Objective:To assess the enhancement characteristics of responsibility plaque of patients with intracranial artery stenosis(ICAS)and explore the correlation between that and stroke by using three dimensional high-resolution magnetic resonance imaging(3D-HR-MRI).Methods:A total of 72 ICAS patients who admitted to Beijing Huairou Hospital from April 2019 to April 2022 were retrospectively selected as the study objects,with a total of 96 atherosclerotic stenosis plaques.The plaques were divided into mild to moderate stenosis group(33 cases)and severe stenosis group(63 cases)according to the results of whole brain digital subtraction angiography.They were also were divided into sub-acute/acute plaque group(within 1 month)(47 cases)and non-acute plaque group(including chronic and non-responsible plaques)(49 cases)according to the time of occurring plaque.The imaging characteristics of the 3D-HR-MRI results were assessed by two radiologists.The degrees of plaque enhancement referred to the degrees of pituitary enhancement,and the degrees of plaque enhancement were divided into significant enhancement group(52 cases)and non-significant enhancement group that included moderate enhancement group and non-enhancement group(44 cases).The relationships between ICAS,degree of plaque enhancement and stroke were analyzed.Results:A total of 96 atherosclerotic stenosis plaques were confirmed in 72 patients.The statistical analysis of Kruskal-Wallis H test of multiple samples showed that there was a significant correlation between the time of occurring plaque and the degree of plaque enhancement(H=3.294,P＜0.05).Univariate Logistic regression analysis indicated that the difference between the acute plaque group and the non-acute plaque group was respectively significant correlations with ICAS degree[P＜0.05,OR(95%CI)=1.0(0.3-2.6)]and degree of plaque enhancement[P＜0.05,OR(95%CI)=1.0(0.4-2.0)].The multivariate Logistic regression analysis demonstrated that both severe arterial stenosis[P＜0.05,OR(95%CI)=1.0(0.3-1.9)]and significant enhancement of plaque[P＜0.05,OR(95%CI)=1.0(0.4-2.1)]were independent risk factors of stroke.Conclusion:Severe ICAS and significant plaque enhancement are the independent risk factors of stroke,which can provide effective basis for clinical prevention,diagnosis and treatment of stroke.

Objective:To investigate the characteristics and distribution of plaque of patients with mild middle cerebral artery(MCA)stenosis by using three dimensional(3D)high-resolution magnetic resonance imaging(3D HR-MRI),and the correlation between that and the occurrence of ischemic stroke.Methods:The clinical data of 64 patients with mild MCA stenosis who admitted to Beijing Huairou hospital from March 2020 to March 2022 were retrospectively analyzed.They were divided into symptomatic group(n=30)and asymptomatic group(n=34)according to whether occurred transient ischemic cerebral attack or ischemic cerebral stroke.The degree and distribution of plaque enhancement between the two groups were assessed and analyzed,and the correlation of plaque features in HR-MRI and ischemic stroke was analyzed.Results:There were a total of 71 plaques in 64 patients,including 30 responsible plaques and 41 non-responsible plaques.The enhancement degree of responsible plaques was significantly stronger than that of non-responsible plaques,and the difference was statistically significant(Z=5.645,P<0.05).Compared with non-responsible plaques,the responsible plaques more concentrated at the dorsal and upper walls of MCA,and the probability of occurring positive remodeling of responsible plaques was greater than that of non-responsible plaques,with statistical significance(x2=7.658,P<0.05).Conclusion:In patients with mild MCA stenosis,the degree enhancement and distribution location of plaque,and positively remodeling index of vessel are closely related to the occurrence of ischemic cerebral stroke.

Objective:To summarize and analyze the clinical data of Chinese patients with colony-stimulating factor 1 receptor (CSF1R)-related leukoencephalopathy, and clarify the phenotypic and genetic characteristics of Chinese patients.Methods:Medical history of patients with CSF1R-related leukoencephalopathy diagnosed from April 1, 2018 to January 31, 2021 in the department of neurology of 22 hospitals in China was collected, and scores of Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MoCA), magnetic resonance severity scale were evaluated. Group comparison was performed between male and female patients.Results:A total of 62 patients were included, and the male-female ratio was 1∶1.95. The age of onset was (40.35±8.42) years. Cognitive impairment (82.3%, 51/62) and motor symptoms (77.4%,48/62) were the most common symptoms. The MMSE and MoCA scores were 18.79±7.16 and 13.96±7.23, respectively, and the scores of two scales in male patients (22.06±5.31 and 18.08±5.60) were significantly higher than those in females (15.53±7.41 , t=2.954, P=0.006; 10.15±6.26, t=3.328 , P=0.003). The most common radiographic feature was bilateral asymmetric white matter changes (100.0%), and the magnetic resonance imaging severity scale score was 27.42±11.40, while the white matter lesion score of females (22.94±8.39) was significantly higher than that of males (17.62±8.74 , t=-2.221, P<0.05). A total of 36 CSF1R gene mutations were found in this study, among which c.2381T>C/p.I794T was the hotspot mutation that carried by 17.9% (10/56) of the probands. Conclusions:The core phenotypic characteristics of CSF1R-related leukoencephalopathy in China are progressive motor and cognitive impairment, with bilateral asymmetrical white matter changes. In addition, there exist gender differences clinically, with severer cognitive impairment and imaging changes in female patients. Thirty-six CSF1R gene mutations were found in this study, and c.2381T>C/p. I794T was the hotspot mutation.

Objective:To validate five-year risk prediction models for atherosclerotic cardiovascular di-sease (ASCVD) in a contemporary rural Northern Chinese population.Methods: Totally 6 489 rural adults aged 40 to 79 years without clinical ASCVD were enrolled at baseline between June and August 2010, and followed up through January 2017.Expected prediction risk using the China-PAR (prediction for ASCVD risk in China) model was compared with the pooled cohort equations (PCE) reported in the American College of Cardiology / American Heart Association guideline.Kaplan-Meier analysis was used to obtain the observed ASCVD event (including nonfatal myocardial infarction, coronary heart disease death, nonfatal or fatal stroke) rate at 5 years, and the expected-observed ratios were calculated to eva-luate overestimation or underestimation in the cohort.The participants in the cohort were divided into 4 categories (<5.0%, 5.0%-7.4%, 7.5%-9.9%, and ≥10.0%) for comparisons based on ASCVD prediction risk.The models were assessed by discrimination C statistic, calibration χ2, and calibration charts and plots for illustration as well.Results: Over an average 5.82 years of follow-up in this validation cohort with 6 489 rural Chinese participants, 955 subjects developed a first ASCVD event.Recalibrated China-PAR model overestimated ASCVD events by 22.2% in men and 33.1% in women, while the overestimations were much higher for recalibrated PCE as 67.3% in men and 53.1% in women.Gender-specific China-PAR model had C statistics of 0.696 (95%CI, 0.669-0.723) for men and 0.709 (95%CI, 0.690-0.728) for women, which were similar to those of 0.702 (95%CI, 0.675-0.730) for men and 0.714 (95%CI, 0.695-0.733) for women in the PCE.Calibration χ2 values in China-PAR were 17.2 and 54.2 for men and women, respectively;however, the PCE showed poorer ca-libration (χ2=192.0 for men and χ2=181.2 for women).In addition, the calibration charts and plots illustrated good agreement between the observations and the predictions only in the China-PAR model, especially for men.Conclusion: In this validation cohort of rural Northern Chinese adults, the China-PAR model had better performance of five-year ASCVD risk prediction than the PCE, indicating that recalibrated China-PAR model might be an appropriate tool for risk assessment and primary prevention of ASCVD in China.

Forty three patients with L5-S1 spondylolisthesis undergoing surgical treatment from April 2012 to November 2014 were included for analysis,including 20 cases received transforaminal lumbar interbody fusion (TLIF group) and 23 cased received posterior lumbar interbody fusion (PLIF group).The incision length,operative time were shorter and blood loss was less in TLIF group than those in PLIF group [(9.6±0.9) vs.(16.1±1.5) cm,(125.6±13.0) vs.(156.4±11.8) minand (218.7±22.5)ml vs.(326.5 ±20.1) ml,respectively,all P =0.000].There was no statistical difference in the S1 pedicle screw (S1PS) insertion point between two approaches[(29.4 ± 1.9) vs.(28.5 ± 1.0) mm,P =0.069],but the distance from the midline to the lateral edge of the screw (12.9 ±3.6) mm,S1PS angle (23.3 ±2.1) ° and length of S1PS length with the sacral body (40.9 ± 2.6) mm in the TLIF group were better than those in PLIF group (P =0.000).Our results demonstrate that the paraspinal muscle approach for the treatment of L5-S1 spondylolisthesis may be superior with less trauma,better functional recovery and stable screw placement.

Objective To compare the short and long term effect of knee osteoarthritis treatment with two therapeutic methods which are simple high cut of fibula and arthroscopic lavage debridement combined with fibular osteotomy.Methods Data of 45 consecutive patients with knee osteoarthritis were retrospectively observed and selected,and then they were divided into two groups according to the operation method.23 patients with simple high cut of fibula were selected as the control group,and 22 patients with arthroscopic lavage debridement combined with fibular osteotomy were selected as the observation group.Results The VAS and AKS scores of the control group at the time of 3m,6m,1 2m were (4.1 3 ±0.76)points,(1 07.04 ±21 .53)points;(2.70 ±0.64)points,(1 41 .1 7 ±1 2.57)points;(2.43 ±0.79)points,(1 48.26 ±5.81 )points;and the scores of the observation group were (3.45 ± 0.60)points,(1 26.64 ±1 4.24)points,(2.70 ±0.73)points,(1 46.45 ±7.26)points,(2.41 ±0.85)points and (1 48.26 ±5.81 )points.The differences between the two groups were statistically significant at the time of 3 months after surgery(t =3.32,-3.62,all P <0.05),the effect of observation group was better than the control group;but the other indices had no statistically significant differences (t =0.51 ,-1 .72,0.1 1 ,-0.20,all P >0.05 ). Conclusion The simple high cut of fibula with small trauma,less cost,less surgical difficulty,and long -term clini-cal curative effect is not less than the arthroscopic lavage and debridement combined with fibular osteotomy.There-fore,it should be carried out in the primary hospitals widely.

Objective To explore the pathway relationship among self consistency and congruence,life events and mental health,and to supply dependable data to psychotherapy and counseling about pilots.Methods Altogether 428 air force pilots were evaluated in air force Hangzhou sanatorium using self consistency and congruence scale (SCCS),life events scale(LES)and symptom checklist 90 (SCL-90).Spearman correlation analysis, one-sample t-test analysis and pathway analysis were used by soft package for social science version 15.0(SPSS 15.0)and AMOSv7.0.Results The results showed that there were significant relationships between all factors of self consistency and congruence and some factors of stressful life events(r=0.134～0.445);there were significant relationships between all factors of self consisteney and congruence and all factors of SCL-90(r=0.110～0.446); and negative life events of family,negative life events of work and negative life events of social communication were all had highly significant relationships with all factors of SCL-90(r=0.248～0.628).The pathway coefficient between life event and mental health Was B=0.39,P<0.01.The pathway coefficient among self consistency and congruence, life event and mental health were B=0.38,B=0.35,P<0.01,and the total adjust effects was 13.3%.Conclusion Self consistency and congruence is a important adjust variable between life events and mental health, can lighten the impact between life events and mental health.

Objective To investigate the effects among social mature,mental health and marriage quality of pilot's couples. Methods SCL-90,EPQ and ENRICH were conducted in 288 of pilot's couples. Correlation,regression were analyzed with SPSS 15.0 software. Results The marriage quality of pilot was significantly affected by the social mature and mental health of pilot himself(β=0.203,-0.274,P<0.001);meanwhile the marriage quality of pilot's wife was significantly affected by the mental health of pilot's couples(β=-0.276,-0.185,P<0.01). Conclusion The social mature and mental health of pilot's couples has a great influence in their marriage quality,so the social mature and mental health of pilot's couples should be taken into the system of the psychological counseling and therapy for pilots.

AIM Analyze on characters of self-consistency and congruence of air force pilots and its in-fluential factors,so as to provide a background for counseling and psychotherapy.Methords Altogether 428 air force pilots were evaluated in our sanatorium using Self Consistency and Congruence Scale,Life Events Scale,Per-ceived Social Support Scale,Social Avoidance and Distress Scale,Trait Coping Styles Questionnaire,Eysenck Per-senality Questionnaire for Adults and Symptom Checklist 90.Results Self-inconsistent and incongruent and self stiffness of air force pilots were lower than that of army force (-13.10≤t≤-2.45,P<0.05) ;but self flexibil-ity was higher (5.11≤t≤11.98,P<0.01) ;the correlation between self-inconsistent and incongruent and the neuroticism of EPQ was good (0.406≤r≤0.529,P<0.001) ;the correlation between self-inconsistent and in-congruent and all the factors of perceived social support were goed(0.212≤r≤0.377,P<0.01) ;the correlation between it and negative family events was good (r=0.445,P<0.01) ;the correlation between self-inconsistent and incongruent as well as self stiffness and negative coping style was good (r=0.595,0.434,P<0.01);also and social distress was also good(r=0.456,P<0.01);then the result of the multiple factors analysis revealed that : the first reason that affect the self-inconsistent and incongruent of air pilots was negative life events β=0.53;and the second reason was mentality ill health β=0.40.Conclusion The self-consistency and congruence of air force pilots can be improved by replying the negative life events and enhancing mentality health.

BACKGROUNDTo study the correlation among the number of tumor-infiltrating dendritic cells (TIDC) in cancer tissues and biological behavior and prognosis in lung cancer patients.

METHODSS-100 protein expression level was determined in 39 patients with lung cancer by immunohistochemistry technique. The number of S-100 + TIDC and DNA ploidy were measured by means of flow cytometry.

RESULTSThe rate of positive S-100 protein expression was 100% in 39 patients, S-100 + cells showed typical morphology of dendritic cells. The percentage of S-100 +TIDC in patients with heteroploid (21.81%±8.18%) was significantly higher than those with diploid (16.03%±4.75%) (P=0.006). There was no statistical difference between lymph node metastasis group (20.43%±7.74%) and no lymph node metastasis group ( 19.41% ±7.76%), between tumor size greater than 3cm group ( 20.90% ±8.65%) and less than 3cm group ( 19.70% ±7.61%), between non-small cell lung cancer group (19.48%±7.98%) and small cell lung cancer group (21.74%±6.17%). No correlation was found between survival time ( 1 year , 1-3 years, greater than 3 years, respectively) and percentage of S-100 +TIDC (21.96%±8.05%, 19.47%±6.18%, 19.14%±8.76%, respectively).

CONCLUSIONSThe number of TIDC should not be chosen as an independent prognostic criterion in human lung cancer.