Objective To study the value of three-dimensional high-resolution magnetic resonance wall imaging (3D-HR-VWI)for ischemic stroke caused by perforating artery infarction.Methods Retrospectively studied 38 patients between 201 6 and 2018.3D-HR-VWI technique were used to examine the structures of the ipsilateral and contralateral lenticulostriate arteries of the lesion,to study the characteristics of the perforating artery lesion.Results There was no statistical significance in the absolute number of lenticulostriate arteries on the lesion side and the normal side (P＝0.251 2).There was statistical significance in the ratio of lenticulostriate arteries between two groups (P＝0.020).The differences of the depth of lenticulostriate arteries on lesion sides were also statistical significant between two groups (P＝0.032).The differences among risk factors including hypertension,diabetes,hyperlipidemia and smoking were not statistically significant.There was no statistical significance on the differences of vascular involvement,length of M1 lesions,etiological types, number of lenticulostriate arteries,and depth of lenticulostriate arteries among the lateral lenticulostriate artery group,the internal lenticulostriate artery group and the internal+lateral lenticulostriate artery group.Conclusion 3D-HR-VWI can show the lesions of lenticulostriate arteries and perforating arteries,which is of important in diagnosis of perforating artery infarction.

Objective Toinvestigatethediagnosticvalueofhigh-resolutionmagneticresonanceimaging (HR-MRI)andCTAin intracranialarterialwallplaques.Methods 27patientswithbothHR-MRIandCTAdatawereenrolled.TheresultsofHR-MRIand CTAdiagnosisonatheroscleroticplaquestypeswerecomparedandanalyzed.Results (1)In59segmentsofbloodvesselswithlesions, 120atheroscleroticplaquesorstenoseswereidentifiedbyCTAand108atheroscleroticplaquesbyHR-MRI.Total122plaqueswere identifiedbybothtechniques,and78plaqueswereconsistentonbothtechniques,including43calcifiedplaques,14mixedplaquesand 21non-calcifiedplaques.ThediagnosisresultsofHR-MRIandCTA werenotconsistentin44plaques:27stenosesidentifiedbyCTA wereshownasnon-calcifiedplaqueson HR-MRI;14calcifiedplaquesidentifiedbyCTA weredifficulttobejudgedon HR-MRI;2 non-calcifiedplaquesidentifiedbyHR-MRIwerepresentasnormalonCTA;onemixedplaqueidentifiedbyCTA wasdiagnosedas non-calcifiedplaquebyHR-MRI.(2)Thereweredifferencesinshowingplaquepatternsbetweenthetwomethods(P＜0.001);CTA hadanadvantageinshowingcalcifiedplaques,whileHR-MRIhadanadvantageovernon-calcifiedplaques(adjustedstandardizedresidual wasgreaterthanthree).Conclusion 3.0T HR-MRIhasagoodabilitytodetectnon-calcifiedplaques,whileCTA hasauniqueadvantage todetectcalcifiedplaques.Twotechniquescomplementingeachothercanimprovethedetectionofatheroscleroticplaques.

Although attention plays an important role in cognitive and perception, there is no simple way to measure one's attention abilities. We identified that the strength of brain functional network in sustained attention task can be used as the physiological indicator to predict behavioral performance. Behavioral and electroencephalogram (EEG) data from 14 subjects during three force control tasks were collected in this paper. The reciprocal of the product of force tolerance and variance were used to calculate the score of behavioral performance. EEG data were used to construct brain network connectivity by wavelet coherence method and then correlation analysis between each edge in connectivity matrices and behavioral score was performed. The linear regression model combined those with significantly correlated network connections into physiological indicator to predict participant's performance on three force control tasks, all of which had correlation coefficients greater than 0.7. These results indicate that brain functional network strength can provide a widely applicable biomarker for sustained attention tasks.

Objective To explore the clinical applicability of diffusion kurtosis imaging (DKI)in children with spastic hemiplegic cerebral palsy.Methods 22 children with spastic hemiplegic cerebral palsy and age-matched 22 normal children were selected in this study,and were treated with routine brain MRI and DKI to test the white matter area of tractus corticospinalis on brainstem plane, anterior limb of internal capsule,posterior limb of inter capsule,genu of corpus callosum and the splenium of corpus callosum.The fractional alanisotropy(FA)value and mean kurtosis (MK)value of deep gray nuclei area in thalamus,lenticular nucleus and head of caudate nucleus were examined.Furthermore,gross motor function classification system (GMFCS)was performed for the children in research group.Two independent sample t test was applied in the comparison of groups.The correlation between DKI parameters and cerebral palsy gross motor function was analyzed by Spearman analysis.Results As for MK value,there were statistically significant differences in all different brain areas between the research group and the control group(P<0.05).And for FA value,there was statistically significant difference only in white matter area between the research group and the control group (P<0.05).However,there was no statistically significant difference in cerebral deep gray nuclei area (P>0.05).The GMFCS score was negatively correlated with the FA value,and was positively correlated with the MK value.Conclusion DKI can reflect the damaged situation of gray matter in children with cerebral palsy,and its parameter values can be used to monitor the children with cerebral palsy as evaluation indicators.

Objective To explore the value of diffusion tensor imaging (DTI)for the cerebral white matter recovery in children with cerebral palsy after cervical perivascular sympathectomy.Methods 30 children with hemiplegic cerebral palsy were recruited for clinical assessment and routine MRI and DTI examination before and after operation.The fractional anisotropy (FA)values for the regions including internal capsule and cerebral peduncle in the preoperative operation side and the opposite side,preoperative and postoperative were measured and compared.Gross motor function classification system (GMFCS)was used to evaluate the movement function of cerebral palsy in children.Paired sample t-test was performed to compare the differences of FA values between the preoperative operation side and the lateral,preoperative and postoperative white matter.Spearman relativity analysis was performed to assess correlation between DTI parameters in different white matter fiber bundles and GMFCS in patients.Results The FA values of white matter fiber bundle in different parts of the preoperative operation side were significantly lower in preoperative contralateral side,and the differences were statistically significant(P<0.001).Compared to preoperative,the FA values of white matter fiber bundle in different parts of the operation side were significantly increased in the six months after surgery (P<0.001),with the improvement of gross motor.Preoperative and postoperative FA value of the white matter fiber bundles in the different parts of the contralateral brain was not statistically significant(P>0.05).Clinical GMFCS in the patients were negatively correlated with the FA values (P<0.001).Moreover,the relativity between the GMFCS and the FA value of internal capsule and cerebral peduncle were both higher(r=-0.800,P<0.001;r=-0.786,P<0.001). Conclusion DTI can be used to quantitatively evaluate the postoperative recovery of white matter in children with cerebral palsy.The FA value can be used as a sensitive index for the evaluation of curative effect in children with cerebral palsy.

The Establishment and improvement of the scientific research incentive mechanism is the key to optimize the internal management, improve the performance, enhance the core competitiveness of the hospital.Research time and energy is limited because University Affiliated Hospital Medical Staff are in charge of medical treatment, teaching and scientific research.It's very important to mobilize the scientific research enthusiasm of the medical staff by using the scientific research incentive mechanism and promote the scientific research strength of hospital.This paper introduced the scientific research incentive mechanism and the achievements in the Second Affiliated Hospital of The Xinjiang Medical University.The exploration and thinking on the results and the existing problems are proposed in the paper.

Objective To evaluate whether the functional MRI could be used to reflect the change of angiogenesis after drug treat-ment,and obtain the related semi quantitative and quantitative parameters by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).Methods The subcutaneous transplantation colorectal cancer were constructed in 20 nude mice,which were treated with Xiaoaifeimi.The transplanted tumor microvascular density,VEGF and PCNA were monitored.The therapeutic effect and MRI monitoring results were evaluated by combining DCE-MRI with the pharmacokinetic model.The semi quantitative and quantitative parameters were obtained for evaluating the effection of medicine.Half of nude mice were sacrificed to obtain the immunohistochem-ical staining.Correlation between pathological findings and parameters were analyzed.Results Compared to the control group,hu-man colon HT-29 cell proliferation rate was significantly decreased (44.87%)(P <0.05),and the apoptosis rate of HT-29 cells was increased 2.45 times (P <0.05)after Uyghur medicine treatment.The correlation between pathological examination and DCE-MRI parameters showed that Ktrans value and Kep were positively correlated with VEGF,MVD and PCNA (P <0.05).Conclusion A good relationship is showed between immunohistochemistry and DCE-MRI quantitative parameters in Uygur drug treating human colon cancer mice.

Objective To discuss the value of the multi-b-value diffusion weighted imaging (DWI)in diagnosis of liver tuberculosis,abscess and atypical hydatid disease.Methods 23 patients with different liver lesions including abscess in 1 1,tuberculosis in 3 and alveolar hydatid in 9 were scanned with conventional MRI and multi-b-value DWI,and the imaging results were retrospectively analyzed.The ADC1 0b maps with 10 b values,three ADClow ones with low b values of 0 s/mm2 ,50 s/mm2 and 100 s/mm2 ,three ADChigh ones with high b values of 500 s/mm2 ,750 s/mm2 and 1 000 s/mm2 were gotten respectively.The ADCperf value was defined as a difference between ADClow and ADChigh values.Two regions of interest (ROI)with the same size were drawn in the liquefied region and mar-ginal area of the mass.The ADC values of ADClow ,ADChigh ,ADCperf and ADC1 0b maps were calculated and analyzed.Differences in b value and region among the three liver diseases were compared.Results The differences in ADC10b and ADChigh values between atypical liver hydatid and liver abscess in the liquefied region and marginal area were significant (P <0.05);the differences in ADC10b and ADCperf val-ues in the marginal area among liver tuberculosis,abscess and atypical hydatid were significant (P <0.05).The differences in ADCperf value in the liquefied region between thydatid disease and abscess,and in ADChigh value in marginal area between tuberculosis and abscess were not statistically significant (P >0.05).No differences in the ADClow value were found in both areas of three lesions (P >0.05). Conclusion Multi-b-value DWI and ADC maps and ADC values can provide valuable information in diagnosis and differentiation of liver tuberculosis,abscess and atypical hydatid disease.Different ADC values play more important role in the diagnosis of liver diseases.

Objective To discuss the safety and advantages of prone-straddle position applied in transvaginal hysteromyomectomy of the posterior wall of the uterus. Methods The clinical data of patients who were admitted into our hospital from March 2013 to Janaury 2015 and received transvaginal hysteromyomectomy were retrospectively analyzed. They were divided into group A ( prone-straddle position, 30 cases) and group B (traditional lithotomy position,24 cases). The exposure of operative field, convenience of operation, time of the placement, time of operation, patient satisfaction, as well as patients’ heart rate, blood pressure, and oxyhemoglobin saturation were observed and ana-lyzed. Results Compared with the lithotomy position, there were significant differences in the time of the placement and the time of opera-tion in the patients treated by prone-straddle position. The patients with prone-straddle position cooperated well, and there was no obvious discomfort. Their vital signs were stable during the operation. The operative field during prone-straddle position exposed better and it was more convenient which make the operation became easier for both the operators and nurses. Conclusion Prone-straddle position applied in transvaginal hysteromyomectomy of the posterior wall of the uterus is safe and practicable, and it is valuable for clinical application.

Objective To assess the value of noninvasive MR imaging biomarkers in evaluating the early efficacy of anti?angiogenesis drugs. Methods Subcutaneous colon cancer xenograft models in thirty nude mice were established. The mice were randomly divided into three groups (n=10 for each): avastin injection group (dose 10 mg/kg), fluorouracil group (dose 150 mg/kg), physiological saline group (dose 20 mg/kg). Dynamic contrast?enhanced (DCE?MRI) and multiple b value diffusion weighted imaging (muti?b?value DWI) were acquired before or 1 h, 24 h and 48 h after the treatment. The parameters of contrast transfer coefficient (Ktrans), reflux constant (Kep), plasma volume fraction (Vp), extravascular extracellular volume fraction (Ve) and various apparent diffusion coefficients (ADCs) (ADC10b, ADChigh and ADCperf) were measured. Forty eight hours after the treatment, the mice were sacrificed following MRI. Aimmunohistochemical examination determined microvessel density (MVD) and proliferating cell nuclear antigen (PCNA) score. A repeated measures analysis of variance was used to compare the difference between the quantitative parameters among the three groups. A multivariate variance analysis was performed to compare the difference between the parameters at the same time point among the three groups. The correlation between MRI quantitative parameters with MVD and PCNA score were analyzed by Pearson and Spearman correlation analysis respectively. Factor analysis method summarized MRI quantitative parameters. Results One hour after the treatment, the parameters of Ktrans, Kep, ADC10b, ADChigh and ADCperf value immediately changed, they were(0.009 ± 0.005)/s,(0.042 ± 0.031)/s,(0.043 ± 0.002)× 10?3 mm2/s,(0.031 ± 0.005)× 10?3 mm2/s,(0.089 ± 0.006)× 10?3 mm2/s, Ktrans, Kep, ADC10b and ADChigh values all had significant differences in the three groups (F=42.058, 25.979, 9.870 and 8.511, respectively, all P<0.05). There were also statistical difference in the change trend of the above parameters among the three groups (F=22.108, 7.280, 65.698 and 19.900, respectively, all P<0.05). The change trend of ADCperf showed significant difference among the three groups (F=38.780, P<0.01). Ktrans, Kep and ADCperf positively correlated with the MVD count and PCNA score (r values were 0.421 to 0.811, both P<0.01), while ADC10b showed a negative correlation (r=-0.656 and-0.560, both P<0.01), ADChigh had negative correlation with the PCNA score (r=-0.568, P<0.05). Ktrans, Vp, Kep and ADCperf were classified as tumor microcirculation factor, whereas ADC10b and ADChigh were normalized for cell metabolism factor through the factor analysis. Conclusions Combination of DCE?MRI and muti?b?value DWI can reflect the early changes of drug therapy from the aspects of tumor microcirculation and cell metabolism. Ktrans, Kep, ADCperf, ADC10b and ADChigh can be taken as noninvasive imaging biomarkers to quantify the early efficacy of anti?angiogenesis drugs.