1.Percutaneous Pulmonary Valve Implantation
Luca GIUGNO ; Alessia FACCINI ; Mario CARMINATI
Korean Circulation Journal 2020;50(4):302-316
Percutaneous pulmonary valve implantation (PPVI) is recognized as a feasible and low risk alternative to surgery to treat dysfunctional right ventricular outflow tract (RVOT) in usually pluri-operated patients. Evolving technology allowed to develop different kind of prosthesis and to go from an initial treatment exclusively of stenotic conduit to an actual approach extended also to wide native RVOT. The Melody transcatheter pulmonary valve (TPV) and the Edwards Sapien valve are nowadays the most commonly implanted prostheses. However, other devices have been developed to treat large RVOT (i.e., the Venus p-valve, the Medtronic Harmony TPV, the Alterra Adaptive Prestent, and the Pulsta valve). Indications for PPVI are the same as for surgical interventions on pulmonary valve, with limits related to the maximum diameter of the available percutaneous prosthesis. Therefore, an accurate preoperative evaluation is of paramount importance to select patients who could benefit from this procedure. The overall periprocedural mortality incidence is around 1.4%, while freedom from RVOT reintervention ranges from 100% at 4 months to 70% at 70 months, according to the different published studies.
Freedom
;
Heart Defects, Congenital
;
Humans
;
Incidence
;
Mortality
;
Prostheses and Implants
;
Pulmonary Valve
;
Venus
2.Concomitant Wrapping of a Moderately Dilated Ascending Aorta during Aortic Valve Replacement: Postoperative Remodeling of a Distinctive Aorta
Hyo Hyun KIM ; Sak LEE ; Seung Hyun LEE ; Byung Chul CHANG ; Young Nam YOUN ; Kyung Jong YOO ; Hyun Chel JOO
Yonsei Medical Journal 2020;61(1):40-47
Freedom from adverse aortic events (aortic dissection or rupture, reoperation, or sudden death) at 10 years was 97.9%. No significant dilation at the level of the sinuses of Valsalva (0.069 mm/year, p=0.524) or ascending aorta (0.152 mm/year, p=0.124) was observed. Significant dilation occurred at the proximal aortic arch (0.343 mm/year, p=0.006). Subgroup analysis with a multivariable linear mixed model identified initial ascending aortic diameter to be a significant predictor of proximal arch dilation (p=0.032). Receiver operating characteristic curve analysis revealed that the cut-off for the prediction of proximal arch redilation was an initial mid-ascending aortic diameter of 47.0 mm (area under the curve 0.747, 90% confidence interval 0.613–0.881, p=0.023).CONCLUSION: Aortic wrapping could be considered as a safe and long-term therapeutic option. Redilation of the proximal arch should be carefully observed during long-term follow-up.]]>
Aorta
;
Aorta, Thoracic
;
Aortic Aneurysm
;
Aortic Valve
;
Follow-Up Studies
;
Freedom
;
Humans
;
Reoperation
;
Retrospective Studies
;
ROC Curve
;
Rupture
3.Antiepileptic Drug Withdrawal after Surgery in Children with Focal Cortical Dysplasia: Seizure Recurrence and Its Predictors.
Sun Ah CHOI ; Soo Yeon KIM ; Woo Joong KIM ; Young Kyu SHIM ; Hunmin KIM ; Hee HWANG ; Ji Eun CHOI ; Byung Chan LIM ; Jong Hee CHAE ; Sangjoon CHONG ; Ji Yeoun LEE ; Ji Hoon PHI ; Seung Ki KIM ; Kyu Chang WANG ; Ki Joong KIM
Journal of Clinical Neurology 2019;15(1):84-89
BACKGROUND AND PURPOSE: This study investigated the seizure recurrence rate and potential predictors of seizure recurrence following antiepileptic drug (AED) withdrawal after resective epilepsy surgery in children with focal cortical dysplasia (FCD). METHODS: We retrospectively analyzed the records of 70 children and adolescents with FCD types I, II, and IIIa who underwent resective epilepsy surgery between 2004 and 2015 and were followed for at least 2 years after surgery. RESULTS: We attempted AED withdrawal in 40 patients. The median time of starting the AED reduction was 10.8 months after surgery. Of these 40 patients, 14 patients (35%) experienced seizure recurrence during AED reduction or after AED withdrawal. Half of the 14 patients who experienced recurrence regained seizure freedom after AED reintroduction and optimization. Compared with their preoperative status, the AED dose or number was decreased in 57.1% of patients, and remained unchanged in 14.3% after surgery. A multivariate analysis found that incomplete resection (p=0.004) and epileptic discharges on the postoperative EEG (p=0.025) were important predictors of seizure recurrence after AED withdrawal. Over the mean follow-up duration of 4.5 years after surgery, 34 patients (48.6% of the entire cohort) were seizure-free with and without AEDs. CONCLUSIONS: Children with incomplete resection and epileptic discharges on postoperative EEG are at a high risk of seizure recurrence after drug withdrawal. Complete resection of FCD may lead to a favorable surgical outcome and successful AED withdrawal after surgery.
Adolescent
;
Anticonvulsants
;
Child*
;
Electroencephalography
;
Epilepsy
;
Follow-Up Studies
;
Freedom
;
Humans
;
Malformations of Cortical Development*
;
Multivariate Analysis
;
Recurrence*
;
Retrospective Studies
;
Seizures*
4.Surgical Ablation of Atrial Fibrillation in Patients Undergoing Bioprosthetic Valve Replacement
WonKyung PYO ; Sung Jun PARK ; Wan Kee KIM ; Ho Jin KIM ; Joon Bum KIM ; Sung Ho JUNG ; Suk Jung JOO ; Cheol Hyun CHUNG ; Jae Won LEE
The Korean Journal of Thoracic and Cardiovascular Surgery 2019;52(2):61-69
BACKGROUND: Scarce data have been reported on the efficacy of concomitant atrial fibrillation (AF) ablation in patients undergoing bioprosthetic valve replacement. METHODS: From 2001 and 2014, 146 consecutive patients (69.3±9.4 years, 84 females) who underwent bioprosthetic heart valve replacement concomitant with AF ablation were assessed. We evaluated long-term rhythm and valve-related outcomes. RESULTS: During 49.1 months of follow-up (interquartile range, 22.5–96.8 months), 7 in-hospital and 49 (6.7% per person-year) post-discharge deaths occurred. The thromboembolic event-free survival rate at 5 years was 79.2%±3.5%. The freedom from AF recurrence rate at 5 years was 59.8%±4.9%. Multivariate analysis showed that old age (hazard ratio [HR], 1.06; 95% confidence interval [CI], 1.02–1.11; p=0.002), previous cardiac operation (HR, 3.01; 95% CI, 1.22–7.43; p=0.02), and a large left atrial (LA) dimension (HR, 1.02; 95% CI, 1.00–1.05; p=0.045) were significantly associated with AF recurrence. CONCLUSION: The overall long-term clinical outcomes in these predominantly elderly patients undergoing AF ablation concomitantly with bioprosthetic valve replacement were satisfactory; however, AF recurrence was frequent. Older age, a history of prior cardiac surgery, and large LA size were associated with an increased risk of AF recurrence.
Aged
;
Anticoagulants
;
Atrial Fibrillation
;
Bioprosthesis
;
Disease-Free Survival
;
Follow-Up Studies
;
Freedom
;
Heart Valves
;
Humans
;
Multivariate Analysis
;
Recurrence
;
Thoracic Surgery
5.Mid-Term Results of Using the Seal Thoracic Stent Graft in Cases of Aortopathy: A Single-Institution Experience
Jun Woo CHO ; Jae Seok JANG ; Chul Ho LEE ; Sun Hyun HWANG
The Korean Journal of Thoracic and Cardiovascular Surgery 2019;52(5):335-341
BACKGROUND: The endovascular approach to aortic disease treatment has been increasingly utilized in the past 2 decades. This study aimed to determine the long-term results of using the Seal thoracic stent graft. METHODS: We retrospectively reviewed the outcomes of patients who underwent thoracic endovascular aortic repair or a hybrid procedure using the Seal thoracic stent graft (S&G Biotech, Seongnam, Korea) from January 2008 to July 2018 at a single institution. We investigated in-hospital mortality and the incidence of postoperative complications. We also investigated the mid-term survival rate and incidence of aorta-related complications. RESULTS: Among 72 patients with stent grafts, 15 patients underwent the hybrid procedure and 21 underwent emergency surgery. The mean follow-up period was 37.86±30.73 months (range, 0–124 months). Five patients (6.9%) died within 30 days. Two patients developed cerebrovascular accidents. Spinal cord injury occurred in 2 patients. Postoperative renal failure, postoperative extracorporeal membrane oxygenation support, and pneumonia were reported in 3, 1, and 6 patients, respectively. Stent-related aortic complications were observed in 5 patients (6.8%). The 1- and 5-year survival and freedom from stent-induced aortic event rates were 81.5% and 58.7%, and 97.0% and 89.1%, respectively. CONCLUSION: The use of the Seal thoracic stent graft yielded good mid-term results. Further studies are needed to examine the long-term outcomes of this device.
Aorta, Thoracic
;
Aortic Diseases
;
Aortic Rupture
;
Blood Vessel Prosthesis
;
Emergencies
;
Endoleak
;
Extracorporeal Membrane Oxygenation
;
Follow-Up Studies
;
Freedom
;
Gyeonggi-do
;
Hospital Mortality
;
Humans
;
Incidence
;
Pneumonia
;
Postoperative Complications
;
Renal Insufficiency
;
Retrospective Studies
;
Spinal Cord Injuries
;
Stents
;
Stroke
;
Survival Rate
6.Preadmission predictors of graduation success from a physical therapy education program in the United States
Gretchen ROMAN ; Matthew Paul BUMAN
Journal of Educational Evaluation for Health Professions 2019;16(1):5-
PURPOSE: The field of physical therapy education is seeking an evidence-based approach for admitting qualified applicants, as previous research has assessed various outcomes, impeding practical application. This study was conducted to identify preadmission criteria predictive of graduation success. METHODS: Data from the 2013–2016 graduating cohorts (n=149) were collected. Predictors included verbal Graduate Record Examination rank percentile (VGRE%), quantitative GRE rank percentile, analytical GRE rank percentile, the admissions interview, precumulative science grade point average (SGPA), precumulative grade point average (UGPA), and a reflective essay. The National Physical Therapy Examination (NPTE) and grade point average at the time of graduation (GGPA) were used as measures of graduation success. Two separate mixed-effects models determined the associations of preadmission predictors with NPTE performance and GGPA. RESULTS: The NPTE model fit comparison showed significant results (degrees of freedom [df]=10, P=0.001), decreasing within-cohort variance by 59.5%. NPTE performance was associated with GGPA (β=125.21, P=0.001), and VGRE%, the interview, the essay, and GGPA (P≤0.001) impacted the model fit. The GGPA model fit comparison did not show significant results (df=8, P=0.56), decreasing within-cohort variance by 16.4%. The GGPA was associated with the interview (β=0.02, P=0.04) and UGPA (β=0.25, P=0.04), and VGRE%, the interview, UGPA, and the essay (P≤0.02) impacted model fit. CONCLUSION: In our findings, GGPA predicted NPTE performance, and the interview and UGPA predicted GGPA. Unlike past evidence, SGPA showed no predictive power. The essay and VGRE% warrant attention because of their influence on model fit. We recommend that admissions ranking matrices place a greater weight on the interview, UGPA, VGRE%, and the essay.
Cohort Studies
;
Education
;
Freedom
;
School Admission Criteria
;
United States
7.Frailty Index is Associated with Adverse Outcomes after Aortic Valve Replacement in Elderly Patients
Bongyeon SOHN ; Jae Woong CHOI ; Ho Young HWANG ; Myoung jin JANG ; Kyung Hwan KIM ; Ki Bong KIM
Journal of Korean Medical Science 2019;34(31):e205-
BACKGROUND: This study was conducted to evaluate the prognostic value of the frailty index based on routine laboratory data (FI-L) in elderly patients who underwent surgical aortic valve replacement (SAVR). METHODS: A total of 154 elderly patients (≥ 75 years) (78.7 ± 3.6 years; men:women = 78:76) who underwent aortic valve replacement with stented bioprosthesis between 2001 and 2018 were enrolled. The FI-L was calculated as the proportion of abnormal results out of 32 items based on laboratory tests, pulse rate and blood pressure. The primary outcome was all-cause mortality. Secondary outcomes included operative mortality and aortic valve-related events (AVREs) during follow-up. The predictive values of FI-L for the early and late outcomes were evaluated using logistic regression and Cox proportional hazards models, respectively. The median follow-up duration was 40 months (interquartile, 15–74). RESULTS: The operative mortality rate was 3.9% (n = 6). Late death occurred in 29 patients. The overall survival (OS) rates at 5, 10, and 15 years were 83.3%, 59.0%, and 41.6%, respectively. The AVREs occurred in 28 patients and the freedom rates from AVREs at 5, 10, and 15 years were 79.4%, 72.7%, and 52.9%, respectively. Multivariable analyses demonstrated that FI-L was a significant factor for OS (hazard ratio, 1.075; 95% confidence interval, 1.040–1.111). A minimal P value approach showed that a FI-L of 25% was the best cutoff value to predict OS after SAVR. CONCLUSION: The FI-L is significantly associated with early and long-term outcomes after SAVR in elderly patients. Frailty rather than a patient's age should be considered in the decision-making process for SAVR in elderly patients.
Aged
;
Aortic Valve Stenosis
;
Aortic Valve
;
Bioprosthesis
;
Blood Pressure
;
Follow-Up Studies
;
Freedom
;
Heart Rate
;
Humans
;
Logistic Models
;
Mortality
;
Proportional Hazards Models
;
Stents
8.Early experiences with robot-assisted prosthetic breast reconstruction
Sung Jae AHN ; Seung Yong SONG ; Hyung Seok PARK ; Se Ho PARK ; Dae Hyun LEW ; Tai Suk ROH ; Dong Won LEE
Archives of Plastic Surgery 2019;46(1):79-83
Robotic surgery facilitates surgical procedures by employing flexible arms with multiple degrees of freedom and providing high-quality 3-dimensional imaging. Robot-assisted nipplesparing mastectomy with immediate reconstruction is currently performed to avoid breast scars. Four patients with invasive ductal carcinoma underwent robot-assisted nipple-sparing mastectomy and immediate robot-assisted expander insertion. Through a 6-cm incision along the anterior axillary line, sentinel lymph node biopsy and nipple-sparing mastectomy were performed by oncologic surgeons. The pectoralis major muscle was elevated, an acellular dermal matrix (ADM) sling was created with robotic assistance, and an expander was inserted into the subpectoral, sub-ADM pocket. No patients had major complications such as hematoma, seroma, infection, capsular contracture, or nipple-areolar necrosis. The mean operation time for expander insertion was 1 hour and 20 minutes, and it became shorter with more experience. The first patient completed 2-stage prosthetic reconstruction and was highly satisfied with the unnoticeable scar and symmetric reconstruction. We describe several cases of immediate robot-assisted prosthetic breast reconstruction. This procedure is a feasible surgical option for patients who want to conceal surgical scars.
Acellular Dermis
;
Arm
;
Breast Implants
;
Breast
;
Carcinoma, Ductal
;
Cicatrix
;
Contracture
;
Female
;
Freedom
;
Hematoma
;
Humans
;
Mammaplasty
;
Mastectomy
;
Necrosis
;
Robotic Surgical Procedures
;
Sentinel Lymph Node Biopsy
;
Seroma
;
Surgeons
;
Tissue Expansion Devices
9.Multi-DOF (Degree of Freedom) Articulating Laparoscopic Instrument is an Effective Device in Performing Challenging Sutures
Sa Hong MIN ; Yo Seok CHO ; Kibum PARK ; Yoontaek LEE ; Young Suk PARK ; Sang Hoon AHN ; Do Joong PARK ; Hyung Ho KIM
Journal of Minimally Invasive Surgery 2019;22(4):157-163
PURPOSE: Although laparoscopic surgery had been performed in clinical practice for over 30 years, there has not been much improvement on instruments. Several articulating laparoscopic instruments have been developed including the robotic system. A new multi-degree of freedom (DOF) articulating laparoscopic device has been developed. We compared the ability to perform challenging sutures between the new device and the robotic system.METHODS: Five experienced surgeons with over 100 laparoscopic surgery cases performed the suture task with both instruments. Everyone was new at articulating instruments including a robotic system. The suturing task consisted of two vertical sutures, downward and upward vertical direction. The duration of needle grabbing, first surgical tie, square tie, and the final reverse tie was measured.RESULTS: When doing the downward suture, the median time to complete the suture was 127 vs. 136 seconds for ArtiSential® and the robot, respectively (p=0.754). Other measurements such as needle grabbing, first tie, second tie and final knot did not show any significant difference between the two instruments. Upward suture also did not show a significant difference. The total completion time was 127 vs. 112 seconds for for ArtiSential® and the robot, respectively (p=0.675). Time taken in each interval did not show any significant difference.CONCLUSION: Both instruments performed the suturing tasks with no difference in duration. ArtiSential® can be mixed up with usual instruments. Surgeons can choose any device, but when articulation is needed, ArtiSential® could be an alternative choice to the robotic system.
Freedom
;
Laparoscopy
;
Needles
;
Robotics
;
Surgeons
;
Sutures
10.The Surgical and Cognitive Outcomes of Focal Cortical Dysplasia
Journal of Korean Neurosurgical Society 2019;62(3):321-327
Focal cortical dysplasia (FCD) is the major cause of intractable focal epilepsy in childhood leading to epilepsy surgery. The overall seizure freedom after surgery ranges between 50–75% at 2 years after surgery and the long-term seizure freedom remain relatively stable. Seizure outcome after surgery depends on a various factors such as pathologic etiologies, extent of lesion, and types of surgery. Therefore, seizure outcome after surgery for FCD should be analyzed carefully considering cohorts' characteristics. Studies of pediatric epilepsy surgery emphasize the early surgical intervention for a better cognition. Early surgical intervention and cessation of seizure activity are important for children with intractable epilepsy. However, there are limited data on the cognitive outcome after surgery in pediatric FCD, requiring further investigation. This paper reviews the seizure and cognitive outcomes of epilepsy surgery for FCD in children. Several prognostic factors influencing seizure outcome after surgery will be discussed in detail.
Child
;
Cognition
;
Drug Resistant Epilepsy
;
Epilepsies, Partial
;
Epilepsy
;
Freedom
;
Humans
;
Malformations of Cortical Development
;
Patient Outcome Assessment
;
Pediatrics
;
Seizures

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