Artificial intelligence (AI) in medicine has gained a lot of momentum in the last decades and has been applied to various fields of medicine. Advances in computer science, medical informatics, robotics, and the need for personalized medicine have facilitated the role of AI in modern healthcare. Similarly, as in other fields, AI applications, such as machine learning, artificial neural networks, and deep learning, have shown great potential in andrology and reproductive medicine. AI-based tools are poised to become valuable assets with abilities to support and aid in diagnosing and treating male infertility, and in improving the accuracy of patient care. These automated, AI-based predictions may offer consistency and efficiency in terms of time and cost in infertility research and clinical management. In andrology and reproductive medicine, AI has been used for objective sperm, oocyte, and embryo selection, prediction of surgical outcomes, cost-effective assessment, development of robotic surgery, and clinical decision-making systems. In the future, better integration and implementation of AI into medicine will undoubtedly lead to pioneering evidence-based breakthroughs and the reshaping of andrology and reproductive medicine.

Male infertility (MI) and male sexual dysfunction (MSD) can often coexist together due to various interplay factors such as psychosexual, sociocultural and relationship dynamics. The presence of each form of MSD can adversely impact male reproduction and treatment strategies will need to be individualized based on patients’ factors, local expertise, and geographical socioeconomic status. The Asia Pacific Society of Sexual Medicine (APSSM) and the Asian Society of Men’s Health and Aging (ASMHA) aim to provide a consensus statement and practical set of clinical recommendations based on current evidence to guide clinicians in the management of MI and MSD within the Asia-Pacific (AP) region. A comprehensive, narrative review of the literature was performed to identify the various forms of MSD and their association with MI. MEDLINE and EMBASE databases were searched for the following English language articles under the following terms: “low libido”, “erectile dysfunction”, “ejaculatory dysfunction”, “premature ejaculation”, “retrograde ejaculation”, “delayed ejaculation”, “anejaculation”, and “orgasmic dysfunction” between January 2001 to June 2022 with emphasis on published guidelines endorsed by various organizations. This APSSM consensus committee panel evaluated and provided evidence-based recommendations on MI and clinically relevant MSD areas using a modified Delphi method by the panel and specific emphasis on locoregional socioeconomic-cultural issues relevant to the AP region. While variations exist in treatment strategies for managing MI and MSD due to geographical expertise, locoregional resources, and sociocultural factors, the panel agreed that comprehensive fertility evaluation with a multidisciplinary management approach to each MSD domain is recommended. It is important to address individual MI issues with an emphasis on improving spermatogenesis and facilitating reproductive avenues while at the same time, managing various MSD conditions with evidence-based treatments. All therapeutic options should be discussed and implemented based on the patient’s individual needs, beliefs and preferences while incorporating locoregional expertise and available resources.

Background: This study was conducted on 93 volunteers with type 2 diabetes to investigate the ability of acetylated wheat starch cake containing 32.1% resistant starch to control postprandial blood glucose levels. Material and methods: The study was designed using a crossover, double-blind trial method. During each testing day, after a minimum of 12 hours of overnight fasting, each participant consumed two identical cakes containing either 80 g of acetylated wheat starch or 80 g natural wheat starch with 330ml of water within 15 minutes. Blood glucose levels were measured at baseline, 60 mins (G1), and 120 mins (G2) after ingestion. The predictive value of factors that contribute to the ability of resistant starch to control postprandial blood glucose was determined by the area under the receiver operating characteristic (ROC) curve based on the combined effect of the cake weight-to-BMI ratio (g/m²BMI) and HbA1c. Results: 60 mins and 120 mins postprandial capillary glucose levels after consuming acetylated wheat starch cake (10.4 ± 1.2 và 9.2 ± 1.2 mmol/L, respectively) were significantly lower compared with natural wheat starch cake (13.3 ± 1.8 và 11.2 ± 1.8 mmol/L, respectively) (p < 0.05). For good control of postprandial blood glucose levels, a maximum of 80 g of acetylated wheat starch can be used per serving for patients with type 2 diabetes with HbA1c ≤ 7.25 without blood glucose-lowering medication is required. Conclusion: acetylated wheat starch has better ontroled of postprandial blood glucose compared with natural wheat starch in patients with type 2 diabetes. This is very suitable in the processing of diets including resistant starch for patients with type 2 diabetes for the purpose of both supporting treatment and improving quality of life.

Background: Currently, there is a lack of guidance on selecting the optimal method for optimizing the AV interval. Objective: To evaluate the technical characteristics of His bundle pacing and compare relation optimal ventricular conduction intervals using cardiac catheterization and echocardiogram. Method: Interventional prospective study. Result: A total of 56 patients underwent His bundle pacing (HBP) with a success rate of 78.5%. The average age was 57.8 ± 19.25, and 68.1% (30 cases) were female. Selective His pacing and non-selective respectively was successfully achieved in 22 out of 44 cases (50%) and 95.4% with pacing threshold was measured at an average of 0.82 ± 0.38 volts and 1.37 ± 0.83 volts with a pulse width of 1ms. The accuracy comparing AV optimization varied in the following order: VTImitral valve > VTIaortic valve > DFTmitral valve for AVsense optimization and VTImitral valve > DFTmitral valve > VTIaortic valve for AVpace optimization. After AV optimization, myocardial contractility increased by an additional 18.6% for AVsense and 26% for AVpace. Conclusion: His bundle pacing procedure success rate of 78.5%. AV optimization results enhancement in left ventricular contractility from 18.6 to 26%.

Background: Fragile X Syndrome (FXS) is the most common cause of inherited mental retardation. The absence of Fragile X Mental Retardation (FMRP) in Fragile X syndrome changes other proteins. Objective: To detect changes of glycoprotein in human serum of Fragile X syndrome. Subject and methods: Affinity chromatography with lectin concanavalin A (ConA) used to receive glycoprotein. The collected glycoprotein was then separated using 2-D electrophoresis. The protein spots were further excised, trypsin digested, and analyzed by nano LC couple with ESI-MS/MS and identified by MASCOT v1.8 software. Results and conclusion: 5 glycoproteins showed the different expression levels in the serum of Fragile X syndrome. Haptoglobin, Ig-J were increased and ceruloplasmin, transferring, Ig kappa were decreased. Using affinity chromatography with lectin concanavalin A (ConA), glycoprotein was received and divided on 2 ways electrokinetic chromatography. The mixture protein was identified with a reliability of 99.5% by 2 ways liquid chromatography combined with continuous spectrum mass.
Fragile X syndrome ; Fragile X Mental Retardation ; proteomics

Background: Effect of salbutamol nebulization in the treatment of acute bronchiolitis in infants is contraverse. Objectives: This study aims to evaluate effect of salbutamol nebulization in infants with bronchiolitis. Subjects and method: Patients were divided into two groups. Treatment group was given salbutamol nebulization with dose of 0.15mg/kg/time, with 2ml sodium 0.9%, 2 times with 30 minute interval and control group. Indicators including Sa02, heart rate and respiratory rate were measured before and after nebuliser of salbutamol. These indicators were compared at times before nebulizing (T1) and after 15 minute (T2), 30 minute (T3), 60 minute (T4). Clinical trends and mean treatment days were compared between two groups. Results: There were 80 infants under 1 year old with bronchiolitis studied from July 2004 to July 2005. Of whom, there were 53 (66.3%) male and 27 (33.7) female. Mean age was 5.4 \xb1 2.69 months. There were 59 infants with mild and moderate forms and 21 infants with severe one. There were 47 infants treated by salbutamol nebulization and 33 infants in the control group. No significant difference of clinical trends and avarage treatment days were found between two groups. Conclusion: Salbutamol nebulization showed no effect on the treatment of acute bronchiolitis in infants.
Bronchiolitis/ therapy ; Albuterol/ diagnostic use

Backgound: Plague disease is one of three most seriously infectious diseases (plague, yellow fever and cholera disease). In Vietnam, this condition has been obviously controlled. The number of new cases and deaths of plague disease have decreased significantly: from 439.6 patients between 1991 and 1995 to 161.2 patients between 1996 and 2000. However, the disease is still circulating in some areas in the world. Objective: To survey plague disease related factors (rats and fleas) at Noi Bai international airport. Subjects and method: A surveillance to inspect plague disease related factors (rats and fleas) was conducted at Noi Bai international airport, Ha Noi, from January/2006 to December/2006. Results and Conclusion: There were two types of rats: R. flavipectus in majority and R. norvegicus. The enrichment index of the two kinds of rats had increased in April and May. R. flavipectus disposed at flat form T1 and R. norvegicus disposed at store area. The only flea species found at the surveillance site was X.cheopis. Bacterial isolation of 236 specimens of liver and spleen, and ELISA tests of 180 blood samples were performed. All of the specimens were negative to Yersinia pestis. The study suggests that the rat populations at Noi Bai airport have not been infected with Yesinia pestis.
Plague/ epidemiology ; pathology ; Siphonaptera/ pathogenicity ; Rats ;

Direct interview 48 doctors and nurses working in 18 district hospitals of 3 provinces Nam Dinh, Hai Duong, Ha Tay. 78.4% of them had examined and prescribed following guidelines of acute respiratory infection (ARI) programme 99.2% of children were prescribed with only one kind of antibiotic. There were 44.5% cases using antibiotics with incorrect indication. 26.1% of antibiotic prescriptions were completely suitable. There were 81% cases to be used one kind of antibiotic. Conclusion: doctors working in district hospitals have high knowledge on guidelines of ARI programme, but they still do not believed the guidelines fully. Overuse of antibiotics and vitamins are common in practice in prescribing for ARI children
Respiratory Tract Infections ; Knowledge ; Attitude

Studying 50 children under 15 years of age (28 boys, 22 girls) with asthma treated at pediatric department of Bach Mai hospital from September 2003 to October 2004. Most patients were less than 5 years old (78%). There were only 2% of children under 1 year of age. The disease rate in boys was more common than in girls (56% vs. 44%). Fever, retraction of respiratory muscles, irritable, fast breathing occurred in children under 5 years more than in children over 5 years old. White blood cells rate increased in children < 5 years. Images of air exceed on chest X-ray were observed in two third of cases and the same in two age groups
Asthma ; Child

The cross-sectional research on disease pattern of 1846 children was conducted in kindergartens, primary and secondary schools in a commune of Ha Tay province during the last two weeks of August 2004 showed that the rate of children having at least one disease was 24.5%. Out of those, the disease rate of children from 5 to 10 years old was highest (33.9%) and lowest disease rate was group of children from 10 to 15 years old (17.3%). The disease rate of male was higher than female in all three age groups (30.9% in male compared with 18.3% in female). According to International Classification Diseases (ICD10), endocrine, nutritional and metabolic diseases have highest rate (23.19%). Followed by respiratory diseases (14.62%) and digestive diseases (14.19%). Other disease groups and abnormal clinical and laboratory findings classified in chapter XVIII 0.87%, in chapter I 0.76%, diseases in chapter XIV and XVII 0.49%, in chapter XII 0.44%,in chapter III 0.27%, in chapter V 0.10% and in chapter IX 0.05%
Child ; Disease