Objective:To evaluate the clinical effect of orbital fat releasing and repositioning through supra-suborbicularis oculi fat (SOOF) in lower eyelid blepharoplasty.Methods:The authors retrospectively analyzed the clinical data of patients who received lower eyelid blepharoplasty in the Department of Plastic Surgery, Beijing Tsinghua Changgung Hospital from January 2017 to January 2023. Lower eyelid blepharoplasty with orbital fat releasing and repositioning through supra-SOOF was performed. The tear trough ligament and orbicularis retaining ligament were released between the orbicularis oculi muscle and SOOF via skin approach. Orbital septal fat was released to this space, lateral fat flap was fixed to the SOOF capsule, medial fat flap was fixed to the superficial fascia of the levator labii superioris muscle, orbital septum was repositioned, and lateral canthus was suspended. After the operation, lower eyelid morphology and complications were evaluated.Results:A total of 58 patients were enrolled, including 8 males and 50 females with the age of (49.8 ± 10.4) years (32 to 70 years). All patients had obvious lower eyelid bags on both sides, combining the tear trough deformity and (or) palabromalar groove. Fifty-seven patients were followed up for (29.1 ± 16.9) months (6-67 months). All patients were satisfied with the operation. The appearance of lower eyelid was greatly improved, with elimination of fat prominence and tear trough deformity. Mild lower eyelid ectropion was observed two cases 1 week after the operation, and were relieved by moderate massage 2 weeks postoperatively. In one case, mild lower eyelid retraction was observed 1 month postoperatively, with no complaint of discomfort or further treatments. Bulbar conjunctival hemorrhage occurred in 1 case and recovered without further interventions.Conclusion:Lower eyelid blepharoplasty with orbital fat releasing and reposting through supra-SOOF can effectively release the tear trough ligament and the orbicularis retaining ligament, with stronger fat fixation and less surgical difficulty. After the operation, eyelid contour was flat and tight with fewer complications and higher patient satisfaction.

Objective:To evaluate the clinical effect of orbital fat releasing and repositioning through supra-suborbicularis oculi fat (SOOF) in lower eyelid blepharoplasty.Methods:The authors retrospectively analyzed the clinical data of patients who received lower eyelid blepharoplasty in the Department of Plastic Surgery, Beijing Tsinghua Changgung Hospital from January 2017 to January 2023. Lower eyelid blepharoplasty with orbital fat releasing and repositioning through supra-SOOF was performed. The tear trough ligament and orbicularis retaining ligament were released between the orbicularis oculi muscle and SOOF via skin approach. Orbital septal fat was released to this space, lateral fat flap was fixed to the SOOF capsule, medial fat flap was fixed to the superficial fascia of the levator labii superioris muscle, orbital septum was repositioned, and lateral canthus was suspended. After the operation, lower eyelid morphology and complications were evaluated.Results:A total of 58 patients were enrolled, including 8 males and 50 females with the age of (49.8 ± 10.4) years (32 to 70 years). All patients had obvious lower eyelid bags on both sides, combining the tear trough deformity and (or) palabromalar groove. Fifty-seven patients were followed up for (29.1 ± 16.9) months (6-67 months). All patients were satisfied with the operation. The appearance of lower eyelid was greatly improved, with elimination of fat prominence and tear trough deformity. Mild lower eyelid ectropion was observed two cases 1 week after the operation, and were relieved by moderate massage 2 weeks postoperatively. In one case, mild lower eyelid retraction was observed 1 month postoperatively, with no complaint of discomfort or further treatments. Bulbar conjunctival hemorrhage occurred in 1 case and recovered without further interventions.Conclusion:Lower eyelid blepharoplasty with orbital fat releasing and reposting through supra-SOOF can effectively release the tear trough ligament and the orbicularis retaining ligament, with stronger fat fixation and less surgical difficulty. After the operation, eyelid contour was flat and tight with fewer complications and higher patient satisfaction.

Objective:To explore the application experience of autologous fat transplantation in improving the facial contour of young cosmetic patients.Methods:From October 2017 to October 2020, the plastic surgery department of Beijing Tsinghua Changgung Hospital admitted 10 young cosmetic patients with poor facial contours, including 1 male and 9 females, aged 18-35 years, with an average of 28 years. Autologous subcutaneous fat was harvested by liposuction and static purification and then injected into the areas with poor facial contour with an amount of 10%-30% over.Results:The facial contour of 10 young cosmetic patients was well improved, and there were no postoperative complications such as facial asymmetry, local uneven skin, skin infection and necrosis or fat embolism. 8 cases were filled once and 2 cases were filled twice. The patients were followed up for 6-24 months and the postoperative effect was good. The excellent and good rate evaluated by patients, plastic surgeon and the third party doctor was more than 80%.Conclusions:The use of autologous fat to improve the facial contour of young cosmetic patients is easy to operate with less trauma and good effect, which is worthy of promotion.

Objective:To explore the safety and effectiveness of medium-frequency electrotherapy for increasing the volume of the latissimus dorsi muscle.Methods:Fifteen adult New Zealand white rabbits were randomly divided into three groups, namely group A, group B, and group C, with 5 rabbits in each group. This was a self-control study, with the right latissimus dorsi muscle as the experimental group and the left latissimus dorsi muscle as the control group. The three groups corresponded to three different current intensity levels: 7.062 mA for group A (6th gear), 10.593 mA for group B (9th gear), and 14.124 mA for group C (12th gear). After the 12th, 24th, and 36th sessions of the experiment, ultrasonography was used to collect the thickness of the latissimus dorsi muscle. After the 36th electrostimulation, the latissimus dorsi muscle samples were collected to measure their in vivo muscle thickness and wet weight and were then sent for HE and MASSON staining.Results:After the 12th, 24th, and 36th electrostimulation sessions, ultrasonographic sampling in groups A and B showed an increase in the thickness of the right latissimus dorsi muscle compared to the left; for example, the thickness on the right of group B increased by 37.8%. The wet weight data collected after the 36th electrostimulation in groups A and B showed an increase in the right latissimus dorsi muscle compared to the left; for example, the wet weight on the right of group B increased by 5.04%.Conclusions:Different electrostimulation modes of medium-frequency therapy technology can induce muscle fiber thickening or atrophy. In this experiment, the 9th gear (10.593 mA) of medium-frequency therapy technology may be a suitable choice for inducing muscle fiber thickening, and the 12th gear (14.124 mA) may be a suitable choice for inducing skeletal muscle thinning.

Persistent inflammation after tissue injury can lead to a chronic wounding status, which will result in tissue fibrosis and impaired function if not treated in time. In recent years, the role of innate immunity in tissue fibrosis has been emphasized. This review summarizes the central role of group 2 innate lymphoid cell(ILC2) in the innate immune system, which is participating in the immune reaction after stimulated by inflammation and infection. Il-33 /ILC2 pathway can be activated by a variety of inflammatory factors and produce type 2 immune cytokines after tissue injury, thus participating in the pathophysiological process of tissue repair and promoting the formation of fibrosis. The clinical correlation between IL-33/ILC2 pathway and typical skin fibrosis diseases (systemic sclerosis) is described, which provides a potential new target and theoretical basis for the drug treatment of other skin fibrosis (including keloid).

Persistent inflammation after tissue injury can lead to a chronic wounding status, which will result in tissue fibrosis and impaired function if not treated in time. In recent years, the role of innate immunity in tissue fibrosis has been emphasized. This review summarizes the central role of group 2 innate lymphoid cell(ILC2) in the innate immune system, which is participating in the immune reaction after stimulated by inflammation and infection. Il-33 /ILC2 pathway can be activated by a variety of inflammatory factors and produce type 2 immune cytokines after tissue injury, thus participating in the pathophysiological process of tissue repair and promoting the formation of fibrosis. The clinical correlation between IL-33/ILC2 pathway and typical skin fibrosis diseases (systemic sclerosis) is described, which provides a potential new target and theoretical basis for the drug treatment of other skin fibrosis (including keloid).

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with lesions first occurring in hair follicle. Lack of curative therapy and the recurrent nature makes HS treatment challenging. We report a rare case of the successful use of botulinum toxin A for axillary HS.

Persistent inflammation after tissue injury can lead to a chronic wounding status, which will result in tissue fibrosis and impaired function if not treated in time. In recent years, the role of innate immunity in tissue fibrosis has been emphasized. This review summarizes the central role of group 2 innate lymphoid cell(ILC2) in the innate immune system, which is participating in the immune reaction after stimulated by inflammation and infection. Il-33 /ILC2 pathway can be activated by a variety of inflammatory factors and produce type 2 immune cytokines after tissue injury, thus participating in the pathophysiological process of tissue repair and promoting the formation of fibrosis. The clinical correlation between IL-33/ILC2 pathway and typical skin fibrosis diseases (systemic sclerosis) is described, which provides a potential new target and theoretical basis for the drug treatment of other skin fibrosis (including keloid).

Persistent inflammation after tissue injury can lead to a chronic wounding status, which will result in tissue fibrosis and impaired function if not treated in time. In recent years, the role of innate immunity in tissue fibrosis has been emphasized. This review summarizes the central role of group 2 innate lymphoid cell(ILC2) in the innate immune system, which is participating in the immune reaction after stimulated by inflammation and infection. Il-33 /ILC2 pathway can be activated by a variety of inflammatory factors and produce type 2 immune cytokines after tissue injury, thus participating in the pathophysiological process of tissue repair and promoting the formation of fibrosis. The clinical correlation between IL-33/ILC2 pathway and typical skin fibrosis diseases (systemic sclerosis) is described, which provides a potential new target and theoretical basis for the drug treatment of other skin fibrosis (including keloid).

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with lesions first occurring in hair follicle. Lack of curative therapy and the recurrent nature makes HS treatment challenging. We report a rare case of the successful use of botulinum toxin A for axillary HS.