1.Treatment of Diabetic Cardiomyopathy with Shengmaisan-like Formulae: A Review
Yinan MA ; Fuyun JIA ; Rui ZHANG ; Zhengwei ZHANG ; Hanwen CUI ; Qiang XU
Chinese Journal of Experimental Traditional Medical Formulae 2025;31(22):291-298
		                        		
		                        			
		                        			Diabetic cardiomyopathy (DCM), a cardiovascular complication caused by diabetes mellitus, is a major cause of heart failure and even sudden cardiac death in diabetic patients. Traditional Chinese medicine (TCM) posits that the core pathogenesis of DCM lies in internal deficiency and superficial excess, characterized by deficiency of both Qi and Yin combined with phlegm and blood stasis. Modern medical treatments for DCM primarily focus on blood glucose control and symptom alleviation yet lack targeted therapeutic strategies. In contrast, TCM offers a wealth of practical experience and a complete theoretical system, demonstrating definite clinical efficacy and high medication safety in DCM management. As a classic formula for tonifying Qi and nourishing Yin, Shengmaisan comprises Ginseng Radix et Rhizoma, Ophiopogonis Radix, and Schisandrae Chinensis Fructus. It contains multiple bioactive components, including ginsenosides, ophiopogonin, schisandrins, and homoisoflavonoids, which exhibit cardioprotective properties. The therapeutic mechanisms of Shengmaisan-like formulae for DCM involve enhancing myocardial contractility, attenuating myocardial fibrosis, modulating mitochondrial quality control, regulating glucose metabolism, mitigating oxidative stress, and suppressing inflammatory responses. Clinically, Shengmaisan-like formulae not only manage hyperglycemic status but also ameliorate cardiac structural and functional impairments and enhance exercise tolerance in DCM patients, playing a vital role in the prevention, treatment, and rehabilitation of DCM. This paper analyzes the feasibility of Shengmaisan-like formulae in DCM management and synthesizes current research achievements regarding their chemical components, mechanisms of action, and clinical applications, aiming to provide a scientific foundation for the use of such formulae in the treatment of DCM. 
		                        		
		                        		
		                        		
		                        	
2.Magnesium promotes vascularization and osseointegration in diabetic states.
Linfeng LIU ; Feiyu WANG ; Wei SONG ; Danting ZHANG ; Weimin LIN ; Qi YIN ; Qian WANG ; Hanwen LI ; Quan YUAN ; Shiwen ZHANG
International Journal of Oral Science 2024;16(1):10-10
		                        		
		                        			
		                        			Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues. Magnesium has been proved to promote bone healing under normal conditions. Here, we elucidate the mechanism by which Mg2+ promotes angiogenesis and osseointegration in diabetic status. We generated a diabetic mice model and demonstrated the alveolar bone healing was compromised, with significantly decreased angiogenesis. We then developed Mg-coating implants with hydrothermal synthesis. These implants successfully improved the vascularization and osseointegration in diabetic status. Mechanically, Mg2+ promoted the degradation of Kelch-like ECH-associated protein 1 (Keap1) and the nucleation of nuclear factor erythroid 2-related factor 2 (Nrf2) by up-regulating the expression of sestrin 2 (SESN2) in endothelial cells, thus reducing the elevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia. Altogether, our data suggested that Mg2+ promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondrial metabolism.
		                        		
		                        		
		                        		
		                        			Mice
		                        			;
		                        		
		                        			Animals
		                        			;
		                        		
		                        			Kelch-Like ECH-Associated Protein 1/metabolism*
		                        			;
		                        		
		                        			Magnesium/metabolism*
		                        			;
		                        		
		                        			Osseointegration
		                        			;
		                        		
		                        			Diabetes Mellitus, Experimental/metabolism*
		                        			;
		                        		
		                        			Endothelial Cells/metabolism*
		                        			;
		                        		
		                        			NF-E2-Related Factor 2/metabolism*
		                        			
		                        		
		                        	
3.Analysis of medical device policy text in Anhui province based on policy tools
Weibo GU ; Hanwen WANG ; Zhuoyun WANG ; Xiaoli ZHANG ; Ying WANG
China Medical Equipment 2024;21(1):166-171
		                        		
		                        			
		                        			Objective:To sort out medical device related policies in Anhui Province,to analyze the distribution of content in each policy text to provide reference for policy optimization in the later stage.Methods:The official websites of the People's Government of Anhui Province and the Anhui Provincial Drug Administration were searched by using the keywords of"medical devices","medical device enterprises",and"medical consumables"to search for medical device related policy documents released from January 2011 to December 2022.The 21 medical device-related policy documents retrieved shall be coded using the content analysis method in the sequence of"policy code-chapter number-unit number-sentence number".A two-dimensional analytical framework of"Basic Policy Instruments-Involved Subjects"was constructed to quantitatively analyze the medical device policy text from the two dimensions of policy instruments-involved subjects.Results:A total of 338 items were codes,including 107 supply-based policy tools(accounting for 31.66%),40 demand-based policy tools(accounting for 11.83%),and 191 environmental policy tools(accounting for 56.51%).The 338 codes involved entities including 202 government departments(accounting for 59.76%),62 operating enterprises(accounting for 18.34%),59 production enterprises(accounting for 17.46%),9 medical institutions(accounting for 2.66%),and 6 industry associations(accounting for 1.78%).Conclusion:The medical device policy in Anhui Province is mainly based on environmental policy tools,and demand-based policy tools are rarely used.The rationality of the distribution of internal items and participating entities in policy tools needs to be improved.There are certain differences in the interaction between each entity and policy tools.Therefore,it is necessary to strengthen the balance of policy tool use,increase the participation of multiple entities,and optimize the synergy between entities and policy tools.
		                        		
		                        		
		                        		
		                        	
4.Magnesium promotes vascularization and osseointegration in diabetic states
Liu LINFENG ; Wang FEIYU ; Song WEI ; Zhang DANTING ; Lin WEIMIN ; Yin QI ; Wang QIAN ; Li HANWEN ; Yuan QUAN ; Zhang SHIWEN
International Journal of Oral Science 2024;16(1):122-133
		                        		
		                        			
		                        			Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues.Magnesium has been proved to promote bone healing under normal conditions.Here,we elucidate the mechanism by which Mg2+ promotes angiogenesis and osseointegration in diabetic status.We generated a diabetic mice model and demonstrated the alveolar bone healing was compromised,with significantly decreased angiogenesis.We then developed Mg-coating implants with hydrothermal synthesis.These implants successfully improved the vascularization and osseointegration in diabetic status.Mechanically,Mg2+ promoted the degradation of Kelch-like ECH-associated protein 1(Keap1)and the nucleation of nuclear factor erythroid 2-related factor 2(Nrf2)by up-regulating the expression of sestrin 2(SESN2)in endothelial cells,thus reducing the elevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia.Altogether,our data suggested that Mg2+ promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondrial metabolism.
		                        		
		                        		
		                        		
		                        	
5.Magnesium promotes vascularization and osseointegration in diabetic states
Liu LINFENG ; Wang FEIYU ; Song WEI ; Zhang DANTING ; Lin WEIMIN ; Yin QI ; Wang QIAN ; Li HANWEN ; Yuan QUAN ; Zhang SHIWEN
International Journal of Oral Science 2024;16(1):122-133
		                        		
		                        			
		                        			Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues.Magnesium has been proved to promote bone healing under normal conditions.Here,we elucidate the mechanism by which Mg2+ promotes angiogenesis and osseointegration in diabetic status.We generated a diabetic mice model and demonstrated the alveolar bone healing was compromised,with significantly decreased angiogenesis.We then developed Mg-coating implants with hydrothermal synthesis.These implants successfully improved the vascularization and osseointegration in diabetic status.Mechanically,Mg2+ promoted the degradation of Kelch-like ECH-associated protein 1(Keap1)and the nucleation of nuclear factor erythroid 2-related factor 2(Nrf2)by up-regulating the expression of sestrin 2(SESN2)in endothelial cells,thus reducing the elevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia.Altogether,our data suggested that Mg2+ promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondrial metabolism.
		                        		
		                        		
		                        		
		                        	
6.Magnesium promotes vascularization and osseointegration in diabetic states
Liu LINFENG ; Wang FEIYU ; Song WEI ; Zhang DANTING ; Lin WEIMIN ; Yin QI ; Wang QIAN ; Li HANWEN ; Yuan QUAN ; Zhang SHIWEN
International Journal of Oral Science 2024;16(1):122-133
		                        		
		                        			
		                        			Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues.Magnesium has been proved to promote bone healing under normal conditions.Here,we elucidate the mechanism by which Mg2+ promotes angiogenesis and osseointegration in diabetic status.We generated a diabetic mice model and demonstrated the alveolar bone healing was compromised,with significantly decreased angiogenesis.We then developed Mg-coating implants with hydrothermal synthesis.These implants successfully improved the vascularization and osseointegration in diabetic status.Mechanically,Mg2+ promoted the degradation of Kelch-like ECH-associated protein 1(Keap1)and the nucleation of nuclear factor erythroid 2-related factor 2(Nrf2)by up-regulating the expression of sestrin 2(SESN2)in endothelial cells,thus reducing the elevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia.Altogether,our data suggested that Mg2+ promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondrial metabolism.
		                        		
		                        		
		                        		
		                        	
7.Magnesium promotes vascularization and osseointegration in diabetic states
Liu LINFENG ; Wang FEIYU ; Song WEI ; Zhang DANTING ; Lin WEIMIN ; Yin QI ; Wang QIAN ; Li HANWEN ; Yuan QUAN ; Zhang SHIWEN
International Journal of Oral Science 2024;16(1):122-133
		                        		
		                        			
		                        			Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues.Magnesium has been proved to promote bone healing under normal conditions.Here,we elucidate the mechanism by which Mg2+ promotes angiogenesis and osseointegration in diabetic status.We generated a diabetic mice model and demonstrated the alveolar bone healing was compromised,with significantly decreased angiogenesis.We then developed Mg-coating implants with hydrothermal synthesis.These implants successfully improved the vascularization and osseointegration in diabetic status.Mechanically,Mg2+ promoted the degradation of Kelch-like ECH-associated protein 1(Keap1)and the nucleation of nuclear factor erythroid 2-related factor 2(Nrf2)by up-regulating the expression of sestrin 2(SESN2)in endothelial cells,thus reducing the elevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia.Altogether,our data suggested that Mg2+ promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondrial metabolism.
		                        		
		                        		
		                        		
		                        	
8.Magnesium promotes vascularization and osseointegration in diabetic states
Liu LINFENG ; Wang FEIYU ; Song WEI ; Zhang DANTING ; Lin WEIMIN ; Yin QI ; Wang QIAN ; Li HANWEN ; Yuan QUAN ; Zhang SHIWEN
International Journal of Oral Science 2024;16(1):122-133
		                        		
		                        			
		                        			Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues.Magnesium has been proved to promote bone healing under normal conditions.Here,we elucidate the mechanism by which Mg2+ promotes angiogenesis and osseointegration in diabetic status.We generated a diabetic mice model and demonstrated the alveolar bone healing was compromised,with significantly decreased angiogenesis.We then developed Mg-coating implants with hydrothermal synthesis.These implants successfully improved the vascularization and osseointegration in diabetic status.Mechanically,Mg2+ promoted the degradation of Kelch-like ECH-associated protein 1(Keap1)and the nucleation of nuclear factor erythroid 2-related factor 2(Nrf2)by up-regulating the expression of sestrin 2(SESN2)in endothelial cells,thus reducing the elevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia.Altogether,our data suggested that Mg2+ promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondrial metabolism.
		                        		
		                        		
		                        		
		                        	
9.Magnesium promotes vascularization and osseointegration in diabetic states
Liu LINFENG ; Wang FEIYU ; Song WEI ; Zhang DANTING ; Lin WEIMIN ; Yin QI ; Wang QIAN ; Li HANWEN ; Yuan QUAN ; Zhang SHIWEN
International Journal of Oral Science 2024;16(1):122-133
		                        		
		                        			
		                        			Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues.Magnesium has been proved to promote bone healing under normal conditions.Here,we elucidate the mechanism by which Mg2+ promotes angiogenesis and osseointegration in diabetic status.We generated a diabetic mice model and demonstrated the alveolar bone healing was compromised,with significantly decreased angiogenesis.We then developed Mg-coating implants with hydrothermal synthesis.These implants successfully improved the vascularization and osseointegration in diabetic status.Mechanically,Mg2+ promoted the degradation of Kelch-like ECH-associated protein 1(Keap1)and the nucleation of nuclear factor erythroid 2-related factor 2(Nrf2)by up-regulating the expression of sestrin 2(SESN2)in endothelial cells,thus reducing the elevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia.Altogether,our data suggested that Mg2+ promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondrial metabolism.
		                        		
		                        		
		                        		
		                        	
10.Magnesium promotes vascularization and osseointegration in diabetic states
Liu LINFENG ; Wang FEIYU ; Song WEI ; Zhang DANTING ; Lin WEIMIN ; Yin QI ; Wang QIAN ; Li HANWEN ; Yuan QUAN ; Zhang SHIWEN
International Journal of Oral Science 2024;16(1):122-133
		                        		
		                        			
		                        			Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues.Magnesium has been proved to promote bone healing under normal conditions.Here,we elucidate the mechanism by which Mg2+ promotes angiogenesis and osseointegration in diabetic status.We generated a diabetic mice model and demonstrated the alveolar bone healing was compromised,with significantly decreased angiogenesis.We then developed Mg-coating implants with hydrothermal synthesis.These implants successfully improved the vascularization and osseointegration in diabetic status.Mechanically,Mg2+ promoted the degradation of Kelch-like ECH-associated protein 1(Keap1)and the nucleation of nuclear factor erythroid 2-related factor 2(Nrf2)by up-regulating the expression of sestrin 2(SESN2)in endothelial cells,thus reducing the elevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia.Altogether,our data suggested that Mg2+ promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondrial metabolism.
		                        		
		                        		
		                        		
		                        	
            
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