Objective:To investigate the teaching effect of blended teaching mode based on BOPPPS in the teaching of Natural Medicinal Chemistry.Methods:The undergraduate students of grade 2019 majoring in pharmacy of a medical college were selected as the research objects and divided into 2 groups randomly.Students in class 2 were set as the control group(n=27)and students in class 1 were set as the experimental group(n=29).The students of the two classes were taught by the same group of teachers.The control group adopted traditional teaching methods and classroom teaching as the main teaching mode combines with multimedia teaching.The experimental group received blended teaching mode based on BOPPPS.The final examination scores,teaching effects and student satisfaction of the two groups were compared and analyzed.Results:The survey results showed that the teaching effect of the blended teaching model based on BOPPPS was recognized by 96.55%of the students in the experimental group.The final examination score in the experimental group was higher than that in the control group(P＜0.05).The teaching effect of the experimental group was significantly better than that of the control group(P＜0.05),and the satisfaction of students in the experimental group was higher than that in the control group(P＜0.05).Conclusion:The application of blended teaching mode based on BOPPPS in the teaching of Natural Medicinal Chemistry can effectively stimulate students'learning interest and improve the teaching quality.

Patients with severe trauma require an extremely timely treatment and transfusion plays an irreplaceable role in the emergency treatment of such patients. An increasing number of evidence-based medicinal evidences and clinical practices suggest that patients with severe traumatic bleeding benefit from early transfusion of low-titer group O whole blood or hemostatic resuscitation with red blood cells, plasma and platelet of a balanced ratio. However, the current domestic mode of blood supply cannot fully meet the requirements of timely and effective blood transfusion for emergency treatment of patients with severe trauma in clinical practice. In order to solve the key problems in blood supply and blood transfusion strategies for emergency treatment of severe trauma, Branch of Clinical Transfusion Medicine of Chinese Medical Association, Group for Trauma Emergency Care and Multiple Injuries of Trauma Branch of Chinese Medical Association, Young Scholar Group of Disaster Medicine Branch of Chinese Medical Association organized domestic experts of blood transfusion medicine and trauma treatment to jointly formulate Chinese expert consensus on blood support mode and blood transfusion strategies for emergency treatment of severe trauma patients ( version 2024). Based on the evidence-based medical evidence and Delphi method of expert consultation and voting, 10 recommendations were put forward from two aspects of blood support mode and transfusion strategies, aiming to provide a reference for transfusion resuscitation in the emergency treatment of severe trauma and further improve the success rate of treatment of patients with severe trauma.

Objective:To investigate the expression and clinical significance of somatostatin receptor 2 (SSTR2), a disintegrin and metalloproteinase-12 (ADAM-12), and friend leukemia virus integration-1 (FLI-1) in small cell lung cancer tissue.Methods:Eighty-two patients with small cell lung cancer who received treatment in Haiyang People's Hospital from January 2020 to January 2021 were included in this study. All patients underwent radical surgical resection. Small cell lung cancer tissues and adjacent tissues more than 2 cm from the edge of cancer tissues were harvested. The positive expression rates of SSTR2, ADAM-12, and FLI-1 in cancer tissues and adjacent tissues were determined by immunohistochemistry. The relationship between SSTR2, ADAM-12, FLI-1, and clinical characteristics were analyzed. The 1-year survival rate of patients with small cell lung cancer was calculated.Results:The positive rates of SSTR2, ADAM-12, and FLI-1 in small cell lung cancer tissue were 79.27% (65/82), 76.83% (63/82), and 78.05% (64/82), respectively, which were significantly higher than 19.51% (16/82), 17.07% (14/82), 20.73% (17/82) in the adjacent tissue ( χ2 = 58.57, 58.78, 53.90, all P < 0.05). SSTR2, ADAM-12, and FLI-1 were positively associated with lymph node metastasis, clinical stage, tissue invasion, tumor size, and histological grade (all P < 0.05). After controlling for gender, age, and others, SSTR2, ADAM-12, and FLI-1 were associated with lymph node metastasis, clinical stage, tissue invasion, tumor size, and histological grade (all P < 0.05). All patients were followed up for 1 year. Six patients were lost to follow-up. The 1-year survival rate of 76 patients with small cell lung cancer was 67.11% (51/76). The survival rate of patients with positive SSTR2, ADAM-12, and FLI-1 expression were lower than that of patients with negative SSTR2, ADAM-12, and FLI-1 expression ( χ2 = 3.93, 6.43, 7.52, all P < 0.05). Conclusion:SSTR2, ADAM-12, and FLI-1 are highly expressed in small cell lung cancer tissue. Combined detection of SSTR2, ADAM-12, and FLI-1 is conducive to the prognosis and evaluation of small cell lung cancer in patients. This study is innovative and scientific.

COVID-19, an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread throughout the world. China has achieved rapid containment of this highly infectious disease following the principles of early detection, early quarantine and early treatment with integrated traditional Chinese and Western medicine. The inclusion of traditional Chinese medicine (TCM) in the Chinese protocol is based on its successful historic experience in fighting against pestilence. Current findings have shown that the Chinese medicine can reduce the incidence of severe or critical events, improve clinical recovery and help alleviate symptoms such as cough or fever. To date there are over 133 ongoing registered clinical studies on TCM/integrated traditional Chinese and Western medicine. The three Chinese patent medicines (/ (Forsythiae and Honeysuckle Flower Pestilence-Clearing Granules/Capsules), (Honeysuckle Flower Cold-Relieving Granules) and (Stasis-Resolving & Toxin-Removing) were officially approved by the National Medical Products Administration to list COVID-19 as an additional indication. The pharmacological studies have suggested that Chinese medicine is effective for COVID-19 probably through its host-directed regulation and certain antiviral effects.

Objective To explore a reasonable transitional care quality management model, in order to standardize the management system of transitional care. Methods Using "three-dimensionalquality structure" mode as the theoretical framework, after reviewed relevant literatures, we established the rudiment of quality evaluation index system.Twenty-two experts were enrolled,and expert consultation was conducted using Delphimethod. The experts were evaluated by authority, positivity and degree of opinion coordination. Results The experts′authority coefficient was 0.846;the coefficient of determination was 0.891;the degree of familiarity was 0.80.The positive coefficients of the two rounds of consultation were 0.958,0.957. The evaluation system for transitional care consisted of 3 level- 1 indicators,12 level-2 indicators,and 64 level-3 indicators.The Kendall coefficients of concordance of the three level Indicators were 0.519, 0.525, and 0.432(P<0.05 for all). Conclusion The quality evaluation index system with With high reliability, providing standard reference for the work of quality management and nursing quality improvement.

Objective : The purpose of this study is to determine the accuracy of implant placement in the edentulous jaw using computer planning and fully-guided mucosa-supported surgical template by Simplant software. Methods: 63 implants were placed in 9 patients (11 fully edentulous jaws), 26 implants were placed in upper edentulous jaw and 37 implants in lower edentulous jaw. Preoperatively, first, a cone beam CT was required for patients with radiographic template and radiographic template respectively. Therefore, the data of CBCT was inputted in Simplant software by DICOM format, followed by virtual implant planning. Hereafter, a mucosa-supported surgical template was designed by dentist and made by Masterilise company to allow implant placement using the template as a guide. To investigate the accuracy of implant placement, a postoperative CBCT scan was obtained and matched to the preoperative scan. The accuracy of implant placement was validated three-dimensionally including divations of implant shoulder, apical point, axial angulation and depth. Results: The survival rate of 63 implamts for a 6 month to 10 year observation period was 100%. The mean divation of implant shoulder was 0.73 ± 0.53 mm, implant apical point was 1.15 ± 0.62 mm, implant depth was 0.95 ± 0.64 mm and implant axial angulationwas 4.10 ° ± 3.23°. Conclusion Divation between virtual and actual implant was existed and it should be considered preoperatively when virtual implant was planned to avoid injuring anatomic structure and keeping surgery safely. Correct manipulation during implant operation are helpful to decrease the divation of implant placement.

Objective To observe the effect of Dorothea Orem's Self-Care Theory on selfcare ability and life quality of patient with hepatic carcinoma undergoing TACE.Methods The data of 84 patients with hepatic carcinoma undergoing TACE from October 2012 to October 2014 in the hospital was retrospectively analyzed.And 40 patients from October 2012 to October 2013 received conventional nursing were as control group,while those received Dorothea Orem's Self-Care Theory nursing from November 2013 to October 2014 were as observation group.Self-care ability and life quality were compared between the two groups.Results The self-care ability and life quality in observation group were much better than that in the control group (P ＜ 0.05).Conclusion Dorothea Orem's Self-Care Theory nursing intervention can improve self-care ability and the quality of life of patients.So it is worthy of clinical promotion.

Objective To observe the effect of Dorothea Orem's Self-Care Theory on selfcare ability and life quality of patient with hepatic carcinoma undergoing TACE.Methods The data of 84 patients with hepatic carcinoma undergoing TACE from October 2012 to October 2014 in the hospital was retrospectively analyzed.And 40 patients from October 2012 to October 2013 received conventional nursing were as control group,while those received Dorothea Orem's Self-Care Theory nursing from November 2013 to October 2014 were as observation group.Self-care ability and life quality were compared between the two groups.Results The self-care ability and life quality in observation group were much better than that in the control group (P ＜ 0.05).Conclusion Dorothea Orem's Self-Care Theory nursing intervention can improve self-care ability and the quality of life of patients.So it is worthy of clinical promotion.

Objective To explore the effect of heat preservation nursing on intraoperative stress and postoperative recovery in patients undergoing general anesthesia.Methods A total of 95 patients in our hospital were divided into control group (44 cases) and observation group (51 cases) according to hospital admission.The patients of the control group were given routine nursing measures and the observation group used heat preservation nursing during the perioperative period on the basis of the control group.The clinical indexes, the stress in operation and the postoperative recovery in two groups were compared.Results There were no significant differences in the intraoperative blood loss, intraoperative fluid volume and operation time between the two groups (P>0.05).The occurrence rate of the observation group was 3.92%, which was significantly lower than 20.45% of the control group, the AD, NE and CR and other intraoperative stress indicators in the observation group were significantly lower than that of the control group, and the tracheal tube time, awake time and PACU retention time were also lower than that of the control group, the differences between the two groups were statistically significant (P<0.05).Conclusion Perioperative heat preservation nursing for general anesthesia can significantly reduce occurrence of low temperature, reduce the stress response, and promote rapid recovery of patients after surgery.

Objective To explore the effect of heat preservation nursing on intraoperative stress and postoperative recovery in patients undergoing general anesthesia.Methods A total of 95 patients in our hospital were divided into control group (44 cases) and observation group (51 cases) according to hospital admission.The patients of the control group were given routine nursing measures and the observation group used heat preservation nursing during the perioperative period on the basis of the control group.The clinical indexes, the stress in operation and the postoperative recovery in two groups were compared.Results There were no significant differences in the intraoperative blood loss, intraoperative fluid volume and operation time between the two groups (P>0.05).The occurrence rate of the observation group was 3.92%, which was significantly lower than 20.45% of the control group, the AD, NE and CR and other intraoperative stress indicators in the observation group were significantly lower than that of the control group, and the tracheal tube time, awake time and PACU retention time were also lower than that of the control group, the differences between the two groups were statistically significant (P<0.05).Conclusion Perioperative heat preservation nursing for general anesthesia can significantly reduce occurrence of low temperature, reduce the stress response, and promote rapid recovery of patients after surgery.