Objective To explore the Lyophilizing Thrombin Powder combined with omeprazole in the treatment of peptic ulcer hemorrhage on clinical effect and influence on the change of the original level of the fiber protein.Methods118 cases of peptic ulcer bleeding from Yongkang Hospital were enrolled in this study, according to the order of hospitalization will be divided into observation group and control group.The control group were only given omeprazole and other conventional treatment;patients in the observation group was combined with Lyophilizing Thrombin Powder for treatment.The clinical treatment effect were compared between the two groups before and after treatment, compared two groups of patients with changes in fibrinogen levels.ResultsAfter treatment, the total efficiency rate of observation group was 91.07%, the total effective rate of control group was 75.81%, there was significant difference between two groups (P<0.05).Before treatment, two groups of patients with fibrinogen level was not statistically significant.With the treatment, the two groups of patients with fibrin the original level decreased, but the patients in the observation group decreased more significantly than the control group, the difference was statistically significant (P<0.05).ConclusionLyophilizing Thrombin Powder combined with omeprazole in the treatment of peptic ulcer bleeding effect significantly, can effectively reduce blood fibrinogen level, hemostasis, and its clinical use is safe and reliable, and is worth to popularize in clinic.

OBJECTIVETo investigate the changes in brain regional homogeneity in first-onset major depressive disorders (MDDs) using resting-state functional magnetic resonance imaging (fMRI).

METHODSEighteen patients with first-onset MDDs and twenty gender- and age-matched healthy controls underwent resting-state fMRI scans to compare the regional homogeneities of the brain regions.

RESULTSCompared with the normal controls, the patients with MDDs showed significantly decreased regional homogeneity in the left posterior cingulated gyrus, bilateral inferior temporal gyrus, bilateral superior temporal gyrus, left inferior frontal gyrus, left hippocampa gyrus, left posterior central gyrus, left angular gyrus, right amygdala, right orbital frontal gyrus, right supplementary motor area, and right cerebellar lobe.

CONCLUSIONPatients with first-onset MDDs have dysfunctions in the brain regions closed related with cognition and emotional control.

Amygdala ; Brain ; physiopathology ; Case-Control Studies ; Cerebellum ; Cognition ; Depressive Disorder, Major ; diagnosis ; Emotions ; Frontal Lobe ; Humans ; Magnetic Resonance Imaging ; Temporal Lobe