OBJECTIVE: To summarize the research progress on the mechanism related to traumatic brain injury (TBI) to promote fracture healing, and to provide theoretical basis for clinical treatment of fracture non-union. METHODS: The research literature on TBI to promote fracture healing at home and abroad was reviewed, the role of TBI in fracture healing was summarized from three aspects of nerves, body fluids, and immunity, to explore new ideas for the treatment of fracture non-union. RESULTS: Numerous studies have shown that fracture healing is faster in patients with fracture combined with TBI than in patients with simple fracture. It is found that the expression of various cytokines and hormones in the body fluids of patients with fracture and TBI is significantly higher than that of patients with simple fracture, and the neurofactors released by the nervous system reaches the fracture site through the damaged blood-brain barrier, and the chemotaxis and aggregation of inflammatory cells and inflammatory factors at the fracture end of patients with combined TBI also differs significantly from those of patients with simple fracture. A complex network of humoral, neural, and immunomodulatory networks together promote regeneration of blood vessels at the fracture site, osteoblasts differentiation, and inhibition of osteoclasts activity. CONCLUSION TBI promotes fracture healing through a complex network of neural, humoral, and immunomodulatory, and can treat fracture non-union by intervening in the perifracture microenvironment.
Humans ; Fracture Healing/physiology* ; Brain Injuries/metabolism* ; Brain Injuries, Traumatic ; Fractures, Bone ; Osteogenesis

BACKGROUND:The remediation and treatment of bone defects present considerable challenges,with a variety of clinical intervention strategies available.One such approach,the Masquelet technique,has demonstrated high rates of success and reliable outcomes and is currently employed in clinical practice.However,the underlying mechanisms of this technique remain incompletely understood,and certain challenges persist in its clinical application,indicating that this technique is not yet fully mature. OBJECTIVE:To compile and categorize the biomaterials currently employed in research aimed at improving the Masquelet technique,in order to provide insights and references for the further development of this technique. METHODS:A literature search of the China National Knowledge Infrastructure and PubMed databases was conducted,spanning publications from January 2013 to November 2022.The search terms used included"Masquelet technique;induced membrane technique;induced membrane;biomaterial;bone defect"in both Chinese and English.A total of 58 articles meeting the inclusion criteria were reviewed. RESULTS AND CONCLUSION:(1)The emergence and continual development of the Masquelet technique provide a therapeutic strategy for treating bone defects.Some researchers are focusing on developing superior spacer materials,autograft substitutes,and membrane materials that mimic the properties of the induced membrane,to simplify the two-stage procedure,shorten treatment duration,and reduce patient distress.(2)Calcium sulfate,silicone,poly(lactic-co-glycolic acid),and polypropylene can replace polymethylmethacrylate bone cement to form induced membranes in animal experiments or clinical applications,each with their advantages.Contrary to expectations,common materials such as titanium and polyvinyl alcohol sponge cannot replace polymethylmethacrylate bone cement.(3)Autograft substitutes are diverse,with allograft bone,β-tricalcium phosphate,absorbable gelatin sponge,α-calcium sulfate hemihydrate,bioactive glass,titanium,and tantalum demonstrating their ability to reduce the quantity of autologous cancellous bone graft required in the second stage of the procedure.Among them,allograft bone,β-tricalcium phosphate,bioactive glass,titanium and tantalum can replace autogenous bone as grafts,and other materials need to be mixed with autogenous bone,in both clinical and fundamental experiments.(4)Biomimetic-induced membranes,human amnion,human decellularized dermis,polytetrafluoroethylene,and even autogenous cortical bone have been shown to possess properties similar to the induced membrane.(5)Most of the application and research of biomaterials in this technology still exist in the stage of basic research and have not been applied in clinical practice or popularized on a large scale,but the above materials can provide more sufficient theoretical basis and new ideas for the exploration of Masquelet technical mechanism,the improvement of surgical methods and clinical application.

The surveillance data of new cases of acute myocardial infarction (AMI) from January 1, 2013, to December 31, 2021, in Tengzhou City, Shandong Province, were used to analyze the incidence rate of AMI and its change trend among residents. The age and gender standardized incidence rate was calculated based on the 7th National Population Census 2020. The Cochran-Armitage trend test was used to analyze the trend of onset time and age. From 2013 to 2021, the crude and standardized incidence rate of total AMI in Tengzhou City declined from 130.07/100 000 and 161.12/100 000 to 76.15/100 000 and 72.77/100 000 ( Z=-13.785 and -20.822, both P<0.001). The crude and standardized incidence rates of males were higher than those of females. In 2016, males aged 45-54 years old and females aged 35-64 years old increased by 33.33%, 103.65%, 106.30%, and 95.75% compared to 2015, and the differences were statistically significant ( χ2=6.512, 4.965, 25.115, and 46.004, all P<0.05). The incidence rate of AMI in men aged<35 and 35-44 years old had an upward trend. From 2013 to 2021, the incidence rate of AMI decreased by 55.15% in urban areas and 36.59% in rural areas ( Z=-8.529 and -11.235, both P<0.001).

The surveillance data of new cases of acute myocardial infarction (AMI) from January 1, 2013, to December 31, 2021, in Tengzhou City, Shandong Province, were used to analyze the incidence rate of AMI and its change trend among residents. The age and gender standardized incidence rate was calculated based on the 7th National Population Census 2020. The Cochran-Armitage trend test was used to analyze the trend of onset time and age. From 2013 to 2021, the crude and standardized incidence rate of total AMI in Tengzhou City declined from 130.07/100 000 and 161.12/100 000 to 76.15/100 000 and 72.77/100 000 ( Z=-13.785 and -20.822, both P<0.001). The crude and standardized incidence rates of males were higher than those of females. In 2016, males aged 45-54 years old and females aged 35-64 years old increased by 33.33%, 103.65%, 106.30%, and 95.75% compared to 2015, and the differences were statistically significant ( χ2=6.512, 4.965, 25.115, and 46.004, all P<0.05). The incidence rate of AMI in men aged<35 and 35-44 years old had an upward trend. From 2013 to 2021, the incidence rate of AMI decreased by 55.15% in urban areas and 36.59% in rural areas ( Z=-8.529 and -11.235, both P<0.001).

This article reports a rare case of proliferative glomerulonephritis with monoclonal immunoglobulin deposits. The patient, a middle-aged woman, exhibited clinical manifestations including nephrotic syndrome, microscopic hematuria, renal insufficiency, hyperglycemia, and bilateral diabetic retinopathy. Notably, monoclonal bands were absent in both blood and urine immunofixation electrophoresis. Renal biopsy revealed membranoproliferative glomerulonephritis, with immunofluorescence revealing exclusive petal-like deposition of IgG3 subtype along the capillary loop. Electron microscopy demonstrated segmental thickening of the glomerular basement membrane, along with electron dense deposits in the subendothelial and mesangial areas, lacking discernible substructure. The diagnosis comprised proliferative glomerulonephritis with monoclonal immunoglobulin deposition concurrent with diabetic nephropathy. Subsequent sequential treatment with daratumumab and cyclophosphamide over 6 months led to partial remission of nephrotic syndrome, normalization of renal function, and significant improvement of anemia. During the 24-month follow-up period, no serious adverse reactions occurred.

Objective:To analyze categories and different classification characteristics of emotional intelligence among community nurses through potential profile to explore its relationship with sense of career success.Methods:Using the convenient sampling method, a total of 380 nurses from 4 community health service centers in Beijing were selected as the research objects from April to May 2019. The general information questionnaire, Emotional Intelligence Scale and Sense of Career Success Scale were used to investigate them. MPlus 7.0 software was used to analyze the latent class of emotional intelligence among community nurses and SPSS 19.0 software was used to analyze the relationship between emotional intelligence and sense of career success.Results:A total of 380 questionnaires were distributed, 352 valid questionnaires were recovered, and the effective recovery rate was 92.63%. The latent class analysis showed that the emotional intelligence of community nurses had obvious classification characteristics, supporting 3 potential category models ( P<0.01) , namely self-awareness, intermediate and negative response. Logistic regression analysis showed that cooperation satisfaction and nurse-patient satisfaction were the influencing factors of self-perceived emotional intelligence of community nurses ( P<0.05) ; children was the influencing factor of intermediate emotional intelligence ( P<0.05) . There were positive correlation between the total score and scores of all dimensions of emotional intelligence and sense of career success score of community nursing staff ( P<0.01) . There were statistically significant differences in the total score of sense of career success and the scores of all dimensions of community nursing staff of different potential categories ( P<0.01) . Conclusions:Emotional intelligence is related to sense of career success of community nursing staff. Managers can promote the transformation of emotional intelligence from negative reaction type to self-awareness type through targeted measures.

Objective:To explore the effects of comprehensive reform of separation of medicine and pharmacy on intent to stay, perceived professional benefit and job satisfaction among nurses so as to provide a theoretical basis for stabilizing nursing team under the new situation of medical reform.Methods:This study was a cross-sectional survey. We selected 600 nurses and 300 inpatients from on one ClassⅡ hospital and two ClassⅢ hospitals in Beijing in June 2017 (before comprehensive reform of separation of medicine and pharmacy) and June 2018 (after comprehensive reform of separation of medicine and pharmacy) as the research objects by convenience sampling. All research objects were investigated with the General Information Questionnaire for Nurses, Questionnaire for Nurse Intention to Remain Employed, Nurses' Perceived Professional Benefits Questionnaire, Job Satisfaction Survey and the Inpatients' Satisfaction with Nursing Job Satisfaction Questionnaire. In June 2017, a total of 600 nurse questionnaires were distributed, and 589 valid questionnaires were recovered with a recovery rate of 98.17%; 300 patient questionnaires were distributed, and 295 valid questionnaires were recovered with a recovery rate of 98.33%. In June 2018, a total of 600 nurse questionnaires were distributed, and 586 valid questionnaires were recovered with a recovery rate of 97.67%; 300 patient questionnaires were distributed, and 296 valid questionnaires were recovered with a recovery rate of 98.67%. We compared the intent to stay, perceived professional benefit and job satisfaction of nurses and patients' satisfaction with nursing work before and after medical reform.Results:After the comprehensive reform of separation of medicine and pharmacy, the score of intent to stay, total scores of perceived professional benefit and job satisfaction were (3.49±0.65) , (130.49±18.23) and (85.76±3.77) respectively among 586 nurses; among 296 patients, the total score of their satisfaction with nursing work was (96.52±2.01) ; those scores were higher than those before reform with statistical differences ( P<0.05) . Conclusions:The implementation of comprehensive reform of separation of medicine and pharmacy has increased the satisfaction of patients with nursing work to a certain extent, and at the same time has increased nurses' intent to stay, perceived professional benefit and job satisfaction which is conducive to the stability of the nursing team and the improvement of the quality of nursing services.

Objective? To explore the current situation of intention to stay and its influencing factors and to analyze the correlations and interactions among resilience, perceived professional benefits and intention to stay. Methods? Cross-sectional survey was used in this study. In June 2017, we selected nurses from three general hospitals of aerospace system as respondents by convenience sampling. All of the nurses were investigated with the general information questionnaire, Nurses' Job Retention Questionnaire, Questionnaire of Nurses' Perceived Professional Benefits and Connor-Davidson Resilience Scale (CD-RISC). A total of 600 questionnaires were sent out and 589 valid questionnaires were collected with 98.17% for the valid recovery rate. The data were analyzed with the Pearson correlation, multiple stepwise regression and mediating effect. Results? Among 589 nurses the total scores of intention to stay, perceived professional benefits and resilience were (3.28±0.58), (128.85±17.48) and (86.55±12.11) respectively. There were statistical differences in the scores of intention to stay among nurses with different ages, authorized sizes, job title, length of care time, operating hours, self-health conditions and burdens of family (P＜ 0.05). Pearson correlation showed that nurses' resilience and perceived professional benefits had positive correlations with the intention to stay (r=0.387, 0.557;P＜0.05). Multiple stepwise regression showed that the five main influencing factors of nurses' intention to stay included health condition, nursing years, positive perceived profession, team sense of belonging and tenacity which explained 35.3% of the variance of nurses' intention to stay. Nurses' resilience had a partial mediation effect between perceived professional benefits and intention to stay with 12.43% for the effect value. Conclusions? Nurses' intension to stay is in a medium level which influenced by many factors. Nursing managers can increase nurses' intension to stay by improving nurses' perceived professional benefits and resilience.

Objective? To review the meta-analysis of lifestyle risk factors for Alzheimer disease in order to find out the quality of the current articles and to provide evidence for preventing Alzheimer disease. Methods? CNKI,Wanfang,CBM,PubMed、EMBASE、ProQuest、Cochrane Library were searched on computer for Meta-analyses in lifestyle risk factors of Alzheimer disease. Two authors independently selected the articles,extracted data,and used JBI to evaluate the quality of literature system evaluation and the evaluation method of meta-analysis evidence grade for methodological and evidence quality evaluation. Results? A total of 34 articles were included which involved smoking,alcohol consumption,exercise,social activities,sleep, diet,coffee/tea. Among them, the effects of smoking and drinking alcohol and coffee/tea need further support by evidence. Conclusions? Intervention on lifestyle can be effective in preventing Alzheimer disease,however, more high quality original studies are needed to explore more risk factors of Alzheimer disease.