Background: The following ancient medical book currently known to us is relatively detailed about ring srel. Herein: a handwritten sutra by Darmo maaramba Luvsanchoidog called “legs bshad be ed’u dkar po’i ‘phreng ba zhes bya ba bzhugs so”. However, there is no academic research on the medicinal use of this supreme precious medicine ring srel in Mongolia. Therefore, we have chosen this topic to make it possible to use the written medical scriptures and woodblock books written about ring srel for research and training, especially to explain and interpret the supreme precious medicine in detail. Purpose: We will study the facts about ring srel in Darmo maaramba Luvsanchoidog’s “ legs bshad be ed’u dkar po’i ‘phreng ba zhes bya ba bzhugs so” manuscript, enrich it with information about ring srel in other ancient medical books, and explain some words. Conclusion Supreme precious medicine is a word that means ring srel in Tibetan, a relic in English or whitish, pill-like stuff from cremation residues, and sharil or chandar (cremains) in Mongolian. There are four categories of ring srel: Body ring srel, hair, and nails ring srel, mustard seed-like ring srel and dharma body ring srel. There are five colors of the ring srel: white from bones, red from flesh, blue from yellow water, gold from skin so on. If we distinguish each of its uses, from the medical point of view: Demons and evil spirits, all diseases can not be attacked and not harmed, and from the ritual point of view: it is said that everything you wish to do by keeping it on your body and wearing it on your body will come true.

“Tanjur” is the greatest sutra written on thick Chinese muutuu paper with red nature dust paint size 22,7 x 71,8 cm and has 107839 pages. It is the largest collection of ten great and small sciences (philosophy, technology, logic, medicine, philology, astrology, model dance, poetics, Abhidarma, and composition) created by ancient Indian and Tibetan scientists and panditas. The Mongolian dust paint printed Tanjur had been translated from Tibetan into Mongolian by over 200 translators under the supervision of reincarnated Janjaa Rolbiidorj and Shireet Luvsandambiinyam between 1741 and 1742 and had been printed in Beijing between 1742 and 1749.
To print “Mongolian Tanjur” from blocks, 2160.9 ounces of silver were used. The “Mongolian Tanjur” contains 8 Indian Ayurvedic medical books. As a result of this research, we have briefly explained each of the 8 Ayurvedic medical books. Namely:
1. “One Hundred Medical Preparations” composed by Nagarjuna Acharya,
2. “Medical Advice for Longevity” composed by Nagarjuna Acharya,
3. “Ritual Ava Medicine” composed by Nagarjuna Acharya,
4. “Essence of Eight Branches” written by master Vagbhata,
5. “An Explanation of Medical Practices called “The Essence of the Eight Branches” written by master Vagbhata,
6. “A Commentary on the Essence of the Eight Branches called Rays of Moonlight on the Meaning of the Words” written by the Kashmiri Candranandana,
7. “Lexicon of Medical Terms from the Commentary on the Essence of Eight Branches” written by the Kashmiri Candranandana and
8.“A powerful healer to treats all diseases and promotes physical strength” written by Sivadasa.
Ayurveda is perceived as one of the most ancient and well-documented systems of medicine, equally relevant in modern times. Its holistic approach, whether for healthy individuals or diseased ones, remains unparalleled. Prevention of disease and promotion of health are the main objectives of Ayurveda. Ayurveda is an ancient medicine system of the Indian subcontinent. It is said to have originated in India about 5000 years back. The word Ayurveda is a conjugation of two Sanskrit words, “ayus,” meaning “life,” and “Veda,” meaning “science,” thus, it literally means the 'science of life. Unlike other medicinal systems, Ayurveda focuses more on healthy living than the treatment of diseases.

Background: In 1904, Monkeberg was first described about the coronary calcification which is the degenerative change that occurs with aging process, but the last decades many studies have been confirmed that coronary calcification was an active process same as the signaling pathways with bone mineralization. Coronary calcification increases the risk of myocardial infarction during bypass graft surgery and PCI (СМ СN. Shanahan, 1999). Goal: To evaluate Agatston Coronary Artery Calcium score using contrast enhanced CT-Coronary angiography. Objectives:
1. To assess Agatston Coronary Artery Calcium score
2. Age and gender relationship of coronary calcification Materials and Methods: We evaluated total 215 patients who were admitted to the Reference center of Diagnostic Imaging named after R.Purev State Laureate, People’s physician and Honorary Professor of the Third State Central Hospital awarded with the Red banner of the Labor diagnosed with the coronary calcification by contrast enhanced 64 slice CT (Philips Ingenuity CT 64) between 2020 to 2022. Patient’s age was considered into 6 groups and coronary calcification was assessed by Agatston’s score. The result of our study determined by common statistical averages and errors and probabilities of the indicators were determined by Student’s criteria. Result: When evaluating Agatston coronary artery calcium scoring by CT-coronary angiography, 11-400 Agatston score was predominantly in our study with p value of (P<0.001). Considering relationship of age and gender, coronary calcification occurs 42.3% of patients aged 50-69, male and female ratio was 1.7:1. Conclusions
1. We established Agatston coronary calcification 11-400 was occurred in 66.96% of the patients.
2. Coronary calcification predominantly occurred in 65% patients aged 50-69 years.

Introduction: According to the manuscript “Imperially commissioned complete record of the body”, the study was selected to clarify the name of the plant, as it is difficult to recognize and translate the medicinal raw materials directly from Manchu, Tibetan, Chinese, Latin, and Sanskrit into Uighur and Mongolian scripts. Methods: We conducted our research using hermeneutic, verification, and checklist methods. Results: “Imperially commissioned complete record of the body” scripture is a rare book based on European anatomical works that combine Western and Eastern medical knowledge. There is reason to believe that European medicine in Mongolia was a witness to the spread of the anthropology of the human body.
It is clear from the 6 books that the two volumes are based on the basic tenets of Indian and Chinese medicine, Buddhist philosophy, and the teachings of the five elements and yin-yang. The study included “Ingredients for Correcting Anxiety”, “Ingredients for Correcting Heart Attack,” and “Ingredients for Correcting Depression”. These three ingredients were the basis of the recipes of Oriental medicine in the European medical books. Comparing the taste, potency, and action of all selected medicinal raw materials using traditional medicine, such as “The quintessence Tantras of Tibetan Medicine” and other books, it is clear that the classical European medical tradition differs from the modern medical classification. Conclusion “Imperially commissioned complete record of the body” manuscript is a documentary scripture used by Mongolian shepherds and herdsmen on the achievements of European medicine, free from religious traditions and taboos. In addition, there found 18 traditional medicinal plants and 7 types of animal medicines used in heart disease.

Introduction: Air pollution has become one of the major problems in socio-economic and health issues in Mongolia. Among the various hazards of particulate matter (PM) pollutants, microorganisms in PM2.5 and PM10 are thought to be responsible for various allergies and for the spread of respiratory diseases. Recent studies have shown that PM2.5 particles can cause chronic heart failure, heart arrhythmias, and strokes, as well as lung damage, cirrhosis, inflammation, cancer, cardiovascular disease, and metabolic disorders. Furthermore, some studies have concluded that PM2.5 particles in the environment are a risk factor for gastrointestinal, liver, colon, and lung cancer as well as it affects the growth and metastasis of various cancer cells caused by other factors. In our country, the health effects of air pollution and the relationship between the pathogenesis of cancer research are scarce. Therefore, the study of the effects of PM2.5 particles on cancer cell proliferation, migration (metastasis) can provide a significant role for cancer treatment, diagnosis, and prevention. Purpose: Determining the effects of PM2.5 particles on cancer cell proliferation, migration (metastasis) in in-vitro Material and Methods: A human liver cancer cell line (HepG2), human gastric cancer cell line (AGS) were obtained from the central scientific research laboratory in the Institute of medical sciences. HepG2, AGS cells were seeded at a concentration of 1*105 cells/mL in a culture flask and cultured in RPMI-1640 medium supplemented with 10% FBS, 1% antibiotic mix (penicillin, streptomycin) in a humidified atmosphere of 5% CO2 at 37 °C. The cytotoxic effect of PM 2.5 in AGS, HepG2 cells were evaluated by MTT, CCK8 assays. AGS, HepG2 cells were incubated in 96 well plates for 24h then treated with different concentrations (0, 5, 10, 25, 50 and 100 μg ) of Bayankhoshuu, Buhiin urguu, and Zaisan samples for 24h, respectively. Results: Concentrations of 10, 25, and 50 μg/ml of samples collected from the Bukhiin urguu and Zaisan in March increased HepG2 cell growth, while doses of 25, 50 μg/ml of samples collected from Bayankhoshuu in March and December increased HepG2 cell growth. Therefore, concentrations of 25 and 50 μg/ml of samples collected from Bayankhoshuu in March increased AGS cell growth, while concentrations of 25, 100 and μg/ml of samples collected in December increased AGS cell growth. However, no cytotoxic effect was observed in the sample collected from Zaisan in March, whereas the PM2.5 sample enhanced AGS cell growth in dose dependent manner in December.(p <0.05) Conclusion High levels of heavy metals were detected in samples collected in December from Bayankhoshuu, Bukhiin urguu and Zaisan of Ulaanbaatar. Concentration of 25 μg/ml of samples collected from the Bukhiin urguu and Zaisan in March increased HepG2 cell growth. Concentrations of 25 μg/ml of PM2.5 collected from three regions around Ulaanbaatar increased HepG2 and AGS cell migration.

Background: Various cytokine dynamics has been associated with chronic hepatitis C virus (HCV) infection. We hypothesized that cytokines have an important role in fibrosis development in HCV infection. Methods: All patients received liver biopsies to validate the severity of chronic hepatitis when enrolled in this study. Fluorescent Bead immunoassay was used to measure the following serum cytokine levels: Interferon γ, tumor necrosis factor α, interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, and IL-12. Various statistical analyses were used as appropriate. Results: From all the liver biopsy proven 92 HCV-infected patients, 49 (53.3%) were male, 23 (25%) patients had advanced (fibrosis grades 3-4) fibrosis, and the mean age of the study population was 51.9 ± 9.4 years. Elevation of baseline IL-4 level (>490 pg/mL) was associated with liver fibrosis grade by X2 test (odds ratio [OR] = 2.99; 95%, CI = 1.02-8.78; p = 0.042) and multivariate logistic regression (OR = 4.26; 95% CI = 1.13-16.02; p = 0.032). Also, IL-4 had strong diagnostic value in advanced liver fibrosis by using area under receiver operating characteristics curve analysis. Assessment of fibrosis score was consequently developed from our findings and compared with other noninvasive serum markers to assess liver fibrosis. Conclusion This study provides evidence that increased IL-4 expression predicted advanced liver fibrosis in treatment of HCV-infected patients.

Background: The American Heart Association estimates that more than 1 million people die each year from acute coronary heart disease and half a million from acute coronary syndrome, and that $ 115 billion a year is spent on diagnosing and treating coronary heart disease [Word Health Organization, 2013]. Goal: In this study we aimed to using coronary computed tomography angiography (CCTA) to diagnose unstable plaques in coronary artery disease. Material and methods: From 2018 to 2021, we performed a coronary computed tomography angiography (CCTA) scan with a Philips Ingenuity 64-slice computed tomography (64 MD-CT) device and examined 47 patients diagnosed with unstable coronary artery disease at the Reference centre on Diagnostic Imaging named after R.Purev State Laureate, People’s physician and Honorary professor of the State Third Central Hospital.
Common statistical measurements such as means and standard errors were calculated. Probability of results were checked using Student’s test. Result: In studying signs of coronary computed tomography angiography (CCTA) to diagnose unstable plaques in coronary artery disease that coronary artery diameters more widening to compared healthy artery 16(34.0%±6.9), low density sites clarify in plaque (lower than +30HU)- 14(29.8%±6.7), small calcification detect in plaque 36 (74.5%±6.4), ring liked additional density (lower than +130 HU) sees in edge of plaque (Halo sign)-9(19.2%±5.8), plaque edge roughness, erosion liked changes- 18 (38.3%±7.1), rupture of intima (dissection)- 8(17.0%±5.5). Conclusion We detect that computed tomography angiography (CCTA)’s specific signs of unstable plaque of coronary artery disease are coronary artery diameters widening, low density sites clarify in plaque (lower than +30HU), small calcification detect in plaque, ring liked additional density (lower than +130 HU) sees in edge of plaque (Halo sign), plaque edge roughness, erosion liked changes and rupture of intima.

Research of function of vitamin D on immune system has been studying since the study revealed that vitamin D receptor is expressed on the surface of the immune cells. 1,2-dihydroxyvitamin D3 [1,25(OH)2D], physiologically active form, can be generated through hydroxylation of 25-hydroxyvitamin D3 [25(OH)D], inactive form of vitamin D, in a liver, connecting with specific VDR make biological action. Vitamin D make different biological actions depends on connecting with different immunological cells. Some studies indicated that Vitamin D plays pivotal role in antibacterial innate immune responses through regulating reaction of the main cells as macrophages and dendritic cells. Moreover, calcitriol, the active form of vitamin D, is connected with VDRE, modulates the innate immune response through directly inducing expression of catelicithin and β-defensin as antimicrobial peptides, reducing secretion of IL-1b, IL-6, TNF-a, RANKL, COX-2 as proinflammatory cytokines and increasing production of IL-10, an anti-inflammatory cytokine. Vitamin D plays in proliferation and differentiation of T and B cells and regulates the activities of over 500 genes. Vitamin D differently impacts on per se stages of T cells’ proliferation. Vitamin D indirectly mitigates the differentiation from immature B cells to plasma B cells while it directly impacts on regulation of overloaded production of antibodies in plasma B cells. In conclusion, vitamin D modulates the innate- and adaptive immune response through regulation on activation of APCells, proliferation and differentiation of immune cells, secretion of some antibacterial peptides.

Since anatomist and doctor Andreas Vesalius (1514-1564) knew that a thorough knowledge of human anatomy was essential to surgery, he devoted much of his time to dissections of cadavers and insisted on doing them himself, instead of relying on untrained assistants. As a result, he created his famous work called “De humani corporis fabrica libri septem” in 1543. This creation was evaluated as scientific discoveryin Europe.
Two hundred forty years later, Dominique Parennin (1665-1741)wrote the book “ManchuAnatomy”by the order of Kangxi Emperor (1654-1722). Thebook was written by hand and the Kangxi Emperor was given three copies. The whole name of the “Manchu Anatomy”is «Imperially-Commissioned Complete Record on the Body. Unfortunately, the Kangxi Emperor did not allow the publication of the book. It was indeed sad that Kangxi Emperor, who distinguished himself by his unusual intelligence and was noted for his encouragement of the arts and sciences, failed to perceive the importance of the «Manchu Anatomy». Had it been printed and disseminated it certainly would have revolutionized Chinese medicine, as Vesalius› «De humani corporis fabrica libri septem” did for European medicine.
However, Dominique Parennin has sent another special copy to the Royal Academy of Science in Paris, which he was a corresponding member. In a letter dated May 1, 1723 accompanying the «Manchu Anatomy» he wrote in old French: Vous serez peut-etre surpris que je vous envoye de- si loin un traite d›Anatomie, un corps de Medecine, et des questions de Physiques ecrites en une langue, qui, sans doute, vous est inconnue; mais votre surprise cessera quand- vous verrez que ce sont vos propres ouvrages que je vous envoye habilles a la Tartare. Oui, Messieurs, ce sont vos pensees et vos ingenieuses decouvertes. In this study, we have translated this letter into Mongolian and explained the content of letter. Thanks to this book, in Europe and America, the book is known as the Manchu Anatomy, and many researchers published several books and scientific articles about the book. However, there is no one who has found that this book has been translated into Mongolian except the Manchu language. Our next study is to compare the Manchus and the Mongolian texts of this book.

Choijamts,the Buddhist image-maker and gelon of the Niislel Khuree (Capital Camp), lived during the last period of the 19th and early 20th centuries. He wrote a book “Gsorig zhungmangbsduspa›ibdudrtsi›isnyingpotshagrangzug rnguselba›ingomtshardga› stongtermdzodzhesbyababzhugs so” in short ngomtshardga› stongtermdzod. This is the comprehensive book about Traditional Mongolian medicine in Tibetan language and written by Mongolian scholar. In his book, the general diagnostic methods of traditional medicine consists of 3 parts: interrogation, pulse diagnosis, and analyzing patient’s urine. The diagnostic method in pediatrics in traditional medicine is based on the general method but different in some ways in consistence with the classification of diseases in children. For instance, there are 3 diagnostic methods in “Ngo mtshardga› stongtermdzod” are as follows:
1. Inquire the symptoms of children from parents and examine the children’s faces
2. Research the method of examining ear veins, identify its scientific nature, and open up possibility to use it in training
3. Define the content and characteristics of methods of examining hot and cold quality of child’s ear by touching, and checking color and shape of veins and include these in curriculum of universities that offers traditional medicine program.
There are a number of interesting approaches to the diagnostic of children›s illnesses in the scope of the Sutra of “Ngo mtshardga› stongtermdzod”. In the future, there is a need for detailed study of each of these methods and input it into the curriculum,and teaching for medical students are essential.