Objective:The present study was designed to strengthen the education of research integrity, and to improve the awareness of academic misconduct and academic literacy of medical post-graduate students.Methods:A questionnaire survey was conducted with master post-graduate students of a university affiliated hospital, and statistical analysis on the education of research integrity and the perception of academic misconduct among the survey respondents was performed.Results:Academic master post-graduate students′ cognitions of the misconduct in scientific research process and overall academic misconduct were better than that of professional master post-graduate students, and there were significant differences ( P<0.05). The more times of participation in research integrity training, the better cognition of misconduct of scientific research process, research results publication process, and overall academic misconduct, with significant differences ( P<0.05). Conclusions:The education on scientific research integrity of medical post-graduates should be carried out systematically, while the content should be improved and the form should be enriched for scientific research integrity education, so that the medical post-graduates can have a deeper understanding of the code of academic practices, and an education model of scientific research integrity for medical post-graduate which is suitable for China′s national conditions can be gradually developed.

Objective:To analyze the research hotspots and frontiers of hospital research management research from 1981 to 2022.Methods:The relevant literature in the field of hospital scientific research management was retrieved from the CNKI database to explore the trends of publications in this research field. A scientific knowledge graph was drawn and a visualization analysis of the information of authors, issuing units, and research institutions were conducted by Cite Space.5.8.R3.Research hotspots were discussed based on keyword emergence, cluster analysis, and keyword time zone graph.Results:The publication trend in this field was generally policy-oriented, but the cooperation among authors and institutions was relatively loose, and the research hotspots were gradually shifting from scientific research funding management to discipline construction, talent training, translational medicine, and informatization. Cluster analysis found that the main content of hospital scientific research management was scientific research funding and clinical scientific research management and the main management objects were the medical and nursing staff.Conclusions:Hospital scientific research managers must adhere to the policy-oriented approach, strengthen the cooperation and exchanges in scientific research management, innovate the scientific research management mode around the research hotspots and development trends, and promote the quality and efficiency of scientific research management.

Objective:To preliminarily evaluate the outcome of fat grafting breast augmentation using filtration-adsorption technique.Methods:Patients undergoing autologous fat grafting (AFG) breast augmentation between July of 2020 and March of 2021 were retrospectively reviewed at Breast Plastic and Reconstructive Surgery Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College. Patients with complete data who followed up for at least 3 months were included. The lipoaspirates were processed with filtration-adsorption technique and AFG breast augmentation were performed (filtration-adsorption group), and then sedimentation method which was commonly used clinically was set as the control group (sedimentation group). During the follow-up, breast palpation and ultrasound inspection were performed, and the breast volumetric change between preoperative and postoperative was quantitatively compared by three-dimensional scanning technique. Demographic and surgical details were statistically analyzed. Postoperative breast volume retention rates and complication rates were calculated and compared. Normally distributed continuous variables were described in the form Mean±SD, and t-test was used for analysis. Non-normal distributed continuous variables were described in the form of M ( Q1, Q3) and analyzed by Mann-Whitney U test. The classified data were analyzed by Fisher exact probability test. Results:A total of 20 female patients (40 breasts) were included, including 10 patients (20 breasts) aged (31.4±2.5) years in sedimentation group and 10 patients (20 breasts) aged (28.5±4.4) years in the filtration-adsorption group. The fat injection volume in the filtration-adsorption group was 151.1 (125.0, 175.0) ml, and 165.0 (151.3, 196.3) ml in sedimentation group, respectively, with no statistical significance ( P>0.05). The breast volume retention rate in filtration-adsorption group was (62.93±14.06)%, which was significantly higher than that in sedimentation group (24.97±11.02)% ( P<0.01). During postoperative breast ultrasound examination, 2 breasts in sedimentation group had palpable nodules (< 6 mm), 1 breast had ultrasonically detectable but clinically inaccessible nodules (< 4 mm), while only 1 breast in the filtration-adsorption group had an oil cyst (4 mm×2 mm). The complication rate in the filtration-adsorption group was lower than that in sedimentation group[5.0%(1/20) vs. 15.0%(3/20), P>0.05]. Conclusion:The filtration-adsorption technique is an ideal method for fat grafting, which would multiply the volume retention rate in large-volume AFG breast augmentation and reduce the rate of complications.

Objective:To preliminarily evaluate the outcome of fat grafting breast augmentation using filtration-adsorption technique.Methods:Patients undergoing autologous fat grafting (AFG) breast augmentation between July of 2020 and March of 2021 were retrospectively reviewed at Breast Plastic and Reconstructive Surgery Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College. Patients with complete data who followed up for at least 3 months were included. The lipoaspirates were processed with filtration-adsorption technique and AFG breast augmentation were performed (filtration-adsorption group), and then sedimentation method which was commonly used clinically was set as the control group (sedimentation group). During the follow-up, breast palpation and ultrasound inspection were performed, and the breast volumetric change between preoperative and postoperative was quantitatively compared by three-dimensional scanning technique. Demographic and surgical details were statistically analyzed. Postoperative breast volume retention rates and complication rates were calculated and compared. Normally distributed continuous variables were described in the form Mean±SD, and t-test was used for analysis. Non-normal distributed continuous variables were described in the form of M ( Q1, Q3) and analyzed by Mann-Whitney U test. The classified data were analyzed by Fisher exact probability test. Results:A total of 20 female patients (40 breasts) were included, including 10 patients (20 breasts) aged (31.4±2.5) years in sedimentation group and 10 patients (20 breasts) aged (28.5±4.4) years in the filtration-adsorption group. The fat injection volume in the filtration-adsorption group was 151.1 (125.0, 175.0) ml, and 165.0 (151.3, 196.3) ml in sedimentation group, respectively, with no statistical significance ( P>0.05). The breast volume retention rate in filtration-adsorption group was (62.93±14.06)%, which was significantly higher than that in sedimentation group (24.97±11.02)% ( P<0.01). During postoperative breast ultrasound examination, 2 breasts in sedimentation group had palpable nodules (< 6 mm), 1 breast had ultrasonically detectable but clinically inaccessible nodules (< 4 mm), while only 1 breast in the filtration-adsorption group had an oil cyst (4 mm×2 mm). The complication rate in the filtration-adsorption group was lower than that in sedimentation group[5.0%(1/20) vs. 15.0%(3/20), P>0.05]. Conclusion:The filtration-adsorption technique is an ideal method for fat grafting, which would multiply the volume retention rate in large-volume AFG breast augmentation and reduce the rate of complications.

Objective:By analyzing the biomedical papers retracted due to the reason that " original data not provided" , to discuss the necessity of preventing scientific data misconduct and the feasible solutions for its management.Methods:Data of the international papers that were published from Jan 2011 to Dec 2021 and retracted due to " original data not provided" were retrieved from Retraction Watch Database. The data of time distribution, institution, journal sources, reasons for retraction, and disciplinary distribution were statistically analyzed and visually processed by using software packages of Excel, Python 3.7, Gephi 0.92.Results:A total number of 529 papers published in the biomedical field were retracted due to " original data not provided" , and the time of publication and retraction occurred mainly in 2019 (27.41%) and 2021 (41.97%). In addition to the reason " original data not provided" used as search term, the reasons for withdrawal were mainly data and image problems caused by scientific data misconduct, and reasons related to the discovery and investigation process of the paper, and these reasons had a strong co-linear relationship. Besides, the 4 disciplinary of biology-cellular, biology-cancer, genetics, medicine-oncology also had a strong co-linear relationship.Conclusions:It is necessary to incorporating scientific research data management into the scientific research code of conduct, strengthen the training on the code of conduct for original scientific research records keeping, establish the scientific research data review mechanism, and promote the prevention and governance of scientific research data misconduct in the biomedical field.

Objective:To analyze the main related factors for undertaking the NSFC project among the in-service master and doctor in a third-grade First-class hospital in 2020.Methods:By collecting and comparing the age of the target population, the type of education and degree, SCI papers publication and experience as principal investigator of scientific research projects and other variables, the factors affecting the commitment of the NSFC project were analyzed.Results:A total of 743 feedbacks from the people with master′s degree and doctor′s degree in this survey, 69 of whom had undertaken the NSFC project (accounting for 9.3% of the total number). By the univariate analysis, age, education, age more than 55 years old, professional Dr. and academic Dr., published SCI paper publication, JCR1/JCR2/JCR3/JCR4 publication and experience as principal investigator of scientific research project should significantly improve the opportunity of undertaking the NSFC project. The multivariate analysis results show that the main factors influencing the commitment of the NSFC project are the professional Dr., the academic Dr. and having hosted projects.Conclusions:Professional or academic doctors and experience as principal investigator of scientific research projects have significant advantages in undertaking the NSFC project. Medical institutions should fully consider the advantages of different types of scientific research personnel and make clear their differences in professional fields, in order to develop more targeted programs to improve the capacity for scientific research.

Objective:To evaluate the clinical effects of 5-fluorouracil in different mass concentrations combined with triamcinolone in the treatment of keloids.Methods:From March 2018 to March 2019, 29 patients with 31 keloids receipted in the Department of Plastic Surgery of Fujian Medical University Union Hospital, 11 patients with 20 keloids receipted in the Department of Dermatology of Pingtan Comprehensive Experimental Area Hospital, and 9 patients with 9 keloids receipted in the Fuzhou Heisey-Dea Aesthetic Clinic were included in this prospectively randomized control study, with 27 males and 22 females, aged (30±9) years. According to the random number table, the keloids were divided into low mass concentration group (19 keloids, 17 patients), medium mass concentration group (21 keloids, 19 patients), and high mass concentration group (20 keloids, 17 patients). Then 5-fluorouracil at mass concentrations of 0.5, 5.0, and 12.5 mg/mL combined with triamcinolone acetonide were injected respectively, once every 4 weeks, for a total of 3 times. Before the first treatment and in 3 months after the last treatment, the appearance of keloids was evaluated by Vancouver Scar Scale (VSS) and pain and pruritus of keloids were evaluated by Visual Analogue Scale (VAS). Then the score differences before and after the treatment were calculated. In 6 months after the last treatment, the patients' efficacy satisfaction was evaluated by efficacy satisfaction rating scale. Adverse reactions during the treatment were recorded. In the follow-up of one year after the last treatment, the recurrence rates of keloids were counted. Data were statistically analyzed with chi-square test, one-way analysis of variance, paired sample t test, least significant difference t test, Wilcoxon rank sum test, Kruskal-Wallis rank sum test, or Fisher′s exact probability test. Results:Before the first treatment, the appearance VSS scores of appearance of keloids in the three groups were similar ( F=0.039, P>0.05). In 3 months after the last treatment, the appearance VSS scores of keloids in low mass concentration group were significantly higher than those in medium mass concentration group and high mass concentration group ( t=2.267, 4.086, P<0.05 or P<0.01). In 3 months after the last treatment, the appearance VSS scores of keloids in low mass concentration group, medium mass concentration group, and high mass concentration group were significantly decreased compared with those before the first treatment ( t=18.222, 44.272, 22.523, P<0.01). The differences of appearance VSS scores of keloids in low mass concentration group before and after treatment were significantly lower than those in medium mass concentration group and high mass concentration group ( t=-4.096, -6.357, P<0.01), and the differences of appearance VSS scores of keloids in medium mass concentration group before and after treatment were significantly lower than those in high mass concentration group ( t=-2.368, P<0.05). Before the first treatment, the pain and pruritus VAS scores of keloids in the three groups were similar ( χ2=0.149, P>0.05). In 3 months after the last treatment, the pain and pruritus VAS scores of keloids in low mass concentration group were significantly higher than those in medium mass concentration group and high mass concentration group ( Z=2.191, 4.386, P<0.05 or P<0.01), and the pain and pruritus VAS scores of keloids in medium mass concentration group were significantly higher than those in high mass concentration group ( Z=2.276, P<0.05). In 3 months after the last treatment, the pain and pruritus VAS scores of keloids in medium mass concentration group and high mass concentration group were significantly decreased compared with those before the first treatment ( Z=-3.904, -3.844, P<0.01). The differences of pain and pruritus VAS scores of keloids in low mass concentration group before and after treatment were significantly lower than those in medium mass concentration group and high mass concentration group ( Z=-4.265, -6.104, P<0.01). In 6 months after the last treatment, the efficacy satisfaction scores of the corresponding patients of keloids were (88±8) points in high mass concentration group, which were significantly higher than (76±8) points in medium mass concentration group and (60±8) points in low mass concentration group ( t=-3.820, -6.675, P<0.01), and the efficacy satisfaction scores of the corresponding patients of keloids in medium mass concentration group were significantly higher than those in high mass concentration group ( t=-2.984, P<0.05). There was only statistically significant difference in pain within the 3 groups ( P<0.01). In the follow-up of one year after the last treatment, the recurrence rate of keloids in high mass concentration group was significantly lower than that in low mass concentration group ( χ2=8.313, P<0.01), and the recurrence rate of keloids in medium mass concentration group was similar to the recurrence rates in low mass concentration group and high mass concentration group ( P>0.05). Conclusions:After treating keloids with high mass concentration of 5-fluorouracil combined with triamcinolone acetonide, the symptoms were significantly improved, the efficacy satisfaction of patients was increased, with no obvious adverse reactions but long lasting efficacy. Their overall effects are better than treatment using medium and low mass concentrations of 5-fluorouracil, which is worthy of clinical promotion.

Objective:The purpose of this study was to introduce an endoscopic approach to harvest latissimus dorsi muscle(LDM)flap using a single transverse axillary incision and evaluate its safety and efficacy to repair the chest deformities of Poland syndrome.Methods:Poland syndrome patients were recruited prospectively to repair the thoracic wall deformity plus breast reconstruction(combined with breast implant insertion) using the endoscopic approach to transfer LDM flap with single transverse axillary incision in the Department of Aesthetic and Reconstructive Breast Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, from October 2015 to January 2018. Information including patient demographics, LDM area, implant size, contralateral symmetry surgery, operative time(endoscopic time for LDM flap harvesting, endoscopic anterior subcutaneous pocket creating time and total time), the survival of LDM flap, deformity of thoracic wall and back and post-operative complications were collected. The pain visual analog scale was used to assess the severity of postoperative pain. The Breast-Q reconstruction module was used to evaluate patients’ psychosocial well-being and satisfaction with the outcome. The disabilities of the arm, shoulder, and hand (DASH) outcome questionnaire was used to evaluate patient upper extremity disabilities. A paired t-test was utilized to analyze the difference between the preoperative and postoperative score of the Breast-Q and DASH questionnaire. Results:Twenty-eight patients were recruited in this study, including 11 males and 17 females aged (22.5±3.9) years old with a body mass index of (20.5±6.1) kg/m 2. Two patients received contralateral implant augmentation and two received fat grafting for breast symmetry. The postoperative follow-up time was (50.4±23.1) months. All the reconstructed breasts or thoracic walls was in a good shape. All the LDM flap survived with good blood supply. The postoperative pain was mild, and there was no obvious abnormality of the thoracic wall and back. The area of harvested LDM flap was (437.2±110.0) cm 2. The size of the implant used for breast reconstruction was (240.4±46.0) ml. Total operation time was (169.4±16.1) minutes for patients without contralateral symmetrical surgery. The endoscopic time for LDM flap harvesting was (69.0±13.9) minutes. The endoscopic anterior subcutaneous pocket creating time was (32.8±6.0) minutes. The postoperative drain time was (7.6±1.4) days. The postoperative complications included one case of early seroma, one case of wound dehiscence, one case of flap malposition. The pain visual score of the patient was 2.7±0.5 on the first day after the operation and decreased to 0.8±0.4 after 1 week. The score of satisfaction with breast before surgery was 27.8±20.8, psychosocial well-being score was 49.6±17.0. The postoperative score of satisfaction with breast was 63.1±11.6, and psychosocial well-being score was 68.1±16.7. The postoperative score of satisfaction with breast ( t=-9.000, P=0.008) and psychosocial well-being ( t=-6.543, P<0.001) were significantly higher than those before surgery. The score of DASH was 3.7±3.3 before surgery and 4.0±3.7 after surgery respectively, with no statistically significant differences ( t=-1.160, P=0.276). All patients were highly satisfied with the result of the surgery. Conclusions:The endoscopic approach to transfer latissimus dorsi muscle flap using a single transverse axillary incision provides a safe and efficient way to repair thoracic wall deformities in Poland syndrome patients with a high satisfaction rate, a better aesthetic outcome, and a minimal complications rate.

Objective:The purpose of this study was to introduce an endoscopic approach to harvest latissimus dorsi muscle(LDM)flap using a single transverse axillary incision and evaluate its safety and efficacy to repair the chest deformities of Poland syndrome.Methods:Poland syndrome patients were recruited prospectively to repair the thoracic wall deformity plus breast reconstruction(combined with breast implant insertion) using the endoscopic approach to transfer LDM flap with single transverse axillary incision in the Department of Aesthetic and Reconstructive Breast Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, from October 2015 to January 2018. Information including patient demographics, LDM area, implant size, contralateral symmetry surgery, operative time(endoscopic time for LDM flap harvesting, endoscopic anterior subcutaneous pocket creating time and total time), the survival of LDM flap, deformity of thoracic wall and back and post-operative complications were collected. The pain visual analog scale was used to assess the severity of postoperative pain. The Breast-Q reconstruction module was used to evaluate patients’ psychosocial well-being and satisfaction with the outcome. The disabilities of the arm, shoulder, and hand (DASH) outcome questionnaire was used to evaluate patient upper extremity disabilities. A paired t-test was utilized to analyze the difference between the preoperative and postoperative score of the Breast-Q and DASH questionnaire. Results:Twenty-eight patients were recruited in this study, including 11 males and 17 females aged (22.5±3.9) years old with a body mass index of (20.5±6.1) kg/m 2. Two patients received contralateral implant augmentation and two received fat grafting for breast symmetry. The postoperative follow-up time was (50.4±23.1) months. All the reconstructed breasts or thoracic walls was in a good shape. All the LDM flap survived with good blood supply. The postoperative pain was mild, and there was no obvious abnormality of the thoracic wall and back. The area of harvested LDM flap was (437.2±110.0) cm 2. The size of the implant used for breast reconstruction was (240.4±46.0) ml. Total operation time was (169.4±16.1) minutes for patients without contralateral symmetrical surgery. The endoscopic time for LDM flap harvesting was (69.0±13.9) minutes. The endoscopic anterior subcutaneous pocket creating time was (32.8±6.0) minutes. The postoperative drain time was (7.6±1.4) days. The postoperative complications included one case of early seroma, one case of wound dehiscence, one case of flap malposition. The pain visual score of the patient was 2.7±0.5 on the first day after the operation and decreased to 0.8±0.4 after 1 week. The score of satisfaction with breast before surgery was 27.8±20.8, psychosocial well-being score was 49.6±17.0. The postoperative score of satisfaction with breast was 63.1±11.6, and psychosocial well-being score was 68.1±16.7. The postoperative score of satisfaction with breast ( t=-9.000, P=0.008) and psychosocial well-being ( t=-6.543, P<0.001) were significantly higher than those before surgery. The score of DASH was 3.7±3.3 before surgery and 4.0±3.7 after surgery respectively, with no statistically significant differences ( t=-1.160, P=0.276). All patients were highly satisfied with the result of the surgery. Conclusions:The endoscopic approach to transfer latissimus dorsi muscle flap using a single transverse axillary incision provides a safe and efficient way to repair thoracic wall deformities in Poland syndrome patients with a high satisfaction rate, a better aesthetic outcome, and a minimal complications rate.

Objective: To investigate the satisfaction and well-being of Chinese women with breast deficiency, and to analyze the relevant influencing factors. Methods: A cross-sectional study was conducted using a self-designed questionnaire to investigate the women with breast deficiency, visiting the Plastic Surgery Hospital of Chinese Academy of Medical Sciences from November 2013 to August 2018. The BREAST-Q BR (breast reconstruction) pre-operation and post-operation modules were used to assess the quality of life. Results: A total of 139 effective questionnaires were collected, including 83 patients before BR surgery and 56 post. There was no difference in quality of life in different ages, marital status, education levels, working status, and causes of breast deficiency. Mean scores of satisfaction with breasts, psychosocial well-being and sexual well-being of patients after breast reconstruction were significantly higher than those of patients without reconstruction (P=0.000), but there was no statistical difference in physical well-being-chest score. The physical well-being abdomen scores of patients with abdominal flap reconstruction was lower than that of the patients without reconstruction (P=0.007). With regard to analysis of specific items, compared with preoperative patients, patients with abdominal flap reconstruction reported lower scores in the items related to abdominal muscle weakness (P<0.05). Conclusions The breast deficiency resulting from Poland syndrome, breast cancer and other causes, can lead to a significant decrease in quality of life. Breast reconstruction can improve satisfaction with breast, psychosocial and sexual well-being in women with breast deficiency. The abdomen well-being of patients with abdominal flap reconstruction is decreased. Therefore, more attention should be paid to retain abdominal muscles to maintain abdominal shape and motor function during operation.