Objective: To understand the interrelationships of parental control, peer relationship, and aggressive behavior in junior high school students, in order to provide a theoretical basis for preventing the occurrence of adolescent aggressive behavior. Methods: During June to July, 2022, 2 564 students of grade one to grade three were selected from 6 junior high schools from each of Suzhou and Xuancheng cities in Anhui Province by using convenient cluster random sampling method, and then the questionnaire survey was administered, including the Chinese version of Parent Control Questionnaire, Chinese version of Buss & Perry Aggression Questionnaire and Adolescent Peer Relationship Questionnaire. Results: Boys scored (185.31±27.49, 21.65±7.43, 21.77 ±8.18, 69.50±11.41, 72.39±11.53) higher than girls (178.21±25.13, 20.08±7.09, 20.61±7.62, 66.56± 11.14 , 70.95± 11.84 ) in parental control, father s psychological control, mother s psychological control, father s behavioral control, and mother s behavioral control ( t =8.63, 5.47, 3.70, 6.60, 3.12), while girls scored (48.41±11.26) higher in peer relationship than boys ( 47.13 ± 10.84 ) ( t =-2.95) ( P <0.01). The scores of first grade students in parental control, father s psychological control, mother s psychological control, father s behavior control, peer relationship, and aggressive behavior (184.67±27.18, 21.83± 7.29 , 22.15±8.07, 68.81±10.95, 50.21±9.57, 80.23±17.66) were higher than those of second gradestudents (180.98±25.46, 20.16±7.82, 20.21±7.55, 68.29±11.69, 45.47±11.67, 74.08±17.70) and third grade students (179.21±26.79, 20.53±7.22, 21.17 ± 8.06 , 66.81± 11.39 , 47.54±11.43, 75.75±16.29) ( F =9.44, 12.87, 13.61, 6.84, 42.85, 30.40, P <0.01). The scores of parental control and peer relationship were positively correlated with the scores of aggressive behavior ( r=0.22, 0.47, P <0.01). Peer relationship partially mediate the relationship between parental control and aggressive behavior, with a partial mediation effect value of 0.04, accounting for 26.39% of the total effect of parental control on aggressive behavior. Conclusions High parental control and poor peer relationship are both positively correlated with the level of aggressive behavior. The peer relationship of teenagers should be improved by establishing appropriate parenting style, tackling campus violence, and maintaining good social norms, in order to reduce the occurrence of aggressive behavior among adolescents.

Mucinous adenocarcinoma of the renal pelvis is rare in clinical practice. This article reported a case of primary renal pelvis mucinous adenocarcinoma mixed with signet ring cell carcinoma. The patient was admitted to hospital due to right low back pain, and was diagnosed with right kidney stones accompanied by hydrops and infection, right kidney abscess, and nonfunctional right kidney after complete examination. Right renal puncture drainage was performed twice, followed by laparoscopic robot assisted right neprectomy. The postoperative pathological diagnosis was right renal pelvis primary mucinous adenocarcinoma (mixed with signet-ring cell carcinoma). Eleven months after the operation, regular "sodium folinate + oxaliplatin + 5-fluorouracil" chemotherapy was performed for 12 courses, and imaging showed no signs of recurrence or metastasis.

Objective: Schizophrenia is a common mental disorder, and mitochondrial function represents a potential therapeutic target for psychiatric diseases. The role of mitochondrial metabolism-related genes (MRGs) in the diagnosis of schizophrenia remains unknown. This study aimed to identify candidate genes that may influence the diagnosis and treatment of schizophrenia based on MRGs. Methods: Three schizophrenia datasets were obtained from the Gene Expression Omnibus database. MRGs were collected from relevant literature. The differentially expressed genes between normal samples and schizophrenia samples were screened using the limma package. Venn analysis was performed to identify differentially expressed MRGs (DEMRGs) in schizophrenia. Based on the STRING database, hub genes in DEMRGs were identified using the MCODE algorithm in Cytoscape. A diagnostic model containing hub genes was constructed using LASSO regression and logistic regression analysis. The relationship between hub genes and drug sensitivity was explored using the DSigDB database. An interaction network between miRNA-transcription factor (TF)-hub genes was created using the Network-Analyst website. Results: A total of 1,234 MRGs, 172 DEMRGs, and 6 hub genes with good diagnostic performance were identified. Ten potential candidate drugs (rifampicin, fulvestrant, pentadecafluorooctanoic acid, etc.) were selected. Thirty-four miRNAs targeting genes in the diagnostic model (ANGPTL4, CPT2, GLUD1, MED1, and MED20), as well as 137 TFs, were identified. Conclusion Six potential candidate genes showed promising diagnostic significance. rifampicin, fulvestrant, and pentadecafluorooctanoic acid were potential drugs for future research in the treatment of schizophrenia. These findings provided valuable evidence for the understanding of schizophrenia pathogenesis, diagnosis, and drug treatment.

Objective: To understand the relationship among pubertal timing, overweight and obesity, and eating disorders among Bengbu adolescents, and to provide a reference for obesity prevention. Methods: Two nine year schools were conveniently selected in Bengbu, with 683 students from grade 5 to grade 8. Puberty Development Scale (PDS) and Eating Disorders Inventory of Children (EDI-C) subscale were used, height and weight were measured. The associations between obesity, pubertal timing and eating disorders were analyzed. Results: The prevalence of overweight and obesity was higher in boys than that in girls, and the rate of early pubertal timing, drive for thinness score, body dissatisfaction score and total eating disorder score were higher in girls than that in boys( χ 2/t =28.69, 57.99, 3.47, 2.59, 3.30, P <0.05). The differences in rate of overweight and obesity, bulimia score and total eating disorder score were statistically significant by grade( χ 2/F =28.39, 5.11, 3.95, P ＜0.01). There was a positive correlation among overweight obesity and early pubertal timing and eating disorder, and a positive correlation between early pubertal timing and eating disorder( r =0.18, 0.17, 0.14, P < 0.01 ). The mediating effect of early pubertal timing between overweiht, obesity and eating disorders partially contributed 14.25% to the total effect. Conclusion Overweight and obesity is associated with eating disorders, and early pubertal timing partially mediate the association between overweight obesity and eating disorders. Healthy lifestyle should be advocated in family and school to effectively prevent adolescents obesity, pubertal timing, and eating disorders.

Central nervous system (CNS) injuries, including stroke, traumatic brain injury, and spinal cord injury, are essential causes of death and long-term disability and are difficult to cure, mainly due to the limited neuron regeneration and the glial scar formation. Herein, we apply extracellular vesicles (EVs) secreted by M2 microglia to improve the differentiation of neural stem cells (NSCs) at the injured site, and simultaneously modify them with the injured vascular targeting peptide (DA7R) and the stem cell recruiting factor (SDF-1) on their surface via copper-free click chemistry to recruit NSCs, inducing their neuronal differentiation, and serving as the nanocarriers at the injured site (Dual-EV). Results prove that the Dual-EV could target human umbilical vascular endothelial cells (HUVECs), recruit NSCs, and promote the neuronal differentiation of NSCs in vitro. Furthermore, 10 miRNAs are found to be upregulated in Dual-M2-EVs compared to Dual-M0-EVs via bioinformatic analysis, and further NSC differentiation experiment by flow cytometry reveals that among these miRNAs, miR30b-3p, miR-222-3p, miR-129-5p, and miR-155-5p may exert effect of inducing NSC to differentiate into neurons. In vivo experiments show that Dual-EV nanocarriers achieve improved accumulation in the ischemic area of stroke model mice, potentiate NSCs recruitment, and increase neurogenesis. This work provides new insights for the treatment of neuronal regeneration after CNS injuries as well as endogenous stem cells, and the click chemistry EV/peptide/chemokine and related nanocarriers for improving human health.

Objective: To explore the influence of parents educational level and family type on the level of parental control, so as to lay a foundation for improving parental education and promoting adolescents mental and physical health. Methods: In April 2019, random cluster sampling was used to select 1 046 students in junior and senior high schools in Bengbu. Information was collected through the Chinese version of Parental Control Questionnaire, and SPSS 25.0 for statistical analysis was used. Results: Mother s behavioral control and mother s educational level were significantly positively correlated( r =0.18), father s behavioral control and father s education level were significantly positively correlated( r =0.16). There was a significant positive correlation between the total score of maternal control and mother s education level( r =0.16). The total score of father s control was positively correlated with the education level of the fathers( r =0.12)( P <0.05). There was significant differences between the parents with different education level on parental control( H =16.93, 32.21, P <0.05). The score on parents behavioral control with primary school education or without education low among the parents with other education levels. There were differences between different family types in the total score of parental control( F =2.63, 3.55, P <0.05). Compared with extended families and nuclear families, single parent families total scored had significantly lower in father s control, and single parent families total scored significantly lower in mother s control scores than extended families. Parents educational level and family type had significantly predicted effect on parental behavioral control. Conclusion Parents educational level and family type have an influence on parents psychological and behavioral control, and have a predictive effect on parents control level. Parental control levels should be improved by improving the family s upbringing environment.

Abstract Adolescent aggressive behavior has become one of the public health problems, and is affected by factors such as society,school,and family.Parents play an important role in the growth of adolescents. Parental control is seen as one of the rearing style,and closely related with adolescent aggressive behavior. This article reviews studies on the concept and classification of parental control, the impact of parental control on the psychological behavior of adolescents, the concept and measurement of aggressive behavior, the influencing factors of adolescent aggressive behavior, the impact of parental control on aggressive behavior, and the influence of demographic factors on both by consulting the existing literature, with the goal of providing references for reducing adolescent aggressive behavior improving parenting ability.

Objective: To explore the relationship between aggressive behavior and emotional management of middle school students. Methods: A total of 1 046 middle and high school students in Bengbu were randomly selected by cluster sampling. Information was collected through the Children s Emotion Management Scales and Buss & Perry Aggression Questionnaire. Results: The scores of emotional management of male students (11.74±2.25, 9.29±1.98) were higher than that of female students(11.19±2.11, 8.76±1.95)( t =4.06, 4.29, P <0.01), and the scores of anger management of grade 8 students (8.55±2.13) were lower than that of grade 9, grade 10 and grade 11 students(9.21±2.06, 9.14±1.73, 9.16±1.85)( F=3.53, P <0.01). The score on anger (18.42± 5.71 ) was high among male students (16.32±5.06) ( t=6.27, P <0.01) and the total score (78.48±16.39) was high among female students(75.78±17.79)( t=-2.55, P <0.01). The aggression level in grade 8 students (82.09±19.21) was significantly higher than grade 9, grade 10 and grade 11 students(76.57±16.83, 75.05±15.34, 74.42±13.09)( H=25.16, P <0.01). The results of correlation analysis showed that sadness management was negatively correlated with physical aggression, angry behavior, hostility and aggressive behavior( r=-0.10, -0.18, -0.08, -0.12, P <0.01), anger management was negatively correlated with physical aggression, verbal aggression, anger, hostility, and aggressive behavior( r=-0.25, -0.09, -0.36, -0.15, -0.29, P <0.05). Regression analysis showed, anger management was negatively associated with aggressive behaviors in both boys( B=-2.48, 95%CI =-3.17- -1.79 ) and girls( B=-2.93, 95%CI =-3.67--2.20), sadness management was negatively associated with girl s hostility( B= -0.26 , 95%CI =-0.54-0.01)( P <0.01). Conclusion Higher level of emotional management, less aggressive behavior. Emotional management improvement among middle school students can effectively prevent and reduce the occurrence of aggressive behavior.

Objective To discuss the safety and efficacy of inserting ureterovesical reimplantation by means of laparoscopy associated with six-stitch suture.Methods There was an retrospective analysis on operation videos and clinical data for 16 participants of inserting ureterovesical reimplantation by means of laparoscopy associated with six-stitch suture with the period from March in 2012 to September in 2015. And these were statistically analyzed including the operation time, intraoperative bleeding volume, postoperative drainage volume, removal time of drainage tube, admission time after operation and the incidence of postoperative complications of vesicoureteric reflux and stenosis.Results The operations of 16 participants were completed successfully without converting to open surgery. The operation time was 60 ~ 125 min (Mean time: 85 min); intraoperative bleeding volume was 20 ~ 50 ml (Mean volume: 32 ml); postoperative drainage volume was 60 ~ 400 ml (Mean volume: 106 ml); removal time of drainage tube was 3 ~ 6 d (Mean time: 4.2 d) and admission time after operation was 7 ~ 10 d (Mean time: 8.5 d). There was the follow-up with 6 ~ 18 months (Mean time: 12 months) for participants. No anastomotic stenosis was present. In addition, one participant was suffered from mild vesicoureteric relfux. And there was no aggravation during 18 months.Conclusions The inserting ureterovesical reimplantation by means of laparoscopy associated with six-stitch suture was safe and effective. It was found that the operation time was significantly shortened and the incidence of postoperative complications of vesicoureteric relfux and anastomotic stenosis was not increased. By contrast, the six-stitch suture could reduce the incidence of anastomotic stenosis.

Objective To investigate the stress distribution on the maxillary anterior teeth retracted with sliding mechanics and micro-implant anchorage using different retraction hook heights and positions.Methods DICOM image data including maxilla and upper teeth were obtained with cone-beam CT.The three-dimensional finite element model was constructed using Mimics software.Brackets and archwire model were constructed using Creo software.The models were instantiated using Pro/Engineer software.Abaqus software was used to simulate the sliding mechanics by loading 2 N force on 0,2,4,6,8,10 mm retraction hooks and three different positions,repectively.Rotation of the occlusal plane,the initial displacement and stress distribution of teeth were analyzed.Results Lingual rotation of maxillary central incisor(0.021°),gingival movement of the maxillary first molar(0.005 mm),and clockwise rotation of the maxillary occlusal plane(0.012°) were observed when the force application point located at the archwire level (0 mm).In contrast,0.235° labial rotation of the maxillary central incisor,0.015 mm occlusal movement of the maxillary first molar,and 0.075° anti-clockwise rotation of the maxillary occlusal plane were observed when the force application point located at the higher level(10 mm retraction hook).The more the force application point was located posteriorly at the archwire level,the less lingual rotation of the maxillary central incisor and the more buccal displacement of maxillary first molar was observed.Conclusions Maxillary anterior tooth rotation and retraction,vertical displacement of posterior segment,and rotation of the occlusal plane could be controlled by adjusting the height and position of the retraction hook in space closure using miniscrew and sliding mechanics.