1.Forecasting the effects of vaccination on the COVID-19 pandemic in Malaysia using SEIRV compartmental models
Mei Cheng LIM ; Sarbhan SINGH ; Chee Herng LAI ; Balvinder Singh GILL ; Mohd Kamarulariffin KAMARUDIN ; Ahmed Syahmi Syafiq MD ZAMRI ; Cia Vei TAN ; Asrul Anuar ZULKIFLI ; Mohamad Nadzmi Md NADZRI ; Nur'ain MOHD GHAZALI ; Sumarni MOHD GHAZALI ; Nuur Hafizah MD IDERUS ; Nur Ar Rabiah Binti AHMAD ; Jeyanthi SUPPIAH ; Kok Keng TEE ; Tahir ARIS ; Lonny Chen Rong Qi AHMAD
Epidemiology and Health 2023;45(1):e2023093-
OBJECTIVES:
This study aimed to develop susceptible-exposed-infectious-recovered-vaccinated (SEIRV) models to examine the effects of vaccination on coronavirus disease 2019 (COVID-19) case trends in Malaysia during Phase 3 of the National COVID-19 Immunization Program amidst the Delta outbreak.
METHODS:
SEIRV models were developed and validated using COVID-19 case and vaccination data from the Ministry of Health, Malaysia, from June 21, 2021 to July 21, 2021 to generate forecasts of COVID-19 cases from July 22, 2021 to December 31, 2021. Three scenarios were examined to measure the effects of vaccination on COVID-19 case trends. Scenarios 1 and 2 represented the trends taking into account the earliest and latest possible times of achieving full vaccination for 80% of the adult population by October 31, 2021 and December 31, 2021, respectively. Scenario 3 described a scenario without vaccination for comparison.
RESULTS:
In scenario 1, forecasted cases peaked on August 28, 2021, which was close to the peak of observed cases on August 26, 2021. The observed peak was 20.27% higher than in scenario 1 and 10.37% lower than in scenario 2. The cumulative observed cases from July 22, 2021 to December 31, 2021 were 13.29% higher than in scenario 1 and 55.19% lower than in scenario 2. The daily COVID-19 case trends closely mirrored the forecast of COVID-19 cases in scenario 1 (best-case scenario).
CONCLUSIONS
Our study demonstrated that COVID-19 vaccination reduced COVID-19 case trends during the Delta outbreak. The compartmental models developed assisted in the management and control of the COVID-19 pandemic in Malaysia.
2.Anterior Cruciate Ligament (ACL) Reconstruction and Extra-Articular Tenodesis in a Contralateral Above-Knee Amputee Following Complex Trauma: A Case Report
Vijayaraj RM ; Balakumaran M ; Ahmad AR ; Solayar GN
Malaysian Orthopaedic Journal 2022;16(No.1):119-121
We report the outcome following arthroscopic ACL
reconstruction combined with a Modified LeMaire
procedure in a patient who underwent multiple surgeries
following an open ipsilateral femoral fracture and an above
knee amputation of the contralateral limb at the time of
initial trauma. This case highlights the importance of
achieving ligamental stability in the contra-lateral limb in
aiding proper rehabilitation following amputation and the
potential pitfalls of retrograde femoral nailing.
3.Isolated Infraspinatous Atrophy from a Spinoglenoid Cyst: A Case Report
Gomez DN ; Zulkahini NF ; Ahmad AR ; Solayar GN
Malaysian Orthopaedic Journal 2022;16(No.1):142-145
We present a case of a 26-year-old gentleman with isolated
right infraspinatus atrophy arising from a spinoglenoid cyst
of the right shoulder. He presented two years following his
shoulder injury and failed conservative rehabilitation alone.
At initial arthroscopic surgery, a superior labral anterior to
posterior (SLAP) tear was diagnosed and the spinoglenoid
cyst was debrided without formal labral repair. The patient’s
condition did not improve, and second arthroscopy was
performed three months following the first with suture
anchor repair of the labral tear and cyst decompression. Postoperative magnetic resonant imaging (MRI) scans showed
complete resolution of the cyst and recovery of infraspinatus
muscle bulk at six months. At final follow-up 18 months post
SLAP repair, he has regained full shoulder function and has
returned to recreational sports. Our case highlights the
importance of proper management of SLAP tears in
resolving spinoglenoid cysts by demonstrating the outcomes
from two different surgical methods in the same patient.
4.API Driven On-Demand Participant ID Pseudonymization in Heterogeneous Multi-Study Research
Shorabuddin SYED ; Mahanazuddin SYED ; Hafsa Bareen SYEDA ; Maryam GARZA ; William BENNETT ; Jonathan BONA ; Salma BEGUM ; Ahmad BAGHAL ; Meredith ZOZUS ; Fred PRIOR
Healthcare Informatics Research 2021;27(1):39-47
Objectives:
To facilitate clinical and translational research, imaging and non-imaging clinical data from multiple disparate systems must be aggregated for analysis. Study participant records from various sources are linked together and to patient records when possible to address research questions while ensuring patient privacy. This paper presents a novel tool that pseudonymizes participant identifiers (PIDs) using a researcher-driven automated process that takes advantage of application-programming interface (API) and the Perl Open-Source Digital Imaging and Communications in Medicine Archive (POSDA) to further de-identify PIDs. The tool, on-demand cohort and API participant identifier pseudonymization (O-CAPP), employs a pseudonymization method based on the type of incoming research data.
Methods:
For images, pseudonymization of PIDs is done using API calls that receive PIDs present in Digital Imaging and Communications in Medicine (DICOM) headers and returns the pseudonymized identifiers. For non-imaging clinical research data, PIDs provided by study principal investigators (PIs) are pseudonymized using a nightly automated process. The pseudonymized PIDs (P-PIDs) along with other protected health information is further de-identified using POSDA.
Results:
A sample of 250 PIDs pseudonymized by O-CAPP were selected and successfully validated. Of those, 125 PIDs that were pseudonymized by the nightly automated process were validated by multiple clinical trial investigators (CTIs). For the other 125, CTIs validated radiologic image pseudonymization by API request based on the provided PID and P-PID mappings.
Conclusions
We developed a novel approach of an ondemand pseudonymization process that will aide researchers in obtaining a comprehensive and holistic view of study participant data without compromising patient privacy.
5.Early Experience of Reverse Total Shoulder Arthroplasty in a Public Hospital in Malaysia
Sam CX ; Anwar AZ ; Ahmad AR ; Solayar GN
Malaysian Orthopaedic Journal 2021;15(No.1):119-123
Introduction: Reverse total shoulder arthroplasty provides a
surgical alternative to standard total shoulder arthroplasty for
the treatment of cuff tear arthropathy, arthritis and fracture
sequelae. This study aimed to assess the short-term outcomes
following reverse total shoulder arthroplasty for patients in a
large public hospital in Malaysia.
Materials and Methods: We identified and performed five
primary reverse total shoulder arthroplasties between 1 May
2019 and 1 June 2020. All patients were contactable and
available for analysis. Assessment of functional outcomes
was performed using the Constant-Murley score, the patient
satisfaction score (PSS), and imaging studies. The mean
follow-up from operation to the time of reporting was 9.6
months (range, 3 to 14 months)
Results: The median age for our patients was 58 years
(±11.91). The most common indication for surgery was posttraumatic arthritis, followed by rotator cuff arthropathy and
osteoarthritis. The mean Constant score improved from 9.0
pre-operatively to 52.3 post-operatively at a mean of 9.6
months. The majority of the patients were satisfied with the
surgery as the post-operative range of motion, especially
anterior elevation and abduction, improved in four of our
patients and there were no short-term complications, for
example, of infection or revisions, reported at the last followup.
Conclusion: This study has shown that reverse total
shoulder arthroplasty can yield good short-term outcomes for
the treatment of complex shoulder problems in addition to
cuff tear arthropathy. It should be considered a treatment for
rotator cuff tears, severe arthritis and ≥ 3 parts proximal
humeral fractures.
6.Explaining Osteomyelitis and Prosthetic Joint Infections (PJI) in terms of Biofilm – A Review
Malaysian Orthopaedic Journal 2021;15(No.2):1-8
Osteomyelitis is a chronic infection of bones. Eradication of
bone infection is usually with antibiotics and debridement,
but it is slow and the infection can recur even after many
years. It is now established that osteomyelitis is due to
biofilm and a better understanding of the process is required.
We review the development of biofilm and apply it to
osteomyelitis management. The planktonic microbes'
response to adverse conditions is the formation of biofilm.
Bacterial infections in planktonic forms cause infections that
can be controlled with antibiotics and immunisation,
however the same microbe when its phenotype becomes
biofilm is more resilient. The understanding of how
planktonic bacteria convert to biofilm is one of the aims set
out for this article.
7.Toolkit to Compute Time-Based Elixhauser Comorbidity Indices and Extension to Common Data Models
Shorabuddin SYED ; Ahmad BAGHAL ; Fred PRIOR ; Meredith ZOZUS ; Shaymaa AL-SHUKRI ; Hafsa Bareen SYEDA ; Maryam GARZA ; Salma BEGUM ; Kim GATES ; Mahanazuddin SYED ; Kevin W. SEXTON
Healthcare Informatics Research 2020;26(3):193-200
Objectives:
The time-dependent study of comorbidities provides insight into disease progression and trajectory. We hypothesize that understanding longitudinal disease characteristics can lead to more timely intervention and improve clinical outcomes. As a first step, we developed an efficient and easy-to-install toolkit, the Time-based Elixhauser Comorbidity Index (TECI), which pre-calculates time-based Elixhauser comorbidities and can be extended to common data models (CDMs).
Methods:
A Structured Query Language (SQL)-based toolkit, TECI, was built to pre-calculate time-specific Elixhauser comorbidity indices using data from a clinical data repository (CDR). Then it was extended to the Informatics for Integrating Biology and the Bedside (I2B2) and Observational Medical Outcomes Partnership (OMOP) CDMs.
Results:
At the University of Arkansas for Medical Sciences (UAMS), the TECI toolkit was successfully installed to compute the indices from CDR data, and the scores were integrated into the I2B2 and OMOP CDMs. Comorbidity scores calculated by TECI were validated against: scores available in the 2015 quarter 1–3 Nationwide Readmissions Database (NRD) and scores calculated using the comorbidities using a previously validated algorithm on the 2015 quarter 4 NRD. Furthermore, TECI identified 18,846 UAMS patients that had changes in comorbidity scores over time (year 2013 to 2019). Comorbidities for a random sample of patients were independently reviewed, and in all cases, the results were found to be 100% accurate.
Conclusions
TECI facilitates the study of comorbidities within a time-dependent context, allowing better understanding of disease associations and trajectories, which has the potential to improve clinical outcomes.
8.LOCKED PUBIC SYMPHYSIS: A CASE REPORT AND REVIEW OF LITERATURE
Journal of University of Malaya Medical Centre 2018;21(2):59-63
Locked pubic symphysis is a rare form of pelvic injury that usually occurs after a lateral compression injury to the pelvis, where the intact pubis is trapped behind the contralateral pubis. To the best of our knowledge, there were 25 similar cases reported in the English literature since it was first described in 1952. We present a case of locked pubic symphysis with a left iliac wing fracture and a left femur shaft fracture requiring open reduction and internal fixation. We also reviewed previous reported cases of locked pubic symphysis and analysed the pattern of presentation and guide to management of such injuries. We propose a classification system for grading overlapping pubic symphysis that will provide a better guide to the management of such injuries
9.The Influence Of Income Level And Remuneration Scheme On Job Satisfaction Among Professional Driving Instructors In Malaysia
Zulhaidi MJ ; Baba MD ; Mohd Hanif S ; Ahmad Azad AR
Malaysian Journal of Public Health Medicine 2018;18(Special Volume (2)):128-134
This study aims to determine the job satisfaction (JS) level among professional driving instructors (PDIs) in the driver training and licensing system in Malaysia. Specifically, it looks at the influence of income level and remuneration scheme on PDI’s satisfaction. The average income of PDI is relatively low with three remuneration schemes: fixed income; fixed income plus commission; and commission only. The study adopted the cross-sectional survey using the 20-item Minnesota Job Satisfaction Questionnaire (MSQ) (short-form) with end-specified 10-point scale. Analysis of the data revealed that PDIs with higher income are more satisfied with their job, t (179) = -3.248, p = 0.001. Similarly, three level One-way ANOVA of JS scores with three remuneration schemes revealed a significant difference of JS across these schemes, F (2,178) = 3.51, p ≤ 0.032. Researchers’ further exploration found a significant interaction between these two variables (income level vs. remuneration scheme), F (5,175) = 4.88, p = 0.001. In general, PDIs with higher income are more satisfied with their job only if they received it as a fixed income (regardless of having commission or not). This insightful finding can be a basis for relevant stakeholders in understanding the influence of income and remuneration scheme towards JS among PDIs in Malaysia.
Job satisfaction
;
professional driving instructor
;
driver training
;
driver licensing
;
Malaysia
10.Role of rigid bronchoscopy in massive haemoptysis
Ng TH ; How SH ; Kuan YC ; R Ahmad MS ; Fauzi AR
Journal of University of Malaya Medical Centre 2010;13(2):107-110
Massive haemoptysis can occur in lung abscess. Massive haemoptysis itself may be life threatening
due to asphyxiation or respiratory failure secondary to acute large airway obstruction by blood
clots. Prompt removal of the obstructing blood clots save life. We describe a case of lung
abscess causing massive haemoptysis resulting in acute airway obstruction which required rigid
bronchoscopy to remove the huge blood clot. (JUMMEC2010; 13(2): 107-110)
Bronchoscopy


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