Background: The treatment of kidney stones by surgery is very important for relieve pain, reduce the risk of infection and protect kidney function. Method: This was descriptive prospective cross-sectional study research to identify the outcome of surgery for kidney stone in the Urology Department of Mahosot Hospital. The research was performed between June-December 2017. The subjects consisted of 120 patients. Data were collected using questionnaires by interview, reviewing hospital charts and following the patients post operation. Data were analyzed by using SPSS. Results: The results showed that the majority of patients were aged 43-52 years (30.0%), were mostly male (60.8%), Lao lum (76.7%), with high school education (28.0%), farmers (50.8%), and family history of having kidney stones (55%), previously treated with herbal medicines (72.5%), and presented with pain (90.8%) and hematuria (57.5%). Ultrasound scans demonstrated pyelo-caliciel calculi (50.8%), blood group “B” (43.3%) and hydronephrosis level II (45%). Operation was by bivalve nephrotomy in 37.5%. The operation duration was one hour (51.7%) and management outcome post surgery was successful in 85%, with complications of anemia (0.8%), need for hemodialysis (1.7%), pyelonephritis (8.3%), wound infection (1.7%), and hemorrhages (1.7%). Conclusion The outcome of surgery for kidney stone success is high, but complications persist. Discussion of interventions to reduce complication rates are needed.