Angiotensin (Ang Ⅱ),a main effector peptide of the renin-angiotensin system (RAS),mediates a hormonal action in the maintenance of blood pressure and electrolyte levels,and thus fluid homeostasis.Recent studies have implicated that it correlates with tumor growth,angiogenesis,metastasis and it has drawn more and more attention.Many studies show that Ang Ⅱ-AT1R/AT2R play crucial roles in tumor growth,metastasis,invasion and tumor angiogenesis,which are formed new targets for treating malignant tumors.

Objective To study the effect of appling a new tension-free three dimension with bilayer mesh herniorraphy(TFTDBMH) in treating inguinal hernia in order to decrease the compilcation and the recurrence rates after herniorraphy. Methods The clinical data of 47 male patients with ingular hernia treated by TFTDBMH were analyzed. All the 47 patients were males with an average age of sixty-five years old. There were 36 patients with indirect hernias and 11 direct hernias in this series. During operation, their inguinal regions were extensively dissected and the transverse fascias were separated from peritoneum after the hernia sacs were completely dissected to reach the hernia sac necks. The base layer of the belayed patch mesh was put into the space between the transverse fascia and the peritoneum, then the hernia sac was put into abdominal cavities. The upper layer of the bilyer patch mesh was saw up to the inguinal ligaments and the arcade inferior boarder,then a three - dimension structures were formed at the inguinal regions. Results After operation, all the patients had no any bad reaction. They could be out-of-bed activity on the first day after operation. They could be discharged on the third day after operation.All the patients were followed up for one to two years, these patients felt well,no scar formation on the operative area,and no recurrence postoperatively. Conclusions This operation could be applied for the patients with inguinal hernia and the inguinal posterior walls need to be repaired. This operation fits to the human body anatomy. The postoperative complication and postoperative recurrence rate are low.This operative procedure is more complicated. It request that the operators must have higher operative technique.

0.05),between the two groups,but in body mass index [(24.451?3.752) vs(22.468?2.434),P=0.030],previous history of pancreatitis(23.8% vs.7.5%,P=0.046) and bloody ascites(95.24% vs.46.24%,P0.05).MODS rate was higher in HL-group(52.4% vs.29%,P=0.04).The two groups had similar operation rates(66.7% vs 80.6%,P=0.178),hospitalization days [(25.476?14.383) vs(22.796?7.191),P=0.216] and mortality rate(28.6% vs.11.8%,P=0.069).Conclusions Hyperlipidemic severe acute pancreatitis has the characters of heavier weight habitus,history of frequent recurrence,high incidence of bloody ascites and prone to develop MOF.