1.Hemorrhagic Complications Following Endovascular Treatment for Atherothrombotic Large Vessel Occlusion
Satoru FUJIWARA ; Kazutaka UCHIDA ; Tsuyoshi OHTA ; Nobuyuki OHARA ; Michi KAWAMOTO ; Hiroshi YAMAGAMI ; Kazunori TOYODA ; Yuji MATSUMARU ; Yasushi MATSUMOTO ; Kenichi TODO ; Mikito HAYAKAWA ; Seigo SHINDO ; Shinzo OTA ; Masafumi MORIMOTO ; Masataka TAKEUCHI ; Hirotoshi IMAMURA ; Hiroyuki IKEDA ; Kanta TANAKA ; Hideyuki ISHIHARA ; Hiroto KAKITA ; Takanori SANO ; Hayato ARAKI ; Tatsufumi NOMURA ; Mikiya BEPPU ; Fumihiro SAKAKIBARA ; Manabu SHIRAKAWA ; Shinichi YOSHIMURA ; Nobuyuki SAKAI
Journal of Stroke 2025;27(1):149-153
2.Hemorrhagic Complications Following Endovascular Treatment for Atherothrombotic Large Vessel Occlusion
Satoru FUJIWARA ; Kazutaka UCHIDA ; Tsuyoshi OHTA ; Nobuyuki OHARA ; Michi KAWAMOTO ; Hiroshi YAMAGAMI ; Kazunori TOYODA ; Yuji MATSUMARU ; Yasushi MATSUMOTO ; Kenichi TODO ; Mikito HAYAKAWA ; Seigo SHINDO ; Shinzo OTA ; Masafumi MORIMOTO ; Masataka TAKEUCHI ; Hirotoshi IMAMURA ; Hiroyuki IKEDA ; Kanta TANAKA ; Hideyuki ISHIHARA ; Hiroto KAKITA ; Takanori SANO ; Hayato ARAKI ; Tatsufumi NOMURA ; Mikiya BEPPU ; Fumihiro SAKAKIBARA ; Manabu SHIRAKAWA ; Shinichi YOSHIMURA ; Nobuyuki SAKAI
Journal of Stroke 2025;27(1):149-153
3.Hemorrhagic Complications Following Endovascular Treatment for Atherothrombotic Large Vessel Occlusion
Satoru FUJIWARA ; Kazutaka UCHIDA ; Tsuyoshi OHTA ; Nobuyuki OHARA ; Michi KAWAMOTO ; Hiroshi YAMAGAMI ; Kazunori TOYODA ; Yuji MATSUMARU ; Yasushi MATSUMOTO ; Kenichi TODO ; Mikito HAYAKAWA ; Seigo SHINDO ; Shinzo OTA ; Masafumi MORIMOTO ; Masataka TAKEUCHI ; Hirotoshi IMAMURA ; Hiroyuki IKEDA ; Kanta TANAKA ; Hideyuki ISHIHARA ; Hiroto KAKITA ; Takanori SANO ; Hayato ARAKI ; Tatsufumi NOMURA ; Mikiya BEPPU ; Fumihiro SAKAKIBARA ; Manabu SHIRAKAWA ; Shinichi YOSHIMURA ; Nobuyuki SAKAI
Journal of Stroke 2025;27(1):149-153
4.A Case of Redo-Mitral Valve Replacement for a Björk-Shiley Delrin Valve Implanted 47 Years Previously
Ryo IKEDA ; Chizuo KIKUCHI ; Yusuke TSUBOKO ; Masaaki IKEHARA ; Saeki WATANABE ; Yukiko YAMADA ; Yuki ICHIHARA ; Azumi HAMASAKI ; Kiyotaka IWASAKI ; Hiroshi NIINAMI
Japanese Journal of Cardiovascular Surgery 2023;52(1):29-33
We report a case of redo mitral valve replacement (MVR) for a Björk-Shiley Delrin valve implanted 47 years previously. A 71-year-old man initially underwent MVR for mitral regurgitation at our hospital at the age of 16 years. Following the operation, follow-up examinations were performed at the outpatient clinic and annual transthoracic echocardiogram findings showed only mild mitral regurgitation, with no adverse events noted. However, a transthoracic echocardiogram examination performed 45 years after the operation revealed mild to moderate mitral regurgitation, while dyspnea with exertion was also noted at that time. As part of a more detailed examination, transesophageal echocardiogram results showed moderate transvalvular leakage. Redo MVR was subsequently performed under the diagnosis of prosthetic valve dysfunction. Analysis of the explanted prosthetic valve revealed wear of the Delrin disk, and widening of the gap between the disk and strut, which were presumed to be the cause of transvalvular leakage. A half century has passed since introduction of the Björk-Shiley valve and the present is a rare case of valve malfunction. Presented here are related details, along with a review of existing literature and results of Björk-Shiley valve use at our hospital.
5.Successful Use of a Stent-Graft for Treating a Pseudoaneurysm Located at the Anastomosis of the Ascending Aorta and the Great Saphenous Vein
Ryo AYATA ; Masaya TAKAHASHI ; Yoshitaka IKEDA ; Noriyasu MORIKAGE ; Hiroshi ITO
Japanese Journal of Cardiovascular Surgery 2023;52(1):46-49
Takayasu Arteritis causes annuloaortic ectasia and coronary ostial stenosis, which may necessitate open heart surgery. However, pseudoaneurysms are sometimes observed postoperatively, making subsequent treatment difficult. We report thoracic endovascular aortic repair of a pseudoaneurysm of the ascending aorta with an anastomosis of the great saphenous vein in a 61-year-old female with a history of multiple open-heart procedures. Thirty years earlier, she underwent aortic valve replacement and coronary artery bypass surgery for aortic regurgitation, and right coronary ostial stenosis. Eleven years after surgery, an ascending aortic aneurysm was found and Bentall's surgery was performed. Multiple open thoracotomies were subsequently performed. Postoperatively, a pseudoaneurysm was found at the anastomosis between the ascending aorta and the great saphenous vein. The patient was transferred to the emergency room owing to hemoptysis and was diagnosed with a ruptured pseudoaneurysm at the anastomosis of the ascending aorta and the great saphenous vein. By inserting a stent graft into the ascending aorta, we avoided further complications and her prognosis was good. She was discharged on postoperative day 18 and did not experience any end leak for a year. Thoracic endovascular aortic repair in the ascending aorta is a minimally invasive procedure that may be useful for high-risk patients.
6.A Case of Total Arch Replacement Using Coil Embolization for a Thoracic Aortic Aneurysm Derived from a Kommerell Diverticulum
Ryunosuke SAKAMOTO ; Masaya TAKAHASHI ; Yoshitaka IKEDA ; Hiroshi ITO
Japanese Journal of Cardiovascular Surgery 2023;52(3):168-171
An 81-year-old man who visited a local physician for evaluation of hoarseness was admitted to our hospital for management of a thoracic aortic aneurysm. Careful examination revealed a thoracic aortic aneurysm, aortic regurgitation, and left ventricular aneurysm. We performed total arch replacement using a frozen elephant trunk prosthesis (combined right axillary artery bypass and coil embolization), aortic valve replacement, papillary muscle approximation, and a septal anterior ventricular exclusion operation. The patient's postoperative course was uneventful, and he was discharged on the 25th postoperative day. A Kommerell diverticulum is located at the origin of an aberrant subclavian artery, and subclavian artery reconstruction via thoracotomy is challenging in such cases. Although increasing numbers of thoracic endovascular aortic repairs have been performed in recent years, the procedure is associated with complications such as endoleak and aortic esophageal fistula, and the surgical risk-benefit ratio should be carefully determined. We report a case of safe non-anatomical subclavian artery reconstruction and coil embolization.
7.A Case of Redo-Aortic Valve Replacement for a Lillehei-Kaster Valve Implanted 42 Years Ago
Ryo IKEDA ; Atomu HINO ; Kozo MORITA ; Azumi HAMASAKI ; Hiroshi NIINAMI
Japanese Journal of Cardiovascular Surgery 2021;50(4):261-264
We present a case of redo aortic valve replacement (AVR) in a 71-year-old man with a Lillehei-Kaster valve implanted 42 years prior. The patient initially underwent AVR and open mitral commissurotomy procedures for aortic regurgitation complicated with mitral stenosis in 1978 at the age of 29. Thereafter, he was followed at our outpatient clinic and treated without anticoagulant therapy for the initial two decades of the postoperative period. During the long-term follow-up, the mean pressure gradient remained between 40 and 60 mmHg and there were no adverse events noted before occurrence of heart failure triggered by tachycardia and pneumonia. Following improvement of heart failure, redo AVR was performed. There was no structural damage, thrombosis, or Lillehei-Kaster valve opening restrictions, though severe pannus growth on the left ventricle side was observed, which was thought to be the cause of the increased pressure gradient. This is the first known report of redo AVR after many years in a patient who underwent Lillehei-Kaster valve implantation. Furthermore, no other study has noted findings regarding pressure gradient change during the long-term follow-up period in such cases.
8.Total Arch Replacement with a 150-mm J-Graft Open Stent Graft for a Syphilitic Aortic Aneurysm
Takahiro IKESHITA ; Hiroshi ITO ; Yoshitaka IKEDA ; Kensuke SAKATA
Japanese Journal of Cardiovascular Surgery 2019;48(6):415-418
A 66-year-old man was under observation as an outpatient for moderate aortic regurgitation and distal aortic arch aneurysm since 2005. He underwent surgery for gradual expansion of the distal aortic arch aneurysm. Preoperative enhanced computed tomography (CT) revealed a fusiform-type aortic aneurysm with a maximum short diameter of 63 mm. The aneurysm extended from the left subclavian artery to the descending aorta, 67 mm ahead. Based on the preoperative CT, a 150-mm open stent graft (OSG) was selected because of an adequate landing zone when inserted from the proximal site of the left subclavian artery. A 33-mm diameter graft was selected with a diameter 10% larger than that of the aorta at the landing zone. Moreover, the preoperative rapid plasma reagin (RPR) test was positive at 5.5 RU, and the fixed Treponema pallidum latex agglutination (TPLA) test was positive at 4,670 TU. He had undergone treatment for syphilis, and we concluded that the patient harbored antibodies after syphilis treatment. In the operating room, median sternotomy was performed. Cardiopulmonary bypass (CPB) was instated with bilateral axillary artery return, and superior vena cave (SVC) -inferior vena cave (IVC) venous drainage was placed. The aortic wall was strongly adherent to the surrounding tissue, similar to that observed in the aortitis syndrome. We performed aortic valve replacement during the systemic cooling. Under hypothermic circulatory arrest at 25°C with selective cerebral perfusion, the aorta was cut between the left common carotid artery and left subclavian artery. From this site, OSG was inserted to the level of the aortic valve. Total arch replacement was performed with a 30-mm bypass graft. Pathological findings indicated infiltration of lymphocytes and plasma cells around the feeding artery in the aortic aneurysm wall, and the aortic media wall showed fibrillation. Based on the intraoperative and postoperative pathologic findings, we diagnosed the patient with syphilitic aortic aneurysm, and started oral administration of amoxicillin 1,500 mg per day for 3 months. He was discharged on the 13th postoperative day without paraplegia, vocal cord paralysis, or other complications. Although syphilitic aortic aneurysm is rarely seen, it must always be considered as one of the causes of aortic aneurysm.
9.Prognostic factors for patients with early-stage uterine serous carcinoma without adjuvant therapy.
Keisei TATE ; Hiroshi YOSHIDA ; Mitsuya ISHIKAWA ; Takashi UEHARA ; Shun ichi IKEDA ; Nobuyoshi HIRAOKA ; Tomoyasu KATO
Journal of Gynecologic Oncology 2018;29(3):e34-
OBJECTIVE: Uterine serous carcinoma (USC) is an aggressive type 2 endometrial cancer. Data on prognostic factors for patients with early-stage USC without adjuvant therapy are limited. This study aims to assess the baseline recurrence risk of early-stage USC patients without adjuvant treatment and to identify prognostic factors and patients who need adjuvant therapy. METHODS: Sixty-eight patients with International Federation of Gynecology and Obstetrics (FIGO) stage I–II USC between 1997 and 2016 were included. All the cases did not undergo adjuvant treatment as institutional practice. Clinicopathological features, recurrence patterns, and survival outcomes were analyzed to determine prognostic factors. RESULTS: FIGO stages IA, IB, and II were observed in 42, 7, and 19 cases, respectively. Median follow-up time was 60 months. Five-year disease-free survival (DFS) and overall survival (OS) rates for all cases were 73.9% and 78.0%, respectively. On multivariate analysis, cervical stromal involvement and positive pelvic cytology were significant predictors of DFS and OS, and ≥1/2 myometrial invasion was also a significant predictor of OS. Of 68 patients, 38 patients had no cervical stromal invasion or positive pelvic cytology and showed 88.8% 5-year DFS and 93.6% 5-year OS. CONCLUSION: Cervical stromal invasion and positive pelvic cytology are prognostic factors for stage I–II USC. Patients with stage IA or IB USC showing negative pelvic cytology may have an extremely favorable prognosis and need not receive any adjuvant therapies.
Adenocarcinoma
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Cytodiagnosis
;
Disease-Free Survival
;
Endometrial Neoplasms
;
Female
;
Follow-Up Studies
;
Gynecology
;
Humans
;
Institutional Practice
;
Multivariate Analysis
;
Obstetrics
;
Prognosis
;
Recurrence
10.Administration of the adrenaline auto-injector at the nursery/kindergarten/school in Western Japan
Seigo KOREMATSU ; Michiko FUJITAKA ; Mika OGATA ; Masafumi ZAITSU ; Chikako MOTOMURA ; Kazuyo KUZUME ; Yuchiro TOKU ; Masanori IKEDA ; Hiroshi ODAJIMA
Asia Pacific Allergy 2017;7(1):37-41
BACKGROUND: In view of the increasing prevalence of food allergies, there has been an associated increase in frequency of situations requiring an emergency response for anaphylaxis at the home, childcare facilities and educational institutions. OBJECTIVE: To clarify the situation of adrenaline auto-injector administration in nursery/kindergarten/school, we carried out a questionnaire survey on pediatric physicians in Western Japan. METHODS: In 2015, self-reported questionnaires were mailed to 421 physicians who are members of the West Japan Research Society Pediatric Clinical Allergy and Shikoku Research Society Pediatric Clinical Allergy. RESULTS: The response rate was 44% (185 physicians) where 160 physicians had a prescription registration for the adrenaline auto-injector. In the past year, 1,330 patients were prescribed the adrenaline auto-injector where 83 patients (6% of the prescribed patients) actually administered the adrenaline auto-injector, of which 14 patients (17% of the administered patients) self-administered the adrenaline auto-injector. “Guardians” at the nursery/kindergarten and elementary school were found to have administered the adrenaline auto-injector the most. Among 117 adrenaline auto-injector prescription-registered physicians, 79% had experienced nonadministration of adrenaline auto-injector at nursery/kindergarten/school when anaphylaxis has occurred. The most frequent reason cited for not administering the adrenaline auto-injector was “hesitation about the timing of administration.” CONCLUSION: If the adrenaline auto-injector was administered after the guardian arrived at the nursery/kindergarten/school, it may lead to delayed treatment of anaphylaxis in which symptoms develop in minutes. Education and cooperation among physicians and nursery/kindergarten/school staff will reduce the number of children suffering unfortunate outcomes due to anaphylaxis.
Anaphylaxis
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Child
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Education
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Emergencies
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Epinephrine
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Food Hypersensitivity
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Humans
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Hypersensitivity
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Japan
;
Nurseries
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Postal Service
;
Prescriptions
;
Prevalence


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