1.Improved visibility of palisade vessels within Barrett’s esophagus using red dichromatic imaging: a retrospective cross-sectional study in Japan
Chise UEDA ; Shinwa TANAKA ; Tetsuya YOSHIZAKI ; Hirofumi ABE ; Masato KINOSHITA ; Hiroya SAKAGUCHI ; Hiroshi TAKAYAMA ; Hitomi HORI ; Ryosuke ISHIDA ; Shinya HOUKI ; Hiroshi TANABE ; Eri NISHIKAWA ; Madoka TAKAO ; Toshitatsu TAKAO ; Yoshinori MORITA ; Takashi TOYONAGA ; Yuzo KODAMA
Clinical Endoscopy 2025;58(2):269-277
Background/Aims:
Visualization of palisade vessels (PVs) in Barrett’s esophagus is crucial for proper assessment. This study aimed to determine whether red dichromatic imaging (RDI) improves PV visibility compared with white-light imaging (WLI) and narrow-band imaging (NBI).
Methods:
Five expert and trainee endoscopists evaluated the PV visibility in Barrett’s esophagus using WLI, NBI, and RDI on 66 images from 22 patients. Visibility was rated on a 4-point scale: 4, excellent; 3, good; 2, fair; and 1, poor. The color difference between the most recognizable PV spots and surrounding areas with undetectable blood vessels was also analyzed.
Results:
Mean visibility scores were 2.6±0.7, 2.3±0.6, and 3.4±0.4 for WLI, NBI, and RDI, respectively. The RDI scores were significantly higher than the WLI (p<0.001) and NBI (p<0.001) scores. These differences were recognized by trainees and expert endoscopists. Color differences in PVs were 7.74±4.96 (WLI), 10.43±5.09 (NBI), and 15.1±6.54 (RDI). The difference in RDI was significantly higher than that in WLI (p<0.001) and NBI (p=0.006).
Conclusions
RDI significantly improved PV visibility compared to WLI and NBI based on objective and subjective measures.
2.Enhanced recovery after laparoscopic distal gastrectomy using articulating laparoscopic instruments in older adults with gastric cancer: a retrospective analysis of prospectively collected data
Seohee CHOI ; Takahiro KINOSHITA ; Kazutaka OBAMA ; Katsunobu SAKURAI ; Naoshi KUBO ; Naruhiko IKOMA ; Ali GUNER ; Hyoung-Il KIM
Annals of Surgical Treatment and Research 2025;108(2):86-92
Purpose:
As the number of older adults with gastric cancer requiring gastrectomy has increased, it has become increasingly important to use techniques that enhance surgical safety and reduce postoperative complications in this vulnerable patient population. Articulating laparoscopic instruments (ALIs) may improve maneuverability and precision, leading to better outcomes in older patients. This study aimed to compare postoperative outcomes of older adults undergoing laparoscopic distal gastrectomy for gastric cancer using conventional versus ALIs.
Methods:
This retrospective study included 147 older patients (aged ≥70 years) who underwent laparoscopic distal gastrectomy for gastric cancer between 2017 and 2024. Surgery was performed using conventional laparoscopic instruments in 61 patients and ALIs in 86 patients. The median follow-up period was 20 months.
Results:
Postoperative hospital stay was significantly shorter in the articulating group than in the conventional group (4.6 ± 2.0 days vs. 5.4 ± 2.4 days, P = 0.030). Time to first flatus was also significantly shorter in the articulating group (2.4 ± 0.7 days vs. 2.8 ± 1.0 days, P = 0.022). However, there were no significant differences in overall complications, major (≥grade III) complications (conventional, 1.2% vs. articulating, 0%; P = 0.398) overall survival, or recurrence-free survival between groups.
Conclusion
The use of articulating instruments in older adults undergoing laparoscopic distal gastrectomy for gastric cancer was associated with shorter postoperative hospital stays and faster recovery of bowel function, with no apparent detrimental effects on complications, recurrence, or survival. These findings suggest that ALIs enhance recovery and possibly overall surgical outcomes in this patient population.
3.Enhanced recovery after laparoscopic distal gastrectomy using articulating laparoscopic instruments in older adults with gastric cancer: a retrospective analysis of prospectively collected data
Seohee CHOI ; Takahiro KINOSHITA ; Kazutaka OBAMA ; Katsunobu SAKURAI ; Naoshi KUBO ; Naruhiko IKOMA ; Ali GUNER ; Hyoung-Il KIM
Annals of Surgical Treatment and Research 2025;108(2):86-92
Purpose:
As the number of older adults with gastric cancer requiring gastrectomy has increased, it has become increasingly important to use techniques that enhance surgical safety and reduce postoperative complications in this vulnerable patient population. Articulating laparoscopic instruments (ALIs) may improve maneuverability and precision, leading to better outcomes in older patients. This study aimed to compare postoperative outcomes of older adults undergoing laparoscopic distal gastrectomy for gastric cancer using conventional versus ALIs.
Methods:
This retrospective study included 147 older patients (aged ≥70 years) who underwent laparoscopic distal gastrectomy for gastric cancer between 2017 and 2024. Surgery was performed using conventional laparoscopic instruments in 61 patients and ALIs in 86 patients. The median follow-up period was 20 months.
Results:
Postoperative hospital stay was significantly shorter in the articulating group than in the conventional group (4.6 ± 2.0 days vs. 5.4 ± 2.4 days, P = 0.030). Time to first flatus was also significantly shorter in the articulating group (2.4 ± 0.7 days vs. 2.8 ± 1.0 days, P = 0.022). However, there were no significant differences in overall complications, major (≥grade III) complications (conventional, 1.2% vs. articulating, 0%; P = 0.398) overall survival, or recurrence-free survival between groups.
Conclusion
The use of articulating instruments in older adults undergoing laparoscopic distal gastrectomy for gastric cancer was associated with shorter postoperative hospital stays and faster recovery of bowel function, with no apparent detrimental effects on complications, recurrence, or survival. These findings suggest that ALIs enhance recovery and possibly overall surgical outcomes in this patient population.
4.Improved visibility of palisade vessels within Barrett’s esophagus using red dichromatic imaging: a retrospective cross-sectional study in Japan
Chise UEDA ; Shinwa TANAKA ; Tetsuya YOSHIZAKI ; Hirofumi ABE ; Masato KINOSHITA ; Hiroya SAKAGUCHI ; Hiroshi TAKAYAMA ; Hitomi HORI ; Ryosuke ISHIDA ; Shinya HOUKI ; Hiroshi TANABE ; Eri NISHIKAWA ; Madoka TAKAO ; Toshitatsu TAKAO ; Yoshinori MORITA ; Takashi TOYONAGA ; Yuzo KODAMA
Clinical Endoscopy 2025;58(2):269-277
Background/Aims:
Visualization of palisade vessels (PVs) in Barrett’s esophagus is crucial for proper assessment. This study aimed to determine whether red dichromatic imaging (RDI) improves PV visibility compared with white-light imaging (WLI) and narrow-band imaging (NBI).
Methods:
Five expert and trainee endoscopists evaluated the PV visibility in Barrett’s esophagus using WLI, NBI, and RDI on 66 images from 22 patients. Visibility was rated on a 4-point scale: 4, excellent; 3, good; 2, fair; and 1, poor. The color difference between the most recognizable PV spots and surrounding areas with undetectable blood vessels was also analyzed.
Results:
Mean visibility scores were 2.6±0.7, 2.3±0.6, and 3.4±0.4 for WLI, NBI, and RDI, respectively. The RDI scores were significantly higher than the WLI (p<0.001) and NBI (p<0.001) scores. These differences were recognized by trainees and expert endoscopists. Color differences in PVs were 7.74±4.96 (WLI), 10.43±5.09 (NBI), and 15.1±6.54 (RDI). The difference in RDI was significantly higher than that in WLI (p<0.001) and NBI (p=0.006).
Conclusions
RDI significantly improved PV visibility compared to WLI and NBI based on objective and subjective measures.
5.Enhanced recovery after laparoscopic distal gastrectomy using articulating laparoscopic instruments in older adults with gastric cancer: a retrospective analysis of prospectively collected data
Seohee CHOI ; Takahiro KINOSHITA ; Kazutaka OBAMA ; Katsunobu SAKURAI ; Naoshi KUBO ; Naruhiko IKOMA ; Ali GUNER ; Hyoung-Il KIM
Annals of Surgical Treatment and Research 2025;108(2):86-92
Purpose:
As the number of older adults with gastric cancer requiring gastrectomy has increased, it has become increasingly important to use techniques that enhance surgical safety and reduce postoperative complications in this vulnerable patient population. Articulating laparoscopic instruments (ALIs) may improve maneuverability and precision, leading to better outcomes in older patients. This study aimed to compare postoperative outcomes of older adults undergoing laparoscopic distal gastrectomy for gastric cancer using conventional versus ALIs.
Methods:
This retrospective study included 147 older patients (aged ≥70 years) who underwent laparoscopic distal gastrectomy for gastric cancer between 2017 and 2024. Surgery was performed using conventional laparoscopic instruments in 61 patients and ALIs in 86 patients. The median follow-up period was 20 months.
Results:
Postoperative hospital stay was significantly shorter in the articulating group than in the conventional group (4.6 ± 2.0 days vs. 5.4 ± 2.4 days, P = 0.030). Time to first flatus was also significantly shorter in the articulating group (2.4 ± 0.7 days vs. 2.8 ± 1.0 days, P = 0.022). However, there were no significant differences in overall complications, major (≥grade III) complications (conventional, 1.2% vs. articulating, 0%; P = 0.398) overall survival, or recurrence-free survival between groups.
Conclusion
The use of articulating instruments in older adults undergoing laparoscopic distal gastrectomy for gastric cancer was associated with shorter postoperative hospital stays and faster recovery of bowel function, with no apparent detrimental effects on complications, recurrence, or survival. These findings suggest that ALIs enhance recovery and possibly overall surgical outcomes in this patient population.
6.Improved visibility of palisade vessels within Barrett’s esophagus using red dichromatic imaging: a retrospective cross-sectional study in Japan
Chise UEDA ; Shinwa TANAKA ; Tetsuya YOSHIZAKI ; Hirofumi ABE ; Masato KINOSHITA ; Hiroya SAKAGUCHI ; Hiroshi TAKAYAMA ; Hitomi HORI ; Ryosuke ISHIDA ; Shinya HOUKI ; Hiroshi TANABE ; Eri NISHIKAWA ; Madoka TAKAO ; Toshitatsu TAKAO ; Yoshinori MORITA ; Takashi TOYONAGA ; Yuzo KODAMA
Clinical Endoscopy 2025;58(2):269-277
Background/Aims:
Visualization of palisade vessels (PVs) in Barrett’s esophagus is crucial for proper assessment. This study aimed to determine whether red dichromatic imaging (RDI) improves PV visibility compared with white-light imaging (WLI) and narrow-band imaging (NBI).
Methods:
Five expert and trainee endoscopists evaluated the PV visibility in Barrett’s esophagus using WLI, NBI, and RDI on 66 images from 22 patients. Visibility was rated on a 4-point scale: 4, excellent; 3, good; 2, fair; and 1, poor. The color difference between the most recognizable PV spots and surrounding areas with undetectable blood vessels was also analyzed.
Results:
Mean visibility scores were 2.6±0.7, 2.3±0.6, and 3.4±0.4 for WLI, NBI, and RDI, respectively. The RDI scores were significantly higher than the WLI (p<0.001) and NBI (p<0.001) scores. These differences were recognized by trainees and expert endoscopists. Color differences in PVs were 7.74±4.96 (WLI), 10.43±5.09 (NBI), and 15.1±6.54 (RDI). The difference in RDI was significantly higher than that in WLI (p<0.001) and NBI (p=0.006).
Conclusions
RDI significantly improved PV visibility compared to WLI and NBI based on objective and subjective measures.
7.Current Status and Influencing Factors of the Stockpiling of Regular Medicines for Disasters in Patients with Chronic Disease
Akira MITOYA ; Ryota KUMAKI ; Ryoo TANIGUCHI ; Mitsuhiro SOMEYA ; Ryuichi KINOSHITA ; Tomoyuki SUZUKI ; Seiichi FURUTA ; Keiko AKAGAWA ; Keiko KISHIMOTO
Japanese Journal of Social Pharmacy 2024;43(1):2-11
To promote the stockpiling of regular medicines for disasters (SMD), we investigated SMD rates and clarified the relationship between SMD status (Yes or No) and the characteristics of patients with chronic diseases. A survey was provided to patients visiting the pharmacies in Hokkaido. SMD was defined as a patient having a supply of regular medicine for 7 days or more and replacing with new medicine within one year. Of a total of 537 participants (51.0% male; mean age 65.8 years), 61.1% had experienced a major disaster. The SMD rate was extremely low at 15.3%. The median score for a patient’s understanding of the regular medicine names (5-point scale: 1=hardly understood, 5=almost understood) was 2. The median number of monthly pharmacy visits was 0.8. 5.4% were recommended SMD by physicians or pharmacists. Results from multiple logistic regression analysis indicated that positive patient characteristics included age (OR=1.154, 95%CI [1.026-1.298], P=0.017), understanding of the regular medicine names (1.724, [1.039-2.859], P=0.035), and recommendation of SMD by physicians or pharmacists (5.991, [2.616-13.722], P<0.001). A negative patient characteristic was the number of pharmacy visits (0.587, [0.383-0.899], P=0.014). The most influential positive factor was the recommendation of SMD by physicians or pharmacists; however, only 5.4% of the participants had experienced this. The findings of this study indicated important that health care providers and the government to work together to devise easy-to-understand measures to inform local residents about the importance of SMD and how to them, conduct educational activities.
8.5-1. Education on Diversity, Inclusion, and Co-Production in the Faculty of Medicine, the University of Tokyo
Yoshihiro SATOMURA ; Akiko KANEHARA ; Suzuka OKUBO ; Tatsuya SUGIMOTO ; Tomoe KATAOKA ; Yuka KONISHI ; Sakurako KIKKAWA ; Ryo KINOSHITA ; Mahiro SUEMATSU ; Yusuke TAKAHASHI ; Yousuke KUMAKURA ; Chie HASEGAWA ; Rie SASAKI ; Sosei YAMAGUCHI ; Utako SAWADA ; Yuki MIYAMOTO ; Norihito OSHIMA ; Shin-Ichiro KUMAGAYA ; Kiyoto KASAI
Medical Education 2024;55(2):121-127
The University of Tokyo Disability Services Office and the University of Tokyo Hospital have striven to advance the inclusion of individuals with disabilities and to encourage the co-production of research as well as mental health services with peer support workers. In convergence with these endeavors, the Center for Diversity in Medical Education and Research (CDMER) was founded in 2021. The Center aims to establish an environment and culture that facilitates the participation and success of medical professionals with disabilities. For this purpose, it is essential to integrate the perspective of the social model of disability into medical education and promote co-production in the medical field, which is among the most challenging areas that can realize co-production. The Center is involved in various educational and research activities, including managing educational programs for medical students and supporting student-led research.
9.Validation of the Japanese Version of the Ethical Decision-making Climate Questionnaire
Tetsuharu KAWASHIMA ; Satomi KINOSHITA ; Yasuyo YOSHINO
Palliative Care Research 2024;19(2):89-97
Purpose: This study aimed to verify the reliability and validity of the Japanese version of the Ethical Decision-making Climate Questionnaire (EDMCQ) for decision making in intensive care units (ICU). Methods: The Japanese version was created by translating the English version of EDMCQ. A survey was conducted by mailing the questionnaires, targeting ICU nurses. The test was retested 14 days later. Results: The test was distributed to 439 ICU nurses. Overall, 204 responses from nurses at 25 facilities were received and analyzed (effective response rate: 46.5%). Cronbach’s α coefficient for the entire scale was 0.91, and the intraclass correlation coefficient was 0.80 (n=101, valid response rate: 23.0%). The indices for model fit in the confirmatory factor analysis were CFI: 0.836, GFI: 0.783, AGFI: 0.741, and RMSEA: 0.071. Conclusion: The Japanese version of the EDMCQ can be considered to be a practical scale for evaluation of ethical climate in Japan.
10.Impact of Motivation for Eating Habits, Appetite and Food Satisfaction, and Food Consciousness on Food Intake and Weight Loss in Older Nursing Home Patients
Hidetaka WAKABAYASHI ; Shoji KINOSHITA ; Tokiko ISOWA ; Kotomi SAKAI ; Haruka TOHARA ; Ryo MOMOSAKI
Annals of Geriatric Medicine and Research 2024;28(1):110-115
Background:
This study analyzed data from the Long-term care Information system For Evidence (LIFE) database to examine the effects of motivation to eat, appetite and food satisfaction, and food consciousness on food intake and weight loss.
Methods:
Of the 748 nursing home residents enrolled in the LIFE database, 336 met the eligibility criteria for this cross-sectional study. Motivation to eat, appetite and food satisfaction, and food consciousness were rated on five-point Likert scales (e.g., good, fair, normal, not so good, and not good). We applied Spearman rank correlation coefficient and multiple regression analyses to analyze the relationships between these three items, daily energy and protein intake, and body weight loss over 6 months.
Results:
The mean participant age was 87.4±8.1 years and 259 (77%) were female. The required levels of care included—level 1, 1 (0%); level 2, 4 (1%); level 3, 107 (32%); level 4, 135 (40%); and level 5, 89 (27%). The mean daily energy intake was 28.2±7.8 kcal/kg. The mean daily protein intake was 1.1±0.3 g/kg. The mean weight loss over six months was 1.2±0.7 kg. We observed strong positive correlations among motivation to eat, appetite and food satisfaction, and food consciousness (r>0.8). These three items were significantly associated with higher daily energy intake but not with daily protein intake. Only appetite and food satisfaction were significantly associated with lower weight loss over six months.
Conclusion
The observed associations of appetite and food satisfaction suggest that these factors may be more important to assess than motivation to eat or food consciousness among older adult residents of long-term care facilities.


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