Heracleum candicans is extensively utilized for its abundant medicinal components,which are applied in various treatments,including insecticides,hemostatic agents,dispersing wind,relieving cough,and alleviating rheumatic pain.This paper reviewed the various chemical constituents and pharmacological effects of Heracleum candicans.It aims to provide new insights for its promotion and application,as well as to provide a basis for establishing quality standards for Heracleum candicans.

We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB-IIA) cervical cancer having risk factors after surgery. The condition was assessed in terms of prognosis, adverse effects, and quality of life. This randomized trial involved nine centers across China. Eligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery. The primary end-point was progression-free survival (PFS). From December 2012 to December 2014, 337 patients were subjected to randomization. Final analysis included 329 patients, including 165 in the adjuvant chemotherapy group and 164 in the adjuvant CCRT group. The median follow-up was 72.1 months. The three-year PFS rates were both 91.9%, and the five-year OS was 90.6% versus 90.0% in adjuvant chemotherapy and CCRT groups, respectively. No significant differences were observed in the PFS or OS between groups. The adjusted HR for PFS was 0.854 (95% confidence interval 0.415-1.757; P = 0.667) favoring adjuvant chemotherapy, excluding the predefined non-inferiority boundary of 1.9. The chemotherapy group showed a tendency toward good quality of life. In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervical cancer having pathological risk factors. Adjuvant chemotherapy alone is a favorable alternative post-operative treatment.
Female ; Humans ; Uterine Cervical Neoplasms/drug therapy* ; Prospective Studies ; Quality of Life ; Neoplasm Staging ; Chemoradiotherapy ; Chemotherapy, Adjuvant/adverse effects* ; Adjuvants, Immunologic ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use* ; Retrospective Studies

Tumor-associated tertiary lymphoid structures(TLSs)are ectopic lymphoid formations within tumor tissue,with mainly B and T cell populations forming the organic aggregates.The presence of TLSs in tumors has been strongly associated with patient responsiveness to immunotherapy regimens and improving tumor prognosis.Researchers have been motivated to actively explore TLSs due to their bright clinical application prospects.Various studies have attempted to decipher TLSs regarding their formation mechanism,structural composition,induction generation,predictive markers,and clinical utilization.Meanwhile,the scientific approaches to qualitative and quantitative descriptions are crucial for TLS studies.In terms of detection,hematoxylin and eosin(H&E),multiplex immunohistochemistry(mIHC),multiplex immunofluorescence(mIF),and 12-chemokine gene signature have been the top approved methods.However,no standard methods exist for the quantitative analysis of TLSs,such as absolute TLS count,analysis of TLS constituent cells,structural features,TLS spatial location,density,and maturity.This study reviews the latest research progress on TLS detection and quantification,proposes new directions for TLS assessment,and addresses issues for the quantitative application of TLSs in the clinic.

Malignancies are diseases resulting from an imbalance of cell growth and proliferation， endangering human health and life. Currently， there is no clinically effective treatment for tumors. Tumor cells may alter cell adhesion and tumor cell migration and movement by degrading the extracellular matrix， generating vascular factors， affecting epithelial-mesenchymal transformation， or altering the tumor microenvironment. The mechanisms which lead to multidrug resistance （MDR） are the regulation of membrane proteins， apoptosis-regulated gene expression， enzyme-mediated multidrug resistance， DNA damage repair， and epithelial-stromal transformation， resulting in ineffective treatment of tumors. Therefore， the search for natural， safe， and effective chemosensitizers has become a critical part in tumor research. Due to the increasing use of Chinese medicine in cancer treatment， researchers have conducted more extensive studies on its monomers and compounds. In addition， the mechanisms of Chinese medicine in inhibiting tumor invasion and metastasis and reversing drug resistance are gradually unraveled. The monomers and compounds of Chinese medicine may inhibit tumor invasion， metastasis， and drug resistance by enhancing the sensitivity of chemotherapy drugs and adjuvant properties. Furthermore， they can also improve the tolerance of patients to chemotherapy drugs， relieve side effects of chemotherapy， reduce the chance of recurrence， and prolong the life of patients. The development of traditional Chinese medicine plays an important role in reducing tumor recurrence and metastasis， reversing drug resistance， prolonging the prognosis of cancer patients， improving their quality of life， and prolonging their survival time. Currently， various types of Chinese medicines have been proven to be capable of reducing tumor invasion and metastasis， and reversing drug resistance. The present article reviewed development and findings of Chinese medicine as an anti-tumor invasion， anti-metastasis， and anti-tumor resistance therapy in recent years， in order to provide ideas for future research on anti-tumor effect of active components in Chinese medicine.

Objective:To explore the effects of continuous nursing on quality of life (QOL) in postoperative laryngeal cancer patients.Methods:The randomized controlled trial (RCT) on effects of continuous nursing on QOL in postoperative laryngeal cancer patients were retrieved in the Cochrane Library, Joanna Briggs Institute (JBI) Library, PubMed, EMbase, Web of Science, CINAHL, Sinomed, Chinese National Knowledge Infrastructure (CNKI) , WanFang data, VIP and ProQuest by computer from building database to October 2019. Two systematic review researchers independent evaluated the literature quality based on the "Australia JBI Critical Appraisal Tool (2016) ". RevMan 5.3 was used to data analysis.Results:A total of 8 RCTs were included. Meta-analysis showed that compared with routine nursing, continuous nursing improved the general health status of QOL among postoperative laryngeal cancer patients with a statistical difference in the merge effect [ SMD=2.59, 95% CI (1.70, 3.48) , Z=5.68, P<0.000 01]. Besides, continuous nursing also improved aspects of QOL, such as physical function, role function, emotional function and social function. Conclusions:The continuous nursing can improve the QOL of postoperative laryngeal cancer patients which is worthy of clinical application.

This study was performed to evaluate the oncological and reproductive outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumors in China. One hundred and forty eight non-epithelial ovarian tumor women treated with FSS between January 1, 2000 and August 31, 2015 from two medical centers in China were identified. Progression-free survival (PFS) was 88.5%, whereas overall survival (OS) was 93.9%. Univariate analysis suggested that delivery after treatment is related to PFS (P = 0.023), whereas histology significantly influenced OS. Cox regression analysis suggested that only histology was associated with PFS and OS (P < 0.05). Among the 129 women who completed adjuvant chemotherapy (ACT), none developed amenorrhea. Among the 44 women who desired pregnancy, 35 (79.5%) successfully had 51 gestations including 35 live births without birth defects. Non-epithelial ovarian tumors can achieve fulfilling prognosis after FSS and chemotherapy. Histology might be the only independent prognostic factor for PFS and OS. FSS followed by ACT appeared to have little or no effect on fertility. Meanwhile, postoperative pregnancy did not increase the PFS or OS. Use of gonadotropin-releasing hormone agonist was not beneficial for fertility.
Adolescent ; Adult ; Chemotherapy, Adjuvant ; adverse effects ; Child ; China ; Female ; Humans ; Infertility, Female ; etiology ; prevention & control ; Neoplasm Staging ; Organ Sparing Treatments ; Ovarian Neoplasms ; drug therapy ; surgery ; Pregnancy ; Pregnancy Rate ; Prognosis ; Retrospective Studies ; Survival Analysis ; Young Adult

Objective To investigate the effects of postoperative semi-reclining position in early stage on the comfort degree of patients with endoscopic sinus surgery under general anesthesia. Methods Totally 106 cases of patients with endoscopic sinus surgery under general anesthesia were selected from the ENT&HN Surgery Department of Beijing Tongren Hospital during September 2014 to May 2015. The patients were randomly divided into the control group (n=54) and the experimental group (n=52). Patients in the control group adopted traditional clinostatism after surgery,while patients in the experimental group adopted early semi-reclining position after surgery. Four hours after surgery,patients' comfort degree with discomfort visual analogue score (VAS) were evaluated,and the incidence of neck-shoulder soreness and waist soreness of patients was compared between two groups. Results In the experimental group,the total discomfort VAS score of patients was 3.00 (2.00~5.00),which was lower than VAS score 4.00 (3.00~6.00) in the control group (Z=-2.270,P<0.05). In the experimental group,the incidence of shoulder-soreness was 0,and the incidence of waist soreness was 3.85%,and they were all lower than those in the control group (16.67%,11.11%) (χ2= 9.471,5.666;P<0.05). Conclusions Early semi-reclining position can effectively reduce the postoperative headache,ear fullness and general discomfort of patients with endoscopic sinus surgery,reduce the occurrence of shoulder-neck soreness and waist soreness of patients,and improve patients' comfort.

MicroRNAs (miRNAs) play critical roles in the development and progression in various cancers.Dysfunctional miR-9 expression remains ambiguous,and no consensus on the metastatic progression of ovarian cancer has been reached.In this study,results from the bioinformatics analysis show that the 3'-UTR of the E-cadherin mRNA was directly regulated by miR-9.Luciferase reporter assay results confirmed that miR-9 could directly target this 3'-UTR.miR-9 and E-cadherin expression in ovarian cancer tissue was quantified by qRTPCR.Migration and invasion were detected by wound healing and Transwell system assay in SKOV3 and A2780.qRT-PCR and Western blot were performed to detect the epithelial-mesenchymal transition-associated mRNA and proteins.Immunofluorescence technique was used to analyze the expression and subcellular localization of Ecadherin,N-cadherin,and vimentin.The results showed that miR-9 was frequently upregulated in metastatic serous ovarian cancer tissue compared with paired primary ones.Upregulation of miR-9 could downregulate the expression of E-cadherin but upregulate the expression of mesenchymal markers (N-cadherin and vimentin).Overexpression of miR-9 could promote the cell migration and invasion in ovarian cancer,and these processes could be effectively inhibited via miR-9 inhibitor.Thus,our study demonstrates that miR-9 may promote ovarian cancer metastasis via targeting E-cadherin and a novel potential therapeutic approach to control metastasis of ovarian cancer.

Objective To investigate the degree of pain, pain control and influencing factors of patients with silicone drainage tube after endoscopic sinus surgery, so as to provide the basis for the management of pain and comfort nursing. Methods From March to August in 2016, 102 patients undergone endoscopic sinus surgery were selected as the research objects. They were treated with silicone drainage tube within 48 h after operation. The patient's pain status and its influencing factors were assessed by the Brief Pain Scale (BPI) at 24 h and 48 h after operation. Results In 24-48 h after surgery, the most degree of pain, the lightest degree of pain, the average degree of pain, the exist degree and the overall degree of pain were significantly reduced than those in 24 h after surgery,and the differences were statistically significant (t=3.446, 4.790, 5.413, 4.758, 5.374;P<0.05); In 24-48 h after the surgery, the pain impact on daily life, mood, work, sleep and overall effects were significantly reduced than those in 24 h after the surgery, and the differences were statistically significant (t=2.729, 2.912, 3.260, 2.080, 2.702; P <0.05); 24-48 h after operation, the overall pain state of patients with patient-controlled analgesia (PCA) (2.15±1.69) was significantly lower than that patients who did not receive the PCA (3.26±1.94), and the difference was statistically significant (t=2.871, P=0.005). Conclusions The pain nursing of the patients with silicone tube should not be neglected, especially in 24 h after surgery nurses should strengthen the assessment and management of pain, and pay attention to the impact of pain; For pain control, we should not use single control mode, but should focus on exploring various ways to control pain.

OBJECTIVE: To analyze the relationship between chronic pain and painprone meutal disorders and investigate the effect of psychological intervention and medication.DATA SOURCES: Related literatures about the relationship between chronic pain and pain-prone mental disorders were searched on computer in Medline and Embase from January 1989 to May 2004 with the retrieval word of "Chronic pain, emotional disorder, treatment", the language was limited to English. The subjects were patients who suffered from chronic pain for above 6 months.STUDY SELECTION: Related literatures about the relationship between chronic pain and pain-prone mental disorders and its therapeutic interventions were carried on primary trial to delete those obsolete and repetitive literatures, and the others were used to search in the full text. The quality was appraised mainly on the basis of the data authenticity, preciseness of the designation, strictness of the implementation and reasonability of the statistical analysis.DATA EXTRACTION: Altogether 20 literatures were obtained and 11literatures were proved accordant with the inclusion standard. 9 literatures were excluded because 7 were repetitive experiments and two were Meta analyses.DATA SYNTHESIS: 11 literatures include experimental group and control group, patients in the experimental group were treated with analgetic combined with psychological intervention and antidepressant while those in the control group were only given analgetic; the outcomes of the two groups were compared.CONCLUSION: Chronic pain may co-exist with emotional disorders. It can be remarkably alleviated by the administration of analgetic combined with psychological intervention and antidepressant, which proves better than single analgetic medication.