1.Polysomnographic Evaluation of Sleep Disorders in Essential Tremor and Essential Tremor Plus: A Comparison With Healthy Controls
Ravi Prakash SINGH ; Mythirayee S ; Doniparthi Venkata SESHAGIRI ; Gulshan KUMAR ; Rohan MOHALE ; Pramod Kumar PAL ; Bindu M KUTTY ; Jitender SAINI ; Nitish L KAMBLE ; Vikram HOLLA ; Ravi YADAV
Journal of Movement Disorders 2025;18(1):45-54
Objective:
To explore sleep patterns in individuals with essential tremor (ET) and essential tremor plus (ET-Plus) compared with healthy controls and assess differences between ET and ET-Plus, given the lack of established polysomnography (PSG) data on these groups and the potential for sleep disturbances to serve as clinical markers.
Methods:
We conducted a prospective cross-sectional study at National Institute of Mental Health and Neurosciences, Bengaluru, from November 2021 to August 2023 on 45 patients (26 ET, 19 ET-Plus) and 45 controls. Tremor severity was assessed using The Essential Tremor Rating Assessment Scale (TETRAS) and Fahn‐Tolosa‐Marin Clinical Rating Scale (FTMRS). Sleep symptoms were assessed via the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Mayo Sleep Questionnaire, restless legs syndrome questionnaire, Berlin questionnaire, Generalized Anxiety Disorder Scale 7, and Patient Health Questionnaire-9. All patients and controls underwent overnight video PSG. Sleep scoring was manually performed by a trained sleep research technician and the first author following the American Academy of Sleep Medicine (2017) guidelines, with data analyzed using R studio.
Results:
Compared with ET-Plus patients, ET patients had a younger onset age (46.8±11.1 years versus 30.8±16.7 years, respectively). Compared with ET patients, ET-Plus patients had higher TETRAS and FTMRS scores (p<0.005). Compared with controls, both ET patients and ET-Plus patients presented poorer sleep quality, excessive daytime sleepiness, rapid eye movement (REM) sleep behavior disorder, and restless legs syndrome symptoms. PSG findings supported these clinical observations, showing an elevated apnea‒hypopnea index, reduced total sleep time, prolonged REM latency, decreased sleep efficiency, increased N1 stage duration, and reduced N2/N3 durations and percentages in patients versus controls.
Conclusion
The study highlights significant sleep architecture abnormalities in both ET and ET-Plus patients compared with healthy controls, with no differences between the ET groups.
2.Thrombolysis in Patients With Versus Without Visible Occlusion: A Secondary Analysis From the AcT Trial
Anwer Zohaib SIDDIQI ; Katrina IGNACIO ; Chitapa KAVEETA ; Fouzi BALA ; Ayoola ADEMOLA ; Aleksander TKACH ; Brian H. BUCK ; Luciana CATANESE ; Gary HUNTER ; Dar DOWLATSHAHI ; Michel SHAMY ; Atif ZAFAR ; Thalia S. FIELD ; Ramana APPIREDDY ; Ankur WADHWA ; Tolulope SAJOBI ; Rick SWARTZ ; Mohammed ALMEKHLAFI ; Andrew DEMCHUK ; Bijoy MENON ; Nishita SINGH
Journal of Stroke 2025;27(1):113-117
3.Letter to Editor: Effect of furosemide on prevertebral soft tissue swelling after anterior cervical fusion: a comparative study with dexamethasone
Sneha SHARMA ; Sanjay Singh RAWAT ; Udit Kumar JAYANT ; Ravikiran VANAPALLI ; Venkatesh KUMAR S. ; Sujit Kumar SINGH
Asian Spine Journal 2025;19(2):330-331
4.Letter to Editor: Effect of furosemide on prevertebral soft tissue swelling after anterior cervical fusion: a comparative study with dexamethasone
Sneha SHARMA ; Sanjay Singh RAWAT ; Udit Kumar JAYANT ; Ravikiran VANAPALLI ; Venkatesh KUMAR S. ; Sujit Kumar SINGH
Asian Spine Journal 2025;19(2):330-331
5.Polysomnographic Evaluation of Sleep Disorders in Essential Tremor and Essential Tremor Plus: A Comparison With Healthy Controls
Ravi Prakash SINGH ; Mythirayee S ; Doniparthi Venkata SESHAGIRI ; Gulshan KUMAR ; Rohan MOHALE ; Pramod Kumar PAL ; Bindu M KUTTY ; Jitender SAINI ; Nitish L KAMBLE ; Vikram HOLLA ; Ravi YADAV
Journal of Movement Disorders 2025;18(1):45-54
Objective:
To explore sleep patterns in individuals with essential tremor (ET) and essential tremor plus (ET-Plus) compared with healthy controls and assess differences between ET and ET-Plus, given the lack of established polysomnography (PSG) data on these groups and the potential for sleep disturbances to serve as clinical markers.
Methods:
We conducted a prospective cross-sectional study at National Institute of Mental Health and Neurosciences, Bengaluru, from November 2021 to August 2023 on 45 patients (26 ET, 19 ET-Plus) and 45 controls. Tremor severity was assessed using The Essential Tremor Rating Assessment Scale (TETRAS) and Fahn‐Tolosa‐Marin Clinical Rating Scale (FTMRS). Sleep symptoms were assessed via the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Mayo Sleep Questionnaire, restless legs syndrome questionnaire, Berlin questionnaire, Generalized Anxiety Disorder Scale 7, and Patient Health Questionnaire-9. All patients and controls underwent overnight video PSG. Sleep scoring was manually performed by a trained sleep research technician and the first author following the American Academy of Sleep Medicine (2017) guidelines, with data analyzed using R studio.
Results:
Compared with ET-Plus patients, ET patients had a younger onset age (46.8±11.1 years versus 30.8±16.7 years, respectively). Compared with ET patients, ET-Plus patients had higher TETRAS and FTMRS scores (p<0.005). Compared with controls, both ET patients and ET-Plus patients presented poorer sleep quality, excessive daytime sleepiness, rapid eye movement (REM) sleep behavior disorder, and restless legs syndrome symptoms. PSG findings supported these clinical observations, showing an elevated apnea‒hypopnea index, reduced total sleep time, prolonged REM latency, decreased sleep efficiency, increased N1 stage duration, and reduced N2/N3 durations and percentages in patients versus controls.
Conclusion
The study highlights significant sleep architecture abnormalities in both ET and ET-Plus patients compared with healthy controls, with no differences between the ET groups.
6.Thrombolysis in Patients With Versus Without Visible Occlusion: A Secondary Analysis From the AcT Trial
Anwer Zohaib SIDDIQI ; Katrina IGNACIO ; Chitapa KAVEETA ; Fouzi BALA ; Ayoola ADEMOLA ; Aleksander TKACH ; Brian H. BUCK ; Luciana CATANESE ; Gary HUNTER ; Dar DOWLATSHAHI ; Michel SHAMY ; Atif ZAFAR ; Thalia S. FIELD ; Ramana APPIREDDY ; Ankur WADHWA ; Tolulope SAJOBI ; Rick SWARTZ ; Mohammed ALMEKHLAFI ; Andrew DEMCHUK ; Bijoy MENON ; Nishita SINGH
Journal of Stroke 2025;27(1):113-117
7.Letter to Editor: Effect of furosemide on prevertebral soft tissue swelling after anterior cervical fusion: a comparative study with dexamethasone
Sneha SHARMA ; Sanjay Singh RAWAT ; Udit Kumar JAYANT ; Ravikiran VANAPALLI ; Venkatesh KUMAR S. ; Sujit Kumar SINGH
Asian Spine Journal 2025;19(2):330-331
8.Polysomnographic Evaluation of Sleep Disorders in Essential Tremor and Essential Tremor Plus: A Comparison With Healthy Controls
Ravi Prakash SINGH ; Mythirayee S ; Doniparthi Venkata SESHAGIRI ; Gulshan KUMAR ; Rohan MOHALE ; Pramod Kumar PAL ; Bindu M KUTTY ; Jitender SAINI ; Nitish L KAMBLE ; Vikram HOLLA ; Ravi YADAV
Journal of Movement Disorders 2025;18(1):45-54
Objective:
To explore sleep patterns in individuals with essential tremor (ET) and essential tremor plus (ET-Plus) compared with healthy controls and assess differences between ET and ET-Plus, given the lack of established polysomnography (PSG) data on these groups and the potential for sleep disturbances to serve as clinical markers.
Methods:
We conducted a prospective cross-sectional study at National Institute of Mental Health and Neurosciences, Bengaluru, from November 2021 to August 2023 on 45 patients (26 ET, 19 ET-Plus) and 45 controls. Tremor severity was assessed using The Essential Tremor Rating Assessment Scale (TETRAS) and Fahn‐Tolosa‐Marin Clinical Rating Scale (FTMRS). Sleep symptoms were assessed via the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Mayo Sleep Questionnaire, restless legs syndrome questionnaire, Berlin questionnaire, Generalized Anxiety Disorder Scale 7, and Patient Health Questionnaire-9. All patients and controls underwent overnight video PSG. Sleep scoring was manually performed by a trained sleep research technician and the first author following the American Academy of Sleep Medicine (2017) guidelines, with data analyzed using R studio.
Results:
Compared with ET-Plus patients, ET patients had a younger onset age (46.8±11.1 years versus 30.8±16.7 years, respectively). Compared with ET patients, ET-Plus patients had higher TETRAS and FTMRS scores (p<0.005). Compared with controls, both ET patients and ET-Plus patients presented poorer sleep quality, excessive daytime sleepiness, rapid eye movement (REM) sleep behavior disorder, and restless legs syndrome symptoms. PSG findings supported these clinical observations, showing an elevated apnea‒hypopnea index, reduced total sleep time, prolonged REM latency, decreased sleep efficiency, increased N1 stage duration, and reduced N2/N3 durations and percentages in patients versus controls.
Conclusion
The study highlights significant sleep architecture abnormalities in both ET and ET-Plus patients compared with healthy controls, with no differences between the ET groups.
9.Thrombolysis in Patients With Versus Without Visible Occlusion: A Secondary Analysis From the AcT Trial
Anwer Zohaib SIDDIQI ; Katrina IGNACIO ; Chitapa KAVEETA ; Fouzi BALA ; Ayoola ADEMOLA ; Aleksander TKACH ; Brian H. BUCK ; Luciana CATANESE ; Gary HUNTER ; Dar DOWLATSHAHI ; Michel SHAMY ; Atif ZAFAR ; Thalia S. FIELD ; Ramana APPIREDDY ; Ankur WADHWA ; Tolulope SAJOBI ; Rick SWARTZ ; Mohammed ALMEKHLAFI ; Andrew DEMCHUK ; Bijoy MENON ; Nishita SINGH
Journal of Stroke 2025;27(1):113-117
10.Occupational Nerve Injuries due to Metallic Foreign Bodies: A Case Series of Eighteen Patients
Gupta P ; Jindal M ; Garg S ; Garg K
Malaysian Orthopaedic Journal 2024;18(No.1):84-90
Introduction: Peripheral nerve injuries (PNIs) remain an
important health problem. PNIs mostly affect young men as
this age group is mostly involved in road traffic accidents
and other injuries at workplace. PNI can occur from foreign
bodies like metal chips while working in industries using
lathe machines. Among PNI’s, injuries to the ulnar nerve, the
brachial plexus and the median nerve are the most frequent
lesions encountered.
Materials and methods: This presentation is on a series of
18 cases of nerve injuries among industrial workers located
from finger level up to the arm excluding the brachial plexus
due to metallic foreign bodies entering while operating lathe
machines over a period of two years with patients being
followed-up over a one year period.
Results: Mean age in this series was 31.3 years with age
range 16-40 years and all were males. Two patients had more
than one nerve involvement and one patient had associated
vascular injury. All the patients showed functional
improvement. Most common nerve injured was median
nerve. Most common site for nerve injury was forearm.
Combined lesions most commonly involved the ulnar and
median nerves.
Conclusion: Social cost of traumatic peripheral nerve
injuries is significant since it has a higher incidence in
young, previously healthy, and economically active
people.


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