Objective:To assess the psychometric properties of the Chinese version of 12-item immediate mood scale(IMS-12) in patients with depression.Methods:From January to June 2018, a total of 459 patients with depression recruited from an outpatient clinic by convenient sampling approach.All the subjects were assessed by the Chinese version of the IMS-12, and 43 of them were assessed again at the end of the first week.The 16-item quick inventory of depressive symptomatology (QIDS-SR16), and the generalized anxiety disorder scale-7(GAD-7) were used as validity indicator.The factor structure of the scale was evaluated by exploratory and confirmatory factor analyses.The internal consistency of the Chinese version of the IMS-12 scale was evaluated by Cronbach’s alpha coefficient.The intraclass correlation coefficient (ICC) was used to evaluate test-retest reliability.Pearson’s correlation coefficient was used to evaluate calibration validity.The softwares of SAS 9.4 and Mplus 8.5 were used for statistical analysis.Results:The exploratory factor analysis indicated that the fitting result of the two-factor model was good(including depression and anxiety factors). The results of the confirmatory factor analysis indicated that the factor model fit well and met the reference standard ( χ2/ df=2.82, CFI=0.936, TLI=0.920, RMSEA=0.088). The Cronbach’s alpha coefficient of the Chinese version of the IMS-12 was 0.95, and the ICC for test-retest reliability was 0.85.The correlation coefficients of the total IMS-12 score with the QIDS-SR16 score and with the GAD-7 score were 0.69 and 0.70, respectively. Conclusion:The Chinese version of the IMS-12 has good reliability and validity and is suitable for the clinical assessment of depressive and anxiety symptoms in patients with depression.

In the past 30 years since its inception, the Chinese Journal of Behavioral Medicine and Brain Science has been constantly pragmatic and innovative, and adhered to the implementation of a series of strong journal plans.The editors taken the construction of high-quality scientific and technological journals as an opportunity, the Chinese Journal of Behavioral Medicine and Brain Science focuses on improving the core competitiveness of journals, expanding the international influence of journals, strengthening the digital construction of journals and improving editor ability to create high-quality scientific and technological journals.It has achieved fruitful results.In the future, the Chinese Journal of Behavioral Medicine and Brain Science will continue to adhere to the principle of " academic first, quality first" , grasp the implementation of the " China Brain Plan" and " Healthy China Action" , adhere to integrity and innovation, continue to create a brand of journals with higher academic influence, and further drive the development of disciplines.

Objective:To analyze the changing trend of articles, authors and citation indexes in Chinese Journal of Behavioral Medicine and Brain Science(CJBMBS), so as to provide basis and guidance for further academic quality and editing and proofreading quality improving, and striving to build high-quality scientific and technological journal.Methods:Chinese Medical Journal Network and Wanfang database were used to obtain the information of articles published from 2009 to 2021.The citation indexes of the CJBMBS and the discipline journals of " neurology and psychiatry" were obtained from the natural science volume of the Citation Report (Core Edition) of Chinese Scientific and Technological Journals from 2002 to 2021.All data were analyzed by Excel 2010.Results:The CJBMBS published 187-314 articles per year from 2015 to 2021, and the annual number of articles decreased year by year.The average number of pages per article was 3.66-6.13 pages/article, showing an increasing trend year by year.Since 2015, the CJBMBS set up 3-7 key topics every year, and published 6.4%-16.2% articles of the annual.From 2009 to 2020, the average citation volume of magazine articles was 12.8-27.9, showing an increasing trend year by year.The average number of authors per article was basically stable at 4-6.From 2001 to 2020, the core impact factor of the CJBMBS was 0.188-1.327, with a wave like change and an overall upward trend.The total frequency of core citations was 155-2 836, with a rapid increase from 2001 to 2009, a stable at 2 500 from 2007 to 2017, and a downward trend after 2014.Compared with average level of the core journals of the discipline " neurology and psychiatry" , the core impact factor and the core total citation frequency of the CJBMBS from 2009 to 2020 were both significantly higher.From 2009 to 2020, the fund paper ratio of CJBMBS was 0.42-0.84, showing an upward trend.Conclusion:The citation indexes of CJBMBS are in the forefront of the discipline in recent years.In the future, we should pay more attention to the academic quality of papers and further expand the influence of the journal.

Objective:To analyze the characteristics of papers on Chinese Journal of Behavioral Medicine and Brain Science based on F5000, so as to provide reference for topic selection planning, soliciting contributions, soliciting contributions and mining high-quality manuscript sources.Methods:The papers selected from Chinese Journal of Behavioral Medicine and Brain Science from 2012 to 2019 were selected as the research objects.The paper magazine published by Chinese Journal of Behavioral Medicine and Brain Science and Wanfang database were used as information sources.The selected year, publication year, fund distribution, high publishing provinces and institutions, and cited frequency were statistically analyzed.Results:From 2012 to 2019, F5000 collected 79 papers in Chinese Journal of behavioral medicine and brain science, which published in 2007-2018.The percentage of fund papers was 82.27%, the percentage of national fund papers was 37.97%, and the average number of fund projects was 1.58.The high produced institutions were concentrated in Jiangsu, Shandong, Chongqing, Shanxi and Beijing.The ratio of cooperation in institutions was 53.2%.The ratio of cooperation in authors was 96.20%.The number of citations was 1 253 , and the average number of citations per article was 15.86.The total citation frequency was 2 404, and the average citation frequency per article was 30.43.Seventy-one articles were included to analyse the key words.The total number of key words was 293, and the average number of keywords per article was 4.13.It mainly focused on emotional disorders, cognitive function, psychological assessment, brain function and structure.Conclusions:Chinese Journal of Behavioral Medicine and Brain Science is relatively stable in terms of fund paper ratio, ratio of cooperation in authors and core author team.It is necessary to further tap the core authors, promote multi-disciplinary and field cooperation, strive for excellent author resources and manuscript resources, so as to improve the core competitiveness of the magazine.

Objective:To investigate the pathological characteristics and the clinical significance of novel coronavirus (2019-nCoV)-infected pneumonia (termed by WHO as coronavirus disease 2019, COVID-19).Methods:Minimally invasive autopsies from lung, heart, kidney, spleen, bone marrow, liver, pancreas, stomach, intestine, thyroid and skin were performed on three patients died of novel coronavirus pneumonia in Chongqing, China. Hematoxylin and eosin staining (HE), transmission electron microcopy, and histochemical staining were performed to investigate the pathological changes of indicated organs or tissues. Immunohistochemical staining was conducted to evaluate the infiltration of immune cells as well as the expression of 2019-nCoV proteins. Real time PCR was carried out to detect the RNA of 2019-nCoV.Results:Various damages were observed in the alveolar structure, with minor serous exudation and fibrin exudation. Hyaline membrane formation was observed in some alveoli. The infiltrated immune cells in alveoli were majorly macrophages and monocytes. Moderate multinucleated giant cells, minimal lymphocytes, eosinophils and neutrophils were also observed. Most of infiltrated lymphocytes were CD4-positive T cells. Significant proliferation of type Ⅱ alveolar epithelia and focal desquamation of alveolar epithelia were also indicated. The blood vessels of alveolar septum were congested, edematous and widened, with modest infiltration of monocytes and lymphocytes. Hyaline thrombi were found in a minority of microvessels. Focal hemorrhage in lung tissue, organization of exudates in some alveolar cavities, and pulmonary interstitial fibrosis were observed. Part of the bronchial epithelia were exfoliated. Coronavirus particles in bronchial mucosal epithelia and type Ⅱ alveolar epithelia were observed under electron microscope. Immunohistochemical staining showed that part of the alveolar epithelia and macrophages were positive for 2019-nCoV antigen. Real time PCR analyses identified positive signals for 2019-nCoV nucleic acid. Decreased numbers of lymphocyte, cell degeneration and necrosis were observed in spleen. Furthermore, degeneration and necrosis of parenchymal cells, formation of hyaline thrombus in small vessels, and pathological changes of chronic diseases were observed in other organs and tissues, while no evidence of coronavirus infection was observed in these organs.Conclusions:The lungs from novel coronavirus pneumonia patients manifest significant pathological lesions, including the alveolar exudative inflammation and interstitial inflammation, alveolar epithelium proliferation and hyaline membrane formation. While the 2019-nCoV is mainly distributed in lung, the infection also involves in the damages of heart, vessels, liver, kidney and other organs. Further studies are warranted to investigate the mechanism underlying pathological changes of this disease.

Objective: To analyze the trend of citation index of Chinese Journal of Behavioral Medicine and Brain Sciences(CJBMBS) from 2011 to 2018, and compare to the average level of Chinese Medical Association(CMA) series journals, so as to provide basis for improving academic quality and journal influence. Methods: Trend analysis on citation index of CJBMBS from 2011 to 2018 and comparison with the average level of Chinese Medical Association series journals were conducted by Microsoft Excel 2010. Results: From 2011 to 2018, the core impact factor(0.849-1.151) and ratio of foundation-supported papers(0.550-0.810) of CJBMBS showed an upward trend, while the core total citation(1 783-2 836) showed a downward trend.The core total citation, core impact factor and ratio of foundation-supported papers of CJBMBS were higher than the average level of CMA series journals(1 355-1 699, 0.497-0.890, 0.335-0.460), but the core other-citation rate was lower than the average level of CMA series journals (0.81-0.85). Conclusion The CJBMBS is at a high level among the core journals of Chinese science and technology, and more attention should be paid to the problem of high self-citation rate.

Objective To investigate the effects of single i.v. subanesthetic dose of ketamine on heart rate, blood pressure and oxygen saturation for antidepressant treatment. Methods Patients with severe depressive disorder were randomized to ketamine group (n=13) and control group (n=14). Ketamine group received ketamine (0.5mg/kg) single injection whereas control group received saline single injection. Escitalopram (10 mg/d) were orally administered for 4 weeks simultaneously. Comparisons were made on the heart rate, blood pressure and oxygen saturation at baseline, 40 min, 100 min, and 280 min after injection between the two groups. Results The main effects of time but not group were significant for all parameters including heart rate, systolic blood pressure and diastolic blood pressure, (P＜0.05). Interaction of time×group was significant (P＜0.05). All parameters including heart rate (F=16.85, P＜0.01), systolic blood pressure (F=15.82, P＜0.01) and diastolic blood pressure (F=8.63, P＜0.01) with time were significant in ketamine group. The heart rate, systolic blood pressure and diastolic blood pressure in ketamine group were significantly higher at 40 min than at other time points (P＜0.05), while were no significant difference among other time points (P＞0.05). There was no statistical significance of main effect of time, group and interaction of time×group in oxygen saturation between the two groups (P＞0.05). Conclusion Single subanesthetic dose ketamine intravenous drip for antidepressant therapy may cause a transient increase in heart rate and blood pressure.

Cerebrovascular disease,Alzheimer's disease,Parkinson's disease and other chronic encephalopathy has become a worldwide public health problem.Cognitive impairment,including mild cognitive impairment to dementia,is closely related to chronic encephalopathy,especially cerebrovascular diseases.Early detection,early diagnosis,early treatment of cognitive impairment has become the focus of the research,in order to reduce the development of dementia,improve the quality of life and reduce the burden of disease.This article elaborates the research progress of cognitive impairment from the aspects of pathological mechanisms,risk factors,clinical diagnosis and strategy prevention and control,and the arguments of domestic experts.

To analyze the mortality risk of stroke in China by literature search.The mortality rate of stroke (age standardized) in China has declined in recent years.The mortality rate of stroke which increases with age is higher in rural areas than in urban areas,and is higher in men than in women in China.There are obvious regional differences and seasonal differences in the mortality of stroke in China.Different subtypes of stroke have different death characteristics.Low or high temperatures can increase the risk of mortality of stroke.With the change of epidemiological characteristics,the risk factors of mortality of stroke in China are also changing.Through the epidemiological study of stroke death,the mortality risk of stroke can be researched effectively,the epidemiological characteristics of stroke can be mastered,and the direction of prevention and treatment of stroke can be understood.Individualized and multi factor intervention for unhealthy lifestyle,unhealthy behavior and metabolic cardiovascular risk factors can promote the establishment of stroke prevention and control strategy in China.

Objective To reproduce a stable animal model of brain death in pigs, observe the change regularity of cerebral oxygen metabolism during the process of brain death, and to evaluate the significance and value of cerebral oxygen metabolism parameters for the diagnosis of brain death. Methods Twelve landrace pigs were used to create the brain death models using modified method of increasing epidural intracranial pressure (ICP). The mean arterial pressure (MAP) and ICP were monitored continuously during the process. The pigs were divided into four groups according to cerebral perfusion pressure (CPP) decreasing degree during brain death, namely CPP normal group and CPP decreasing 0%-30%, 30%-70%, and 70%-100% groups. Blood gas analysis of the external carotid artery and internal jugular vein were monitored discontinuously. The changes in cerebral oxygen metabolism parameters, including external carotid artery-internal jugular vein bulb oxygen content difference (AJDO2), internal jugular bulb-external carotid artery carbon dioxide partial pressure difference (DPCO2) and DPCO2/AJDO2 ratio, were observed. Results Brain death model were successfully reproduced in 12 experimental pigs. With MAP and ICP monitoring, the models at different stages of CPP could be repeatedly induced. The levels of AJDO2 and DPCO2 were increased gradually and then decreased, while the ratio of DPCO2/AJDO2 was constantly increased with the decrease of CPP. The level of AJDO2 in CPP decreasing 0%-30%group was significantly higher than that in CPP normal group [(5.86±1.21)% vs. (3.92±0.64)%], the levels of DPCO2 in CPP decreasing 0%-30% and CPP decreasing 30%-70% groups were significantly higher than those in CPP normal group [mmHg (1 mmHg = 0.133 kPa): 10.33±1.83, 11.48±2.32 vs. 6.11±1.43], and the ratios of DPCO2/AJDO2 in CPP decreasing 30%-70% and CPP decreasing 70%-100% groups were significantly higher than those in CPP normal group and CPP decreasing 0%-30% group (2.81±0.53, 4.12±1.07 vs. 1.57±0.64, 1.62±0.81). All the differences above were statistically significant (all P < 0.05). Conclusions With the decrease of CPP, cerebral oxygen metabolism showed a regular change during brain death. DPCO2 combined with DPCO2/AJDO2 is a reliable blood gas analysis index indicating intracranial hypoperfusion, which has certain reference value for the determination of brain death.