1.Microvessel density and expression of VEGF and AR in the prostates of men who received re-operation after TURP for benign prostatic hyperplasia
Tongyu GUAN ; Qingzeng SUN ; Jingguang QI ; Jingyi CAO ; Gang WU ; Ning YANG ; Zhengyu CHENG ; Jie LIANG ; Qian WANG
Chinese Journal of Urology 2009;30(12):845-847
Objective To discuss microvessel density (MVD) and expression of vascular endothelial growth factor(VEGF), androgen receptor(AR) in the prostates of men who received re-operation after TURP. Methods Fifty cases were performed re-TURP (re-TURP group) and the remaining 50 cases served as controls. 150 specimens were collected. Sections were stained for CD34 and VEGF, AR by immuno-histo-chemistry(S-P). Statistical analysis of the results was performed using t-test or Pearson Chi-Square test Results The expression of VEGF, AR and MVD were significantly higher in the re-TURP group compared to controls(P<0. 05),but in re-TURP group, difference in VEGF and AR expression as well as MVD were not found to be significantly different between the first and the second TURP(P>0.05). Conclusion Over expression of VEGF and AR as well as high MVD in prostatic tissue might play an important role in the pathological process of BPH after TURP.
2.Experimental Studies on Zhuye Shigao Decoction for the Treatment of Deep Candidiasis in Mice
Jiabin TAI ; Lin LI ; Jingdong GAO ; Qingzeng GUAN
Journal of Guangzhou University of Traditional Chinese Medicine 2001;0(01):-
[Objective] To observe the therapeutic effect of Zhuye Shigao Decoction (ZSD) for the treatment of deep candidiasis in mice. [Methods] One hundred and sixty mice were randomized into immunosuppressive (IS) group and non-immunosuppressive (NIS) group, 80 in each group. The IS mice were given with intraperitoneal injection of cyclophosphamide 200mg/kg and the NIS mice were given with normal saline 0.2mL. Five days later, both groups were vaccinated with Candida albicans solution 0.2 mL through the caudal veins (8 ? 109/L for the NIS mice and 3 ? 109/L for the IS mice). Three hours after vaccination, 20 of the two groups were treated with ZSD 30g/kg, 20 with fluconazole (Img/kg for IS mice and 0.5mg/kg for NIS mice), 20 with ZSD and fluconazole (the medication interval being one hour) and other 20 with same volume of distilled water. The treatment lasted 7 days and the mean survival time and survival colony in the kidney were observed. [Results] ZSD prolonged the survival time (P

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