A 49-year-old man presented with an incidentally detected right renal mass on a health examination. The abdominal computed tomography and magnetic resonance imaging showed a 3-cm right renal mass suspected of being a hypovascular tumor, such as papillary renal cell carcinoma, and an osteoblastic metastatic lesion on the right iliac bone. However, we missed a bone lesion at the time of diagnosis. A laparoscopic radical nephrectomy was performed and the final pathology confirmed unclassified renal cell carcinoma. The follow-up imaging studies showed several neck lymph nodes and multiple bone metastases at the lumbar spine, right iliac bone, and left femur. Thirteen cycles of temsirolimus were administered to the patient, but follow-up positron emission tomography showed newly developed liver and left adrenal metastasis and increased bone metastasis. It is important to note that T1a renal cell carcinoma can present with distant metastasis and thus demands scrupulous examination even though the tumor size may be small.
Carcinoma, Renal Cell ; Femur ; Follow-Up Studies ; Humans ; Liver ; Lymph Nodes ; Magnetic Resonance Imaging ; Middle Aged ; Neck ; Neoplasm Metastasis ; Neoplasms by Histologic Type ; Nephrectomy ; Osteoblasts ; Positron-Emission Tomography ; Sirolimus ; Spine

PET is essential for the post-treatment assessment of lymphomas because a negative PET scan after treatment is required for a complete remission and curative outcome. Functional imaging with 18F-FDG PET enables evaluation of the early metabolic changes rather than the moprphologic changes of the lymphoma occurring later. Among 186 patients diagnosed with Hodgkin's Disease or Non-Hodgkin's Lymphoma who were referred to the PET Center in this institution from April 2002 to June 2010, 35 patients were included in this study. All 14 patients who only had end-of-chemotherapy scans without midcycle scans had no tumor recurrence on subsequent scan/s, with a median follow-up of 17.5 months. Of the remaining 21 patients, 11 patients had positive studies, 9 had negative studies and 1 had an indeterminate study of the midcycle scans. All the patients obtained similar results on the subsequent scans, excluding 5 with no follow-up scans, with median follow-ups of 13 months for the PET-positive patients and 23 months for the PET-negative patients. These results support the strong prognostic value of PET for aggressive lymphomas, whether the imaging is performed at the end of therapy or after only a few cycles of chemotherapy. PET has consistently been shown to identify positive respondents with higher survival probabilities and longer progression-free survival periods from non-responders on subsequent scans.
Human ; Male ; Female ; Aged 80 and over ; Aged ; Middle Aged ; Adult ; Young Adult ; Adolescent ; LYMPHOMA ; NEOPLASMS ; NEOPLASMS BY HISTOLOGIC TYPE

pEight cases of primary thyroid lymphoma were reported in a tertiary government hospital from January 2005 to August 2011. All patients presented with a diffuse enlargement of both thyroid lobes with associated obstructive symptoms. Five of these cases were extranodal marginal zone lymphoma and three were diffuse large B-cell lymphoma. Clinical features that would favor a thyroid lymphoma include tumor size of greater than 7 cm, obstructive symptoms, clinical hypothyroidism or history of Hashimoto thyroiditis. Thus, these features must be considered in evaluating thyroid nodules during fine-needle aspiration biopsy. Histologically, extranodal marginal zone B-cell lymphoma shows vaguely nodular to diffuse infiltrates of small to intermediate size atypical lymphoid cells infiltrating the thyroid follicles while diffuse large B-cell lymphoma shows sheets of large atypical lymphoid cells infiltrating the thyroid follicular epithelium./p
Human ; Male ; Female ; Aged 80 and over ; Aged ; Middle Aged ; Adult ; THYROID GLAND ; ENDOCRINE GLANDS ; LYMPHOMA ; LYMPHOMA, B-CELL ; NEOPLASM ; NEOPLASMS BY HISTOLOGIC TYPE ; BIOPSY, FINE-NEEDLE

Basal cell nevus syndrome (BCNS), or Gorlin Syndrome, is an autosomal dominant disorder, characterized by multiple developmental abnormalities and associated with germline mutations in the PTCH gene. Patients show multiple and early onset basal cell carcinomas (BCCs) in skin, odontogeniccysts in the jaw, pits on palms and soles, medulloblastoma, hypertelorism, and calcification of the falx cerebri. Clinical features of BCCs in these patients are indistinguishable from ordinary BCCs. However, some patients show variable histologic findings in subtypes of BCCs, and only one case associated with several histologic types of BCCs in the syndrome has been reported in Korea. We present a case of BCNS characterized by multiple BCCs, odontogenic keratocysts, multiple palmar pits, and calcified falx cerebri. Histopathologic findings of BCCs showed several patterns, which were nodular, superficial, and pigmented types.
Basal Cell Nevus Syndrome ; Carcinoma, Basal Cell ; Germ-Line Mutation ; Humans ; Hypertelorism ; Jaw ; Korea ; Medulloblastoma ; Neoplasms by Histologic Type ; Odontogenic Cysts ; Skin

Objective. Classic high-grade osteosarcoma is uncommon in preadolescents (less than or equal to 10 years of age). The possibilities of clinicopathologic differences from the typical adolescent osteosarcoma patient have been raised. We sought to compare the presentation, treatment and survival of this subgroup of patients with published rates in order to determine if there is a need to use a treatment regimen different from that for regular adolescent osteosarcoma patients. Methods. Records of the University of the Philippines-Musculoskeletal Tumor Unit (UP-MuST) over a 15-year period (1993-2008) were reviewed and data collected on patients 10 years and younger with biopsy-proven classic high-grade intramedullary osteosarcoma who underwent complete treatment by the Unit. Demographics and survival rates were then compared with published rates for preadolescent and regular adolescent osteosarcoma cases. Results. There were fourteen patients; (6M:8F; age: 4-10 years). The most common presentation was a painful mass in the distal femur (8); the tumors most commonly had osteoblastic histology (12). Treatment consisted of neoadjuvant chemotherapy, wide surgical excision through ablation (9) or limb-saving surgery (5), and postoperative chemotherapy. There was a good histologic response (over 90% tumor necrosis) in four patients. Seven patients are ANED (alive no evidence of disease) 25 to 186 months after diagnosis. Five-year survival estimate is 52%, compared to a dismal 5 to 10% 15 years ago. Conclusion. Clinicopathologic presentation, clinical course, and overall survival in this subgroup of patients are comparable with published results for both preadolescent and adolescent osteosarcoma patients. There is no need to alter the present treatment regimen for this group of young patients.
Human ; Male ; Female ; Child ; Child Preschool ; OSTEOSARCOMA ; THERAPEUTICS ; THERAPY ; NEOPLASMS ; NEOPLASMS BY HISTOLOGIC TYPE ; NEOPLASMS, CONNECTIVE AND SOFT TISSUE ; NEOPLASMS, CONNECTIVE TISSUE ; NEOPLASMS, BONE TISSUE ;

Primary sinonasal ameloblastoma is an extremely rare odontogenic epithelial tumor histomorphologically identical to its gnathic counterparts but with distinct epidemiologic and clinicopathologic characteristics. We present a case of a 46-year-old female with a one year history of recurrent epistaxis, nasal obstruction and frontonasal headache. Clinical examination, CT scan and subsequent surgical excsion revealed an intranasal mass attached to the lateral nasal cavity with histomorphologic features of ameloblastoma and was signed out as extragnathic soft tissue ameloblastoma of the sinonasal area. Extraosseous extragnathic primary sinonasal ameloblastoma are rare but do occur and should be distinguished from infrasellar craniopharyngiomas.

Human ; Female ; Middle Aged ; AMELOBLASTOMA ; ODONTOGENIC TUMORS ; CALCIFYING EPITHELIAL ODONTOGENIC TUMOR ; NEOPLASMS BY HISTOLOGIC TYPE ; NEOPLASMS ; EPISTAXIS ; RECURRENCE ; DIAGNOSTIC IMAGING ; MEDICAL IMAGING ; DIAGNOSTIC TECHNIQUES AND PROCEDURES ; TOMOGRAPHY SCANNERS, X-RAY COMPUTED

Multiple extramedullary (soft tissue) plasmacytoma is a rare neoplasm of plasma cells. This is a case of a 63-year-old male who presented with back pain and a one month history of a painful, progressively growing mass at the right anterior chest wall. Since radiographs and computed tomography of the chest showed lytic lesions on the ribs and L4 compression deformity, the patient was referred for whole body bone scintigraphy to evaluate the remainder of the skeleton. Bone scintigraphy revealed osteoblastic lesions and osteolytic lesions in the thoracic cage. Diagnosis of plasmacytoma was established by biopsy and confirmation of microscopic characteristics and immunohistochemical staining.

Human ; Male ; Middle Aged ; Neoplasms ; Neoplasms By Histologic Type ; Neoplasms, Plasma Cell ; Radionuclide Imaging ; Diagnosis ; Diagnostic Techniques And Procedures ; Diagnostic Imaging ; Back Pain ; Biopsy ; Bone Diseases ; Plasma Cells ; Plasmacytoma ; Thoracic Wall ; Tomography ; Whole Body Imaging

Background: Non-Hodgkin's lymphoma is a malignant (cancerous) growth of B or T white blood cells (lymphocytes) in the lymph system. Many lymphoma classifications were proposed. All were based by groups of the original cells, histopathological appearances and clinical features. Purpose: Histological classification of lymph node malignant non - \r\n", u'Hodgkin lymphoma based on the new WHO 2001 classification. Objectives: To apply new WHO 2001 classification of 165 cases of malignant non Hodgkin lymphoma were histopathologically and immunohisto chemically studied at K hospital in Hanoi. Subjects and method: The study included 165 patients with malignant non Hodgkin lymphoma were examined and treated at K hospital in Hanoi from 2000 to 2003. Results: The study based on new WHO 2001 classification of 165 cases of malignant non Hodgkin lymphoma showed results B lymphoma: Diffuse large B - cell lymphoma accounts for 63.3%, follicular lymphoma: 17.5%, small lymphocytic lymphoma: 12.5%, mantle cell lymphoma: 1.7% and the others are at low rate. T lymphoma: large T-cell lymphoma accounts for 35.0%, T lymphoblastic lymphoma: 30.0%, angioimmunoblastic T-cell lymphoma: 12.5%, peripheral T- cell lymphoma, unspecified: 10.0%, the others are at low rate. Conclusion: We concluded that new WHO classification of malignant non Hodgkin is reproducible in our practice and should be useful in the treatment decision. \r\n', u'
Lymphoma ; Non-Hodgkin/ pathology ; epidemiology Neoplasms by Histologic Type

A histological study on gastric cancers was carried out on 452 gastric cancers diagnosed at K hospital. The results: (1) Gastric cancers are commonest at the age 61-70, the male/female rate is 1.38. (2) The great majority of gastric cancers are gastric carcinomas (96.68%) with the highest rate of tubular adenocarcinoma (56.16%) and most of these cases are highly differentiated (40.24%); stromal tumors and malignant lymphomas are very rare tumors (1.55% for each type); Non mucinous carcinoma rate is higher than that of mucinous carcinoma rate is higher than that of mucinous carcinomas (94.47% vs. 5.53%). (3) Immunohistochemical is very useful in the diagnosis of small cell carcinomas, one neuroendocrine tumor, one c-kit mutation gastrointestinal stromal tumor (Cajal cell tumor) and three gastric T cell lymphomas. The significance of the data was discussed.
Neoplasms by Histologic Type ; Stomach Neoplasms

WATER HYDROXIDES INORGANIC CHEMICALS OXYGEN COMPOUNDS OXIDES TRANSITION TEMPERATURE TEMPERATURE THERMODYNAMICS PHYSICAL PHENOMENA ANGIOFIBROMA NEOPLASMS ; VASCULAR TISSUE NEOPLASMS BY HISTOLOGIC TYPE NEOPLASMS THERAPEUTICS THERAPY