Objective:To conduct a scoping review of domestic and international risk prediction models for the recurrence of diabetic foot ulcers (DFU) and provide a basis for clinical nursing practices and related research.Methods:A computer search of nine databases in both Chinese and English was conducted, with the search period extending up to September 1, 2023. Two researchers independently performed data selection and extraction. The methodological quality of the included studies was assessed using the Prediction model Risk of Bias Assessment Tool (PROBAST) .Results:A total of seven studies were included, comprising thirteen risk prediction models. History of previous foot ulcers, smoking, duration of diabetes, and foot lesions were identified as the primary predictive factors, with predictive discrimination ranging from 0.660 to 0.943.Conclusions:Nursing staff should pay close attention to the risk factors for recurrence of DFU, develop low-bias and highly applicable risk prediction models, and validate and refine existing models.

Objective To investigate the effects of glycosylphosphatidylinositol-anchored HDL-binding protein (GPIHBP1) on glioma growth and macrophage infiltration. Methods Initially, the expression of GPIHBP1 in glioma samples and macrophage infiltration were analyzed using TCGA database, and these bioinformatics results were validated in clinical tissue samples. A stable glioma cell line overexpressing GPIHBP1 was then established to further explore the effects of GPIHBP1 overexpression on glioma cell proliferation, apoptosis, migration, and invasion. Finally, the impact of GPIHBP1 overexpression on tumor growth and macrophage infiltration was verified through xenograft experiments. Results TCGA database analysis revealed that GPIHBP1 expression was higher in low-grade gliomas compared to normal tissues, while it was lower in high-grade gliomas. Additionally, the expression level of GPIHBP1 in low-grade gliomas was higher than in high-grade gliomas, which was confirmed by immunohistochemistry (IHC). Western blot analysis confirmed the successful construction of the GPIHBP1-overexpressing glioma cell line. CCK-8, flow cytometry, scratch and Transwell assays demonstrated that the proliferation, migration and invasion capabilities of the stable cell line were reduced compared to the control group. Xenograft experiments further showed that the tumor growth and macrophage infiltration were decreased in the stable cell line. Conclusion The differential expression of GPIHBP1 in different grades of gliomas may be associated with tumor progression. Overexpression of GPIHBP1 can inhibit glioma growth, possibly by influencing the tumor microenvironment and promoting the polarization of macrophages towards the antitumor M1 phenotype, thereby inhibiting glioma growth.

Objective:To summarize the best evidence of psychological intervention for patients receiving assisted reproductive technology (ART).Methods:All evidence on psychological interventions for patients receiving ART was searched in UpToDate, BMJ Best Practice, Joanna Briggs Institute, GIN, NICE, NGC, SIGN, CMA Infobase, Cochrane Library, PubMed, Web of Science, CINHAL, Embase, psycINFO, China Guideline Clearinghouse (CGC), guides in medlive.cn, CNKI, Wanfang Data, SinoMed, and VIP databases. The evidence retrieved included clinical practice, recommendations, guidelines, expert opinions, consensus, systematic reviews and meta-analyses, and the search time limit was from the establishment of the database to January 2023. Two researchers conducted evidence extraction, aggregation, and quality evaluation.Results:A total of 797 references were obtained at the initial retrieval, and 27 papers were finally included, including 1 clinical best practice, 2 guidelines, 1 recommended practice, and 23 systematic evaluations. The evidence summary summarized 16 best evidences, including four aspects of psychological assessment, psychological intervention, drug treatment and personnel training for ART patients, of which 50% were class 1 evidences and 87.5% of the evidences were recommended with strength A.Conclusions:Enhanced personnel training in assisted reproduction facilities and early identification of the psychological state of infertile patients by medical staff and targeted psychological intervention or medication are the key to improving the psychological status of ART patients.

Objective     To analyse the consistency of perioperative self-reported pain scores of lung cancer patients with clinical records to provide a basis for optimal pain management. Methods    The patients with lung cancer who underwent surgical treatment in the Department of Thoracic Surgery, Sichuan Cancer Hospital from November 2017 to January 2020 were selected. They were divided into two groups based on the source of pain data. The self-report group used a questionnaire in which patients self-reported their pain scores, and the pain scores for the clinical record group were extracted from the electronic medical record system. Kappa test was used to compare the concordance of pain scores between the two groups preoperatively, on postoperative 1-6 days and on the day of discharge. McNemar's paired χ2 test was used to compare the differences in pain intensity levels between the two groups. Binary logistic multi-factor regression was used to analyse the factors influencing the concordance of severe pain (7-10 points) between the two groups. Results     Totally 354 patients were collected, including 191 males and 163 females, with an average age of 55.64± 10.34 years. The median postoperative hospital stay was 6 days. The consistency of pain scores between the two groups was poor (Kappa=–0.035 to 0.262, P<0.05), and the distribution of pain levels at each time point was inconsistent and statistically significant (P<0.001). The percentage of inconsistent severe pain assessment ranged from 0.28% to 35.56%, with the highest percentage of inconsistent severe pain assessment on postoperative day 1 (35.56%). Single-port thoracoscopic surgical access was an influencing factor for inconsistent assessment of severe pain on postoperative day 3 (OR=2.571, P=0.005). Conclusion     Self-reported perioperative pain scores of lung cancer patients are poorly aligned with clinical records. Clinical measures are needed to improve the accuracy of patient pain data reporting by choosing the correct assessment method, increasing education, and developing effective quality control measures.

The number of investigator initiated research (IIR) is increasing. But the recognition and management of IIR in China is still in its infancy, and there is a lack of specific and operable guidance for the implementation process. Based on our practical experiences, previous literature reports, and current policy regulations, the authors took prospective IIR as an example to summarize the implementation process of IIR into 14 steps, which are as the following: study initiation, ethical review, study registration, study filing, case report form design, database establishment, standard operating procedure making, investigator training, informed consent, data collection, data entry, data verification, data locking and data archiving.

Objective:To study the clinical results of robot-assisted laparoscopic resection for choledochal cysts.Methods:From October 2020 to June 2022, clinical data on 20 patients who underwent choledochal da Vinci robot-assisted laparoscopic choledochal cyst resection at Fujian Provincial Hospital were retrospectively analyzed. Forty-two children with choledochal cysts were included in this study. There were 16 males and 26 females, aged 25 (range 15.0 to 45.0) months. The operations were carried out by the same team of surgeons. These patients were divided into two groups based on the surgical methods: children who underwent da Vinci robot-assisted laparoscopic surgery were in the robotic group ( n=20) and children who underwent single-port (transumbilical) laparoscopic surgery were in the laparoscopic group ( n=22). The general clinical data, operation time, intraoperative blood loss, fasting time, hospital stay, total medical costs and complications were collectd and analysed. Follow-up was performed in outpatient visits. Results:Both the 2 groups underwent surgery successfully, and no patient was converted to laparotomy. When compared with the laparoscopic group, intraoperative blood loss [(10.65±3.75) vs. (14.86±3.75) ml], indwelling time of abdominal drainage tube [(5.45±2.21) vs. (7.05±1.94) d] and fasting time [(4.00±1.49) vs. (6.05±1.43) d] in the robotic group were significantly less, while the operation time [394(299, 422) vs. 351(269, 380) min] and hospitalization cost [(79 200±4 000) vs. (31 100±3 000) yuan] were significantly increased (all P<0.05). The differences in postoperative complication rates and pain score between the two groups showed no significant differences (all P>0.05). On follow-up, no patients developed complications such as cholangitis, jaundice, intestinal obstruction and cholangiocarcinoma, except for one patient in the laparoscopic group who developed cholangitis after surgery. Conclusion:Robot-assisted laparoscopic choledochal cystectomy was effective and safe in treatment of children with choledochal cysts.

Objective To compare the clinical effects of 577 nm and 532 nm laser panretinal photocoagulation in the treatment of severe non-proliferative diabetic retinopathy (NPDR).Methods A prospective,controlled trial was conducted in 42 patients(64 eyes)with severe NPDR,who were randomly divided into 577 nm group and 532 nm group.All of patients received PRP with the single-point model.Preoperative and postoperative 1 day,1 month,3 and 6 months,the best corrected visual acuity (BCVA),fundus,optical coherence tomography (OCT) and full field flash electroretinogram (F-ERG) were examined.After treatment 3 and 6 months,fundus fluorescein angiography (FFA) examination was performed between two groups.Results In 577 nm group and 532 nm group,the average number of laser spot was (1969.25 ± 278.19) and (2098.16 ± 289.27) respectively;average laser power was (425.23 ± 50.15)mW and (438.15 ± 38.48)mW respectively;and average energy density was (7.54 ± 1.54) mW · ms · μm-2 and (7.68 ± 3.01)mW · ms · μm-2.There was no difference in number of laser spot(t =2.68),laser power (t =1.46) and energy density (t =2.15) between the two groups (all P ＞ 0.05),and the differences of macular central thickness after treatment 1 month,3 and 6 months (t =1.98,1.88,1.81 respectively) approached no statistical significance between the two groups (all P ＞ 0.05),while F-ERG a,b wave amplitudes after treatment 1 month,3 and 6 months (a wave:t =5.94,5.19,6.97;b wave:t =5.67,4.56,5.12) had significant differences between groups (all P ＜ 0.05).The effective rate of treating 6 months after operation in the two groups were 87.5％ and 46.9％ respectively,with significant difference (x2 =7.56,P ＜ 0.05).Conclusion 577 nm laser is more effective and has less damage to visual function than 532 nm laser in the treatment of NPDR.

Objective To analysis the development tendency and research focus of long-term care of chronic disease between China and abroad and guide the research and application of long-term care of chronic disease in China. Methods The PubMed database and China National Knowledge Infrastructure (CNKI) database were searched and co-word clustering analysis and multidimensional scaling analysis with Bicomb and SPSS 21.00 software were used. Results Foreign hot spots are summarized as follows:oxygen inhalation therapy; mental disorder patients; the needs and demands of long term care. And the following domestic hot spots: long term care for the aged; long term care insurance and social support. Conclusions Long-term care researches in China is still in the exploratory stage and combining with domestic and foreign research hot spots, proposal of long term care in China are summarized as follows:expand the study population of the domestic long-term care, such as the disabled and the mental disorder;enrich domestic long-term care research topics, such as long-term care model, caregivers, care quality, etc.

Objective Based on the theory of preventive treatment and constitution regulation, to observe the clinical efficacy of point application for stable chronic obstructive pulmonary disease (COPD).Methods Seventy-nine qi deficiency or yang deficiency patients in stable COPD were randomized into a treatment group of 40 cases and a control group of 39 cases. The control group received conventional medication and the treatment group additionally received point application in canicular days or the three-nine days in winter. The frequency of catching cold, the situation of acute exacerbation of chronic obstructive pulmonary disease (AECOPD), constitution types and scores of traditional Chinese medicine (TCM), pulmonary function [the level of forced expiratory volume in one second (FEV1), the percentage of FEV1 in predicted value, FEV1’s ratio to forced vital capacity (FVC)], BODE index (body mass index, airflow obstruction, dyspnea and exercise capacity index) and therapeutic effects were recorded in the two groups before and after the treatment. The correlation analysis was performed between the scores of constitution and the frequency of catching cold, AECOPD, syndrome scores of TCM, BODE index.Results The cold times, AECOPD attack times, times of hospitalization for AECOPD and syndrome scores of TCM were significantly changed in the treatment group after treatment (P<0.01,P<0.05). There were statistically significant changes in the cold times, AECOPD attack times, and syndrome scores of TCM in the two groups after treatment (P<0.05). The total effective rate was 85.7% in the treatment group versus 70.3% in the control group, and the difference was statistically significant (P<0.05). The scores of the main abnormal constitution (qi deficiency or yang deficiency) and balanced constitution were significantly changed in the treatment group after treatment (P<0.01,P<0.05). There were statistically significant differences in the scores of the main abnormal constitution and balanced constitution between the two groups after treatment (P<0.01,P<0.05). There were no statistically significant changes in each item of pulmonary function in the two groups after treatment (P>0.05). After the treatment, the change of the BODE score in the treatment group was significantly different from that in the control group (P<0.01). A significant positive correlation was found between the main abnormal constitution scores and the cold times, AECOPD attack times, times of hospitalization for AECOPD, syndrome scores of TCM in the treatment group after treatment (P<0.05,P<0.01). A significant negative correlation was found between the balanced constitution scores and the cold times, AECOPD attack times, times of hospitalization for AECOPD, syndrome scores of TCM in the treatment group after treatment (P<0.05,P<0.01).Conclusion Point application is an effective method for stable COPD.

Objective To investigate the impact of daily life ability, self-efficacy and social support on post-stroke depression. Methods This was a cross-sectional questionnaire survey. A convenience sample of stroke patients from neurology department was created. Data were collected from patients about their level of daily life ability, self-efficacy, social support and depression measured. Inferential statistics multiple regression analysis was used to estimate the relationships between the predictors and post-stroke depression. Results A total of 144 (96.00%) of 150 stroke patients completed the questionnaires. The level of depression was 14.19 ± 9.25 with 25.00% (36/144) of incidence of post-stroke depression. Self-efficacy scored 40.45 ± 11.41, social support scored 28.34 ± 8.02, which negatively predicted depression (r=-0.834 and-0.736, P<0.01 respectively). Self-efficacy had the most significant impact on depression (t=-6.433, P < 0.01), however, the impact from daily life ability scored 76.74 ± 22.12, which had not statistically significant impact on depression (t=-1.773, P=0.083). Conclusions During treatment and nursing management of post-stroke depression, attention should be paid to the psychiatric variable such as self-efficacy and social support.