Objective : To evaluate the effect of screw-retained abutment integrated crown and cement-retained in first molar tooth implant restorations． Methods : A retrospective study was conducted to select 91 patients．A total of 104 implant restorations were completed，of which 52 were screw-retained abutment integrated crown (SR) and 52 were cement-retained ( CR) ．The data of the patients on the day of implant restoration and 6th and 12th month after teeth were conducted，the bone height of the mesial and distal edges of the implants were measured，the perio- dontal clinical indexes around the implants and the patient satisfaction score were recorded at the time of reexamina- tion，and the proximal contacts after implant crown restoration was evaluated according to Barnes evaluation stand- ard. Results : 6 and 12 months after restoration，the implant retention rate in SR group and CR group was 100% ; in the screw retention group，the retention screws of 3 restorations were loosen at 6 months，and the torch force was applied to 35 N / cm ; at 12 months after restoration，the qualified rate of proximal contacts in the screw retention group was 90．38% ，which was significantly lower than that of 99. 04% in the adhesive retention group ( P = 0. 037) ．There was no difference in marginal bone absorption and periodontal soft tissue indexes mPLI and mSBI between the two groups． Conclusion The two retention methods can both achieve good implant effects，and ce- ment-retained restorations has more advantages in the first molar tooth restoration of proximal contact and the pre- vention of food impaction.

OBJECTIVETo study the change of endogenous metabolites of SD rats administrated of aqueous extract of Evodiae rutaecarpa.

METHODSix SD rats had been successively administrated aqueous extract of E. rutaecarpa (0.3857 g x kg(-1)) for 33 days. An agilent 1200 6410 triplequadrupole mass spectrometer was used for the analysis of endogenous metabolites in rat urine samples. These data was analyzed by the principal component analysis (PCA) and PLS-DA using the SIMCA-P 10.0 software.

RESULTThe significant difference in metabolic profiles between the control group and the dosed group was well observed by PCA of the MS data.

CONCLUSIONThe E. rulaecarpa has changed the endogenous metabolites of SD rats. This work can provide the base for the further research on the interpretation of drug property of E. rulaecarpa.

Animals ; Evodia ; chemistry ; Female ; Gene Expression ; drug effects ; Male ; Metabolomics ; methods ; Plant Extracts ; pharmacology ; Principal Component Analysis ; Rats ; Rats, Sprague-Dawley