1.Simulation research on three dimension electrical impedance tomography and evaluation of image reconstruction quality.
Juan DENG ; Qingguo WEI ; Hong SHA ; Shu ZHAO ; Yan WANG ; Chaoshi REN ; Fusheng LI
Journal of Biomedical Engineering 2013;30(6):1195-1199
		                        		
		                        			
		                        			Three dimensional electrical impedance tomography (3D-EIT) became an important branch of EIT recently. It is important to research imaging and image quality evaluation methods for single targets of different positions and multi-targets in 3D field. Using finite element subdivision method, 3D-EIT field was dispersed into cube unit in the present study for models with single target located in the center of field, middle of field, and near to the edge, respectively. For models with two targets and four targets near to the field edge, Tikhonov-Noser algorithm was adopted in image reconstruction. Imaging error function ER and structure similarity degree function SSIM were introduced to evaluate the reconstructed images. For the models with signal target, with the movement of the target from the center to the edge of the field, the value of ER increased and SSIM decreased, and reconstruction quality decreased. For the models with multi-targets near to the field edge, ER and SSIM increased and decreased respectively with the increase of target number, mage quality also decreased. Tikhonov-Noser algorithm is an effective 3D-EIT algorithm. ER and SSIM are adaptive for the characteristic of 3D-EIT images, and it can quantitatively evaluate the 3D-EIT imaging effect from the two perspective of imaging error and structure quality.
		                        		
		                        		
		                        		
		                        			Algorithms
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		                        			Electric Impedance
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		                        			Image Processing, Computer-Assisted
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		                        			Imaging, Three-Dimensional
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		                        			Tomography
		                        			
		                        		
		                        	
2.Noninvasive gastric motility measurement and evaluation by bioimpedance
Chaoshi REN ; Zhangyong LI ; Wei WANG ; Shu ZHAO ; Juan DENG
Chinese Journal of Tissue Engineering Research 2010;14(9):1653-1657
		                        		
		                        			
		                        			BACKGROUND:Bioimpedance method can be used to extract physiology and pathology information relative to the gastricmotility states,to investigate the courses of contraction,peristalsis,transmission and emptying of the stomach,to measure andevaluate gastric motility function.However,early studies mainly focused on the emptying of the stomach,and few studies onevaluation of gastric motility by extracting gastric motility information.OBJECTIVE:To understand the gastric motility from electricity-mechanism composite concept and to establish a noninvasive,convenience measurement method of gastric motility impedance.METHODS:Based on the characters of gastric motility impedance signal,a measurement method of impedance gastric motility isintroduced.Some foundation experiments about the gastric emptying measurement,the gastric motility compare between fastingand repast,the gastric motility comparison of healthy volunteers during different periods and some medicine effects on gastricmotility have carried out.The gastric motility measurement of the patients with functional dyspepsia and gastric motility evaluationfor the patients with erosive gastritis had been reported.RESULTS AND CONCLUSION:Using electrical bioimpedance method,according to the electrical property of the stomach tissueor the food in stomach and the change rules of the property,the physiology and pathology information relative to the gastricmotility states can be extracted,the courses of contraction,peristalsis,transmission and emptying of the stomach can beinvestigated and noninvasive measure and evaluation of gastric motility function can be realized.
		                        		
		                        		
		                        		
		                        	
3.A quadrature demodulation method based on DSP Builder and the circuit design used in EIT
You WU ; Hong SHA ; Chaoshi REN
International Journal of Biomedical Engineering 2009;32(5):276-279
		                        		
		                        			
		                        			Objective To design and develop a quadrature demodulation circuit for detection of ampli-tude and phase information in EIT measurement. Methods A model structure file was built in matlab/simulink using the elements in Ahera DSP Builder and verified by simulated stimulation. Then the model file was convert-ed to VHDL file via Signal Compiler, and the synthesis, adaptation, simulation and hardware implementation were accomplished. Results The simulation and testing results show that the circuit can extract the real and imagi-nary information of the measured signal and it also meets the EIT measuring requirement, with acceptable mea-sure error. Conclusion The demodulation circuit based on DSP Builder can precisely give real and imaginary information of EIT and provides technological support for full-information complex impedance measurement.
		                        		
		                        		
		                        		
		                        	
4.Diagnosis of functional dyspepsia and an electrical bio-impedance technique
Zhangyong LI ; Na HU ; Chaoshi REN
International Journal of Biomedical Engineering 2009;32(2):125-127
		                        		
		                        			
		                        			Functional dyspepsia is a common disease in clinical service.Its etiology and pathogenesis are related to a variety of factors,and among them,gastric motility and gastrointestinal motility dysfunction are major causes.At present,diagnosis of functional dyspepsia depends maindy on the complaint of patients and no gastric motility detection method or means are effective enough to complete the diagnosis objectively.The electrical bioimpedance technique extracts information of gastric electrical activity and mechanical movement base on the recngnition of electricity-mechanism compound system and studies complicated procedure of gastric electrical activity,mechanical contraction and gastric peristalsis.The electrical bio-impedance technique has shown a promising clinical application and development prospects.
		                        		
		                        		
		                        		
		                        	
5.Clinical-application developments of electrical impedance tomography
International Journal of Biomedical Engineering 2008;31(5):279-283
		                        		
		                        			
		                        			Electrical impedance tomography(EIT) is a novel medical imaging technique, which was developed in recent 20 years following morphology imaging and structure imaging. With the outstanding advantages of noninvasiveness, functional imaging, and medical image monitoring, EIT has a bright and fascinating future in medical application. This paper reviews the htest development of its clinical appLication both in our country and abroad, including measurement of lung density and air volume, strategy to enhance protective ventilation, breast cancer detection, virtual bladder biopsy, acute stroke imaging,and monitoring of intraperitoneal bleeding, etc.
		                        		
		                        		
		                        		
		                        	
6.Simulation study of line electrode for electrical impedance tomography.
Yan WANG ; Hong SHA ; Chaoshi REN
Journal of Biomedical Engineering 2007;24(5):986-989
		                        		
		                        			
		                        			In this paper, a simulation research software platform for EIT electrode structure and parameter optimizing design has been developed, which is based on the coercive equipotential node model of line electrode. By the method, which is presented for electrode structure and parameter optimizing design, the influences of electrode structure parameters on reconstructed image and measure sensitivity have been studied and the optimal structure parameters of electrode for the object in different depth have been determined.
		                        		
		                        		
		                        		
		                        			Computer Simulation
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		                        			Electric Impedance
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		                        			Electrodes
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		                        			Electromagnetic Fields
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		                        			Equipment Design
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		                        			Humans
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		                        			Models, Biological
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		                        			Plethysmography, Impedance
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		                        			instrumentation
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		                        			methods
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		                        			Software
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		                        			Tomography
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		                        			methods
		                        			
		                        		
		                        	
7.Experiment Study on the Impedance Spectroscopy Analysis Method t o measure RBC Aggregation.
Journal of Medical Research 2006;0(02):-
		                        		
		                        			
		                        			In order to test validity and fea si bility of the impedance spectroscopy analysis method,a series of blood experime n ts have been carried out to study influences of the hematocrit,the plasma conc e ntration and the dextran concentration in suspend medium on the blood impedance and the RBC aggregation.The results show that the blood impedance of lower freq uency R_0 increases with increase of Hctc,the time constant T has little chang e when Hctc hange from 28.9 to 48.9;with the increase of plasma concentration ,t he RBC aggregation radius increases;When the dextran concentration is about 4g/ 100ml,the RBC aggregate reaches its maximum.It suggests that the impedance spe ctroscopy analysis method is a new,effective method to study RBC aggregation.
		                        		
		                        		
		                        		
		                        	
8.An Impedance Spectroscopy Analysis Method to measure RBC aggregation1
Journal of Medical Research 2006;0(04):-
		                        		
		                        			
		                        			Objective From the Maxwell-Wagner theory for suspensions of spherical and the electrical property of blood,an equation has been derived to calculate RBC aggregate radius,a new method based on the impedance spectroscopy analysis has been developed to evaluate the Red Blood Cell (RBC) aggregation property. According the new method,the impedance spectroscopy of blood has been measured at first with the multi-frequency technique,then to get the impedance - frequency curve by a fit method,the time constant T has been extracted from the curve,at last,the RBC aggregate radius R has been gotten. According to the changes of R during the RBC aggregation,the measurement and evaluation of RBC aggregation property can be realized. The impedance spectroscopy analysis method introduced in this paper is a new,effective method to study RBC aggregation.
		                        		
		                        		
		                        		
		                        	
9.Electrical bio-impedance method to measure gastric motility function
International Journal of Biomedical Engineering 2006;0(02):-
		                        		
		                        			
		                        			During the digest course the electrical property of the stomach alters obviously due to the change in shape, dimension, volume of gastric and the composition of stomach. The regulation of the impedance change is corresponding to the gastric motility and the correlation between them is evident. The impedance technique can be used to monitor gastric motility function no-invasively with high sensitivity and accuracy. Based on introduction of the gastric motility function and its measurement method, the development, key technique and existing problem of the gastric motility measurement using the electrical bio-impedance method are reviewed in this paper.
		                        		
		                        		
		                        		
		                        	
10.Advanced Development of Multi-information Acquisition System on Pulse Tracings of Traditional Chinese Medicine
Hong SHA ; Shu ZHAO ; Yan WANG ; Chaoshi REN ;
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(01):-
		                        		
		                        			
		                        			According to the multi-information characteristic of pulse tracings in traditional Chinese medicine(TCM) and the dynamic analysis and identification technique of sonogram,the multi-information detection system of pulse examination was constructed by combining B-type ultrasound and flexible transducer.It made information integration of supersonic dynamic image,pressure pulse wave,photoelectric capacity pulse wave and electrocardiogram,and though the aggregate analysis of computer information processing technique,established the pulse tracings signature analysis method,formed optimized solving scheme for describing the four attributes("location,velocity,shape and potential") of pulse examination in TCM.From the multi-information data of healthy people's pulse tracings collected by this system,it can be infer that the new method of objectification of pulse examination referred in this article is feasible,and have gain the prospective effect.It provides a new method and characteristic data for the clinical study of objectification of pulse examination and teaching of TCM.
		                        		
		                        		
		                        		
		                        	
            
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