Introduction: Khat chewing has been a common habit throughout the Horn of Africa and the Arabian Peninsula for thousands of years. It is estimated that more than 20 million people in Africa and the Arabian Peninsula are adolescents. This study aimed to assess the knowledge, attitude, and self-efficacy of khat chewing among adolescents in Mogadishu, Somalia. Method: A cross-sectional study with a sample of 284 adolescents was used. A self-administered pretested questionnaire was used after obtaining an ethical approval from Universiti Putr Malaysia. Data were coded, entered, and statistically analyzed. Results: The prevalence of khat chewing among respondents was 10.2%. Almost more than half of the participants had poor knowledge (184, 64.8%) and self-efficacy (154, 54.2%), while 140 (49.3%) respondents had positive attitudes. Significant predictors of the students’ knowledge of khat chewing included monthly income of more than 500$ (AOR: 2.145), family history such as cousin (AOR=0.347), fathers with a high school (AOR=1.75) and a college degree (AOR=2.21). Significant predictors of the students’ attitude towards khat chewing included family income of 100-299 USD (AOR=0.5), fathers’ with a high school (AOR=2.5) and college (AOR=2.4). Significant predictors of the students’ self-efficacy to resist khat chewing included family income of 100- 300$ (AOR=2.25), fathers with a high school (AOR=2.6), and khat accessibility that is fairly difficult (AOR=0.63) and fairly easy (AOR=0.55). Conclusion: The study highlights the need for increased awareness and education about the adverse effects of khat chewing and the importance of addressing social norms and peer pressure in shaping adolescent attitudes toward Khat.

Introduction: Despite the importance of postpartum type-2 diabetes mellitus (T2DM) screening to ensure early detection and effective management of T2DM among women previously diagnosed with gestational diabetes mellitus, low uptake has been reported. In view of the proven effectiveness of theory-based interventions, this study aimed to evaluate the effectiveness of Information Motivation Behavioural Skills (IMB)-based intervention to improve postpartum T2DM screening uptake among pregnant women with GDM in Negeri Sembilan, Malaysia. Methods: A prospective quasi-experimental study was carried out among comparable respondents in the intervention and control groups, involving 61 and 55 respondents respectively. Validated and reliable self-administered questionnaire was used to measure pre- and post-intervention of knowledge, attitude and self-efficacy, based on the constructs of the IMB model, with postpartum T2DM screening uptake measured at 6-week postpartum. Results: The IMB-based intervention was effectively improved knowledge on gestational diabetes mellitus (GDM), and attitude as well as self-efficacy related to the screening, with significant difference in the 6-week postpartum T2DM screening uptake between the intervention and control groups. Between groups comparison revealed significantly higher mean scores for knowledge (ηp 2 =0.11), attitude (ηp 2 =0.031) and self-efficacy (ηp 2 =0.52) in the intervention group compared to the control group, with self-efficacy is showing the largest size effect. Conclusion: The IMB-based health intervention had effectively improved the 6-week postpartum T2DM screening among women with GDM in the intervention group, through the significant improvement of knowledge on GDM and attitude as well as self-efficacy related to the screening.

Introduction: Malaria is a vector-borne disease caused by the bites of infected female mosquitoes that transmit the parasite to humans. In Guinea, the entire population is at risk of malaria infection. The objective of this study is to develop, implement and evaluate the effectiveness of the Malaria Free Zone program using the Health Belief Model (HBM) to improve malaria prevention knowledge, attitudes, and practices among university students in Conakry, Guinea. Methods: The study design is a clustered randomized controlled trial (RCT). Students are selected using the clustered sampling method, with each university representing one group, either the intervention or control group. The sample size is 113 university students from each group. The content of the Malaria Free Zone program includes eight sessions, which are based on the HBM constructs. This program takes approximately 6 hours and 30 minutes to complete. Respondents are required to complete a questionnaire over four time points. Generalized Estimating Equation (GEE) will be used to determine the effectiveness of the Malaria Free Zone program on malaria prevention knowledge, attitudes, and practices, adjusted with covariates. Conclusion: It is expected that there will be a significant difference in knowledge, attitude, and practice of malaria prevention in the post-test, 2-week and 2-month follow up of the intervention group after the Malaria Free Zone program. Students in the intervention group will have significant higher knowledge, attitude and practice of malaria prevention compared to students in the control group. Trial Registration: PACTR202102614259601

Introduction: Increasing prevalence of dementia and the associated caregiving burden are expected due to longer life expectancy. This review aimed to critically assess dementia-driven caregiving burden and the associated factors in Malaysia. Methods: A systematic search using several combinations of keywords was conducted in Ovid Medline, PubMed, Science Direct, ProQuest, and Ebscohost databases. The primary outcome was the score or level of caregiver burden, while the secondary outcome was the factors associated with such burden. The quality of the individual articles was assessed using the Newcastle–Ottawa Scale and the Joanna Briggs Institute checklist. Results: The systematic search resulted in seven studies being reviewed, consisting of six cross-sectional studies and one quasi-experimental study. Using the Zarit Burden Interview, two studies reported moderate caregiver burden with mean scores of 35.4 (15.08) and 46.0 (17.0). High levels of burden or strain were reported using the Caregiver Strain Index in other studies. The three main associated factors with burden identified in these studies were the presence of behavioural and psychological symptoms of dementia (BPSD), higher education level, and lack of social support. Conclusion: Moderate to severe caregiving burden level were found to be experienced by dementia caregivers in this country. High education, lack of support, as well as taking care of patient with BPSD being the most prominent factors associated with burden. Therefore, burden should be regularly assessed among the dementia caregivers especially among those with lack of social support and manage family members with BPSD, as to prevent adverse outcome from dementia caregiving.

Objective: Pharmacotherapy including mood stabilizers and antipsychotics are frequently used in bipolar disorder (BD); however, the lack of consensus regarding the definition of polypharmacy hinders conducting comparative studies across different settings and countries. Research on Asian Prescription Pattern (REAP) is the largest and the longest lasting international collaborative research in psychiatry in Asia. The objective of REAP BD was to investigate the prescription patterns of psychotropic medications across Asian countries. The rates of polypharmacy and psychotropic drug load were also analyzed. Methods: The data collection was web-based. Prescription patterns were categorized as (1) mood stabilizer monotherapy: one mood stabilizer; (2) antipsychotic monotherapy: one antipsychotic; (3) simple polypharmacy: one mood stabilizer and one antipsychotic; and (4) complex polypharmacy: ≥ 2 mood stabilizers or/and antipsychotics. The psychotropic drug load in each patient was calculated using the defined daily dose method. Results: Among 2003 patients with BD (52.1% female, 42.4 years) from 12 countries, 1,619 (80.8%) patients received mood stabilizers, 1,644 (82.14%) received antipsychotics, and 424 (21.2%) received antidepressants, with 14.7% mood stabilizer monotherapy, 13.4% antipsychotic monotherapy, 48.9% simple polypharmacy, 20.3% complex polypharmacy, and 2.6% other therapy. The average psychotropic drug load was 2.05 ± 1.40. Results varied widely between countries. Conclusion Over 70% of psychotropic regimens involved polypharmacy, which accords with the high prevalence of polypharmacy in BD under a permissive criterion (2 or more core psychotropic drugs) worldwide. Notably, ≥ 80% of our sample received antipsychotics, which may indicate an increasing trend in antipsychotic use for BD treatment.

Introduction: The emergence of a novel Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a pandemic. Rapid and accurate diagnosis method is crucial to reduce the disease burden and to improve early diagnosis approaches to control of the disease. Real time Reverse transcriptase PCR (qRT-PCR) has been identified by the World Health Organization as the most sensitive and specific method of detection. However, the success of this assay relies on the quantity and quality of the extracted viral RNA. Methods: Various methods have been developed for nucleic acid extraction however, the methods have not been assessed. RNA extraction was performed from 24 nasopharyngeal swab samples using a manual extraction kit (GF-1) and an automated extraction kit (Genolution). The concentration and purity of the extracted RNA samples were measured, and its performance were tested using qRT-PCR. Results: The average concentration and purity of the RNA samples extracted using GF-1 kit was higher compared to Genolution. Similarly, the qRT-PCR assay using the RNA samples extracted using manual extraction was better compared to automated kit. Conclusion: Both the manual and automated extraction kits have its advantages and disadvantages in terms of yield and purity. However, with proper optimization, both methods may be used for routine molecular diagnostic of COVID-19 in laboratories.

Diminished vision due to choroidal metastasis as the first manifestation of lung carcinoma is rare. Here, we report a case of a 22-year-old non-smoker man, with no known medical illness presented with painless loss of vision in the right eye for one month, which became painful after two weeks. The anterior segment examination of the right eye revealed an anteriorly subluxated crystalline lens with angle-closure glaucoma secondary to a retrolental choroidal mass. Prompt assessment and investigation revealed right eye choroidal metastasis secondary to small cell carcinoma. The right eye responded well to chemotherapy evidenced by a reduction of intraocular pressure and size of the choroidal mass. It is crucial to have a high index of suspicion to exclude non-ocular primary tumours as probable causes in any choroidal masses.

Introduction: The universal truth surrounding the benefits of exclusive breastfeeding has seldom been disputed. However, the success of exclusive breastfeeding has not been guaranteed despite the availability of numerous interventions. The objective of this study is to review the effectiveness of various breastfeeding promotion education delivery methods in promoting exclusive breastfeeding. Design: A systematic search of leading databases was conducted for scholarly peer-reviewed randomized trials published between January 2014 and May 2019. Data sources: Eight articles were identified as relevant, all were published in English and assessed exclusive breastfeeding. Review Methods: Articles were analyzed for overall quality of evidence using the PEDro Scale. Results: A significant increase in the duration of exclusive breastfeeding was found in seven of the eight studies, with three interventions using combination verbal and written delivery methods and four interventions delivered verbally. Conclusion: Verbal delivery method was the most effective method and many studies use combination method of verbal and written to achieve the objective of their studies.

Introduction: In the recent years, there is remarkable increased in the prevalence of Type 2 Diabetes Mellitus (T2DM) in Middle East countries including Oman. There is good evidence that Mediterranean Diet (MedDiet) is effective over diabetes control and several cardiovascular risk factors in different populations, with little compelling evidence among Omanis. This paper describes the protocol of a wait-list, open labelled, randomized control trial, with its main objective aimed to determine the effectiveness of Mediterranean Diet intervention on glycaemic control and cardiovascular risks among T2DM patients in Oman. Methods: A total of 140 eligible T2DM patients will be recruited. Participants in the intervention group will undergo a six-month MedDiet program comprising of different activities (individual dietary counseling, cooking classes, phone calls and social media messages) while the control group will continue with standard diabetes care. Data collection will be conducted at baseline, after three and six months. The 2 x 3 mixed-design ANOVA will be used to determine the mean changes in outcome variables over the full study period between the two groups. Discussion: Epidemiology studies on nutrition and health had focused on dietary pattern, which provides an opportunity to account for nutrient-nutrient interactions lately. Mediterranean Diet has produced consistent findings on its protective role in diabetes management, with little information on its effectiveness in population outside of Mediterranean basin, including Oman. The outcomes of current study will be used to inform community and health care professionals on the effectiveness and practically of MedDiet on diabetes management.

Introduction: There are a growing number of parents who hesitate to vaccinate their children. Therefore, the current study was conducted to assess future parents-to-be intention to vaccinate their children, as well as to investigate contributing factors of vaccination intention and to identify sources of information on childhood vaccination. Method: A cross-sectional study was conducted among Foundation Program students at a public university for five months, from April to August 2019. Factors studied included sociodemographic characteristics, knowledge and attitudes toward childhood immunization, and religiosity. Data were collected using a validated self-completed questionnaire. Simple random sampling was conducted, with a total of 371 students were recruited as respondents. Multiple logistic regression was performed to determine the predictors. The significance level is set at alpha less than 5%. Results: Approximately 95% of respondents indicated an intention to vaccinate their future. The mean age of respondents was 19 ± 0.37 years old. A motive to vaccinate their future children was high among females (AOR: 4.20, 95% CI: 1.59, 11.08, p: 0.004), having sufficient knowledge about childhood vaccination (AOR: 3.92, 95% CI: 1.23, 12.45, p: 0.021), and having a positive attitude toward childhood vaccination (AOR: 9.56, 95% CI: 2.15, 42.46, p: 0.003). There was no significant association between intention to have their future children vaccinated and religiosity. The sources of information about childhood vaccination were mainly the Internet (72%), mass media (68.2%), and social media (61.7%). Conclusion: Readiness of foundation program students was satisfactory. However, policymakers and program planners should target improving knowledge and attitudes of young people about childhood immunization especially among young men as they will head the household. This effort may sustain the readiness of young people to vaccinate their future children. The approach should include the Internet, mass media, and social media.