1.Mapping Brain-Wide Neural Activity of Murine Attentional Processing in the Five-Choice Serial Reaction Time Task.
Yin YUE ; Youming TAN ; Pin YANG ; Shu ZHANG ; Hongzhen PAN ; Yiran LANG ; Zengqiang YUAN
Neuroscience Bulletin 2025;41(5):741-758
Attention is the cornerstone of effective functioning in a complex and information-rich world. While the neural activity of attention has been extensively studied in the cortex, the brain-wide neural activity patterns are largely unknown. In this study, we conducted a comprehensive analysis of neural activity across the mouse brain during attentional processing using EEG and c-Fos staining, utilizing hierarchical clustering and c-Fos-based functional network analysis to evaluate the c-Fos activation patterns. Our findings reveal that a wide range of brain regions are activated, notably in the high-order cortex, thalamus, and brain stem regions involved in advanced cognition and arousal regulation, with the central lateral nucleus of the thalamus as a strong hub, suggesting the crucial role of the thalamus in attention control. These results provide valuable insights into the neural network mechanisms underlying attention, offering a foundation for formulating functional hypotheses and conducting circuit-level testing.
Animals
;
Attention/physiology*
;
Mice
;
Brain/physiology*
;
Male
;
Electroencephalography
;
Reaction Time/physiology*
;
Brain Mapping
;
Mice, Inbred C57BL
;
Choice Behavior/physiology*
;
Proto-Oncogene Proteins c-fos/metabolism*
2.Job Preferences of Centers for Disease Control and Prevention Workers: A Discrete Choice Experiment in China.
Yan GUO ; Han Lin NIE ; Hao CHEN ; Stephen NICHOLAS ; Elizabeth MAITLAND ; Si Si CHEN ; Lie Yu HUANG ; Xiu Min ZHANG ; Xue Feng SHI
Biomedical and Environmental Sciences 2025;38(6):740-750
OBJECTIVE:
This study explored the job choice preferences of Center for Disease Prevention and Control (CDC) workers to provide CDC management information and recommendations for optimizing employee retention and motivation policies.
METHODS:
A discrete choice experiment was conducted in nine provinces across China. Seven key attributes were identified to analyze the job preferences of CDC workers. Mixed logit models, latent class models, and policy simulation tools were used.
RESULTS:
A valid sample of 5,944 cases was included in the analysis. All seven attributes significantly influenced the job choices of CDC workers. Heterogeneity analyses identified two main groups based on different levels of preference for attribute utility. Income-prioritizers were concerned with income and opportunities for career development, whereas bianzhi-prioritizers were concerned with bianzhi and welfare benefits. The policy simulation analysis revealed that income-prioritizers had a relatively higher sensitivity to multiple job preference incentives.
CONCLUSION
Income and bianzhi were the two key attributes influencing the job choices and retention preferences of CDC workers. Heterogeneity in job preferences was also identified. Based on the preference characteristics of different subgroups, policy content should be skewed to differentiate the importance of incentives.
China
;
Humans
;
Male
;
Female
;
Adult
;
Centers for Disease Control and Prevention, U.S.
;
Middle Aged
;
Choice Behavior
;
Career Choice
;
Motivation
3.Analysis on Care Service Preferences of Community Patients With Severe Mental Disorders in Beijing Based on Discrete Choice Experiment.
Jin-Qi ZHU ; Wei LU ; Yu XIN ; Yun CHEN ; Qing-Zhi HUANG ; Jun-Li ZHU
Acta Academiae Medicinae Sinicae 2025;47(3):425-433
Objective To gain insights into the care service preferences and willingness of patients with severe mental disorders in Beijing,analyze the main factors affecting their participation in care services,and provide data support and decision-making reference for the optimal design of care services for patients with severe mental disorders and the improvement of relevant policies.Methods In July 2022,a questionnaire survey was conducted for a part of Beijing community patients with severe mental disorders selected by multi-stage stratified sampling,including the basic personal information and the preferences of discrete choice experiment.A mixed Logit model was used to perform regression analysis on the care service preferences,and the trade off between general and monetary attributes was quantified by willingness to pay(WTP).Results A total of 242 questionnaires were distributed,and 181 valid questionnaires were collected,with a response rate of 74.79%.The regression coefficients for the four attributes-service type,service content,service frequency,and service cost-all showed statistical significance(all P<0.05).Patients' most preferred attribute level was a service frequency covering about 90% of the time per month/year( β=1.059),while the least preferred was full-time residential care( β=-1.025).Increasing the service frequency from 30% to 90% corresponded to a WTP of 492.5 yuan,while changing the service type from home-based care to full-time residential care resulted in a WTP of -476.6 yuan.Moreover,there were differences in care service preferences and WTP among patient groups with different characteristics(all P<0.05).Conclusions Service type,service content,service frequency,and service cost all significantly affect the care service preferences of patients with severe mental disorders.There is heterogeneity in care service preferences among patient groups with different characteristics.
Humans
;
Mental Disorders/therapy*
;
Patient Preference
;
Beijing
;
Surveys and Questionnaires
;
Male
;
Female
;
Choice Behavior
;
Adult
;
Middle Aged
4.Smartphone Usage Influences the Eating Habits of Middle School Students
Soo Jin CHO ; Ji Na KIM ; Soo Jin PARK ; Weon Sun SHIN
Journal of the Korean Dietetic Association 2018;24(3):199-211
This study was a correlation study to analyze the effects of smartphone usage time on food choice perceptions and behavior in middle school students in Seoul areas. The subjects to be surveyed were middle school students attending junior high schools in Mapo-gu, Seoul. A total of 133, 102, and 102 students were in the first second, and third grades, respectively. The usage time of smartphones was the weekday and weekend usage time except for the call function. Food choice perception and its behavior as dietary habits were constructed referring to previous research and food balance wheels data for the correct dietary habits of the Ministry of Health & Welfare and Korean Nutrition Society. The food choice behavior was categorized into non-recommended food and recommended food. The results are summarized as follows. First, the longer the time spent on smartphones, the less favorable the perception of correct food choices. Second, the higher the dependence on smartphones, the less favorable the perception of correct food choices. Third, the correct perception of food choices has been shown to reduce food choices, known as non-recommended foods. In addition, proper perception of food choices has been shown to increase the choice of recommended foods. In conclusion, the usage time and reliance of smartphones of middle school students was found to affect the food choice behavior by lowering the perception of correct food choices. This research is expected to form the basis for the development of programs and educational materials that can be of assistance to adolescents who are experiencing difficulties.
Adolescent
;
Choice Behavior
;
Eating
;
Food Habits
;
Humans
;
Seoul
;
Smartphone
;
Statistics as Topic
5.Intervention Effect of Repetitive TMS on Behavioral Adjustment After Error Commission in Long-Term Methamphetamine Addicts: Evidence From a Two-Choice Oddball Task.
Qiongdan LIANG ; Jia LIN ; Jiemin YANG ; Xiang LI ; Yijiang CHEN ; Xianxin MENG ; Jiajin YUAN
Neuroscience Bulletin 2018;34(3):449-456
Behavioral adjustment plays an important role in the treatment and relapse of drug addiction. Nonetheless, few studies have examined behavioral adjustment and its plasticity following error commission in methamphetamine (METH) dependence, which is detrimental to human health. Thus, we investigated the behavioral adjustment performance following error commission in long-term METH addicts and how it varied with the application of repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC). Twenty-nine male long-term METH addicts (for > 3 years) were randomly assigned to high-frequency (10 Hz, n = 15) or sham (n = 14) rTMS of the left DLPFC during a two-choice oddball task. Twenty-six age-matched, healthy male adults participated in the two-choice oddball task pretest to establish normal performance for comparison. The results showed that 10 Hz rTMS over the left DLPFC significantly decreased the post-error slowing effect in response times of METH addicts. In addition, the 10 Hz rTMS intervention remarkably reduced the reaction times during post-error trials but not post-correct trials. While the 10 Hz rTMS group showed a more pronounced post-error slowing effect than the healthy participants during the pretest, the post-error slowing effect in the posttest of this sample was similar to that in the healthy participants. These results suggest that high-frequency rTMS over the left DLPFC is a useful protocol for the improvement of behavioral adjustment after error commission in long-term METH addicts.
Adjustment Disorders
;
etiology
;
therapy
;
Adult
;
Amphetamine-Related Disorders
;
complications
;
therapy
;
Case-Control Studies
;
Central Nervous System Stimulants
;
adverse effects
;
Choice Behavior
;
physiology
;
Functional Laterality
;
Humans
;
Male
;
Methamphetamine
;
adverse effects
;
Middle Aged
;
Prefrontal Cortex
;
physiology
;
Reaction Time
;
physiology
;
Transcranial Magnetic Stimulation
;
methods
;
Young Adult
6.Impact of financial background and student debt on postgraduate residency choices of medical students in Singapore.
Jie Ming Nigel FONG ; Yeong Tze Wilnard TAN ; Andrew Arjun SAYAMPANATHAN ; Niraj MOHAN ; Yun Qing KOH ; Jin Hao Justin JANG ; Jin Rong Ivan LOW ; Anupama VASUDEVAN ; Chew Lip NG ; Paul Ananth TAMBYAH
Singapore medical journal 2018;59(12):647-651
INTRODUCTION:
Medical school fees are rising globally. Student debt and financial background may affect residency choices, but few studies have been conducted in Asia. This study aimed to explore the relationship between financial background, student debt and postgraduate residency choices among medical students in Singapore.
METHODS:
An anonymised survey of all medical students in Singapore was conducted and had a response rate of 67.9%.
RESULTS:
40.5% of our study population would graduate with debt. Medical students with monthly per capita household income < SGD 1,000 were more likely to graduate with debt (unadjusted odds ratio [OR] 2.0, 95% confidence interval [CI] 1.6-2.7; p < 0.001) and feel burdened by the cost of medical education (unadjusted OR 2.8, 95% CI 2.0-3.9; p < 0.001). Students with monthly per capita household income < SGD 1,000 (unadjusted OR 1.818, 95% CI 1.338-2.470, p < 0.001; adjusted OR 1.692, 95% CI 1.202-2.381, p = 0.003) and those with debt (unadjusted OR 1.623, 95% CI 1.261-2.090, p < 0.001; adjusted OR 1.393, 95% CI 1.048-1.851, p = 0.022) were more likely to rank at least one economic factor as 'very significant' in influencing their postgraduate training choices.
CONCLUSION
It is concerning that despite financial aid schemes, the cost of medical education remains a burden to students from lower-income households in Singapore. Student debt and financial background may distort postgraduate career choices, creating an undue push towards high-paying specialties.
Career Choice
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Choice Behavior
;
Education, Medical
;
economics
;
Humans
;
Internship and Residency
;
economics
;
Odds Ratio
;
Schools, Medical
;
economics
;
Singapore
;
Social Class
;
Students, Medical
;
statistics & numerical data
;
Surveys and Questionnaires
;
Training Support
7.Medical school factors and the consideration of family and community medicine as a future specialty by third to fifth year medical students during Academic Year 2015-2016.
The Filipino Family Physician 2017;55(1):22-30
BACKGROUND: Compared to other specialties, a lower number of medical students contemplate later choosing Family and Community Medicine. At the UP College of Medicine, only a small fraction of graduates pursue residency training in the specialty. A multitude of factors have been shown to have influenced the medical students of specialty considerations.
OBJECTIVE: To determine whether the Family and Community Medicine curriculum and medical school factors influence third to fifth year students of UP College of Medicine to consider Family and Community Medicine as a future specialty.
METHODOLOGY: UP College of Medicine third to fifth year students during Academic Year 2015-2016 rotating in the Department of Family and Community Medicine from January to June 2016 were asked to participate. A descriptive study design was used. Consideration of Family and Community Medicine was compared from pre- to post- rotation and factors associated with inclination towards residency training in the specialty were examined post-rotation through a questionnaire.
RESULTS: Of the medical students who planned to pursue residency training, 8% had Family and Community Medicine in the top three choices for residency training at the start of the rotation, which increased to 15% at the end of the rotation. Family and Community Medicine as a future specialty was "considered a little" by the three year levels at the start and end of the rotation. Many factors were deemed by the medical students to have no effect on considering the specialty. Some factors were considered to have a strong positive influence on choosing Family and Community Medicine, especially for medical clerks. A few factors were perceived to have a negative influence in considering the specialty.
CONCLUSION: Curriculum and medical school factors have an influence on the consideration of Family and Community Medicine as a future specialty.
Human ; Male ; Female ; Adult ; Choice Behavior ; Community Medicine ; Curriculum ; Internship And Residency ; Medicine ; Schools, Medical ; Students, Medical ; Surveys And Questionnaires ; Family Practice
8.Dietary Behavior of Marriage Migrant Women according to Their Nationality in Multicultural Families.
Korean Journal of Community Nutrition 2016;21(1):53-64
OBJECTIVES: Nowadays, the multicultural families make up significant portion of Korean population and communities. Successful re-settling in a new country can be difficult, particularly when there are disparities in dietary behavior compared to home country. The objective of the study was to investigate the dietary behavior of marriage migrant women according to their nationality in multicultural families. METHODS: The primary research was conducted targeting 94 marriage migrant women who came from China (40.4%), Vietnam (26.6%), and other countries except for Japan (33.0%). We investigated their dietary behavior, such as eating attitude and food choice behavior for Korea acculturation. We also studied dietary behavior among 14 selected subjects who had high level of integration and assimilation acculturation patterns by administering the Focus Group Interview (FGI). RESULTS: The multicultural families had more integration acculturation patterns, which could have been influenced by their nationality. Vietnamese origin has the highest cultural adaptation as marginalization pattern. The common types of Korea acculturation were integration (3.03 +/- 1.08), separation (3.10 +/- 0.59), marginalization (3.10 +/- 0.58), followed by assimilation (2.84 +/- 0.51). There were significant differences in the four types of acculturation by marriage immigrant women's country of origin (p<0.05). According to dietary behavior, 'eliminating hunger' was the most important value in a meal. Chinese marriage migrant women, who had higher level of food intake attitude significantly, also considered 'being healthy' an important value. Regarding food choice behavior, Vietnamese had lowest frequency of homeland food intake. Most of marriage immigrant women were satisfied with the Korean food, and need for education was very high with interest for cooking, good nutrition, and managing their children's dietary life. CONCLUSIONS: Coping with a change in dietary behavior is one of the biggest transitional difficulties, and family members may need support to find their familiar food items and to continue their cultural food choice behavior in the local areas. Further researches with quantitative and qualitative analysis are needed to understand the effect of dietary behavior for acculturation in multicultural families.
Acculturation
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Asian Continental Ancestry Group
;
China
;
Choice Behavior
;
Cooking
;
Eating
;
Education
;
Emigrants and Immigrants
;
Ethnic Groups*
;
Female
;
Focus Groups
;
Humans
;
Japan
;
Korea
;
Marriage*
;
Meals
;
Transients and Migrants*
;
Vietnam
9.Specialty choice preference of medical students according to personality traits by Five-Factor Model.
Korean Journal of Medical Education 2016;28(1):95-102
PURPOSE: The purpose of this study was to determine the relationship between personality traits, using the Five-Factor Model, and characteristics and motivational factors affecting specialty choice in Korean medical students. METHODS: A questionnaire survey of Year 4 medical students (n=110) in July 2015 was administered. We evaluated the personality traits of Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness by using the Korean version of Big Five Inventory. Questions about general characteristics, medical specialties most preferred as a career, motivational factors in determining specialty choice were included. Data between five personality traits and general characteristics and motivational factors affecting specialty choice were analyzed using Student t-test, Mann-Whitney test and analysis of variance. RESULTS: Of the 110 eligible medical students, 105 (95.4% response rate) completed the questionnaire. More Agreeableness students preferred clinical medicine to basic medicine (p=0.010) and more Openness students preferred medical departments to others (p=0.031). Personal interest was the significant motivational factors in more Openness students (p=0.003) and Conscientiousness students (p=0.003). CONCLUSION: Medical students with more Agreeableness were more likely to prefer clinical medicine and those with more Openness preferred medical departments. Personal interest was a significant influential factor determining specialty choice in more Openness and Conscientiousness students. These findings may be helpful to medical educators or career counselors in the specialty choice process.
Adult
;
Choice Behavior
;
Female
;
Humans
;
Male
;
*Medicine
;
*Motivation
;
*Personality
;
Republic of Korea
;
*Specialization
;
*Students, Medical
;
Surveys and Questionnaires
10.Knowledge and factors determining choice of contraception among Singaporean women.
Arundhati GOSAVI ; Yueyun MA ; Hungchew WONG ; Kuldip SINGH
Singapore medical journal 2016;57(11):610-615
INTRODUCTIONThe study aimed to assess the level of awareness and knowledge of contraception among women in Singapore, and identify the factors that influence contraception choice.
METHODSWe conducted a cross-sectional survey of 259 female patients, aged 21-49 years, who attended the Obstetrics and Gynaecology Clinic at National University Hospital, Singapore. An original questionnaire on nine contraceptive methods was used. Respondents who had ≥ 2 correct answers for a method (out of four questions) were considered to have good knowledge of the method. Participants were asked to rate factors known to influence contraceptive choice as important or not important.
RESULTSAwareness of the following methods was high: condom (100.0%), oral contraception pill (89.2%), tubal ligation (73.0%) and copper intrauterine device (IUD) (72.2%). The women were least aware of hormonal IUD (24.3%). Women who were parous, had a previous abortion, had completed their family or used contraception previously were more likely to have a higher awareness of contraception. 89.2% of the women had good knowledge of the condom; among those aware of hormonal IUD, only 46.0% had good knowledge of it. Women who had used hormonal IUD and the condom were more likely to have good knowledge of them. Many rated efficacy (90.5%) and a healthcare professional's advice (90.1%) as important in contraceptive choice. Few considered peer influence (21.0%) and cultural practices (16.3%) to be important.
CONCLUSIONWomen in Singapore have poor awareness and knowledge of contraception, especially long-acting reversible methods. More effective ways are needed to educate women about contraceptive methods.
Abortion, Induced ; Adult ; Choice Behavior ; Condoms ; Contraception ; methods ; Contraceptives, Oral ; Cross-Sectional Studies ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Intrauterine Devices ; Middle Aged ; Parity ; Patient Education as Topic ; Singapore ; Social Class ; Sterilization, Tubal ; Surveys and Questionnaires ; Young Adult


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