Introduction: It is agreed all over the world that liver cancer can influence a woman's approach of self-acceptance and self-efficacy. Limited literature addressing levels of self-acceptance and self-efficacy separately among women with liver cancer is available in Pakistani population. Objectives: The aim was to study the role of self-acceptance and self-efficacy among women with liver cancer, and to analyse the influence of socio-personal characteristics of women with their self-efficacy. . Data Source and Settings: To address the objectives, a sample of 60 women (N=60) was selected from different hospitals of Islamabad. Period: The duration of the study was 6 months Methods : The present study made use of the two scales i.e., self-efficacy scale and Self-Acceptance. Clinical group was selected through random sampling to collect data from different hospitals of Islamabad. Results: To determine the psychometric properties; alpha correlation, and t-test analysis and ANOVA were computed. Self-acceptance and self-efficacy was found significantly associated with each other. Results indicated that the low sense of identity as a whole, leads women to be low self-efficacy regarding their abilities in their daily lives. There was also a significant difference in demographic variables on Self-acceptance and self-efficacy. Conclusion It is concluded from the finding of the current study that women suffering from liver cancer demonstrated low level of Self-Acceptance. Several associated factors with self-acceptance and self-efficacy were also found among female liver cancer patients of Islamabad.