Epigallocatechin gallate(EGCG) is the most abundant component in green tea catechins. It has the functions of anti-oxidation stress, anti-inflammatory response and regulating cell apoptosis. EGCG is effective in preventing and treating tumors, improving metabolic diseases such as obesity and diabetes, treating cardiovascular diseases and neuroprotection. EGCG is the main component of tea polyphenols that plays a biological role. This paper searched and summarized the literatures related to the neuropharmacological effects of EGCG at home and abroad, so as to provide more theoretical basis for the clinical application of EGCG in the prevention and treatment of nerve injury, neurodegenerative diseases, cognitive impairment and so on.

The glycogen of astrocytes is decomposed to produce lactic acid, which is transported to neurons through monocarboxylate transporters to provide energy, and plays an important role in excitatory transmission and synaptic plasticity regulation of neurons; this mechanism is called astrocyte neuron lactate shuttle (ANLS). Abnormal ANLS impairs neuro-energy regulation and homeostasis is associated with learning and memory, exhaustive exercise, addiction and many other neurological diseases. This paper summarizes the latest research progress of ANLS in multiple brain functions, diabetes cognitive impairment, schizophrenia, traumatic brain injury, depression and a variety of neurodegenerative diseases, so as to provide basis for basic research, drug design and other related clinical treatment strategies of nervous system diseases targeting ANLS.