1.Study on peripheral nerves and location of the moxibustion points on vertebra
Choijamts G ; Amarsanaa J ; Uuvanbaatar B
Diagnosis 2024;110(3):30-34
Background:
According to the theory of traditional medicine, there are 19 active veins that pierce down from the brain stem like a root, through which the lhung runs and performs the movement of the body. It is believed that the water veins or white veins exist in all four limbs and solid organs and play an important role in regulating the body's activities by lhung action, while in traditional medicine, the nervous system regulates the activities of all organ systems and ensures the unity of the body's activities and adapts to the external environment. It is considered as a system that creates conditions for the body to interact as a whole, and moxibustion is a treatment that provides beneficial therapeutic changes to the diseased organ through the arc of reflection. Purpose
Purpose :
Establishing importance of moxibustion treatment and coherence of moxibustion points and peripheral nerve fibers.
Survey Methodology:
Data collection method: 31 pairs of neurological terms from European and traditional medical books and texts, judge which organs to go to for innervation and the degree of branching of white veins and summarize the translated material
Comparative method:
To develop results by comparing the data collected from the literature and sources of traditional medicine and European medicine which are the main materials of this research
Research results:
The 13 inner and 6 outer veins from the white vein were filtered from traditional medical commentaries and compared with the peripheral nerve branches of the spinal cord medicine. Compared with nerve, nerve branches from the anterior horn of the spinal cord, including the shoulder, lumbar were compared with 6 fibers running outside, and from the nerve branches from the shoulder where N. medialis, N. radialis, and N. ulnaris nerves were located and branched. According to the comparison of jajid, and Radna veins, the N. femoralis nerve coming from the lumbar with internal branches of the Vugujin vein, and the N. sciaticus or sciatic nerve coming from the lumbar were compared depending on the location of the outer branches of the Vugujin nerve and the end of the branching.
Studied how the nerves branching out from the main 20 junctions located in the posterior confluence of moxibustion therapy, and in doing so, compared the spinal nerve and vegetative nerve branches that exit from the confluence separately and assigned their locations. It is considered the feature of forming a network and separating from it to go to the innervation organ.
Conclusion
The white veins have 13 inner veins, outer veins 6, and the inner veins are 4 lhung veins, 2 heart, 2 in the small intestine, the 4 tripa (tiba) veins are in the lungs, colon, liver, and gallbladder, and the 4 badkan veins are in the stomach, spleen, kidney, bladder veins connects with vesicle of regeneration. It is mentioned in the majority of texts that it will connect with also vesicle of regeneration, but there are differences in two sources saying that 2 veins of lhung 2 in large intestine, 1 vein of badkan connects with lungs, and the 13 branches of white veins correspond to the organs innervating the vagus nerve in the medical theory. The branch of the nerve that connects with the back points of moxibustion is connected with the branch of the nerve from the anterior horn of the spinal cord, the ganglion of the sympathetic nerve from the external horn and its branches. It is considered more important to consider the branching of nodes.
2.Effect of “shilajit+golden rosa” or vitos preparation on immune response cells (CD4, CD8, IGG, CD64) by azathioprine induced immunosuppression in mice
Batchimeg B ; Davaasambuu T ; Badamtsetseg S ; Bayanmunkh A ; Odongerel A ; Tsetsegmaa S ; Choijamts G ; Lkhagva L ; Khurelbaatar L
Mongolian Pharmacy and Pharmacology 2022;20(1):39-44
Introduction:
During many decides, compounds derived from natural raw materials have demonstrated their effectiveness as therapeutic agents in different areas, such as metabolic disorder, immune system diseases and its regulations. Natural based products, like herbal medicines and minerals are implicated in the regulation of immune function. They control the immune system in a pleiotropic manner and participate in various processes of the adaptive/innate immunity. Therefore, natural raw material has great potential for targeted immune modulators, in the treatment of certain types of immunologic and inflammatory diseases, like rheumatoid arthritis, plaque psoriasis, ankylosing spondylitis and immune deficiency. The purpose of this survey was to study influence of “Shilajit +Golden Rosa” combined shot preparation named by Vitos on immune system in the experimental and preclinical circumstances.
Goal:
The purpose of this survey was to study influence of “Shilajit +Golden Rosa” Vitos shot preparation
on immune system in the experimental and preclinical circumstances.
Material and Methods:
The immune deficiency was to created by Azathioprine through 5 days in the Balb/c mice after that control group, preparation of “Shilajit +Golden Rosa” Vitos shot were administrated appropriate doses by oral during 10 days. Then we collected blood and quantified amount of CD4+, CD8+, IgG and CD64 (Mouse Elisa Kit Assay: Catalog.No:WAM-568, Elisa Reader, 450 нм, Melsin Medical Co.LTD, www. melsin.com) on the 5th, 10th days.
Results:
All statistical analyses were conducted with SPSS version 20.0 software (IBM, Armonk, NY). Oneway ANOVA was used to assess statistical significance between “Shilajit +Golden Rosa” Vitos shot group and days of observation. Mean values of CD4+, CD8+, CD4/CD8 ratio, IgG, CD64 levels determined in the control and sample group. CD4+, CD8+, CD4/CD8 ratio, IgG and CD64 levels were significantly increased in the “Shilajit +Golden Rosa” Vitos shot group compared with control group by 20.8-67.8 per cent (p<0.05, p<0.01).
Conclusion
It’s concluded that, “Shilajit +Golden Rosa” Vitos shot preparation shows immune-stimulator activity not only in the level of cellular (T cells:CD4+, CD8+) but also humoral immunity (B cells: IgG, CD64) in the previously using Azathioprine (75mg/kg) to provoke pathological model of immunosuppression
3.The result of pharmacological studies on traditional medicine Chun-7
Davaasambuu T ; Munkh-Erdene R ; Batchimeg B ; Enkhzul T ; Tsedensodnom Ch ; Bayanmunkh A ; Khandmaa D ; Choijamts G ; Tsetsegmaa S ; Lkhagva L ; Khurelbaatar L
Mongolian Pharmacy and Pharmacology 2022;21(2):35-40
Abstract:
CHUN-7 a Mongolian traditional recipe consisting of 7 medicinal plants is described in the scripture named “༆༆ །།གཡུ་ཐོག་པའི་མཛད་པའི་རིམས སྲུང་ཁྱུ་ལྔ་རྒྱམ་ཏོན་གསལ་བ །།”. The ingredients including Caowu (Radix
Aconiti kusnezoffii, CW) and Glehniae Radix (GR) have the effects of suppressing pneumonia, viral pneumonia, relieving pain, stimulating the immune system and reducing fever. The present study was aimed to determine acute and chronic toxicity properties of traditional drug.
Materials and methods:
CHUN 7 traditional drug were prepared in the traditional medicine sector of the Drug research Institute of Monos group. All WISTAR rats were kept in the same feed, under 12 hours lighting and 12 hours darkness housing. The study of acute and chronic toxicity of CHUN-7 traditional drug was studied by using IP and oral administration were performed on ten WISTAR rats and continued for a total of 28 days with 102.9 mg / kg dose (calculated from human dose: 16.7 mg/kg) in accordance with the WHO General Guidelines for the Evaluation and Study of Traditional Medicine.
Results:
The result showed no structural changes in the internal organs according to tissue morphology when we administrated CHUN-7 traditional drug.
Conclusion
This study showed CHUN-7 traditional drug has no toxic effects to internal organs including liver, kidney, stomach, lungs and heart. Therefore, CHUN-7 traditional drug has potential to use orally without any toxicology.
4.Result of nephroprotective effect of aqueous extracts of Iris Tenuifolia Pall and Iris Lactea Pall
Sosorburam B ; Davaasambuu T ; Oyunchimeg B ; Bayanmunkh A ; Choijamts G ; Lkhagva L ; Khurelbaatar L
Mongolian Pharmacy and Pharmacology 2019;14(1):12-18
Background:
Iris Tenuifolia and Iris Lactea known for its various medicinal properties are
also a natural antichloristic and a kidney protective as agent.
Goal:
To evaluate the nephrite activity of aqueous extract of Iris Tenuifolia and Iris Lactea in
a rodent model of kanamycin induced nephrotoxicity.
Materials and Methods:
In the experimental design, thirty-six Wistar rats were randomly isolated into four groups of one control and three experimental. Nephrotoxicity in rats induced by intramuscular injection of Kanamycin {250 mg/kg) daily for 5 days5. The doses of 25 mg/kg, 50 mg/kg, 75 mg/kg, 100 mg/kg of aqueous extract of Iris Lactea and dose of 25 mg/kg Iris Tenuifolia Pall were administrated by oral gavages for 14 consecutive days in rats. At 14 days for the rest of them, serum samples were collected for renal function biochemical tests (Creatinine, Creatinine Clearance, Urea UV and GFR-Glomerulus Filtration Rate).
Results:
All statistical analyses were conducted with SPSS version 20.0 software (IBM,
Armork. NY). One-way ANOVA was used to assess statistical significance between experimental
groups and control group. Mean values of creatinine, creatinine clearance, urea UV and GFR levels
determined in the control and experimental groups. Kanamycin treatment caused nephrotoxicity
as evidenced by marked elevation in serum creatinine, creatinine clearance, GFR and urea UV,
Iris Tenuifolia 25 mg/kg blood serum creatinine (62.49±1.24 (38%), 56.38±1.41 (4.5% μmol/L), serum creatinine clearance (4.79±0.16 (45%), (5.80±0.36 (6%) ml/minute), serum GFR (191.6±6.58
(45%). (232±14.65 (5.9%) ml/minute), serum urea UV (8.64±0.63 (9.6%), (8.40±0.07 (20.23%), Iris
Lactea 75 mg/kg blood serum creatinine 68.92±4.08(31%), 58.87±1.95 (0.4% μmol/L), serum creatinine clearance (5.27±0.67(60%), (5.67±0.28(3.6%) ml/minute), serum GFR (210.9±26.78 (60%),
(226.8±11.28 (3.5%) ml/minute), serum urea UV (7.73±0.58 (19.14%), (7.48±0.35 (28.96%) respectively when compared to the control treated groups. Oral administration of Iris Lactea 75 mg/kg extract decreased the rise in these parameters in a dose dependent manner.
Conclusion
Our studies suggest that aqueous extract of Iris Lactea 75 mg/kg and Iris tenuifolia 25 mg/kg results are shown good effect for anti-inflammatory of renal.
5.The role of CD28, CD40, CD45 RO and immunoglobulin G(FcyRI, FcyRII) in expression of T and B cells in mice
Davaasambuu T ; Choijamts G ; Bayanmunkh A ; Lkhagva L ; Khurelbaatar L
Mongolian Pharmacy and Pharmacology 2019;14(1):24-28
Purpose:
In generally, T cell activation evaluates by CD4 +, CD8 +, B cell immunoglobulin's (IgG, IgM,
IgA) in Azathioprine caused secondary immunodeficiency in serum. May it does not make clearly
interpret for regulation of cell-mediated and humoral immune response using interaction T and B
cells. In this review, we discuss the multifaceted roles of cytokines as enhancers and expression of
B and T cell.
Cell-mediated Immunity and Humoral Immunity
Based on the type of immunodeficiency, the types of defects can vary. While some bacterial
infections may be a key feature of B cell and T cell defects are feature of combined T and B cell
immunodeficiency. Also other defects can be cause of phagocytes cell and complement deficiency.
The present study provides evidence special cytokines which are involved to expression of T and B
cells that CD40, IgG, IgM, FcyRII (CD32) need to be define with B cell deficiency, CD40, CD45RO
define combined T and B cell deficiency and FcyRI (CD64), CD45RO define for phagocytes cell deficiency and CD4+, FcyRI (CD32), FcyRI (CD64) define for complement deficiency. In this review,
we have done pharmacological study of immunosuppressant injection which is with Mongolian
Astragalus Mongolicus Bge and determined CD28, CD40, CD64, and CD45 cytokines in the blood
serum of mice. It will be clarifying the immune system interaction between cell-mediated immunity
and humoral immune for T cells and B cell interactions.
6.STUDY OF “AKHIZUNBER” SOLUTION FOR THE TREATMENT OF INFLAMMATORY ORAL STOMATITIS
Urjinlkham J ; Batsuuri M ; Bulgan Ch ; Sapaar B ; Davaadagva D ; Munkhbat S ; Oyunbat B ; Choijamts G ; Bayarchimeg B ; Oyun-Enkh P ; Oyunkhishig Kh ; Nyamsuren E
Innovation 2018;12(4):8-11
ABSTRACT.
Recurrent aphthous stomatitis, or RAS, is common oral disorder of uncertain etiopathogenesis for which only symptomatic therapy is available. This article reviews the current clinical features of RAS among study patients and the result of therapeutic effects of the herbal preparation Akhizunber. Over the past four years we have treated 61 RAS patients with different clinical forms by herbal preparation Akhizunber or Alumekatin. The distribution of clinical forms RAS RAS among study patients were minor aphthae -75.4%, major aphthae -16.4% and herpetiform ulcers -8.2% respectively. The healing time of treated Akhizunber was in minor aphthae -9.28±4.82 days, major aphthae -14 days and herpetiform ulcers -12 days. Of the total study participants, the patients treated by Akhizunber reported a rapid and complete recovery from RAS during treatment compared with treated patients by Alumekatin. Treatment with herbal preparation Akhizunber can be effective for patients suffering from RAS in any clinic form, regardless of their ulcer number and size.
7.Impact of vegetative preparation of Saposhnikovia divaricata (Turcz) Schischk) in collagen induced arthritis
Gundegmaa Ts ; Chimedtseren S ; Batbaatar G ; Choijamts G
Mongolian Medical Sciences 2015;173(3):36-38
BACKGROUND: 70-80% of the world’s population uses herbal therapy and drug preparations of traditional medicine for health and first aid treatment [1]. SDS is used for relieving fever and also used as an anti-inflammatory medicine.1-2 It is also used in the treatment of cancer and infectious disease in Eastern and Chinese medicine. It is important to study the pharmacological actions and do a genome study in order to use natural resources wisely and to access biological effects on the plant.
AIM: The study of the herbal preparation Saposhnikovia Divaricata on joint inflammation
MATERIALS AND METHODS: All the experimental procedures and protocols used in the study were reviewed and approved by the Bio-Medical Ethical Committee of Mongolian National University of Mongolia. A dry extract of SDS is root was prepared by the lyophilization method and used in the study. CIA pathology model were determined by the David D Brand (2005) method. Statistical Analysis: Statistical analysis of data was performed by SPSS 16.0 program and analyzed statistically using criteria of Student t test.
RESULTS: As a result the treatment group of mice with the use of the drug Saposhnikovia divaricata and groups of mice were treated with sodium salicylate, the body weight of mice increased significantly, and histological signs of inflammation were pronounced. In the mice of the control group who did not receive treatment, body weight decreased significantly, and histological signs of inflammation of the joints were expressed significantly.
CONCLUSION: Preparation of Saposhnikovia divaricata decreased inflammation of arthritis.
8.Study result of SDS (saposhnikovia divaricata) preparation in lipid peroxidation in the process effects on kanamycin-induced nephrotoxicity in rats
Gundegmaa Ts ; Davaasambuu T ; Chimgee Ts ; Bayanmunkh A ; Choijamts G
Mongolian Medical Sciences 2015;173(3):39-43
BACKGROUND: A recent day is one of a rare drug plant, which use in traditional medicine a long time ago. Therefore based on nature resource of traditional medicine, on the base of evaluating pharmacological and biological action to develop a new drug of plant origin is important not only for treatment, but also has a economic significance. This plant has profound medicinal use and is a proved antipyretic, analgesic anti inflammatory and anti-cancer. No detail report was found in literature to evaluate renal damage experimentally in rats. The present study was hence designed to determine protective effect (Saposhnikovia divaricate (Turcz) Schischk) kanamycin-induced nephrotoxicy in rats. In addition, we attempted to test and compare the possible action of Saposhnikovia divaricate (Turcz) Schischk) kanamycin-induced nephrotoxicity in rats.
MATERIALS AND METHODS:
Experimental animals
A dry extract of SDS is root was prepared by the lyophilization method and used in the study. Threemonth old Wistar albino rats of either sex weighing 150-250 g were used for the study. The animals were placed at random and allocated to treatment groups in polypropylene cages with paddy husk as bedding. Animals were housed at a temperature of 24 ± 2⁰C and relative humidity of 30-70%. A 12/12 h light and dark cycle was followed. All animals were fed on standard balanced diet and provided with water ad libitum. All the experimental procedures and protocols used in the study were reviewed and approved by the Bio-Medical Ethical Committee of Mongolian National University of Mongolia.
Biochemical estimation
At the end of experimental period, rats were anaesthetized with ether. The pathological model of kidney we use lipid peroxidation in the process of kidney inflammation kidney tissue, blood serum, erythrocyte MDA of membrane amount on 3, 7, 14 day by using spectrophotometer apparatus of “Shimadzu” firm of Japan and measured absorption at 535 nm.
Statistical Analysis: Statistical analysis of data was performed by SPSS 16.0 program and analyzed statistically using criteria of Student t test.
RESULTS: When we studied effect of extract of SDS preparation to condition of lipid peroxidation activation in the process of kidney inflammation by the indices of MDA which contains in blood plasma and erythrocyte membrane, MDA amount in renal tissue, amount of MDA decreased and it showed effect of decreasing lipid peroxidation MDA of plasma.
CONCLUSION: The extract of Saposhnikoviadivaricata (Turcz) Schischk) has action of protecting kidney and decreasing lipid per oxidation.
9. A C OMPARISON OF SYSTEMIC AND INHALED CORTICOSTEROID THERAPY IN PATIENTS WITH EXACERBATION OF COPD
Odonchimeg P ; Ichinnorov D ; Choijamts G
Innovation 2013;7(3-S):38-43
Objective: To compare the efficacy of systemic and inhaled corticostcroid in patients with acute exacerbation of COPD.Methods: In this randomized, parallel-group study 80 patients (average age 59,7±7.7) were randomized to receive inhaled corticosteroid (fluticasone propionate 1000-1200 meg/daily, n -40) or systemic corticosteroid (intravenous dcxamethasone 4-8 mg every 24 hours, n-40). Outcome variables included the lung function tests (FEV1, FVC, FEV1/FVC), 6MWT, and 1 Symptoms. 2. Activity and 3. Impact components of St George's Respiratory Questionnaire for t OPD patients (SGRQ-C).Results: In group with systemic corticosteroid increased the FF.V1 from 63.5±9 to 68.118.1, FVC from 78.7±11.8 to 86.6±11, FEV1/FVC from 64.918.7 to 69.917.3; score of SGRQ-C improved I.from 58.5114.3 to 31 5ÈË 2. from 60.6116.7 to 37.7117.2, 3.1'rom 44.9+14.5 to 21.5113. In group wi«fi fluticasone propionate increased the FEV1 improved from 64.719 to 68.718.5, FVC from 79.7111.3 to 88.1110.7, and FEV1/FVC from 64.9+8.6 to 69.517.5; score of SGRQ-C I .from 58.5111.1 to 36.4113,0. 2.from 59.9117.2 to 39.1 + 16.8. 3.from 45.7114.7 to 23.5+13.8. The difference in efficacy of treatment in two groups was not significant.Conclusion:I fioth inhaled and systemic GSs improve airflow and lung function test in C'OPI) patients with ^cute exacerbation.2.1 ligh dose of ICSs may be an alternative to systemic corticosteroid in the treatment of non-severe acute exacerbation of COPD.3. Using of systemic and inhaled corticosteroids improve quality of life in COPD patients with acute exacerbation.
10.Diagnosis and treatment principles on adults with community acquired pneumonia in the out of hospital condition
Ulziisaikhan S ; Ichinnorov D ; Ariunsanaa B ; Choijamts G
Mongolian Medical Sciences 2012;159(1):64-72
Abstract. This article refers to the management of adults with community acquired pneumonia (CAP) of all ages in the community or in hospital. Details of general investigations for patients managed in the community and for patients admitted to hospital, treatment in community, hospitals and in intensive care unit, follow up planning, empirical antibiotic choice, duration of antibiotic administration, failure to improve, the level of evidence of recommendations are given in the text and are summarized in figures and tables. Severity assessment is recommended as the key to planning appropriate management both in the community and in hospital. Certain adverse prognostic features have been associated with an increased risk of death and should be assessed in all patients. Patients who have two or more “core” adverse prognostic features are at high risk of death and should be managed as having severe pneumonia. Patients who display no adverse prognostic features can be managed as having non-severe pneumonia and may be suitable for outpatient treatment or early hospital discharge.
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