1.Analyses of the factors relevant to revision tympanomastoid surgery.
Li LI ; Zhaomin FAN ; Yuechen HAN ; Lei XU ; Dong CHEN ; Haibo WANG
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2016;51(5):333-337
OBJECTIVETo analyze factors relevant to revisional tympanomastoid surgery for chronic otitis media(COM).
METHODSThe clinical data of 159 patients (159 ears), who exhibited either wet ear or relapsed after the initial operation, and were subjected to revisional tympanomastoid surgery, were retrospectively analyzed in this study. Of those 159 consecutive patients, 85 were males and 74 were females, aged 11-64 years, with a median age of 36 years old. The situations in terms of intra-operative findings, surgical procedures, change dressing post-operation, dry ear time, and the improvement of aural ability during the second operation, were recorded and analyzed.
RESULTSThe second surgery found that, of those 159 patients underwent the re-operation, 67 presented with cholesteatoma and 92 had no cholesteatoma. In addition, the inadequate skeletonization and insufficient opening for mastoid cavity accounted for 70.4% (112/159) of all previous operations, the external auditory canal stenosis for 98.7% (157/159), the high facial ridge leading to insufficient drainage for 61.0% (97/159), the lesion in tympanic ostium of Eustachian tube for 34.6% (55/159), the insufficient drainage due to inappropriate post-operating dressing for 5.0% (8/159), the postauricular incision for 30.8% (49/159), and the endaural incision for 69.2% (110/159). As for the re-operation of the canal wall down mastoidectomy, tympanoplasty plus plastic repairing of cavity of concha were performed in 94 cases, the modified Bondy plus plastic repairing of cavity of concha in four cases, the radical mastoidectomy plus plastic repairing of cavity of concha in 59 cases, and the simple cleaning for mastoid cavity in two cases. Since one to two weeks after the revisional operations, the post-operating dressing was performed with aid of microscopy once a week on average. The average dry ear time ranged from 2 to 6 weeks (median=3 weeks). During a period of 6-93 months for the follow-up, all patients presented with dry ears. The epithelialization of the operating cavity was well and the tympanic membranes were integrity. Neither granulation tissue nor cholesteatoma was found to reoccur. Both pure tone hearing thresholds and air-bone gap decreased in 87 cases after the revisional operation, with statistically significant different in comparison to those two parameters before the operation (P<0.05).
CONCLUSIONThe primary causes responsible for the wet ear or reoccurrent cholesteatoma after tympanomastoid surgery may be related to the improper operation procedures and selection of incision, the non-standard operation, inexhaustive removal of pathological tissues, as well as the irregular postoperation change dressing, and other factors.
Adolescent ; Adult ; Child ; Cholesteatoma, Middle Ear ; surgery ; Chronic Disease ; Ear Auricle ; surgery ; Eustachian Tube ; pathology ; Female ; Humans ; Male ; Mastoid ; surgery ; Middle Aged ; Otitis Media ; surgery ; Postoperative Period ; Reconstructive Surgical Procedures ; Reoperation ; Retrospective Studies ; Treatment Outcome ; Tympanic Membrane ; pathology ; surgery ; Tympanoplasty ; Young Adult
2.Long-term Outcome of Cochlear Implant in Patients with Chronic Otitis Media: One-stage Surgery Is Equivalent to Two-stage Surgery.
Jeong Hun JANG ; Min Hyun PARK ; Jae Jin SONG ; Jun Ho LEE ; Seung Ha OH ; Chong Sun KIM ; Sun O CHANG
Journal of Korean Medical Science 2015;30(1):82-87
		                        		
		                        			
		                        			This study compared long-term speech performance after cochlear implantation (CI) between surgical strategies in patients with chronic otitis media (COM). Thirty patients with available open-set sentence scores measured more than 2 yr postoperatively were included: 17 who received one-stage surgeries (One-stage group), and the other 13 underwent two-stage surgeries (Two-stage group). Preoperative inflammatory status, intraoperative procedures, postoperative outcomes were compared. Among 17 patients in One-stage group, 12 underwent CI accompanied with the eradication of inflammation; CI without eradicating inflammation was performed on 3 patients; 2 underwent CIs via the transcanal approach. Thirteen patients in Two-stage group received the complete eradication of inflammation as first-stage surgery, and CI was performed as second-stage surgery after a mean interval of 8.2 months. Additional control of inflammation was performed in 2 patients at second-stage surgery for cavity problem and cholesteatoma, respectively. There were 2 cases of electrode exposure as postoperative complication in the two-stage group; new electrode arrays were inserted and covered by local flaps. The open-set sentence scores of Two-stage group were not significantly higher than those of One-stage group at 1, 2, 3, and 5 yr postoperatively. Postoperative long-term speech performance is equivalent when either of two surgical strategies is used to treat appropriately selected candidates.
		                        		
		                        		
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Aged
		                        			;
		                        		
		                        			Cholesteatoma, Middle Ear/epidemiology
		                        			;
		                        		
		                        			Chronic Disease/therapy
		                        			;
		                        		
		                        			Cochlear Implantation/*adverse effects
		                        			;
		                        		
		                        			Cochlear Implants/*adverse effects
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Hearing Loss, Sensorineural/*surgery
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Inflammation/epidemiology
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Middle Aged
		                        			;
		                        		
		                        			Otitis Media/*surgery
		                        			;
		                        		
		                        			Retrospective Studies
		                        			;
		                        		
		                        			*Speech Articulation Tests
		                        			;
		                        		
		                        			Treatment Outcome
		                        			;
		                        		
		                        			Young Adult
		                        			
		                        		
		                        	
3.Metabolic risk and nutritional state according to breakfast energy level of Korean adults: Using the 2007~2009 Korea National Health and Nutrition Examination Survey.
So Hyoun JANG ; Yoon Suk SUH ; Young Jin CHUNG
Journal of Nutrition and Health 2015;48(1):46-57
		                        		
		                        			
		                        			PURPOSE: The aim of this study was to determine an appropriate energy level of breakfast with less risk of chronic disease for Korean adults. METHODS: Using data from the 2007~2009 Korean National Health & Nutrition Examination Survey, from a total of 12,238 adults aged 19~64, the final 7,769 subjects were analyzed except subjects who were undergoing treatment for cancer or metabolic disorder. According to the percent of breakfast energy intake versus their estimated energy requirement (EER), the subjects were divided into four groups: < 10% (very low, VL), 10~20% (low, L), 20~30% (moderate, M), > or = 30% (sufficient, S). All data were analyzed on the metabolic risk and nutritional state after application of weighted value and adjustment of sex, age, residential area, income, education, job or jobless, and energy intake using a general linear model or logistic regression. RESULTS: The subjects of group S were 16.9% of total subjects, group M 39.2%, group L 37.6%, and group VL 6.3%. The VL group included more male subjects, younger-aged (19 to 40 years), urban residents, higher income, higher education, and fewer breakfasts eaters together with family members. Among the 4 groups, the VL group showed the highest waist circumference, while the S group showed the lowest waist circumference, body mass index, and serum total cholesterol. The groups of VL and L with lower intake of breakfast energy showed high percent of energy from protein and fat, and low percent of energy from carbohydrate. With the increase of breakfast energy level, intake of energy, most nutrients and food groups increased, and the percentage of subjects consuming nutrients below EAR decreased. The VL group showed relatively higher intake of snacks, sugar, meat and eggs, oil, and seasonings, and the lowest intake of vegetable. Risk of obesity by waist circumference was highest in the VL group by 1.90 times of the S group and the same trend was shown in obesity by BMI. Risk of dyslipidemia by serum total cholesterol was 1.84 times higher in the VL group compared to the S group. Risk of diabetes by Glu-FBS (fasting blood sugar) was 1.57 times higher in the VL group compared to the S group. CONCLUSION: The results indicate that higher breakfast energy level is positively related to lower metabolic risk and more desirable nutritional state in Korean adults. Therefore, breakfast energy intake more than 30% of their own EER would be highly recommended for Korean adults.
		                        		
		                        		
		                        		
		                        			Adult*
		                        			;
		                        		
		                        			Body Mass Index
		                        			;
		                        		
		                        			Breakfast*
		                        			;
		                        		
		                        			Cholesterol
		                        			;
		                        		
		                        			Chronic Disease
		                        			;
		                        		
		                        			Dyslipidemias
		                        			;
		                        		
		                        			Ear
		                        			;
		                        		
		                        			Education
		                        			;
		                        		
		                        			Eggs
		                        			;
		                        		
		                        			Energy Intake
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Korea
		                        			;
		                        		
		                        			Linear Models
		                        			;
		                        		
		                        			Logistic Models
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Meat
		                        			;
		                        		
		                        			Nutrition Surveys*
		                        			;
		                        		
		                        			Obesity
		                        			;
		                        		
		                        			Ovum
		                        			;
		                        		
		                        			Seasons
		                        			;
		                        		
		                        			Snacks
		                        			;
		                        		
		                        			Vegetables
		                        			;
		                        		
		                        			Waist Circumference
		                        			
		                        		
		                        	
4.Noise-Induced Hearing Loss in the Police Force.
Kyaw N WIN ; Nayake B P BALALLA ; Min Z LWIN ; Alice LAI
Safety and Health at Work 2015;6(2):134-138
		                        		
		                        			
		                        			BACKGROUND: Noise-induced hearing loss (NIHL) is a major preventable occupational health problem with 250 million people worldwide known to have disabling impairment of moderate to greater severity. The aims of the study are to estimate the prevalence of NIHL in the police force; and study its association with age, sex, duration of service (years), smoking and alcohol habits, use of hearing protective devices, as well as preexisting chronic diseases. METHODS: A cross-sectional study was conducted on 543 police personnel who had undergone periodic medical examination over a 12-month period. The diagnostic criteria for NIHL were (1) history of occupational noise exposure, (2) bilateral hearing loss, (3) hearing loss of > or = 25 dBA at 4,000 Hz in two consecutive audiograms, and (4) no significant medical history affecting hearing. Severity of NIHL was based on the World Health Organization grading. RESULTS: Males (74.8%) made up the majority of the police force. The mean age for police personnel was 35.55 +/- 9.57 years, and the mean duration of service was 14.75 +/- 9.39 years. Compliance with the usage of hearing protective devices was seen in 64.4%. The prevalence of NIHL in this study population was 34.2%, with a higher prevalence in males (37.7%) than in females (23.9%). The study also showed strong associations between NIHL and male sex (odds ratio, 1.9; P < 0.05), and hypertension (odds ratio, 3.3; P < 0.001). Overall, 93% were found to have mild NIHL, 3.5% had moderate NIHL, and 3.5% had severe NIHL. No police personnel were found to have profound hearing loss. CONCLUSION: The prevalence of NIHL in this study is high compared to other similar studies among police personnel. This study shows that increasing age, male, presence of hypertension, diabetes, and longer duration of service are significant associated factors for NIHL. Preventative strategies include health surveillance, implementation of a hearing conservation program, and legislation.
		                        		
		                        		
		                        		
		                        			Chronic Disease
		                        			;
		                        		
		                        			Compliance
		                        			;
		                        		
		                        			Cross-Sectional Studies
		                        			;
		                        		
		                        			Ear Protective Devices
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Hearing
		                        			;
		                        		
		                        			Hearing Loss
		                        			;
		                        		
		                        			Hearing Loss, Bilateral
		                        			;
		                        		
		                        			Hearing Loss, Noise-Induced*
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Hypertension
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Noise, Occupational
		                        			;
		                        		
		                        			Occupational Health
		                        			;
		                        		
		                        			Police*
		                        			;
		                        		
		                        			Prevalence
		                        			;
		                        		
		                        			Smoke
		                        			;
		                        		
		                        			Smoking
		                        			;
		                        		
		                        			World Health Organization
		                        			
		                        		
		                        	
5.Middle Ear Actinomycosis Involving Facial Nerve and Lateral Semicircular Canal.
Sungsu LEE ; Hyong Joo PARK ; Hyong Ho CHO
Korean Journal of Otolaryngology - Head and Neck Surgery 2015;58(1):57-60
		                        		
		                        			
		                        			Actinomycosis is a chronic granulomatous disease caused by the species of Actinomyces. Although it has become a rare disease in the present antibiotics era, it still needs long term antibiotic treatment and often mis- or delayed- diagnosed due to no typical sign and symptoms. Most often, it occurs in the cervicofacial region. Middle ear is not a common site for Actinomycosis, and the inner ear involvement is extremely rare. Here, we report a case of middle ear Actinomycosis involving facial nerve and lateral semicircular canal.
		                        		
		                        		
		                        		
		                        			Actinomyces
		                        			;
		                        		
		                        			Actinomycosis*
		                        			;
		                        		
		                        			Anti-Bacterial Agents
		                        			;
		                        		
		                        			Ear, Inner
		                        			;
		                        		
		                        			Ear, Middle*
		                        			;
		                        		
		                        			Facial Nerve*
		                        			;
		                        		
		                        			Granulomatous Disease, Chronic
		                        			;
		                        		
		                        			Rare Diseases
		                        			;
		                        		
		                        			Semicircular Canals*
		                        			;
		                        		
		                        			Temporal Bone
		                        			
		                        		
		                        	
6.The Prevalence and Risk Factors of Tinnitus in Korean Adolescents.
Chang Yong KIM ; Se Won JEONG ; Ji Young SEO ; Yong Ju LEE ; Sang Chul PARK ; Hyun Seung CHOI
Korean Journal of Otolaryngology - Head and Neck Surgery 2015;58(1):12-18
		                        		
		                        			
		                        			BACKGROUND AND OBJECTIVES: Tinnitus is the perception of sound in the absence of any outside acoustic stimulus with high prevalence. Multiple risk factors for tinnitus have been identified. So far, most of studies have concentrated on prevalence and associated chronic disease of tinnitus in adults. In the present study, we focused on tinnitus in adolescents which has not been adequately evaluated. The main goal of this study was to assess the prevalence and associated risk factors of tinnitus in adolescents. SUBJECTS AND METHOD: This study was a retrospectively designed analysis of data from the 5th Korea National Health and Nutrition Examination Survey conducted in 2011-2012. We used tinnitus related interview data, the results of physical and audiological evaluation by ENT specialists, the results of daily intake of vitamin using a 24-hour dietary recall method, and blood samples in 1370 subjects. RESULTS: The prevalence of tinnitus was 22.2% in the age range of 12 and 19 years old. Logistic regression is a statistical method used to assess the association between tinnitus and independent variables. The following factors were independently and positively associated with tinnitus; sex (adjusted OR=1.531, CI=1.097-2.137), excessive earphone use (adjusted OR=1.422, CI=1.026-1.970), Non-occupational noise (adjusted OR=4.096, CI=1.702-9.859), explosive noise (adjusted OR=4.100, CI=1.703-9.872), niacin intake (adjusted OR=0.966, CI=0.940-0.993), vitamin (vit.). D serum concentration (adjusted OR=0.959, CI=0.925-0.994). CONCLUSION: This study showed an association between tinnitus prevalence in adolescents and gender, noise exposure, and vit. D supplement. Tinnitic patients are recommended to reduce excessive noise and use hearing protection devices such as earplugs or earmuffs; they are also recommended to obtain a supply vit. D from adequate sun exposure and outside activities.
		                        		
		                        		
		                        		
		                        			Acoustics
		                        			;
		                        		
		                        			Adolescent*
		                        			;
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Chronic Disease
		                        			;
		                        		
		                        			Ear Protective Devices
		                        			;
		                        		
		                        			Hearing
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Korea
		                        			;
		                        		
		                        			Logistic Models
		                        			;
		                        		
		                        			Niacin
		                        			;
		                        		
		                        			Noise
		                        			;
		                        		
		                        			Nutrition Surveys
		                        			;
		                        		
		                        			Prevalence*
		                        			;
		                        		
		                        			Retrospective Studies
		                        			;
		                        		
		                        			Risk Factors*
		                        			;
		                        		
		                        			Solar System
		                        			;
		                        		
		                        			Specialization
		                        			;
		                        		
		                        			Tinnitus*
		                        			;
		                        		
		                        			Vitamins
		                        			
		                        		
		                        	
7.The application of autologous conchal cartilage in ossicular chain reconstruction.
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(19):1680-1682
		                        		
		                        			OBJECTIVE:
		                        			To evaluate the efficiency of autologous conchal cartlage in ossicular chain reconstruction in patients with chronic suppurative otitis media.
		                        		
		                        			METHOD:
		                        			Seventy-three cases of chronic suppurative otitis media (COM) with or without cholesteatoma who had undergone mastoidectomy with tympanoplasty and ossicular chain reconstruction(OCR) using autologous conchal cartilage as prosthesis were studied retrospectively. Sixty-six cases of COM who had undergone mastoidectomy with tympanoplasty and without OCR were studied as control. The examination of pure tone hearing level of air conduction(AC) and bone conduction(BC) was done before operation, 2 months and 6 months after operation respectively. The pure tone average (PTA) of 0.5, 1.0, 2.0 kHz was observed.
		                        		
		                        			RESULT:
		                        			The average air conduction gain was more than 15dB or the PTA (AC) was less than 25 dB 2 months after operation in 35 out of 73 cases who had undergone OCR. Nevertheless, the data became 56 out of 73 cases 6 months after operation. In the control group, The average air conduction gain was more than 15dB or the PTA(AC) was less than 25 dB 2 months after operation in 10 out of 66 cases who had not undergone OCR. The data became 14 out of 66 cases 6 months after operation. In OCR group, air bone gap(ABG) was less than 20 dB in 39 cases 2 months after operation and in 57 cases 6 months after operation. In the control group without OCR, ABG was less than 20 dB only in 11 cases 2 months after operation and in 16 cases 6 months after operation. By statistically analysis, there was significant difference of postoperative hearing improvement between the two groups.
		                        		
		                        			CONCLUSION
		                        			The autologous conchal cartilage can be used as the material of prosthesis for ossicular chain reconstruction in the operation of chronic otitis media. It has many advantages, such as easily--obtained, good histocompatibility, easy to shape and so on.
		                        		
		                        		
		                        		
		                        			Audiometry, Pure-Tone
		                        			;
		                        		
		                        			Bone Conduction
		                        			;
		                        		
		                        			Cartilage
		                        			;
		                        		
		                        			transplantation
		                        			;
		                        		
		                        			Cholesteatoma
		                        			;
		                        		
		                        			surgery
		                        			;
		                        		
		                        			Chronic Disease
		                        			;
		                        		
		                        			Ear Auricle
		                        			;
		                        		
		                        			Hearing
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Mastoid
		                        			;
		                        		
		                        			surgery
		                        			;
		                        		
		                        			Ossicular Prosthesis
		                        			;
		                        		
		                        			Ossicular Replacement
		                        			;
		                        		
		                        			Otitis Media, Suppurative
		                        			;
		                        		
		                        			surgery
		                        			;
		                        		
		                        			Postoperative Period
		                        			;
		                        		
		                        			Reconstructive Surgical Procedures
		                        			;
		                        		
		                        			Retrospective Studies
		                        			;
		                        		
		                        			Treatment Outcome
		                        			;
		                        		
		                        			Tympanoplasty
		                        			
		                        		
		                        	
8.Tympanosclerosis etiology and treatment.
Xueling JIN ; Jian ZHANG ; Wugen LUO
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2014;28(22):1811-1814
		                        		
		                        			
		                        			Tympanosclerosis is the middle ear tissue hyalinization and calcification caused by chronic middle ear inflammation, which mainly results in conductive deafness with unobvious clinical symptom. Etiology is unclear. The treatment is given priority to surgical treatment at present, while long-term effect reported mostly poor. This article analyzed etiology and treatment of the tympanic cavity sclerosis.
		                        		
		                        		
		                        		
		                        			Calcinosis
		                        			;
		                        		
		                        			Chronic Disease
		                        			;
		                        		
		                        			Ear, Middle
		                        			;
		                        		
		                        			Hearing Loss, Conductive
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Myringosclerosis
		                        			;
		                        		
		                        			complications
		                        			;
		                        		
		                        			etiology
		                        			;
		                        		
		                        			therapy
		                        			;
		                        		
		                        			Otitis Media
		                        			;
		                        		
		                        			Sclerosis
		                        			
		                        		
		                        	
9.Correlation analysis of bacterial biofilm formation and bacterial culture in chronic otitis media.
Xingzhi GU ; Abulajiang TUOHETI ; Youledusi KEYOUMU ; Xiuqing CHENG ; Yuanyuan TANG ; Dongmei SHI ; Hua ZHANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2014;28(13):935-938
		                        		
		                        			OBJECTIVE:
		                        			To study the correlation between the bacterial biofilm formation and bacterial culture in chronic otitis media.
		                        		
		                        			METHOD:
		                        			As a prospective reserch, we used scanning electron microscopy to examinate patients samples which collected from 32 cases of patients with chronic suppurative otitis media and middle ear cholesteatoma in the operations, and performed the middle ear secretions bacterial culture. According to the different types of chronic otitis media group, we analysised the relationship between chronic otitis media bacterial biofilm formation and the bacterial culture results.
		                        		
		                        			RESULT:
		                        			Chronic suppurative otitis media (activity) and middle ear cholesteatoma bacterial biofilm formation rate were 87.5%, 81.3%, chi-square (P > 0.05). Compared bacterial biofilm results with the results of bacterial cultured in chronic otitis media, sensitivity was 70.37%, specificity was 60.00%, the misdiagnosis rate was 40.00%, the missed diagnosis was 29.63%, positive predictive value was 90. 46%, negative predictive value was 27.27%, accuracy was 68.75%. Youden index was 30. 37%, and Pearson correlation coefficient was 0.232 (P > 0.05).
		                        		
		                        			CONCLUSION
		                        			Chronic suppurative otitis media (activity) and middle ear cholesteatoma bacteria had a higher biofilm formation rate. The routine bacterial culture results can't reflecte bacterial biofilm formation in chronic otitis media. We need to explore more reliable experimental methods to accurately reveal the infection status of chronic otitis media.
		                        		
		                        		
		                        		
		                        			Adolescent
		                        			;
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Bacteria
		                        			;
		                        		
		                        			growth & development
		                        			;
		                        		
		                        			Biofilms
		                        			;
		                        		
		                        			Cholesteatoma, Middle Ear
		                        			;
		                        		
		                        			microbiology
		                        			;
		                        		
		                        			Chronic Disease
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Middle Aged
		                        			;
		                        		
		                        			Otitis Media, Suppurative
		                        			;
		                        		
		                        			microbiology
		                        			;
		                        		
		                        			Sensitivity and Specificity
		                        			;
		                        		
		                        			Young Adult
		                        			
		                        		
		                        	
10.Auricular acupuncture combined with body acupuncture for 42 cases of chronic urticaria.
Chinese Acupuncture & Moxibustion 2013;33(8):719-720
		                        		
		                        		
		                        		
		                        			Acupuncture Points
		                        			;
		                        		
		                        			Acupuncture, Ear
		                        			;
		                        		
		                        			Adolescent
		                        			;
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Aged
		                        			;
		                        		
		                        			Child
		                        			;
		                        		
		                        			Chronic Disease
		                        			;
		                        		
		                        			therapy
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Middle Aged
		                        			;
		                        		
		                        			Urticaria
		                        			;
		                        		
		                        			therapy
		                        			;
		                        		
		                        			Young Adult
		                        			
		                        		
		                        	
            
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