OBJECTIVE To evaluate the cost-utiliby of capivasertib combined with fulvestrant for the second-line treatment of hormone receptor-positive/human epidermal growth factor receptor-2-negative （HR+/HER2－） advanced breast cancer from the perspective of the Chinese healthcare system. METHODS A partitioned survival model was constructed using clinical data from the CAPItello-291 trial. Costs and quality-adjusted life years （QALYs） were used as the output indicators of the model， and the incremental cost-effectiveness ratio （ICER） was used as the evaluation indicator of the model. Using three times the per capita gross domestic product （GDP） of China in 2024 as the willingness-to-pay threshold （WTP）， this study analyzed the cost-utility of capivasertib combined with fulvestrant versus fulvestrant monotherapy in the treatment of HR+/HER2－ advanced breast cancer， and conducted sensitivity analysis and scenario analysis under conditions where the price of capivasertib was reduced by 50%， 60%， 70% and 95%， respectively. RESULTS The results of the basic analysis showed that compared with the fulvestrant monotherapy regimen， the ICER of capivasertib combined with fulvestrant was 843 038.46 yuan/QALY， which was higher than the WTP（287 247 yuan/QALY）. The one-way sensitivity analysis revealed that the top three factors with the most substantial influence on ICER were the utility value in the progression disease state， the price of capivasertib， and the utility value inthe progression free survival state. Probabilistic sensitivity analysis demonstrated the robustness of the basic analysis results. Scenario analysis revealed that even if the price of capivasertib were reduced by 95%， capivasertib combined with fulvestrant did not exhibit cost-effectiveness at the current WTP. CONCLUSION At a WTP of three times China’s GDP per capita in 2024， compared to fulvestrant monotherapy， capivasertib combined with fulvestrant as the second-line treatment for HR+/ HER2－ advanced breast cancer is not cost-effective.

Objective:This study aims to obtain the prevalence and features associated with Violence Against Children (VAC) in China and, thus, formulate a prevention strategy.Methods:The mortality-related data of VAC was sourced from the National Disease Surveillance Points System (DSP) during 2013-2021. We analyzed the DSP data regarding children aged 0-17 years old who died from violence. The hospital cases of VAC was sourced from the National Injury Surveillance System (NISS), 2013-2021. We analyzed the data from NISS with the parameter of "intentional injury" caused by VAC in children aged between 0-17 years. Using robust linear regression, we analyze the time trend in the proportion of violence incidence. To understand the variations in the incidence of different types of violence across genders, we apply the chi-square test and adjusted Pearson residuals.Results:The overall trend of death caused by VAC has declined; it was reduced to 0.14/100 000 in 2021 from 0.33/100 000 in 2013. In 2021, male VAC mortality (0.15/100 000) was higher than females (0.13/100 000). The proportion of VAC cases to all injury cases has declined from 3.34% in 2013 to 2.29% in 2021. Among 9 344 VAC cases supervised by hospitals in 2021, the number of males (7 503 cases) was around 4 times that of females (1 841 cases), and the top three modes of violence were blunt tools (64.77%), falls (7.46%) and sharp instruments (6.18%), and 45 cases of sexual violence included 38 girls and 7 boys.Conclusions:The declining death rate due to VAC may be related to the benign development of Chinese society. Prevention strategies targeting training in parenting skills and problem-solving should be prioritized.

Objective:To explore the policy synergy of 71 Diagnosis-Intervention Packet(DIP)pilot cities from the perspective of policy synergy at both the national and provincial levels.Methods:Policy evaluation dimensions were constructed by text mining method,and the surface plots of policy consistency were drawn by the Policy Modeling Consistency Index(PMC),and the degree of policy synergy between each city and national policies and with cities in the province were calculated by correlation analysis.Results:Different levels of policy in pilot cities and the policy differences among pilot cities mainly focus on policy disclosure,core elements,and infrastructure,at the central level,most cities maintain a high degree of consistency with the state in terms of policy nature,management measures,infrastructure,and policy evaluation,and the policy timeliness,policy perspective,and core elements still need to be improved;at the provincial level,cities within the 20 provinces show characteristics in low level of complete synergy,high level of close synergy and differentiated partial synergy.Conclusion:The 71 DIP pilot cities have established a preliminary policy system,but there are still more cities with missing policies and a lack of coordination.In the future,efforts should be made to advance the policy development process,promote the improvement of the policy system,and promote coordination among pilot cities in policy implementation.

Objective:To explore the policy synergy of 71 Diagnosis-Intervention Packet(DIP)pilot cities from the perspective of policy synergy at both the national and provincial levels.Methods:Policy evaluation dimensions were constructed by text mining method,and the surface plots of policy consistency were drawn by the Policy Modeling Consistency Index(PMC),and the degree of policy synergy between each city and national policies and with cities in the province were calculated by correlation analysis.Results:Different levels of policy in pilot cities and the policy differences among pilot cities mainly focus on policy disclosure,core elements,and infrastructure,at the central level,most cities maintain a high degree of consistency with the state in terms of policy nature,management measures,infrastructure,and policy evaluation,and the policy timeliness,policy perspective,and core elements still need to be improved;at the provincial level,cities within the 20 provinces show characteristics in low level of complete synergy,high level of close synergy and differentiated partial synergy.Conclusion:The 71 DIP pilot cities have established a preliminary policy system,but there are still more cities with missing policies and a lack of coordination.In the future,efforts should be made to advance the policy development process,promote the improvement of the policy system,and promote coordination among pilot cities in policy implementation.

Objective:To explore the policy synergy of 71 Diagnosis-Intervention Packet(DIP)pilot cities from the perspective of policy synergy at both the national and provincial levels.Methods:Policy evaluation dimensions were constructed by text mining method,and the surface plots of policy consistency were drawn by the Policy Modeling Consistency Index(PMC),and the degree of policy synergy between each city and national policies and with cities in the province were calculated by correlation analysis.Results:Different levels of policy in pilot cities and the policy differences among pilot cities mainly focus on policy disclosure,core elements,and infrastructure,at the central level,most cities maintain a high degree of consistency with the state in terms of policy nature,management measures,infrastructure,and policy evaluation,and the policy timeliness,policy perspective,and core elements still need to be improved;at the provincial level,cities within the 20 provinces show characteristics in low level of complete synergy,high level of close synergy and differentiated partial synergy.Conclusion:The 71 DIP pilot cities have established a preliminary policy system,but there are still more cities with missing policies and a lack of coordination.In the future,efforts should be made to advance the policy development process,promote the improvement of the policy system,and promote coordination among pilot cities in policy implementation.

Objective:To explore the policy synergy of 71 Diagnosis-Intervention Packet(DIP)pilot cities from the perspective of policy synergy at both the national and provincial levels.Methods:Policy evaluation dimensions were constructed by text mining method,and the surface plots of policy consistency were drawn by the Policy Modeling Consistency Index(PMC),and the degree of policy synergy between each city and national policies and with cities in the province were calculated by correlation analysis.Results:Different levels of policy in pilot cities and the policy differences among pilot cities mainly focus on policy disclosure,core elements,and infrastructure,at the central level,most cities maintain a high degree of consistency with the state in terms of policy nature,management measures,infrastructure,and policy evaluation,and the policy timeliness,policy perspective,and core elements still need to be improved;at the provincial level,cities within the 20 provinces show characteristics in low level of complete synergy,high level of close synergy and differentiated partial synergy.Conclusion:The 71 DIP pilot cities have established a preliminary policy system,but there are still more cities with missing policies and a lack of coordination.In the future,efforts should be made to advance the policy development process,promote the improvement of the policy system,and promote coordination among pilot cities in policy implementation.

Objective:To explore the policy synergy of 71 Diagnosis-Intervention Packet(DIP)pilot cities from the perspective of policy synergy at both the national and provincial levels.Methods:Policy evaluation dimensions were constructed by text mining method,and the surface plots of policy consistency were drawn by the Policy Modeling Consistency Index(PMC),and the degree of policy synergy between each city and national policies and with cities in the province were calculated by correlation analysis.Results:Different levels of policy in pilot cities and the policy differences among pilot cities mainly focus on policy disclosure,core elements,and infrastructure,at the central level,most cities maintain a high degree of consistency with the state in terms of policy nature,management measures,infrastructure,and policy evaluation,and the policy timeliness,policy perspective,and core elements still need to be improved;at the provincial level,cities within the 20 provinces show characteristics in low level of complete synergy,high level of close synergy and differentiated partial synergy.Conclusion:The 71 DIP pilot cities have established a preliminary policy system,but there are still more cities with missing policies and a lack of coordination.In the future,efforts should be made to advance the policy development process,promote the improvement of the policy system,and promote coordination among pilot cities in policy implementation.

Objective:To explore the policy synergy of 71 Diagnosis-Intervention Packet(DIP)pilot cities from the perspective of policy synergy at both the national and provincial levels.Methods:Policy evaluation dimensions were constructed by text mining method,and the surface plots of policy consistency were drawn by the Policy Modeling Consistency Index(PMC),and the degree of policy synergy between each city and national policies and with cities in the province were calculated by correlation analysis.Results:Different levels of policy in pilot cities and the policy differences among pilot cities mainly focus on policy disclosure,core elements,and infrastructure,at the central level,most cities maintain a high degree of consistency with the state in terms of policy nature,management measures,infrastructure,and policy evaluation,and the policy timeliness,policy perspective,and core elements still need to be improved;at the provincial level,cities within the 20 provinces show characteristics in low level of complete synergy,high level of close synergy and differentiated partial synergy.Conclusion:The 71 DIP pilot cities have established a preliminary policy system,but there are still more cities with missing policies and a lack of coordination.In the future,efforts should be made to advance the policy development process,promote the improvement of the policy system,and promote coordination among pilot cities in policy implementation.

Objective:To explore the policy synergy of 71 Diagnosis-Intervention Packet(DIP)pilot cities from the perspective of policy synergy at both the national and provincial levels.Methods:Policy evaluation dimensions were constructed by text mining method,and the surface plots of policy consistency were drawn by the Policy Modeling Consistency Index(PMC),and the degree of policy synergy between each city and national policies and with cities in the province were calculated by correlation analysis.Results:Different levels of policy in pilot cities and the policy differences among pilot cities mainly focus on policy disclosure,core elements,and infrastructure,at the central level,most cities maintain a high degree of consistency with the state in terms of policy nature,management measures,infrastructure,and policy evaluation,and the policy timeliness,policy perspective,and core elements still need to be improved;at the provincial level,cities within the 20 provinces show characteristics in low level of complete synergy,high level of close synergy and differentiated partial synergy.Conclusion:The 71 DIP pilot cities have established a preliminary policy system,but there are still more cities with missing policies and a lack of coordination.In the future,efforts should be made to advance the policy development process,promote the improvement of the policy system,and promote coordination among pilot cities in policy implementation.

Objective:To explore the policy synergy of 71 Diagnosis-Intervention Packet(DIP)pilot cities from the perspective of policy synergy at both the national and provincial levels.Methods:Policy evaluation dimensions were constructed by text mining method,and the surface plots of policy consistency were drawn by the Policy Modeling Consistency Index(PMC),and the degree of policy synergy between each city and national policies and with cities in the province were calculated by correlation analysis.Results:Different levels of policy in pilot cities and the policy differences among pilot cities mainly focus on policy disclosure,core elements,and infrastructure,at the central level,most cities maintain a high degree of consistency with the state in terms of policy nature,management measures,infrastructure,and policy evaluation,and the policy timeliness,policy perspective,and core elements still need to be improved;at the provincial level,cities within the 20 provinces show characteristics in low level of complete synergy,high level of close synergy and differentiated partial synergy.Conclusion:The 71 DIP pilot cities have established a preliminary policy system,but there are still more cities with missing policies and a lack of coordination.In the future,efforts should be made to advance the policy development process,promote the improvement of the policy system,and promote coordination among pilot cities in policy implementation.