ObjectiveMetabolomics was utilized to investigate the preventive effect of notoginseng total saponins（NTS） on aspirin（acetyl salicylic acid， ASA）-induced small bowel injury in rats. MethodFifty male SD rats were randomly divided into normal and model groups， NTS high-dose and low-dose groups（62.5， 31.25 mg·kg^-1）， and positive drug group（omeprazole 2.08 mg·kg^-1+rebamipide 31.25 mg·kg^-1）， with 10 rats in each group. Except for the normal group， rats in other groups were given ASA enteric-coated pellets 10.41 mg·kg^-1 daily to establish a small intestine injury model. On this basis， each medication group was gavaged daily with the corresponding dose of drug， and the normal group and the model group were gavaged with an equal amount of drinking water. Changes in body mass and fecal characteristics of rats were recorded and scored during the period. After 14 weeks of administration， small intestinal tissues of each group were taken for hematoxylin-eosin（HE） staining， scanning electron microscopy to observe the damage， and the apparent damage of small intestine was scored. Serum from rats in the normal group， the model group， and the NTS high-dose group was taken and analyzed for metabolomics by ultra-performance liquid chromatography-quadrupole-electrostatic field orbitrap high-resolution mass spectrometry（UPLC-Q-Exactive Orbitrap MS）， and the data were processed by multivariate statistical analysis， the potential biomarkers were screened by variable importance in the projection（VIP） value≥1.0， fold change（FC）≥1.5 or ≤0.6 and t-test P<0.05， and pathway enrichment analysis of differential metabolites was performed in conjunction with Human Metabolome Database（HMDB） and Kyoto Encyclopedia of Genes and Genomes（KEGG）. ResultAfter 14 weeks of administration， the average body mass gain of the model group was lower than that of the normal group， and the NTS high-dose group was close to that of the normal group. Compared with the normal group， the fecal character score of rats in the model group was significantly increased（P<0.05）， and compared with the model group， the scores of the positive drug group and the NTS high-dose group were reduced， but the difference was not statistically significant. HE staining and scanning electron microscopy results showed that NTS could significantly improve ASA-induced small intestinal injury， compared with the normal group， the small bowel injury score of the model group was significantly increased（P<0.01）， compared with the model group， the small bowel injury scores of the NTS low and high dose groups were significantly reduced（P<0.05， P<0.01）. Serum metabolomics screened a total of 75 differential metabolites between the normal group and the model group， of which 55 were up-regulated and 20 were down-regulated， 76 differential metabolites between the model group and the NTS groups， of which 14 were up-regulated and 62 were down-regulated. NTS could modulate three differential metabolites（salicylic acid， 3-hydroxybenzoic acid and 4-hydroxybenzoic acid）， which were involved in 3 metabolic pathways， namely， the bile secretion， the biosynthesis of folic acid， and the biosynthesis of phenylalanine， tyrosine and tryptophan. ConclusionNTS can prevent ASA-induced small bowel injury， and the underlying mechanism may be related to the regulation of bile secretion and amino acid metabolic pathways in rats.

High-quality development of digital health industry is an important symbol of realizing a healthy and digital China,and it is a new economic growth point.Using literature and other research methods,it comprehensively explores the theoretical logic,practical bottlenecks and solutions to the high-quality development of digital health industry driven by new quality productivity.It concludes that the new quality productivity can promote the high-quality development of digital health industry by strengthening the effect of institutional innovation,creating a good development environment for the industry;strengthening the effect of structural optimization,driving the upgrading of the industry;strengthening the effect of strengthening and complementing the chain,prolonging the industrial value chain;strengthening the effect of organizational remodeling,improving the industrial organizational system;and strengthening the effect of factor enhancement,fostering the high-end innovation factors.Aiming at the bottlenecks of unsound institutional mechanism,deep structural traps,low-end locking of the value chain,weak integration capacity of health organizations,and insufficient allocation of innovative elements,proposing to promote the deep integration of new elements and resources,and to accumulate the kinetic energy of innovation and development of the digital health industry;strengthening the status of digital health enterprise as the main body of innovation,and to stimulate the vitality of health management organizations;vertically and horizontally integrating the digital health industry chain,and comprehensively excavating the value of the digital health industry;driving the digital health industry to change the new and new,rooting the foundation of digital health industry development;deepening the reform of the digital health management system and mechanism,and improving the system to ensure the relief of the system.

High-quality development of digital health industry is an important symbol of realizing a healthy and digital China,and it is a new economic growth point.Using literature and other research methods,it comprehensively explores the theoretical logic,practical bottlenecks and solutions to the high-quality development of digital health industry driven by new quality productivity.It concludes that the new quality productivity can promote the high-quality development of digital health industry by strengthening the effect of institutional innovation,creating a good development environment for the industry;strengthening the effect of structural optimization,driving the upgrading of the industry;strengthening the effect of strengthening and complementing the chain,prolonging the industrial value chain;strengthening the effect of organizational remodeling,improving the industrial organizational system;and strengthening the effect of factor enhancement,fostering the high-end innovation factors.Aiming at the bottlenecks of unsound institutional mechanism,deep structural traps,low-end locking of the value chain,weak integration capacity of health organizations,and insufficient allocation of innovative elements,proposing to promote the deep integration of new elements and resources,and to accumulate the kinetic energy of innovation and development of the digital health industry;strengthening the status of digital health enterprise as the main body of innovation,and to stimulate the vitality of health management organizations;vertically and horizontally integrating the digital health industry chain,and comprehensively excavating the value of the digital health industry;driving the digital health industry to change the new and new,rooting the foundation of digital health industry development;deepening the reform of the digital health management system and mechanism,and improving the system to ensure the relief of the system.

High-quality development of digital health industry is an important symbol of realizing a healthy and digital China,and it is a new economic growth point.Using literature and other research methods,it comprehensively explores the theoretical logic,practical bottlenecks and solutions to the high-quality development of digital health industry driven by new quality productivity.It concludes that the new quality productivity can promote the high-quality development of digital health industry by strengthening the effect of institutional innovation,creating a good development environment for the industry;strengthening the effect of structural optimization,driving the upgrading of the industry;strengthening the effect of strengthening and complementing the chain,prolonging the industrial value chain;strengthening the effect of organizational remodeling,improving the industrial organizational system;and strengthening the effect of factor enhancement,fostering the high-end innovation factors.Aiming at the bottlenecks of unsound institutional mechanism,deep structural traps,low-end locking of the value chain,weak integration capacity of health organizations,and insufficient allocation of innovative elements,proposing to promote the deep integration of new elements and resources,and to accumulate the kinetic energy of innovation and development of the digital health industry;strengthening the status of digital health enterprise as the main body of innovation,and to stimulate the vitality of health management organizations;vertically and horizontally integrating the digital health industry chain,and comprehensively excavating the value of the digital health industry;driving the digital health industry to change the new and new,rooting the foundation of digital health industry development;deepening the reform of the digital health management system and mechanism,and improving the system to ensure the relief of the system.

High-quality development of digital health industry is an important symbol of realizing a healthy and digital China,and it is a new economic growth point.Using literature and other research methods,it comprehensively explores the theoretical logic,practical bottlenecks and solutions to the high-quality development of digital health industry driven by new quality productivity.It concludes that the new quality productivity can promote the high-quality development of digital health industry by strengthening the effect of institutional innovation,creating a good development environment for the industry;strengthening the effect of structural optimization,driving the upgrading of the industry;strengthening the effect of strengthening and complementing the chain,prolonging the industrial value chain;strengthening the effect of organizational remodeling,improving the industrial organizational system;and strengthening the effect of factor enhancement,fostering the high-end innovation factors.Aiming at the bottlenecks of unsound institutional mechanism,deep structural traps,low-end locking of the value chain,weak integration capacity of health organizations,and insufficient allocation of innovative elements,proposing to promote the deep integration of new elements and resources,and to accumulate the kinetic energy of innovation and development of the digital health industry;strengthening the status of digital health enterprise as the main body of innovation,and to stimulate the vitality of health management organizations;vertically and horizontally integrating the digital health industry chain,and comprehensively excavating the value of the digital health industry;driving the digital health industry to change the new and new,rooting the foundation of digital health industry development;deepening the reform of the digital health management system and mechanism,and improving the system to ensure the relief of the system.

High-quality development of digital health industry is an important symbol of realizing a healthy and digital China,and it is a new economic growth point.Using literature and other research methods,it comprehensively explores the theoretical logic,practical bottlenecks and solutions to the high-quality development of digital health industry driven by new quality productivity.It concludes that the new quality productivity can promote the high-quality development of digital health industry by strengthening the effect of institutional innovation,creating a good development environment for the industry;strengthening the effect of structural optimization,driving the upgrading of the industry;strengthening the effect of strengthening and complementing the chain,prolonging the industrial value chain;strengthening the effect of organizational remodeling,improving the industrial organizational system;and strengthening the effect of factor enhancement,fostering the high-end innovation factors.Aiming at the bottlenecks of unsound institutional mechanism,deep structural traps,low-end locking of the value chain,weak integration capacity of health organizations,and insufficient allocation of innovative elements,proposing to promote the deep integration of new elements and resources,and to accumulate the kinetic energy of innovation and development of the digital health industry;strengthening the status of digital health enterprise as the main body of innovation,and to stimulate the vitality of health management organizations;vertically and horizontally integrating the digital health industry chain,and comprehensively excavating the value of the digital health industry;driving the digital health industry to change the new and new,rooting the foundation of digital health industry development;deepening the reform of the digital health management system and mechanism,and improving the system to ensure the relief of the system.

High-quality development of digital health industry is an important symbol of realizing a healthy and digital China,and it is a new economic growth point.Using literature and other research methods,it comprehensively explores the theoretical logic,practical bottlenecks and solutions to the high-quality development of digital health industry driven by new quality productivity.It concludes that the new quality productivity can promote the high-quality development of digital health industry by strengthening the effect of institutional innovation,creating a good development environment for the industry;strengthening the effect of structural optimization,driving the upgrading of the industry;strengthening the effect of strengthening and complementing the chain,prolonging the industrial value chain;strengthening the effect of organizational remodeling,improving the industrial organizational system;and strengthening the effect of factor enhancement,fostering the high-end innovation factors.Aiming at the bottlenecks of unsound institutional mechanism,deep structural traps,low-end locking of the value chain,weak integration capacity of health organizations,and insufficient allocation of innovative elements,proposing to promote the deep integration of new elements and resources,and to accumulate the kinetic energy of innovation and development of the digital health industry;strengthening the status of digital health enterprise as the main body of innovation,and to stimulate the vitality of health management organizations;vertically and horizontally integrating the digital health industry chain,and comprehensively excavating the value of the digital health industry;driving the digital health industry to change the new and new,rooting the foundation of digital health industry development;deepening the reform of the digital health management system and mechanism,and improving the system to ensure the relief of the system.

High-quality development of digital health industry is an important symbol of realizing a healthy and digital China,and it is a new economic growth point.Using literature and other research methods,it comprehensively explores the theoretical logic,practical bottlenecks and solutions to the high-quality development of digital health industry driven by new quality productivity.It concludes that the new quality productivity can promote the high-quality development of digital health industry by strengthening the effect of institutional innovation,creating a good development environment for the industry;strengthening the effect of structural optimization,driving the upgrading of the industry;strengthening the effect of strengthening and complementing the chain,prolonging the industrial value chain;strengthening the effect of organizational remodeling,improving the industrial organizational system;and strengthening the effect of factor enhancement,fostering the high-end innovation factors.Aiming at the bottlenecks of unsound institutional mechanism,deep structural traps,low-end locking of the value chain,weak integration capacity of health organizations,and insufficient allocation of innovative elements,proposing to promote the deep integration of new elements and resources,and to accumulate the kinetic energy of innovation and development of the digital health industry;strengthening the status of digital health enterprise as the main body of innovation,and to stimulate the vitality of health management organizations;vertically and horizontally integrating the digital health industry chain,and comprehensively excavating the value of the digital health industry;driving the digital health industry to change the new and new,rooting the foundation of digital health industry development;deepening the reform of the digital health management system and mechanism,and improving the system to ensure the relief of the system.

High-quality development of digital health industry is an important symbol of realizing a healthy and digital China,and it is a new economic growth point.Using literature and other research methods,it comprehensively explores the theoretical logic,practical bottlenecks and solutions to the high-quality development of digital health industry driven by new quality productivity.It concludes that the new quality productivity can promote the high-quality development of digital health industry by strengthening the effect of institutional innovation,creating a good development environment for the industry;strengthening the effect of structural optimization,driving the upgrading of the industry;strengthening the effect of strengthening and complementing the chain,prolonging the industrial value chain;strengthening the effect of organizational remodeling,improving the industrial organizational system;and strengthening the effect of factor enhancement,fostering the high-end innovation factors.Aiming at the bottlenecks of unsound institutional mechanism,deep structural traps,low-end locking of the value chain,weak integration capacity of health organizations,and insufficient allocation of innovative elements,proposing to promote the deep integration of new elements and resources,and to accumulate the kinetic energy of innovation and development of the digital health industry;strengthening the status of digital health enterprise as the main body of innovation,and to stimulate the vitality of health management organizations;vertically and horizontally integrating the digital health industry chain,and comprehensively excavating the value of the digital health industry;driving the digital health industry to change the new and new,rooting the foundation of digital health industry development;deepening the reform of the digital health management system and mechanism,and improving the system to ensure the relief of the system.

Objective:To investigate the effects of anterolateral femoral perforator flaps pedicled with oblique branch of lateral circumflex femoral artery and carrying fascia lata in repairing destructive wounds and rebuilding function of hands or feet.Methods:This study was a retrospective observational study. From January 2022 to March 2023, 16 patients with destructive wounds in hands or feet combined with extensor tendon defects who met the inclusion criteria were admitted to Suzhou Ruihua Orthopedic Hospital, including 12 males and 4 females, aged 3 to 63 years. The wounds were located on the hands in 12 cases and on the feet in 4 cases. The number of defective extensor tendon ranged one to five, and the length of the defect ranged from 2.5 to 6.0 cm. The wound area was 11.0 cm×5.5 cm to 29.0 cm×9.5 cm after debridement. The wounds were repaired with anterolateral femoral perforator flaps pedicled with oblique branch of lateral circumflex femoral artery and carrying fascia lata, and the flap area was 12.0 cm×6.5 cm to 30.0 cm×11.0 cm. The fascia lata was used to repair the extensor tendon defects, and the harvesting area of fascia lata was 8.0 cm×3.0 cm to 12.0 cm×8.0 cm. The wounds in flap donor areas in 15 patients were sutured directly, and the wound in flap donor area in 1 patient was covered with medium-thickness skin graft from lower abdomen. The survival of flaps and the wound healing in donor and recipient areas of flaps were observed within 1 week after operation. The number of patients who underwent thinning and plastic surgery or tenolysis was recorded during postoperative follow-up. At the last follow-up, the recovery of sensory function of the transplanted flaps on hands or feet was evaluated, the efficacy of flap repair was evaluated according to the comprehensive flap evaluation scale, and the function of hands was evaluated according to the trial standards for evaluation of partial function of upper extremity by the Hand Surgery Society of Chinese Medical Association. The following two indexes were compared, including the measured total active motion of the injured fingers and the foot function assessed using Maryland foot function scale between before surgery and at the last follow-up.Results:Arterial crisis occurred in flaps in 2 patients after operation, and the flaps survived after timely exploration; the flaps in the rest patients survived well after operation. No obvious scar hyperplasia or ulceration was observed in donor and recipient areas of flaps after operation. All patients were followed up for 8 to 16 months, of which 6 patients underwent flap thinning and plastic surgery 6 to 7 months after operation, and 4 patients underwent tenolysis 3 to 6 months after operation. At the last follow-up, the recovery of sensory function of flaps reached S1 level in 5 cases and S2 level in 11 cases, and the two-point discrimination only had 1 point. The efficacy of flap repair scored 80 to 91, which were evaluated as excellent in 5 cases, good in 9 cases, and acceptable in 2 cases. The hand function was evaluated as excellent in 5 cases, good in 5 cases, and acceptable in 2 cases. The active extension function of the injured finger/toe was reconstructed successfully, and the total active motion of the injured finger was (225±22)° at the last follow-up, which was significantly higher than (117±20)° before surgery ( t=119.59, P<0.05); the foot function score was 86±7 at the last follow-up, which was significantly higher than 29±7 before surgery ( t=222.68, P<0.05), and the foot function was evaluated as excellent in 2 cases, good in 1 case, and acceptable in 1 case. Conclusions:The operation of harvesting the anterolateral femoral perforator flap pedicled with oblique branch of lateral circumflex femoral artery is relatively simple. After the wounds on hands or feet being repaired with the flaps, the appearance and function are good, with no obvious scar hyperplasia in donor and recipient areas of flaps. The fascia lata carried by the flap can repair the extensor tendon defect at the same time and improve the movement of the finger/toe.