Introduction: The job satisfaction of family health center nurses, and the factors affecting it, directly affect the stability of the nursing workforce and the quality and performance of their work. This in turn impacts nursing care provided to family clients of all ages. It is important to value nurses’ work, productivity, and job satisfaction with certain periodicity to improve the nursing management system. Aim: To determine the job satisfaction of family health center nurses. Methods: A descriptive cross-sectional design was used for the study. 102 nurses from family health centers participated in the survey. The Nurse's satisfaction instrument (The American Nursing Associations’ "Satisfaction of Nurses ",2021) has 43 items, and 3 subscales (nurses satisfaction, influencing factors for nurses' satisfaction, and possible solutions). The nurse’s satisfaction was rated as poor <0-60, average <61-122, and good <123-180 points. Questions were collected on paper from December 2022 to March 2023. The survey took 15-20 minutes to complete. Results: The job satisfaction of family health center nurses is at a good level (131.98±13.06). Considering the results of the subgroups, the nurse satisfaction group was (mean=32.8±4.06) average, the factors affecting nurse satisfaction were (mean=58.6±8.05) good, and the possible solutions were (mean=40.4±3.04) indicating agreed. There were results that nurses' workload, professional value, salary, and human resources are the most important factors affecting for job satisfaction of nurses. Conclusion According to the research, there is a need for an integrated policy program to improve the job satisfaction of family health center nurses and the factors affecting it.