1.Improved visibility of palisade vessels within Barrett’s esophagus using red dichromatic imaging: a retrospective cross-sectional study in Japan
Chise UEDA ; Shinwa TANAKA ; Tetsuya YOSHIZAKI ; Hirofumi ABE ; Masato KINOSHITA ; Hiroya SAKAGUCHI ; Hiroshi TAKAYAMA ; Hitomi HORI ; Ryosuke ISHIDA ; Shinya HOUKI ; Hiroshi TANABE ; Eri NISHIKAWA ; Madoka TAKAO ; Toshitatsu TAKAO ; Yoshinori MORITA ; Takashi TOYONAGA ; Yuzo KODAMA
Clinical Endoscopy 2025;58(2):269-277
		                        		
		                        			 Background/Aims:
		                        			Visualization of palisade vessels (PVs) in Barrett’s esophagus is crucial for proper assessment. This study aimed to determine whether red dichromatic imaging (RDI) improves PV visibility compared with white-light imaging (WLI) and narrow-band imaging (NBI). 
		                        		
		                        			Methods:
		                        			Five expert and trainee endoscopists evaluated the PV visibility in Barrett’s esophagus using WLI, NBI, and RDI on 66 images from 22 patients. Visibility was rated on a 4-point scale: 4, excellent; 3, good; 2, fair; and 1, poor. The color difference between the most recognizable PV spots and surrounding areas with undetectable blood vessels was also analyzed. 
		                        		
		                        			Results:
		                        			Mean visibility scores were 2.6±0.7, 2.3±0.6, and 3.4±0.4 for WLI, NBI, and RDI, respectively. The RDI scores were significantly higher than the WLI (p<0.001) and NBI (p<0.001) scores. These differences were recognized by trainees and expert endoscopists. Color differences in PVs were 7.74±4.96 (WLI), 10.43±5.09 (NBI), and 15.1±6.54 (RDI). The difference in RDI was significantly higher than that in WLI (p<0.001) and NBI (p=0.006). 
		                        		
		                        			Conclusions
		                        			RDI significantly improved PV visibility compared to WLI and NBI based on objective and subjective measures. 
		                        		
		                        		
		                        		
		                        	
2.An Experiment of Orthoptic Therapy for a Patient with Diplopia in a Convalescent Rehabilitation Ward Where a Certified Orthoptist is Unavailable
Masamune EBARA ; Rina ABE ; Takashi HARADA ; Kentaro KANARI ; Tsuyoshi MIZUSHIRI
The Japanese Journal of Rehabilitation Medicine 2025;():24021-
		                        		
		                        			
		                        			Oculomotor disorder and diplopia cause a decline in quality of life and activities of daily living. The usefulness of orthoptic exercise for oculomotor disorder has been proven. However, there are few reports about orthoptic therapy with diplopia after a cerebrovascular accident in a convalescent rehabilitation ward which usually has no certified orthoptist. A previous study reported that diplopia caused by traumatic subarachnoid hemorrhage was improved after binocular gaze training. On the other hand, it was also reported that binocular training alone did not lead to complete recovery of diplopia, as no improvement was seen after the sixth day. We experienced a case of abducens nerve palsy and diplopia due to subarachnoid hemorrhage. Orthoptic treatment without special equipment restores disordered eye movement and improves double vision. Notably, binocular gazing training, devised to move the gazing target farther away or to the side, improved over a long period, unlike in a previous report. We report this case because it showed the availability of our attempted treatment for oculomotor disorder in a convalescent rehabilitation ward.
		                        		
		                        		
		                        		
		                        	
3.An Experiment of Orthoptic Therapy for a Patient with Diplopia in a Convalescent Rehabilitation Ward Where a Certified Orthoptist is Unavailable
Masamune EBARA ; Rina ABE ; Takashi HARADA ; Kentaro KANARI ; Tsuyoshi MIZUSHIRI
The Japanese Journal of Rehabilitation Medicine 2025;62(3):297-304
		                        		
		                        			
		                        			Oculomotor disorder and diplopia cause a decline in quality of life and activities of daily living. The usefulness of orthoptic exercise for oculomotor disorder has been proven. However, there are few reports about orthoptic therapy with diplopia after a cerebrovascular accident in a convalescent rehabilitation ward which usually has no certified orthoptist. A previous study reported that diplopia caused by traumatic subarachnoid hemorrhage was improved after binocular gaze training. On the other hand, it was also reported that binocular training alone did not lead to complete recovery of diplopia, as no improvement was seen after the sixth day. We experienced a case of abducens nerve palsy and diplopia due to subarachnoid hemorrhage. Orthoptic treatment without special equipment restores disordered eye movement and improves double vision. Notably, binocular gazing training, devised to move the gazing target farther away or to the side, improved over a long period, unlike in a previous report. We report this case because it showed the availability of our attempted treatment for oculomotor disorder in a convalescent rehabilitation ward.
		                        		
		                        		
		                        		
		                        	
4.Improved visibility of palisade vessels within Barrett’s esophagus using red dichromatic imaging: a retrospective cross-sectional study in Japan
Chise UEDA ; Shinwa TANAKA ; Tetsuya YOSHIZAKI ; Hirofumi ABE ; Masato KINOSHITA ; Hiroya SAKAGUCHI ; Hiroshi TAKAYAMA ; Hitomi HORI ; Ryosuke ISHIDA ; Shinya HOUKI ; Hiroshi TANABE ; Eri NISHIKAWA ; Madoka TAKAO ; Toshitatsu TAKAO ; Yoshinori MORITA ; Takashi TOYONAGA ; Yuzo KODAMA
Clinical Endoscopy 2025;58(2):269-277
		                        		
		                        			 Background/Aims:
		                        			Visualization of palisade vessels (PVs) in Barrett’s esophagus is crucial for proper assessment. This study aimed to determine whether red dichromatic imaging (RDI) improves PV visibility compared with white-light imaging (WLI) and narrow-band imaging (NBI). 
		                        		
		                        			Methods:
		                        			Five expert and trainee endoscopists evaluated the PV visibility in Barrett’s esophagus using WLI, NBI, and RDI on 66 images from 22 patients. Visibility was rated on a 4-point scale: 4, excellent; 3, good; 2, fair; and 1, poor. The color difference between the most recognizable PV spots and surrounding areas with undetectable blood vessels was also analyzed. 
		                        		
		                        			Results:
		                        			Mean visibility scores were 2.6±0.7, 2.3±0.6, and 3.4±0.4 for WLI, NBI, and RDI, respectively. The RDI scores were significantly higher than the WLI (p<0.001) and NBI (p<0.001) scores. These differences were recognized by trainees and expert endoscopists. Color differences in PVs were 7.74±4.96 (WLI), 10.43±5.09 (NBI), and 15.1±6.54 (RDI). The difference in RDI was significantly higher than that in WLI (p<0.001) and NBI (p=0.006). 
		                        		
		                        			Conclusions
		                        			RDI significantly improved PV visibility compared to WLI and NBI based on objective and subjective measures. 
		                        		
		                        		
		                        		
		                        	
5.Improved visibility of palisade vessels within Barrett’s esophagus using red dichromatic imaging: a retrospective cross-sectional study in Japan
Chise UEDA ; Shinwa TANAKA ; Tetsuya YOSHIZAKI ; Hirofumi ABE ; Masato KINOSHITA ; Hiroya SAKAGUCHI ; Hiroshi TAKAYAMA ; Hitomi HORI ; Ryosuke ISHIDA ; Shinya HOUKI ; Hiroshi TANABE ; Eri NISHIKAWA ; Madoka TAKAO ; Toshitatsu TAKAO ; Yoshinori MORITA ; Takashi TOYONAGA ; Yuzo KODAMA
Clinical Endoscopy 2025;58(2):269-277
		                        		
		                        			 Background/Aims:
		                        			Visualization of palisade vessels (PVs) in Barrett’s esophagus is crucial for proper assessment. This study aimed to determine whether red dichromatic imaging (RDI) improves PV visibility compared with white-light imaging (WLI) and narrow-band imaging (NBI). 
		                        		
		                        			Methods:
		                        			Five expert and trainee endoscopists evaluated the PV visibility in Barrett’s esophagus using WLI, NBI, and RDI on 66 images from 22 patients. Visibility was rated on a 4-point scale: 4, excellent; 3, good; 2, fair; and 1, poor. The color difference between the most recognizable PV spots and surrounding areas with undetectable blood vessels was also analyzed. 
		                        		
		                        			Results:
		                        			Mean visibility scores were 2.6±0.7, 2.3±0.6, and 3.4±0.4 for WLI, NBI, and RDI, respectively. The RDI scores were significantly higher than the WLI (p<0.001) and NBI (p<0.001) scores. These differences were recognized by trainees and expert endoscopists. Color differences in PVs were 7.74±4.96 (WLI), 10.43±5.09 (NBI), and 15.1±6.54 (RDI). The difference in RDI was significantly higher than that in WLI (p<0.001) and NBI (p=0.006). 
		                        		
		                        			Conclusions
		                        			RDI significantly improved PV visibility compared to WLI and NBI based on objective and subjective measures. 
		                        		
		                        		
		                        		
		                        	
6.Comparative advantages of activities with lumbosacral preservation for adult spinal deformity surgery: a retrospective Japanese cohort study
Yoshinori ISHIKAWA ; Takashi KOBAYASHI ; Eiji ABE ; Ryo SHOJI ; Naohisa MIYAKOSHI
Asian Spine Journal 2024;18(5):699-705
		                        		
		                        			 Methods:
		                        			Among 399 patients who underwent ASD surgery, 62 (≥5 levels fused, >2-year follow-up) underwent fusion from T9–10 to L5 (group L, n=21) or to S2–alar–iliac (group S, n=41). Spinal alignments, Scoliosis Research Society (SRS)-22 scores, performance of activities (clipping toenail, wiping buttock, and wearing socks), proximal and distal junctional failure (PJF+DJF), rod fractures (RFs), and overall revision rates (RRs) were compared between the groups. 
		                        		
		                        			Results:
		                        			Group L included younger patients and had longer follow-ups when compared with group S. Although the preoperative pelvic incidence and SRS sagittal modifiers were better in group L, postoperative spinal restorations were nonpathological in both groups. Both groups showed similar deformity progression at the 2-year follow-up; however, group L had lower SRS-22 pain scores. Although “wiping buttocks” did not differ between the groups, the performance of “clipping toenails” and “wearing socks” was poorer in group S at 2 years (possible, group S; 40% vs. group L; 85%–90%). The RRs did not differ between the groups; however, the PJF+DJF rate was higher in group L. DJF was not observed in group S, but occurrence of RFs was noted. 
		                        		
		                        			Conclusions
		                        			Although poorer SRS-22 pain scores might be related to lumbosacral mobility, sufficient restoration, equivalent deformity progression, and similar RRs with better activity imply that lumbosacral preservation should be considered in younger patients with moderate deformities. 
		                        		
		                        		
		                        		
		                        	
7.Assessing the utility of osteoporosis self-assessment tool for Asians in patients undergoing hip surgery
Keisuke UEMURA ; Kazuma TAKASHIMA ; Ryo HIGUCHI ; Sotaro KONO ; Hirokazu MAE ; Makoto IWASA ; Hirohito ABE ; Yuki MAEDA ; Takayuki KYO ; Takashi IMAGAMA ; Wataru ANDO ; Takashi SAKAI ; Seiji OKADA ; Hidetoshi HAMADA
Osteoporosis and Sarcopenia 2024;10(1):16-21
		                        		
		                        			 Objectives:
		                        			Diagnosis and treatment of osteoporosis are instrumental in obtaining good outcomes of hip surgery.Measuring bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA) is the gold standard for diagnosing osteoporosis. However, due to limited access to DXA, there is a need for a screening tool to identify patients at a higher risk of osteoporosis. We analyzed the potential utility of the Osteoporosis Self-assessment Tool for Asians (OSTA) as a screening tool for osteoporosis. 
		                        		
		                        			Methods:
		                        			A total of 1378 female patients who underwent hip surgery at 8 institutions were analyzed. For each patient, the BMD of the proximal femoral region was measured by DXA (DXA-BMD), and the correlation with OSTA score (as a continuous variable) was assessed. Receiver operating characteristic (ROC) curve analysis was performed to assess the ability of OSTA score to predict osteoporosis. Lastly, the OSTA score was truncated to yield an integer (OSTA index) to clarify the percentage of patients with osteoporosis for each index. 
		                        		
		                        			Results:
		                        			DXA-BMD showed a strong correlation with OSTA (r = 0.683; P < 0.001). On ROC curve analysis, the optimal OSTA score cut-off value of − 5.4 was associated with 73.8% sensitivity and 80.9% specificity for diagnosis of osteoporosis (area under the curve: 0.842). A decrease in the OSTA index by 1 unit was associated with a 7.3% increase in the probability of osteoporosis. 
		                        		
		                        			Conclusions
		                        			OSTA is a potentially useful tool for screening osteoporosis in patients undergoing hip surgery. Our findings may help identify high-risk patients who require further investigation using DXA. 
		                        		
		                        		
		                        		
		                        	
8.Malnutrition and inflammation status in nonobese patients with inflammatory bowel disease are associated with nonalcoholic fatty liver disease: a retrospective study
Takahiro NAGATA ; Sadahiro FUNAKOSHI ; Daisuke MORIHARA ; Satoshi SHAKADO ; Keiji YOKOYAMA ; Kazuhide TAKATA ; Takashi TANAKA ; Atsushi FUKUNAGA ; Ryo YAMAUCHI ; Hiromi FUKUDA ; Hiroki MATSUOKA ; So IMAKIIRE ; Hideto SAKISAKA ; Satoshi MATSUOKA ; Nobuaki KUNO ; Koichi ABE ; Hideki ISHIBASHI ; Shinya ASHIZUKA ; Fumihito HIRAI
Intestinal Research 2023;21(4):471-480
		                        		
		                        			 Background/Aims:
		                        			The frequency and details of nonalcoholic fatty liver disease (NAFLD) complications in patients with inflammatory bowel disease (IBD) remain unclear. This study aimed to clarify characteristics of NAFLD in patients with IBD. 
		                        		
		                        			Methods:
		                        			We retrospectively identified and enrolled patients with IBD diagnosed with or without NAFLD by undergoing abdominal computed tomography (CT) at our institution between 2005 and 2020. The primary endpoint was the complication rate of NAFLD in patients with IBD. Secondary endpoints were the clinical characteristics of nonobese patients with IBD and comorbid NAFLD and their association with nutritional and inflammatory parameters. 
		                        		
		                        			Results:
		                        			Twenty-one (21.9%) of 96 eligible patients with IBD also had NAFLD. In nonobese patients (defined as patients with a body mass index <25 kg/m2), C-reactive protein (CRP; P<0.001) and alanine aminotransferase (P=0.018) levels were higher and the albumin level (P=0.005) and prognostic nutritional index (PNI; P=0.002) values were lower in patients with NAFLD than in those without NAFLD. The PNI value was positively correlated (P<0.001) and the CRP level was negatively correlated (P=0.001) with the hepatosplenic ratio. However, in the NAFLD combined group, PNI (P<0.05) and CRP values (P<0.001) were improved over time after CT imaging by continuing IBD treatment. 
		                        		
		                        			Conclusions
		                        			Worsening nutritional and inflammatory status in IBD patients is associated with complications of NAFLD. Diagnosis of NAFLD in IBD patients using CT imaging might be useful not only for early detection of NAFLD but also in assessing the need for therapeutic intervention for IBD. 
		                        		
		                        		
		                        		
		                        	
9.Remote Cardiac Rehabilitation With Wearable Devices
Atsuko NAKAYAMA ; Noriko ISHII ; Mami MANTANI ; Kazumi SAMUKAWA ; Rieko TSUNETA ; Megumi MARUKAWA ; Kayoko OHNO ; Azusa YOSHIDA ; Emiko HASEGAWA ; Junko SAKAMOTO ; Kentaro HORI ; Shinya TAKAHASHI ; Kaoruko KOMURO ; Takashi HIRUMA ; Ryo ABE ; Togo NORIMATSU ; Mai SHIMBO ; Miyu TAJIMA ; Mika NAGASAKI ; Takuya KAWAHARA ; Mamoru NANASATO ; Toshimi IKEMAGE ; Mitsuaki ISOBE
Korean Circulation Journal 2023;53(11):727-743
		                        		
		                        			
		                        			 Although cardiac rehabilitation (CR) has been shown to improve exercise tolerance and prognosis in patients with cardiovascular diseases, there remains low participation in outpatient CR. This may be attributed to the patients’ busy schedules and difficulty in visiting the hospital due to distance, cost, avoidance of exercise, and severity of coronary disease. To overcome these challenges, many countries are exploring the possibility of remote CR. Specifically, there is increasing attention on the development of remote CR devices, which allow transmission of vital information to the hospital via a remote CR application linked to a wearable device for telemonitoring by dedicated hospital staff. In addition, remote CR programs can support return to work after hospitalization. Previous studies have demonstrated the effects of remote CR on exercise tolerance. However, the preventive effects of remote CR on cardiac events and mortality remain controversial. Thus, safe and effective remote CR requires exercise risk stratification for each patient, telenursing by skilled staff, and multidisciplinary interventions. Therefore, quality assurance of telenursing and multi-disciplinary interventions will be essential for remote CR. Remote CR may become an important part of cardiac management in the future. However, issues such as costeffectiveness and insurance coverage still persist. 
		                        		
		                        		
		                        		
		                        	
10.Clinical Impact of Different Reconstruction Methods on Remnant Gastric Cancer at the Anastomotic Site after Distal Gastrectomy
Kei MATSUMOTO ; Shinwa TANAKA ; Takashi TOYONAGA ; Nobuaki IKEZAWA ; Mari NISHIO ; Masanao URAOKA ; Tomoatsu YOSHIHARA ; Hiroya SAKAGUCHI ; Hirofumi ABE ; Tetsuya YOSHIZAKI ; Madoka TAKAO ; Toshitatsu TAKAO ; Yoshinori MORITA ; Hiroshi YOKOZAKI ; Yuzo KODAMA
Clinical Endoscopy 2022;55(1):86-94
		                        		
		                        			 Background/Aims:
		                        			The anastomotic site after distal gastrectomy is the area most affected by duodenogastric reflux. Different reconstruction methods may affect the lesion characteristics and treatment outcomes of remnant gastric cancers at the anastomotic site. We retrospectively investigated the clinicopathologic and endoscopic submucosal dissection outcomes of remnant gastric cancers at the anastomotic site. 
		                        		
		                        			Methods:
		                        			We recruited 34 consecutive patients who underwent endoscopic submucosal dissection for remnant gastric cancer at the anastomotic site after distal gastrectomy. Clinicopathology and treatment outcomes were compared between the Billroth II and non-Billroth II groups. 
		                        		
		                        			Results:
		                        			The tumor size in the Billroth II group was significantly larger than that in the non-Billroth II group (22 vs. 19 mm; p=0.048). More severe gastritis was detected endoscopically in the Billroth II group (2 vs. 1.33; p=0.0075). Moreover, operation time was longer (238 vs. 121 min; p=0.004) and the frequency of bleeding episodes was higher (7.5 vs. 3.1; p=0.014) in the Billroth II group. 
		                        		
		                        			Conclusions
		                        			Compared to remnant gastric cancers in non-Billroth II patients, those in the Billroth II group had larger lesions with a background of severe remnant gastritis. Endoscopic submucosal dissection for remnant gastric cancers in Billroth II patients involved longer operative times and more frequent bleeding episodes than that in patients without Billroth II. 
		                        		
		                        		
		                        		
		                        	
            

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