1.Kawasaki Disease: Highlighting Importance of Laboratory Criteria and Minor Atypical Features of This Enigmatic Entity- A Case Series
Ashish Gupta ; Deepa Shreyas ; Dinesh M Nayak ; Ramya Nayak
Malaysian Journal of Medicine and Health Sciences 2022;18(No.1):337-340
Introduction: Kawasaki disease (KD) is an acute febrile illness of unknown etiology that primarily affects children
younger than 5 years of age. The diagnosis is predominantly clinical and at times difficult, due to the absence of any
confirmatory and specific diagnostic test. Early diagnosis of this disease is of paramount importance due to long term
cardiovascular complications related to coronary artery aneurysm. Literature search has revealed many atypical presentations of Kawasaki disease not fulfilling the clinical diagnostic criteria. The reason for this could be the diversity
in clinical manifestations involving gastrointestinal, endocrinal, musculoskeletal and nervous system. Case Series:
Here we describe three cases with non-classic presentation of Kawasaki disease. These three cases presented with
persistent fever unresponsive to antibiotics. Two cases (case one and three) later developed perianal rash and peeling
that helped in early diagnosis. In the remaining case (case two) sequential appearance of features helped in the establishment of diagnosis. It was interesting to note that all the three cases were having identical laboratory parameters,
highlighting the importance of laboratory investigations in case of atypical presentation. Conclusion: This case series
culminates the importance of keeping the possibility of atypical Kawasaki disease (KD) as one of the differentials in
patients with prolonged fever not responding to antibiotics, in the absence of classical diagnostic criteria.

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