 1984 to 2015 were collected and divided into 1984-1993,1994-2003 and 2004-2015 periods.The incidence changes of HFRS in time,district and population in different periods were analyzed,and the time distribution of HFRS cases was analyzed on a seasonal basis.Results A cumulative total of 12 692 cases (accounting for 4.94/100 000) of HFRS,including 56 deaths,were reported in Shijiazhuang from 1984 to 2015.The particular years with the two peeks of HFRS epidemic were 1986 and 1999,the incidences of HFRS were 16.14/100 000 and 14.25/100 000,respectively.The incidence of HFRS maintained at a high level from 1998 to 2002,the average annual incidence was 12.21/100 000.And then,the incidence of HFRS declined quickly.The incidence of HFRS in Shijiazhuang kept at a lower level in 2011-2015,the average annual incidence was 0.26/100 000.42.91％ (5 446/12 692) of cases mainly occurred in spring;90.44％ (11 479/12 692) of cases were concentrated in 11 counties (cities,districts) of the eastern part of Shijiazhuang.Most cases were young males,the ratio of males to females was 2.43:1.00 (8 997/3 695),and 93.20％ (1 1 829/12 692) of them were adults.The majority of the cases were framers,accounting for 70.91％ (9 000/12 692),and the second large group was workers,accounting for 11.13％(1 413/12 692).Conclusions Overall,the incidence rate of HFRS has reduced continuously and maintained at a low level in recent years;epidemic areas are widely distributed,but in uneven distribution,and presented with obvious regional characteristics;these cases have mainly occurred in spring.The specific measures for control and prevention of HFRS should be taken according to the epidemic characters in different areas.

[Abstrict]Objective To explore the key points and clinical value of combined direct and indirect extracranial-in?tracranial (EC-IC) bypass in patients with adult moyamoya disease. Methods Retrospective analysis of combined revas?cularization surgery in 25 adult patients with moyamoya disease. The frontal branch and parietal branch of the superficial temporal artery (STA) were dissected. Combined revascularization surgery consisted of direct (anastomosis between the su?perficial temporal artery and cortical branch of the middle cerebral artery) and indirect (encephalodurogaleosynan-giosis EDAS) surgeries. Clinical status was evaluated using the modified Rankin Scale and NIHSS score at 1 day before, 1 week and 3 months after surgery. Results Thirty lateralities were successfully performed on 25 patients. Postoperative angiogra?phy or CTA and cranial computer tomography perfusion imaging(CTP) were conducted to examine the patency of the di?rect anastomosis and cerebral blood flow in 23 patientswithin 1 weeks after surgery . The results showed that the anasto?motic vascular patency was excellent and the cerebral blood flow increased in parallel to the relief of the patients’s isch?emic symptoms. The median mRS scores were 3 (1,3) before surgery, 2 (1,3) 1 week and 1 (0,3) 1 month after surgery.The median mRS scores were significantly improved (Z=15.14, P<0.01). The median NIHSS scores was 5 (4,8) preopera?tively and 4(2,7) postoperation 1 week and 3(1,4) 3 months. The median NIHSS scores were also significantly improved (Z=11.36, P<0.01). Unfortunately, two patients had complication and left hemiparesis. One patient complicated with con?tralateral hemisphere infarction and the another one complicated with ipsilateral hemispheric hemorrhage after operation. Conclusions Combined revascularization surgery may result in satisfying improvement in clinical, angiographic, and he?modynamic states and prevention of recurrent stroke. The stabilized hemodynamic is the key point in peroperative period for moyamoya patients.

ObjectiveTo investigate the situation of mother to child transmission of HIV after mothers acquired HIV prenatally or before pregnancy and the related factors. Methods Two hundred and seventy-seven mothers who acquired HIV prenatally or before pregnancy and their 322children from Yi-ning city of Xinjiang Uygur autonomous region and some counties of central China were enrolled in this study from January 2000 to December 2009.Subtypes of HIV were determined by detection of Gag sequence,the rate of HIV transmission from mother to child was calculated and its related factors were analyzed by Chi-square test and Logistic regression analysis.ResultsThe HIV subtype of all mothers who were infected through blood (n=174) was B'.The major subtype of mothers who were infected via sexuality (n =58) was recombined subtype CRF01-BC (n=35) and CRF-AE (n=20),accounting for 60.3％ and 34.5％,respectively,and only 3 mothers with B'subtype (5.2％).Twelve infants died before HIV detection,and 108 infants out of the rest 310infants were found to be HIV positive, giving the HIV mother-to-child transmission rate of 34.8％ (95％ CI:29.5％-40.1％).The infection rate of bottle feeding infants was lower than that of breastfeeding infants [12.5％ (6/48) vs 38.9％ (102/262),x2 =12.484,P=0.000].The infection rate of the infants whose mothers' HIV infection ＜7 years was lower than that of the infants whose mothers' HIV infection ≥7 years [28.8％ (46/160) vs 54.2％ (32/59),x2 =12.211,P=0.000].Multi-factor Logistic analysis showed that the duration of maternal HIV infection (OR =1.342,95％ CI:1.189-1.515,P=0.000) and duration of breastfeeding (OR =1.137,95％ CI:1.053-1.227,P=0.001) were risk factors of HIV vertical transmission.ConclusionsThe HIV subtypes might be associated with transmission route.Formula feeding could decrease the vertical transmission rate of HIV,while long duration of maternal HIV infection and breastfeeding might increase the vertical transmission rate of HIV.

Objective To investigate the management of external iliac artery mycotic hemorrhage after kidney transplantation. Methods A case of external iliac artery mycotic hemorrhage after kidney transplantation managed by the use of hypogastric artery autograft was reported with review of the literature.The massive blooding occurred 3 times after kidney transplantation in a male patient 25 years of age on the 22nd,24th and 38th day after transplantation.The blooding amounted to 800 ml,2500 ml and 3800 ml respectively.The blood loss was replaced and prompt surgical exploration was carried out with the blooding site at the anastomosis sutured up on the 1st and 2nd episode of bleeding.On the 3rd occurrence of bleeding, the diseased external iliac artery segment, about 2cm in length, was resected and the gap was replaced by a 3cm long hypogastric artery autograft. Results The blood flow through the repaired external iliac artery and the blood supply to the lower extremity was adequate.Periodic hemodialysis had been restored and the patient waited for reimplantation. Conclusions External iliac artery mycotic hemorrhage after kidney transplantation is a serious and fatal complication.Simple arterial repair is usually noneffective.Resection of the diseased mycotic segment of the external iliac artery with repairing of the gap with a hypogastric artery autograft is rational,feasible and simple.The procedure is highly recommended.