Palm olein (POo) has been perceived as atherogenic due to its high proportion of palmitic acid (41.2%) content. It is interesting that most of the palmitic acid of POo is located at stereospecific numbering sn-1 and sn-3 positions of the triacylglycerol (TAG) backbone. The present study aims to investigate the effects of positional distribution of fatty acids on the lipid profiles of POo or chemically interesterified palm olein (CIE POo) fed hamsters in comparison to high oleic sunflower oil (HOSO) fed hamsters. Male weanling Syrian golden hamsters (n=10 for each group), were fed diets formulated with the above oils for 12 weeks. There was no significant difference between CIE POo and HOSO groups for total cholesterol (TC). CIE POo with increased amount of palmitic acid (43.2%) at sn-2 position did not cause significant increases in TC levels compared to the HOSO group. In addition, the POo group has significantly higher high-density lipoprotein cholesterol (HDL-C) than that of the HOSO group, P = 0.011 (< 0.05) while the HOSO group has significantly lower total cholesterol (TC) levels than that of the POo group, P = 0.012 (< 0.05).

Introduction: Caffeine is a psychoactive substance widely consumed over the past decades. The effect of caffeine can be either beneficial or harmful. It increases cognitive performances, including attention, alertness and concentration. However, high caffeine intake may also induce an anxiogenic effect, causing symptoms such as rapid heart rate, restlessness and nervousness. This study aimed to determine the association between caffeine intake and mental health disorders such as anxiety and depression among undergraduate pharmacy students at UiTM Puncak Alam. Methods: This was a cross-sectional study with stratified random convenience sampling. A total of 270 undergraduate pharmacy students in UiTM Puncak Alam, Selangor participated in this study. A set of questionnaires was distributed using the Google Form platform. Standard General Anxiety Disorder (GAD-7) and Patient Health Questionnaire (PHQ-9) scoring were used to assess the level of anxiety and depression among the respondents, respectively. SPSS version 27.0 was used to analyse the data. Results: About 70.4% of the students consumed caffeine, while 29.6% of the students did not consume caffeine. No significant association was found between caffeine status and the mental health scoring of GAD-7 (χ2 =4.639, p=0.200) and PHQ-9 (χ2 =5.256, p=0.262). Conclusion: Non-daily consumption and a low dose of caffeine intake patterns are good practises to prevent the development of anxiety or depression conditions, although the associations were not significant. Public awareness on possible anxiogenic effect and mental related disorders due to caffeine consumption need to be initiated, as nowadays, the caffeine intake behaviour has become a trendy lifestyle among the young adults.