Acute lung injury (ALI) has been a kind of acute and severe disease that is mainly characterized by systemic uncontrolled inflammatory response to the production of huge amounts of reactive oxygen species (ROS) in the lung tissue. Given the critical role of ROS in ALI, a Fe₃O₄ loaded bovine serum albumin (BSA) nanocluster (BF) was developed to act as a nanomedicine for the treatment of ALI. Combining with NIR irradiation, it exhibited excellent ROS scavenging capacity. Significantly, it also displayed the excellent antioxidant and anti-inflammatory functions for lipopolysaccharides (LPS) induced macrophages (RAW264.7), and Sprague Dawley rats via lowering intracellular ROS levels, reducing inflammatory factors expression levels, inducing macrophage M2 polarization, inhibiting NF-κB signaling pathway, increasing CD4⁺/CD8⁺ T cell ratios, as well as upregulating HSP70 and CD31 expression levels to reprogram redox homeostasis, reduce systemic inflammation, activate immunoregulation, and accelerate lung tissue repair, finally achieving the synergistic enhancement of ALI immunotherapy. It finally provides an effective therapeutic strategy of BF + NIR for the management of inflammation related diseases.

Objective:To comparative analyze the role and effectiveness of different healthcare consortium support models in enhancing the capacity of community health centers.Methods:Using community health service centers under the loose medical association support mode and the close medical association support mode as research subjects,the data on medical service capacity were quantitatively analyzed using DID(Difference-in-Difference).Results:Both close medical association and the loose medical association support models have increased the number of outpatient and emergency room visits,Chinese medicine consultations,and referrals to community health centers.The close medical association support model also increased the number of discharges from the community health centers.Conclusion:Close medical consortium can enhance the capacity of community health centers,and the effect is better than loose medical consortium.

Objective:To comparative analyze the role and effectiveness of different healthcare consortium support models in enhancing the capacity of community health centers.Methods:Using community health service centers under the loose medical association support mode and the close medical association support mode as research subjects,the data on medical service capacity were quantitatively analyzed using DID(Difference-in-Difference).Results:Both close medical association and the loose medical association support models have increased the number of outpatient and emergency room visits,Chinese medicine consultations,and referrals to community health centers.The close medical association support model also increased the number of discharges from the community health centers.Conclusion:Close medical consortium can enhance the capacity of community health centers,and the effect is better than loose medical consortium.

Objective:To comparative analyze the role and effectiveness of different healthcare consortium support models in enhancing the capacity of community health centers.Methods:Using community health service centers under the loose medical association support mode and the close medical association support mode as research subjects,the data on medical service capacity were quantitatively analyzed using DID(Difference-in-Difference).Results:Both close medical association and the loose medical association support models have increased the number of outpatient and emergency room visits,Chinese medicine consultations,and referrals to community health centers.The close medical association support model also increased the number of discharges from the community health centers.Conclusion:Close medical consortium can enhance the capacity of community health centers,and the effect is better than loose medical consortium.

Objective:To comparative analyze the role and effectiveness of different healthcare consortium support models in enhancing the capacity of community health centers.Methods:Using community health service centers under the loose medical association support mode and the close medical association support mode as research subjects,the data on medical service capacity were quantitatively analyzed using DID(Difference-in-Difference).Results:Both close medical association and the loose medical association support models have increased the number of outpatient and emergency room visits,Chinese medicine consultations,and referrals to community health centers.The close medical association support model also increased the number of discharges from the community health centers.Conclusion:Close medical consortium can enhance the capacity of community health centers,and the effect is better than loose medical consortium.

Objective:To comparative analyze the role and effectiveness of different healthcare consortium support models in enhancing the capacity of community health centers.Methods:Using community health service centers under the loose medical association support mode and the close medical association support mode as research subjects,the data on medical service capacity were quantitatively analyzed using DID(Difference-in-Difference).Results:Both close medical association and the loose medical association support models have increased the number of outpatient and emergency room visits,Chinese medicine consultations,and referrals to community health centers.The close medical association support model also increased the number of discharges from the community health centers.Conclusion:Close medical consortium can enhance the capacity of community health centers,and the effect is better than loose medical consortium.

Objective:To comparative analyze the role and effectiveness of different healthcare consortium support models in enhancing the capacity of community health centers.Methods:Using community health service centers under the loose medical association support mode and the close medical association support mode as research subjects,the data on medical service capacity were quantitatively analyzed using DID(Difference-in-Difference).Results:Both close medical association and the loose medical association support models have increased the number of outpatient and emergency room visits,Chinese medicine consultations,and referrals to community health centers.The close medical association support model also increased the number of discharges from the community health centers.Conclusion:Close medical consortium can enhance the capacity of community health centers,and the effect is better than loose medical consortium.

Objective:To comparative analyze the role and effectiveness of different healthcare consortium support models in enhancing the capacity of community health centers.Methods:Using community health service centers under the loose medical association support mode and the close medical association support mode as research subjects,the data on medical service capacity were quantitatively analyzed using DID(Difference-in-Difference).Results:Both close medical association and the loose medical association support models have increased the number of outpatient and emergency room visits,Chinese medicine consultations,and referrals to community health centers.The close medical association support model also increased the number of discharges from the community health centers.Conclusion:Close medical consortium can enhance the capacity of community health centers,and the effect is better than loose medical consortium.

Objective:To comparative analyze the role and effectiveness of different healthcare consortium support models in enhancing the capacity of community health centers.Methods:Using community health service centers under the loose medical association support mode and the close medical association support mode as research subjects,the data on medical service capacity were quantitatively analyzed using DID(Difference-in-Difference).Results:Both close medical association and the loose medical association support models have increased the number of outpatient and emergency room visits,Chinese medicine consultations,and referrals to community health centers.The close medical association support model also increased the number of discharges from the community health centers.Conclusion:Close medical consortium can enhance the capacity of community health centers,and the effect is better than loose medical consortium.

Objective:To compare the difference of chemical compositions of single decoction and mixed decoction of Gypsum Fibrosum - Anemarrhenae Rhizoma medicinal pair with different proportion.Methods:The Ultra Performance Liquid Chromatography (UPLC) and Ion Chromatography (IC) fingerprints of each sample were collected, and the independent sample t-test on the ratio of "peak area/weight" value of common peaks which was from the single decoction and mixed decoction samples was performed through SPSS 26.0.Results:In the UPLC fingerprint, there was significant difference in the "peak area/weight" values of peak 1, peak 2, peak 3, peak 6 and peak 13 between mixed decoction and single decoction with different compatibility ratios (1:1, 3:2, 2:1, 5:2, 3:1)( P<0.05), while peak 5 and peak 11 were without significant difference ( P>0.05). When the compatibility ratio of Gypsum Fibrosum and Anemarrhenae Rhizoma was 1:1, 3:2, 5:2, 3:1, there was significant difference in the "peak area/weight" values of peak 7 (neomangiferin) ( P<0.05). In the IC fingerprint, there was significant difference in the "peak area/weight" values of peak 1 between mixed decoction and single decoction with different compatibility ratios (1:1, 3:2, 2:1, 5:2, 3:1) ( P<0.05), while there was no significant difference in peak 5 (calcium ion) ( P>0.05). Conclusion:There are differences in the chemical component content of Gypsum Fibrosum-Anemarrhenae Rhizoma medicinal pair for single decoction and mixed decoction.