Cervical Bronchogenic cysts (BC) is a rare congenital abnormality caused by abnormal budding of the embryonic foregut diverticulum. Mediastinal and intrapulmonary types are the most common sites of occurrence, and thyroid BC is rare. This article aims to report a case of resection of thyroid BC with video-assistance technology to improve the understanding of the imaging, pathology and clinical aspects of this disease.

Papillary thyroid microcarcinoma(PTMC),which lacks lymph node metastasis,distant metastasis,extra-thyroid invasion,high-risk subtypes,and invasion of the trachea or recurrent laryngeal nerve,may be classified as low-risk PTMC based on clinical assessment.Surgical intervention such as lobectomy or total thyroidectomy is the primary treatment modality for PTMC.This study comprised 124 patients who underwent conformal thyroidectomy and revealed that this innovative surgical approach yielded long-term oncological outcomes comparable to those who received lobectomy or total thyroidectomy.The surgical intervention may play a significant role in the comprehensive management of PTMC,while the implementation of PTMC precision medicine necessitates the utilization of genetic testing,molecular typing,and other advanced technologies to detect early-stage high-risk factors like lymph node microinvasion and integrate biology-based surgery concept for optimal outcomes.

Colorectal cancer is a common malignant tumor of the digestive tract, and surgical resection is one of its main treatment methods. The reconstruction of the digestive tract in colorectal surgery is a crucial step that directly affects the postoperative recovery and quality of life of patients. The key points of colorectal surgery reconstruction include reasonable planning of the digestive tract reconstruction path, trying to preserve the neural innervation and blood supply of the intestine as much as possible, and selecting appopriate surgical instruments and anastomotic materials. This article aims to explore in depth the quality control strategies for gastrointestinal reconstruction in colorectal surgery, including precise preoperative evaluation, optimized surgical plans, meticulous intraoperative procedures, and effective quality monitoring systems. By comprehensively analyzing and elaborating on these aspects, scientific basis and practical guidance are provided to improve the quality of digestive tract reconstruction in colorectal surgery.

Since the concept of GIST was proposed in 1983, the diagnosis and treatment of GIST in China have continuously progress. Over the two decades from 1990 to 2010, the diagnosis and treatment of GIST had achieved a foundation of development through the collective efforts of GIST scholars, from the first pathological review to the first expert consensus. The period from 2010 to 2020 marked rapid development. Besides the updates of expert consensus, other relevant expert consensus was published regarding pathology, surgery, targeted therapy, therapeutic drug monitoring, and patient' management. Based on the above development, China's first GIST guideline, the "CSCO Gastrointestinal Stromal Tumor Diagnosis and Treatment Guidelines (2020 Edition)", was published. This guideline considers regional development disparities, accessibility of treatments and diagnostic methods, and the social value of cancer care, maintaining its scientific rigor, fairness, and timeliness. Over the past 30 years, the diagnosis and treatment of GIST in China significantly development. However, we should recognize that further development must require more original Chinese research, which would better benefit the Chinese population.

Colorectal cancer is a common malignant tumor of the digestive tract, and surgical resection is one of its main treatment methods. The reconstruction of the digestive tract in colorectal surgery is a crucial step that directly affects the postoperative recovery and quality of life of patients. The key points of colorectal surgery reconstruction include reasonable planning of the digestive tract reconstruction path, trying to preserve the neural innervation and blood supply of the intestine as much as possible, and selecting appopriate surgical instruments and anastomotic materials. This article aims to explore in depth the quality control strategies for gastrointestinal reconstruction in colorectal surgery, including precise preoperative evaluation, optimized surgical plans, meticulous intraoperative procedures, and effective quality monitoring systems. By comprehensively analyzing and elaborating on these aspects, scientific basis and practical guidance are provided to improve the quality of digestive tract reconstruction in colorectal surgery.

Since the concept of GIST was proposed in 1983, the diagnosis and treatment of GIST in China have continuously progress. Over the two decades from 1990 to 2010, the diagnosis and treatment of GIST had achieved a foundation of development through the collective efforts of GIST scholars, from the first pathological review to the first expert consensus. The period from 2010 to 2020 marked rapid development. Besides the updates of expert consensus, other relevant expert consensus was published regarding pathology, surgery, targeted therapy, therapeutic drug monitoring, and patient' management. Based on the above development, China's first GIST guideline, the "CSCO Gastrointestinal Stromal Tumor Diagnosis and Treatment Guidelines (2020 Edition)", was published. This guideline considers regional development disparities, accessibility of treatments and diagnostic methods, and the social value of cancer care, maintaining its scientific rigor, fairness, and timeliness. Over the past 30 years, the diagnosis and treatment of GIST in China significantly development. However, we should recognize that further development must require more original Chinese research, which would better benefit the Chinese population.

Objective:To explore the clinical features, treatment and prognosis of patients with pneumatosis cystoides intestinalis (PCI).Methods:The clinical data of 25 PCI patients at Peking University People's Hospital admitted from Jan 2011 to Dec 2020 were retrospectively analyzed .Results:Among these 25 PCI patients, there were 9 males and 16 females with a median age of 69 (55-78) years. Six patients were asymptomatic, while the main complaint of the remaining patients was abdominal pain (12 cases), followed by diarrhea (4 cases), constipation (2 cases), and abdominal distension (1 case). Fifteen patients with PCI also had hypoalbuminemia. The main radiological manifestation of PCI was the presence of multiple gas-filled cysts within the intestinal wall, with 23 cases occurring in the colon and 17 cases combined with free intra-abdominal gas. All patients were cured with conservative treatment, with no PCI-related deaths during follow-up .Conclusions:PCI is a rare gastrointestinal disease with atypical clinical manifestations. Conservative management is an effective treatment with good prognosis.

Objective:To investigate the effect of tumor deposit(TD) on the prognosis of patients with gastric cancer after radical surgery.Methods:A retrospective analysis was performed on gastric cancer patients who underwent radical surgery at the Department of Gastrointestinal Surgery, Peking University People's Hospital from Jan 2021 to Dec 2023. The relationship between the status of tumor deposit and clinicopathological features, as well as the impact on the overall postoperative survival of gastric cancer patients were evaluated.Results:Pathological examination revealed that among 212 patients with gastric cancer, 12 patients (5.1%) had tumor deposits (TD). The occurrence of TD was found to be associated with preoperative T stage, N stage, and extramural vascular invasion (EMVI) (all P<0.05). During the follow-up period, 31 patients experienced recurrence, metastasis, or death. The COX multivariate analysis indicated that N stage ( P=0.07), preoperative serum CEA level ( P<0.001), EMVI ( P=0.001), and TD ( P=0.011) were independent risk factors affecting the overall postoperative survival . Among patients who received neoadjuvant therapy and on pT4 stage, pN+ status, and EMVI status before surgery, the presence of TD was closely correlated with overall survival. Patients with TD had a worse prognosis and shorter overall survival( P<0.05). Conclusion:Tumor deposit is an important risk factor affecting the prognosis of patients after radical gastrectomy and may be a predictive biomarker of early peritoneal metastasis.

Objective:To explore CT imaging features related to disease-free survival (DFS) for gastric cancer (GC) patients with no clinical lymph node metastasis (cN0).Methods:From January 2005 to December 2018, 298 patients with GC were collected retrospectively in Peking University People′s Hospital. All the patients performed CT scanning before operation, and cT1-4N0M0 was defined by CT images. The clinical tumor stage (cT), extramural vessel invasion (EMVI), tumor morphological type, location and size were defined and recorded based on preoperative contrast-enhanced CT images. According to the pathological results, the patients were divided into pT1-2, pT3-4, pN0, and pN1-3 subgroups, with 148, 150, 135, and 163 cases, respectively. Progressive events and corresponding time were recorded during follow-up. DFS was defined as the time from radical operation to progressive events; if no progressive events occurred, DFS was defined as the time from radical operation to the last follow-up. The Kaplan-Meier curve and log-rank test were used to analyze the differences in cumulative DFS among patients with different CT imaging features, and Cox survival analysis was used to explore the independent CT imaging risk factors affecting DFS of cN0 patients. The log-rank test was used to test the effect of independent risk factors on cumulative DFS in different subgroups.Results:The follow-up time of enrolled patients was 36.0 (14.9, 59.3) months. The 3-year cumulative DFS rates of cT3-4 and cT1-2 GC patients were 61.2% and 85.6%, respectively, and the difference of DFS was statistically significant (χ 2=22.72, P<0.001). The 3-year cumulative DFS rate of EMVI-positive patients was 46.3%, which was lower than that of EMVI-negative patients (77.1%), and the difference was statistically significant (χ 2=21.34, P<0.001). There was no significant difference in 3-year cumulative DFS between different tumor locations and morphological types (χ 2=1.75, 1.73, P=0.189, 0.196). The difference in 3-year cumulative DFS between the tumor maximal diameter ≥3.4 cm and <3.4 cm groups was statistically significant (χ 2=17.58, P<0.001). On Cox survival analysis, cT (HR=5.203, P=0.001) and EMVI (HR=1.971, P=0.025) were independent risk factors for 3-year DFS in patients with cN0 GC. The results of subgroup analysis showed that the effect of EMVI on the 3-year DFS in pN0, pN1-3, pT1-2 and pT3-4 subgroups was statistically significant ( P<0.05). The effect of cT on the 3-year DFS was statistically significant in pN0, pN1-3, and pT1-2 subgroups ( P<0.05), but not in pT3-4 group (χ 2=2.58, P=0.108). Conclusion:cT and EMVI defined on preoperative CT examination are independently prognostic factors of 3-year DFS for patients with cN0 GC.

Objective:to study the mutation of p53 gene in colorectal cancer, analyze the relationship between p53 gene mutation and numb expression pattern, and explore its clinicopathological significance in colorectal cancer.Methods:p53 gene mutation in 60 colorectal cancer tissues was analyzed by polymerase chain reaction (PCR) and DNA sequencing, and the expression of numb protein was detected by Western blot. The colon cancer cell lines HCT116 (+), HCT116 (-) and flow cytometry were used. The survival curve was drawn by Kaplan Meier method.Results:p53 gene mutation was found in 31 of 60 tissues (52%), and the mutation times of exons (E) 5, 6, 7 and 8 were 5, 6, 12 and 11 respectively. The expression level of numb in p53 mutation group was significantly lower than that in non mutation group ( P=0.009). The prognosis of patients with low expression of numb (39 cases) was worse than that of high expression of numb (21 cases) ( P=0.015). Its expression level is closely related to the degree of differentiation, lymph node metastasis and TNM stage (all P<0.05). After the two cell lines were transferred into numb, the cell cycle appeared G2-M phase arrest and proliferation was inhibited, while dapt had G1-S phase arrest. Conclusion:p53 gene mutation related to the expression of numb in colon cancer, which has significant effect on the prognosis.