1.The Association of Family and Friend Networks with Appetite: Structural Equation Modeling of the Indirect Effects of Depression among Community-Dwelling Older Adults
Kento NORITAKE ; Keisuke FUJII ; Daiki NAKASHIMA ; Yuta KUBO ; Kyosuke YOROZUYA ; Naoki TOMIYAMA ; Takahiro HAYASHI ; Fumihiko GOTO ; Hidehiro WATANABE ; Akihiro YOSHIDA
Annals of Geriatric Medicine and Research 2025;29(1):131-137
		                        		
		                        			 Background:
		                        			Appetite loss in older adults raises the risk of malnutrition and frailty. The recent emphasis on psychological and social support for appetite loss reveals the importance of robust social networks. Depression is linked to a decline in appetite and social networks. Social networks may influence appetite directly and indirectly through depression. This exploratory cross-sectional study categorizes social networks into family and friend networks to elucidate their direct and indirect effects.  
		                        		
		                        			Methods:
		                        			The study analyzed 193 community-dwelling older adults (women 78.2%; mean age 77.1±5.3 years) who participated in health-checkup events in two cities in Japan. Appetite was assessed using the Japanese version of the Simplified Nutritional Appetite Questionnaire, and family and friend networks were assessed using the Lubben Social Network Scale-6. Depression was assessed using the Geriatric Depression Scale-15. Based on previous research, we constructed a causal model examining the impacts of family and friend social networks and depression on appetite and calculated the direct and indirect effects through structural equation modeling.  
		                        		
		                        			Results:
		                        			The family network had a direct effect on appetite (path coefficient=0.18) and an indirect effect via depression (path coefficient=0.0608). Conversely, the friend network was not directly associated with appetite but had an indirect effect through depression (path coefficient=0.095). The model exhibited a good fit. The mechanism of influence on appetite varied between the networks. 
		                        		
		                        			Conclusion
		                        			To prevent appetite loss, social networks with family and friends should be assessed separately, and tailored support should be provided for each. 
		                        		
		                        		
		                        		
		                        	
2.Impact of Japan’s Revised Infectious Disease Control Law on Older Adults’ Social Life during the COVID-19 Pandemic
Kohji IWAI ; Yuta KUBO ; Takeshi YAMAZAKI ; Takahiro HAYASHI
Annals of Geriatric Medicine and Research 2025;29(1):53-57
		                        		
		                        			 Background:
		                        			In May 2023, Japan reclassified coronavirus disease 2019 (COVID-19) under the Infectious Disease Control Law. However, there have been insufficient examinations on how the change in classification has impacted citizens’ lives. This study examined the impact of revisions to the Infectious Disease Control Law in Japan on the social frailty and social life of older adults in the community. 
		                        		
		                        			Methods:
		                        			From mid-March to mid-April 2023, a self-administered survey targeting community-dwelling older adults aged 65 years and over was conducted by mail, before the revision of the Infectious Disease Control Law. From mid-February to mid-March 2024, after the revision of the law, a second survey was conducted among those who had responded to the first one. Ultimately, data from 240 cases were collected. The survey included social information such as mask-wearing when going out, status of long-term care insurance, presence of polypharmacy, sleep status, long outings, presence of COVID-19 infection, presence of post-COVID-19 syndrome (if infected), social frailty, and the Kihon Checklist, alongside basic demographic information. 
		                        		
		                        			Results:
		                        			After the revision of the Infectious Disease Control Law, there was an increase in the number of individuals receiving benefits from long-term care insurance and those identified as socially frail. However, no significant differences were observed in the other surveyed items. 
		                        		
		                        			Conclusion
		                        			The increase in socially frail individuals and those with long-term care insurance suggests that, despite the revision of the Infectious Disease Control Law, the connections within the local community that had once weakened due to the COVID-19 pandemic have not been fully restored. 
		                        		
		                        		
		                        		
		                        	
3.The Association of Family and Friend Networks with Appetite: Structural Equation Modeling of the Indirect Effects of Depression among Community-Dwelling Older Adults
Kento NORITAKE ; Keisuke FUJII ; Daiki NAKASHIMA ; Yuta KUBO ; Kyosuke YOROZUYA ; Naoki TOMIYAMA ; Takahiro HAYASHI ; Fumihiko GOTO ; Hidehiro WATANABE ; Akihiro YOSHIDA
Annals of Geriatric Medicine and Research 2025;29(1):131-137
		                        		
		                        			 Background:
		                        			Appetite loss in older adults raises the risk of malnutrition and frailty. The recent emphasis on psychological and social support for appetite loss reveals the importance of robust social networks. Depression is linked to a decline in appetite and social networks. Social networks may influence appetite directly and indirectly through depression. This exploratory cross-sectional study categorizes social networks into family and friend networks to elucidate their direct and indirect effects.  
		                        		
		                        			Methods:
		                        			The study analyzed 193 community-dwelling older adults (women 78.2%; mean age 77.1±5.3 years) who participated in health-checkup events in two cities in Japan. Appetite was assessed using the Japanese version of the Simplified Nutritional Appetite Questionnaire, and family and friend networks were assessed using the Lubben Social Network Scale-6. Depression was assessed using the Geriatric Depression Scale-15. Based on previous research, we constructed a causal model examining the impacts of family and friend social networks and depression on appetite and calculated the direct and indirect effects through structural equation modeling.  
		                        		
		                        			Results:
		                        			The family network had a direct effect on appetite (path coefficient=0.18) and an indirect effect via depression (path coefficient=0.0608). Conversely, the friend network was not directly associated with appetite but had an indirect effect through depression (path coefficient=0.095). The model exhibited a good fit. The mechanism of influence on appetite varied between the networks. 
		                        		
		                        			Conclusion
		                        			To prevent appetite loss, social networks with family and friends should be assessed separately, and tailored support should be provided for each. 
		                        		
		                        		
		                        		
		                        	
4.Impact of Japan’s Revised Infectious Disease Control Law on Older Adults’ Social Life during the COVID-19 Pandemic
Kohji IWAI ; Yuta KUBO ; Takeshi YAMAZAKI ; Takahiro HAYASHI
Annals of Geriatric Medicine and Research 2025;29(1):53-57
		                        		
		                        			 Background:
		                        			In May 2023, Japan reclassified coronavirus disease 2019 (COVID-19) under the Infectious Disease Control Law. However, there have been insufficient examinations on how the change in classification has impacted citizens’ lives. This study examined the impact of revisions to the Infectious Disease Control Law in Japan on the social frailty and social life of older adults in the community. 
		                        		
		                        			Methods:
		                        			From mid-March to mid-April 2023, a self-administered survey targeting community-dwelling older adults aged 65 years and over was conducted by mail, before the revision of the Infectious Disease Control Law. From mid-February to mid-March 2024, after the revision of the law, a second survey was conducted among those who had responded to the first one. Ultimately, data from 240 cases were collected. The survey included social information such as mask-wearing when going out, status of long-term care insurance, presence of polypharmacy, sleep status, long outings, presence of COVID-19 infection, presence of post-COVID-19 syndrome (if infected), social frailty, and the Kihon Checklist, alongside basic demographic information. 
		                        		
		                        			Results:
		                        			After the revision of the Infectious Disease Control Law, there was an increase in the number of individuals receiving benefits from long-term care insurance and those identified as socially frail. However, no significant differences were observed in the other surveyed items. 
		                        		
		                        			Conclusion
		                        			The increase in socially frail individuals and those with long-term care insurance suggests that, despite the revision of the Infectious Disease Control Law, the connections within the local community that had once weakened due to the COVID-19 pandemic have not been fully restored. 
		                        		
		                        		
		                        		
		                        	
5.The Association of Family and Friend Networks with Appetite: Structural Equation Modeling of the Indirect Effects of Depression among Community-Dwelling Older Adults
Kento NORITAKE ; Keisuke FUJII ; Daiki NAKASHIMA ; Yuta KUBO ; Kyosuke YOROZUYA ; Naoki TOMIYAMA ; Takahiro HAYASHI ; Fumihiko GOTO ; Hidehiro WATANABE ; Akihiro YOSHIDA
Annals of Geriatric Medicine and Research 2025;29(1):131-137
		                        		
		                        			 Background:
		                        			Appetite loss in older adults raises the risk of malnutrition and frailty. The recent emphasis on psychological and social support for appetite loss reveals the importance of robust social networks. Depression is linked to a decline in appetite and social networks. Social networks may influence appetite directly and indirectly through depression. This exploratory cross-sectional study categorizes social networks into family and friend networks to elucidate their direct and indirect effects.  
		                        		
		                        			Methods:
		                        			The study analyzed 193 community-dwelling older adults (women 78.2%; mean age 77.1±5.3 years) who participated in health-checkup events in two cities in Japan. Appetite was assessed using the Japanese version of the Simplified Nutritional Appetite Questionnaire, and family and friend networks were assessed using the Lubben Social Network Scale-6. Depression was assessed using the Geriatric Depression Scale-15. Based on previous research, we constructed a causal model examining the impacts of family and friend social networks and depression on appetite and calculated the direct and indirect effects through structural equation modeling.  
		                        		
		                        			Results:
		                        			The family network had a direct effect on appetite (path coefficient=0.18) and an indirect effect via depression (path coefficient=0.0608). Conversely, the friend network was not directly associated with appetite but had an indirect effect through depression (path coefficient=0.095). The model exhibited a good fit. The mechanism of influence on appetite varied between the networks. 
		                        		
		                        			Conclusion
		                        			To prevent appetite loss, social networks with family and friends should be assessed separately, and tailored support should be provided for each. 
		                        		
		                        		
		                        		
		                        	
6.Impact of Japan’s Revised Infectious Disease Control Law on Older Adults’ Social Life during the COVID-19 Pandemic
Kohji IWAI ; Yuta KUBO ; Takeshi YAMAZAKI ; Takahiro HAYASHI
Annals of Geriatric Medicine and Research 2025;29(1):53-57
		                        		
		                        			 Background:
		                        			In May 2023, Japan reclassified coronavirus disease 2019 (COVID-19) under the Infectious Disease Control Law. However, there have been insufficient examinations on how the change in classification has impacted citizens’ lives. This study examined the impact of revisions to the Infectious Disease Control Law in Japan on the social frailty and social life of older adults in the community. 
		                        		
		                        			Methods:
		                        			From mid-March to mid-April 2023, a self-administered survey targeting community-dwelling older adults aged 65 years and over was conducted by mail, before the revision of the Infectious Disease Control Law. From mid-February to mid-March 2024, after the revision of the law, a second survey was conducted among those who had responded to the first one. Ultimately, data from 240 cases were collected. The survey included social information such as mask-wearing when going out, status of long-term care insurance, presence of polypharmacy, sleep status, long outings, presence of COVID-19 infection, presence of post-COVID-19 syndrome (if infected), social frailty, and the Kihon Checklist, alongside basic demographic information. 
		                        		
		                        			Results:
		                        			After the revision of the Infectious Disease Control Law, there was an increase in the number of individuals receiving benefits from long-term care insurance and those identified as socially frail. However, no significant differences were observed in the other surveyed items. 
		                        		
		                        			Conclusion
		                        			The increase in socially frail individuals and those with long-term care insurance suggests that, despite the revision of the Infectious Disease Control Law, the connections within the local community that had once weakened due to the COVID-19 pandemic have not been fully restored. 
		                        		
		                        		
		                        		
		                        	
7.Phase Angle as a Nutritional Assessment Method in Patients with Hip Fractures: A Cross-Sectional Study
Yuta KUBO ; Kento NORITAKE ; Taiji NOGUCHI ; Takahiro HAYASHI
Annals of Geriatric Medicine and Research 2024;28(1):95-100
		                        		
		                        			 Background:
		                        			Phase angle, which is associated with cellular health, has attracted attention as a noninvasive and objective method for nutritional assessment. However, the association between malnutrition and phase angle in older inpatients with hip fractures has not been reported. Therefore, this study investigated this association in older inpatients (aged ≥65 years) with hip fractures and determined the cutoff phase angle for determining malnutrition. 
		                        		
		                        			Methods:
		                        			This cross-sectional study retrospectively analyzed the data of 96 inpatients with hip fractures who were hospitalized in rehabilitation units after surgery (male, 29.4%; mean age, 82.4±6.2 years). Nutritional status was assessed using the Geriatric Nutritional Risk Index (GNRI), with malnutrition defined as a GNRI ≥98. Bioelectrical impedance analysis was used to measure phase angles.  
		                        		
		                        			Results:
		                        			The phase angle was associated with malnutrition (B=−1.173; odds ratio=0.310; 95% confidence interval 0.58–0.83; p=0.015). The area under the receiver operating characteristic curve was 0.71. The cutoff phase angle for malnutrition was 3.96° (sensitivity=0.85, specificity=0.63).  
		                        		
		                        			Conclusion
		                        			Phase angle could be an indicator of malnutrition in older inpatients with hip fractures. Our findings will help formulate rehabilitation strategies for these patients. 
		                        		
		                        		
		                        		
		                        	
8.Accurate and Easy Measurement of Sliding Distance of Intramedullary Nail in Trochanteric Fracture.
Nobuaki CHINZEI ; Takafumi HIRANAKA ; Takahiro NIIKURA ; Takaaki FUJISHIRO ; Shinya HAYASHI ; Noriyuki KANZAKI ; Shingo HASHIMOTO ; Yoshitada SAKAI ; Ryosuke KURODA ; Masahiro KUROSAKA
Clinics in Orthopedic Surgery 2015;7(2):152-157
		                        		
		                        			
		                        			BACKGROUND: In daily clinical practice, it is essential to properly evaluate the postoperative sliding distance of various femoral head fixation devices (HFD) for trochanteric fractures. Although it is necessary to develop an accurate and reproducible method that is unaffected by inconsistent postoperative limb position on radiography, few studies have examined which method is optimal. Therefore, the purpose of this study is to prospectively compare the accuracy and reproducibility of our four original methods in the measurement of sliding distance of the HFD. METHODS: Radiographs of plastic simulated bone implanted with Japanese proximal femoral nail antirotation were taken in five limb postures: neutral, flexion, minute internal rotation, greater external rotation, and flexion with external rotation. Orthopedic surgeons performed five measurements of the sliding distance of the HFD in each of the flowing four methods: nail axis reference (NAR), modified NAR, inner edge reference, and nail tip reference. We also assessed two clinical cases by using these methods and evaluated the intraclass correlation coefficients. RESULTS: The measured values were consistent in the NAR method regardless of limb posture, with an even smaller error when using the modified NAR method. The standard deviation (SD) was high in the nail tip reference method and extremely low in the modified NAR method. In the two clinical cases, the SD was the lowest in the modified NAR method, similar to the results using plastic simulated bone. The intraclass correlation coefficients showed the highest value in the modified NAR method. CONCLUSIONS: We conclude that the modified NAR method should be the most recommended based on its accuracy, reproducibility, and usefulness.
		                        		
		                        		
		                        		
		                        			*Bone Nails
		                        			;
		                        		
		                        			*Dimensional Measurement Accuracy
		                        			;
		                        		
		                        			Fracture Fixation, Intramedullary/instrumentation/*methods
		                        			;
		                        		
		                        			Hip Fractures/*surgery
		                        			;
		                        		
		                        			Prospective Studies
		                        			;
		                        		
		                        			Reproducibility of Results
		                        			
		                        		
		                        	
9.Follow-up Study on Electroconvulsive Therapy in Treatment-resistant Depressed Patients after Remission: A Chart Review.
Yuki TOKUTSU ; Wakako UMENE-NAKANO ; Takahiro SHINKAI ; Reiji YOSHIMURA ; Tatsuya OKAMOTO ; Asuka KATSUKI ; Hikaru HORI ; Atsuko IKENOUCHI-SUGITA ; Kenji HAYASHI ; Kiyokazu ATAKE ; Jun NAKAMURA
Clinical Psychopharmacology and Neuroscience 2013;11(1):34-38
		                        		
		                        			
		                        			OBJECTIVE: Electroconvulsive therapy (ECT) has proven to be effective in treatment-resistant depression (TRD). In recent reports, 70% to 90% of patients with TRD responded to ECT. However, post-ECT relapse is a significant problem. There are no studies investigating risk factors associated with reintroducing ECT in depressive patients after remission previously achieved with former ECT. The aim of the present study is to examine such risk factors using a sample of TRD patients. METHODS: We conducted a chart review to examine patient outcomes and adverse events over short- and long-term periods. Forty-two patients met the criteria for major depressive disorder. RESULTS: The response rate was 85.7% (36/42). There were no significant differences in the baseline characteristics of patients exhibiting remission, response or non-response. The rate of adverse events was 21.4% (9/42). Among 34 patients who were available for follow-up, 18 patients relapsed (relapse rate, 52.9%), and 6 patients were reintroduced to ECT. The patients' age and age of onset were significantly higher in the re-ECT group than non re-ECT group. CONCLUSION: Our results suggest that older age and older age of onset might be considered for requirement of re-ECT after remission previously achieved with former ECT.
		                        		
		                        		
		                        		
		                        			Age of Onset
		                        			;
		                        		
		                        			Aging
		                        			;
		                        		
		                        			Depression
		                        			;
		                        		
		                        			Depressive Disorder, Treatment-Resistant
		                        			;
		                        		
		                        			Electroconvulsive Therapy
		                        			;
		                        		
		                        			Follow-Up Studies
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Recurrence
		                        			;
		                        		
		                        			Risk Factors
		                        			
		                        		
		                        	
10.Usefulness of Intraductal Ultrasonography in the Diagnosis of Cholangiocarcinoma and IgG4-Related Sclerosing Cholangitis.
Takahiro NAKAZAWA ; Itaru NAITOH ; Kazuki HAYASHI
Clinical Endoscopy 2012;45(3):331-336
		                        		
		                        			
		                        			The technique of intraductal ultrasonography (IDUS) of the bile duct with a thin-caliber probe and a ropeway system has provided excellent images of the bile duct and periductal structures and is an easy transpapillary approach. In addition, once the guide wire is inserted into the bile duct, IDUS and transpapillary biopsy after endoscopic retrograde cholangiopancreatography can be performed in a single session. Here, we review the usefulness of IDUS in the diagnosis of cholangiocarcinoma and IgG4-related sclerosing cholangitis.
		                        		
		                        		
		                        		
		                        			Bile Ducts
		                        			;
		                        		
		                        			Biopsy
		                        			;
		                        		
		                        			Cholangiocarcinoma
		                        			;
		                        		
		                        			Cholangiopancreatography, Endoscopic Retrograde
		                        			;
		                        		
		                        			Cholangitis, Sclerosing
		                        			
		                        		
		                        	
            
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