Objective:To investigate the diagnostic value of ultrasonic measurement of optic nerve sheath diameter (ONSD) and optical disk elevation (ODE) for intracranial hypertension in patients with cerebral venous sinus thrombosis(CVST).Methods:A total of 50 patients with CVST who underwent lumbar puncture and ONSD examination in the Department of Neurology and Emergency Department of Xuanwu Hospital, Capital Medical University from January 2021 to December 2021 were retrospectively enrolled. After lumbar puncture, the patient′s initial intracranial pressure was recorded. Normal ICP was defined as ICP between 80 and 200 mmH 2O, and increased ICP was defined as ICP>200 mmH 2O. Fifty patients with CVST were divided into normal ICP group (14 cases) and increased ICP group (36 cases). The differences of baseline data, ONSD and ODE between the two groups were compared, and the receiver operating characteristic (ROC) curve was generated. The area under the curve (AUC) and the diagnostic cut-off value of ONSD were analyzed. Spearman correlation analysis was used to analyze the correlation between ONSD, ODE, CVST involvement range scores and intracranial pressure. Results:①There were no significant differences in gender, age and body mass index between the normal ICP group and the increased ICP group (all P>0.05). ②The ONSD and ODE in the increased ICP group were higher than those in the normal ICP group, and the differences were statistically significant [(4.83±0.33)mm vs (4.21±0.21)mm, (0.67±0.44)mm vs (0.24±0.29)mm, all P<0.001]. Spearman correlation analysis showed that ONSD and ODE were positively correlated with intracranial pressure ( rs=0.74, 0.51, all P<0.001). ③The extent of CVST involvement in the intracranial hypertension group was higher than that in the normal intracranial pressure group, and the difference was statistically significant [5.0(3.0, 7.5) vs 2.5(2.0, 5.0), P=0.015]. Spearman correlation analysis showed that CVST involvement score was positively correlated with intracranial pressure ( rs=0.43, P<0.001). ④In the diagnosis of intracranial hypertension in patients with cerebral venous sinus thrombosis, the AUC of ONSD was 0.935, the best diagnostic threshold of ONSD was 4.5 mm, the sensitivity was 0.81, and the specificity was 0.93. Conclusions:ONSD and ODE measured by ultrasound are reliable imaging methods to identify intracranial hypertension in patients with CVST.

Objective:To explore the clinical effect of the V-Y plasty of musculocutaneous flap in repairing the excessive width of inner canthus deformity.Methods:Retrospective analysis was performed between July 2018 and June 2021 in patients treated with this method. V-Y design along the inner corner of the eye before operation. The key points of operation are the elevated under the orbicularis oculi muscle. The skin orbicularis oculi muscle flaps are formed on both sides of the incision. After the V-Y of the outside myocutaneous flap is advanced and formed at the new medial canthus point, the V-Y of the orbicularis oculi muscle and the skin are sutured in layers. The degree of reduction of the inner canthus width, epicanthal fold shape, incision scarring, and patient satisfaction was followed up. All patients were measured at the preoperative and postoperative review to record data of the intercanthal distance, and used paired t-test for statistical analysis. P<0.05 was statistically significant. Results:83 patients, including 81 female patients and 2 males, with an average age of 28 years (19 to 56 years) were followed up from 3 months to 2 years, with an average of 1 year. The overexposure of the tear caruncle was significantly reduced, the asymmetry of the bilateral inner corners has been improved, the shape of the epicanthal folds reverted to its natural appearance and the old scars became inconspicuous; patient satisfaction evaluation: very satisfied 34.94% (29/83), satisfied 54.22% (45/83), relatively dissatisfied 6.02% (5/83), dissatisfied 4.82% (4/83). Among the 4 cases of dissatisfaction, 2 cases were due to insufficient correction and were re-operated to obtain satisfactory result, 1 case was improved by reoperating due to excessive correction which led to the reduction of inner canthal distance, 1 case regrets surgery the next day after surgery and cannot accept the appearance and strongly requires removal and restoration. The distance between intercanthal distance of the patients was 28.8 mm to 38.0 mm, average (33.58±3.34) mm before the operation, and 32.2 mm to 41.5 mm, average (37.47±2.90) mm after the operation, an average increase of 3.89 mm ( t=-15.78, P<0.001) after the operation. Conclusions:The V-Y plasty of musculocutaneous flap is suitable for the repair of excessive width of inner canthus deformity after epicanthoplasty. The design idea is simple, the postoperative effect is reliable, and the postoperative satisfaction rate of patients is high.

Objective:To explore the clinical effect of the V-Y plasty of musculocutaneous flap in repairing the excessive width of inner canthus deformity.Methods:Retrospective analysis was performed between July 2018 and June 2021 in patients treated with this method. V-Y design along the inner corner of the eye before operation. The key points of operation are the elevated under the orbicularis oculi muscle. The skin orbicularis oculi muscle flaps are formed on both sides of the incision. After the V-Y of the outside myocutaneous flap is advanced and formed at the new medial canthus point, the V-Y of the orbicularis oculi muscle and the skin are sutured in layers. The degree of reduction of the inner canthus width, epicanthal fold shape, incision scarring, and patient satisfaction was followed up. All patients were measured at the preoperative and postoperative review to record data of the intercanthal distance, and used paired t-test for statistical analysis. P<0.05 was statistically significant. Results:83 patients, including 81 female patients and 2 males, with an average age of 28 years (19 to 56 years) were followed up from 3 months to 2 years, with an average of 1 year. The overexposure of the tear caruncle was significantly reduced, the asymmetry of the bilateral inner corners has been improved, the shape of the epicanthal folds reverted to its natural appearance and the old scars became inconspicuous; patient satisfaction evaluation: very satisfied 34.94% (29/83), satisfied 54.22% (45/83), relatively dissatisfied 6.02% (5/83), dissatisfied 4.82% (4/83). Among the 4 cases of dissatisfaction, 2 cases were due to insufficient correction and were re-operated to obtain satisfactory result, 1 case was improved by reoperating due to excessive correction which led to the reduction of inner canthal distance, 1 case regrets surgery the next day after surgery and cannot accept the appearance and strongly requires removal and restoration. The distance between intercanthal distance of the patients was 28.8 mm to 38.0 mm, average (33.58±3.34) mm before the operation, and 32.2 mm to 41.5 mm, average (37.47±2.90) mm after the operation, an average increase of 3.89 mm ( t=-15.78, P<0.001) after the operation. Conclusions:The V-Y plasty of musculocutaneous flap is suitable for the repair of excessive width of inner canthus deformity after epicanthoplasty. The design idea is simple, the postoperative effect is reliable, and the postoperative satisfaction rate of patients is high.

Objective: To introduce the SVF-gel as a filling, and the application of SVF-gel for the treatment of horizontal neck wrinkles. Methods: This investigation presented a retrospective study of 30 patients (age ranged from 25 to 56 years, with mean 36 years) in Guangzhou Eye-Nose-Fat Cosmetic Plastic Clinic from December 2017 to June 2019. We used the SVF-gel injection for horizontal neck wrinkles for the patients. The effectiveness was observed 1 to 6 months later. Results: No serious complications occurred in all patients. Postoperative evaluation of horizontal neck wrinkles showed that the swelling time lasted for 1-3 days, and the satisfactory rate of the doctors and patients after one month was 83.33% and 86.67%, and that after 6 months was 86.67 % and 83.33%, respectively. Conclusions SVF-gel is an effective treatment for horizontal neck wrinkles.

Objective To evaluate the clinical result of Hering's law in the correction of asymmetric bilateral ptosis.Methods From January 2014 to July 2016,165 cases divided into 2 groups with asymmetric bilateral ptosis in mild and moderate ptosis were corrected with aponeurosis advancement type correction:A group of 15 cases,in which the surgery does not consider the influence of Hering's law,the first correction of mild side,and then corrected the heavier side;B group of 150 cases,in which the Hering's law was applied,the first correction of severe side so that the margin reached the edge of the cornea is tangent or low 0.5-1.0 mm,and then corrected mild side.That the difference of symmetry between the two sides of the palpebral fissure was less than 0.5 mm,and the follow-up was more than 3 months.The Pearson chi square test was used to compare the differences between the two groups.Results In this group,165 cases were followed up for 3-24 months,10 cases (66.67％) was satisfactory in group A (15 cases);145 cases (96.67％) was satisfactory in group B (150 cases);After 3 months,all the failure cases got satisfactory result by using the Hering's law in corrective surgery again.The P value of chi square test between groups was less than 0.05.Conclusions The application of Hering's law in the correction of asymmetry bilateral ptosis is more satisfactory.

Objective]To measure and compare the MRI artifacts caused by common metal ic dental materials and common ceramic dental materials on different field-strength magnets.[Methods] A total of 3 common metal ic dental materials and 2 common ceramic dental materials were tested with 0.35T, 1.5T and 3.0T MR imagers. The artifact areas on these 3 different field-strength magnets were measured and statistical y compared. [Results]Zirconia in three field magnetic resonance(NMR) in T1 and T2 as no artifacts, casting porcelain, metal al oy, nickel chromium al oy and CoCr-al oy in three fields magnetic resonance(NMR) in T1 and T2 as al can produce different degree of artifacts, and artifacts area increased in turn. Cobalt chromium al oy and nickel chromium al oy measurements on the high side, the cobalt chromium al oy than other four kinds of materials on the high side( P<0.05),high nickel-chromium al oy was precious metal al oy, casting porcelain( P<0.05). [Conclusions]Commonly used metal ic dental materials could cause MR artifacts and image degradation. Compared with that on 0.35T, the artifact was increased on 1.5T magnet. Compared with that on 1.5T, the artifact was increased on 3.0T magnet.

Objective To compare the efficacy and safety of sertraline plus doxazosin and tadalafil in the treatment of premature ejaculation (PE).Methods From Feb.to Aug.2011,One hundred and five patients from 19 to 52 years old with PE but without any obvious organic cause were enrolled in this study.They were randomly divided into Groups A,B and C in equal number.All the three Groups received 50 mg sertraline daily 4 to 6 hours before planned sexual activity for 12 weeks,Group B were added with 4 mg Doxazosin every day 8 to 9 hour before planned sexual activity,and Group C were given 20 mg Tadalafil as needed one hour before planned sexual activity.The mean intravaginal ejaculatory latency time,the mean intercourse satisfaction domain values and the sexual activity satisfaction domain values of the patient couples of group A before treatment were 0.6±±0.1 min,8.3±1.3,5.3±1.4; Group B were 0.6±0.1 min,7.6± 1.5,5.6± 1.5 ; Group C were 0.6±0.1 min,8.1 ± 1.1,5.0± 1.2,respectively.We observed before and after the treatment for 12 weeks and the effects were evaluated.Results The mean intravaginal ejaculatory latency time,the mean intercourse satisfaction domain values and the sexual activity satisfaction domain values of the patient couples of group A were 3.9±0.l min,10.6±0.1,9.7±0.1,respectively; Group B were 4.5 ± 0.1 min,12.8±1.3,11.9±1.6; Group C were 5.6±0.3 min,14.6±1.4,13.1±1.5,respectively.The mean intravaginal ejaculatory latency time improved in all of the 3 groups,but more significantly in Group B and C (P＜0.05).The mean intercourse satisfaction domain values of the IIEF were significantly greater in Group B and C than in Group A (P＜0.05) after the treatment; and the sexual activity satisfaction domain values of the patient couples were greater in Group C than in Group B after the treatment,but it is not significant.As for the side effects,5 cases in group A felt headaches and dizzy (14.3％),8 cases in group B felt headaches and dizzy (22.9％),and in group C,9 cases felt headaches and dizzy (25.7％),6 cases experienced flushing episodes on the body (17.1％).there was a higher rate of headaches (P＜0.05) and flushing episodes (P＜0.05) in Group B and C than in Group A.Conelusions Sertraline combined with Tadalafil or Doxazosin can achieve significantly better results than sertraline alone in patients with premature ejaculation.However,the combined treatment is associated with a slightly increased in the drug related side effects,and there is no significant difference in the efficacy of Sertraline Plus Tadalafil or Doxazosin in the treatment of premature ejaculation.

Objective To investigate the correlation between G753A and C1040T polymorphisms in the gene encoding region of thrombin-activatable fibrinolysis inhibitor (TAFI )and cerebral infarction in patients with cerebral infarction in Chinese Han population. Methods C1040T and G753A poly-morphisms in the TAFI gene encoding region in 130 patients with cerebral infarction and 118 healthy subjects (control group)were analyzed retrospectively and they were detected by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP ). Results The GG genotyping of the TAFI gene G753A polymorphism in the cerebral group was 41. 5%(n=54)and the A allele carriers were 58. 5%(n=76),while those in the control group were 44. 9%(n=53)and 55. 1%(n=65)respectively. There were no significant differences in the GG genotyping of TAFI gene G753A polymorphism and the A allele carriers between the cerebral infarction group and the control group (χ2 =0. 288,P=0. 592). In the cerebral infarction group,the CC genotyping of C1040T polymorphism was 50. 0%(n=65)and T allele carriers were 50. 0%(n=65),while those in the control group were 51. 7%(n=61)and 48. 3%(n=57)respectively. There were no significant differences in the GG genotyping of C1040T polymorphism and the T allele carriers between the two groups (χ2 =0.071,P =0.790 ). Multivariate logistic regression analysis showed that G753A and C1040T single nucleotide polymorphisms (GA or AA genotype)in the TAFI gene encoding region were not the independent risk factors for cerebral infarction. Conclusion There are no significant differences in the correlation between the G753A and C1040T polymorphisms in the TAFI gene encoding region and cerebral infarction. They are not the independent risk factors for the onset of cerebral infarction.

Evidence-based medicine was applied in the clinic teaching and ward inspection of superficial bladder cancer as far as no consensus was reached on its treatment.Some preferred to total cystectomy while others favored transurethral resection of bladder tumor and bladder instillation.In order to solve this problem,evidence-based medicine was applied in our clinic teaching procedure.Students were asked to read relative papers and draw the final conclusions with evidence-based medicine.Clinical guidance was provided for the students to promote clinical application.

Butanol production from acid hydrolysate of Jerusalem artichoke juice by Clostridium acetobutylicum L7 was investigated, and it was found that natural components of the hydrolysate were suitable for solvent production with the species. With batch fermentation using the medium containing 48.36 g/L total sugars, 8.67 g/L butanol was produced at 60 h, and the ratio of butanol to acetone to ethanol was 0.58:0.36:0.06, which were similar to the fermentation with fructose as carbon source, but both of these two fermentations were slower than that with glucose as carbon source, indicating the fructose transport of the species might not be effective as that for glucose. When the total sugars of the medium were increased to 62.87 g/L, the residual sugars increased slightly from 3.09 g/L to 3.26 g/L, but butanol production of the fermentation system was improved significantly, with 11.21 g/L butanol produced and the ratio of butanol to acetone to ethanol at 0.64:0.29:0.05, which illustrated that an excess in sugars enhanced the butanol biosynthesis of the species by compromising its acetone production. When the sugar concentration of the medium was further increased, much more sugars were remained unconsumed, making the process economically unfavourable.
Butanols ; metabolism ; Clostridium acetobutylicum ; metabolism ; Fermentation ; Helianthus ; chemistry ; Industrial Microbiology ; methods