3.Machine learning model predicts the occurrence of acute kidney injury after open surgery for abdominal aortic aneurysm repair.
Chang SHENG ; Mingmei LIAO ; Haiyang ZHOU ; Pu YANG
Journal of Central South University(Medical Sciences) 2023;48(2):213-220
		                        		
		                        			OBJECTIVES:
		                        			Abdominal aortic aneurysm is a pathological condition in which the abdominal aorta is dilated beyond 3.0 cm. The surgical options include open surgical repair (OSR) and endovascular aneurysm repair (EVAR). Prediction of acute kidney injury (AKI) after OSR is helpful for decision-making during the postoperative phase. To find a more efficient method for making a prediction, this study aims to perform tests on the efficacy of different machine learning models.
		                        		
		                        			METHODS:
		                        			Perioperative data of 80 OSR patients were retrospectively collected from January 2009 to December 2021 at Xiangya Hospital, Central South University. The vascular surgeon performed the surgical operation. Four commonly used machine learning classification models (logistic regression, linear kernel support vector machine, Gaussian kernel support vector machine, and random forest) were chosen to predict AKI. The efficacy of the models was validated by five-fold cross-validation.
		                        		
		                        			RESULTS:
		                        			AKI was identified in 33 patients. Five-fold cross-validation showed that among the 4 classification models, random forest was the most precise model for predicting AKI, with an area under the curve of 0.90±0.12.
		                        		
		                        			CONCLUSIONS
		                        			Machine learning models can precisely predict AKI during early stages after surgery, which allows vascular surgeons to address complications earlier and may help improve the clinical outcomes of OSR.
		                        		
		                        		
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Aortic Aneurysm, Abdominal/complications*
		                        			;
		                        		
		                        			Endovascular Procedures/methods*
		                        			;
		                        		
		                        			Retrospective Studies
		                        			;
		                        		
		                        			Blood Vessel Prosthesis Implantation/adverse effects*
		                        			;
		                        		
		                        			Acute Kidney Injury/etiology*
		                        			;
		                        		
		                        			Machine Learning
		                        			;
		                        		
		                        			Treatment Outcome
		                        			;
		                        		
		                        			Postoperative Complications/etiology*
		                        			;
		                        		
		                        			Risk Factors
		                        			
		                        		
		                        	
4.Indications and complications prevention and management of phaseⅡ implantation of Provox Vega voice prosthesis after total laryngectomy.
Chun Ping WU ; Xiao Hui YUAN ; Duo ZHANG ; Ling CHEN ; Lei TAO
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2023;58(1):52-58
		                        		
		                        			
		                        			Objective: To explore the indications and management of common postoperative complications of phase II tracheoesophageal puncture (TEP) for Provox Vega voice prosthesis after total laryngectomy. Methods: The clinical data of 20 patients undergoing phase II TEP for Provox Vega voice prosthesis in our hospital between May 2021 and January 2022 were analyzed. Among them, there were 19 males and 1 female, aged from 37 to 76 years, with an average age of (60.0±8.4)years. The surgical indications and the prevention and treatment of common postoperative complications were summarized. Descriptive analysis was used in this research. Results: The basic surgical indications were as following: after total laryngectomy, there was no stenosis of the stoma and esophagus entrance, no scar constitution, no mouth opening restriction, no stiffness and backward restraint of the neck after radiotherapy, and more than half a year apart surgery or radiotherapy. Among the 20 patients, 18 underwent implantation successfuly, 1 failed in the operation, and for 1 patient, the prosthesis was removed due to bleeding 1 week after implantation. The common postoperative complications included TEP fistula infection (2 cases), the TEP fistula bleeding(1 case), deep neck (prevertebral) abscess (1 case), granulation at the inner side of the TEP fistula (1 case), invagination of the prosthesis (2 cases) and leakage around the prosthesis (2 cases). All patients were cured with different interventions. Conclusions: The Provox Vega voice prosthesis is generally safe for phase Ⅱ implantatione, but implantation indications need to be established. Common postoperative complications can be solved through preventive and remedial interventions.
		                        		
		                        		
		                        		
		                        			Male
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Larynx, Artificial/adverse effects*
		                        			;
		                        		
		                        			Laryngectomy/adverse effects*
		                        			;
		                        		
		                        			Prosthesis Implantation/adverse effects*
		                        			;
		                        		
		                        			Esophagus/surgery*
		                        			;
		                        		
		                        			Postoperative Complications/etiology*
		                        			;
		                        		
		                        			Prosthesis Design
		                        			
		                        		
		                        	
5.Application of "Fabulous" stent system to improve aortic remodeling after TEVAR for type B aortic dissection.
Chengkai HU ; Jue YANG ; Wei WANG ; Xiangchen DAI ; Xinwu LU ; Youfei QI ; Hongpeng ZHANG ; Yuchong ZHANG ; Ye YUAN ; Enci WANG ; Yi SI ; Weiguo FU ; Lixin WANG
Chinese Medical Journal 2023;136(10):1231-1233
6.Clinical efficacy of simple taper retentive implants in immediate posterior dental implantation for 5-7 years.
Bihui REN ; Shuigen GUO ; Yehao XU ; Jieting DAI ; Hongwu WEI
West China Journal of Stomatology 2023;41(3):341-349
		                        		
		                        			OBJECTIVES:
		                        			This study aimed to evaluate the long-term clinical efficacy of simple taper retentive implants in the posterior dental area after immediate implantation for 5-7 years.
		                        		
		                        			METHODS:
		                        			Selected from January 2015 to December 2017 in the Fourth Affiliated Hospital of Nanchang University dental clinic line tooth area immediately after the implant prosthesis, a total of 38 patients, 53 implants, were deep into (bone under 2 mm or higher) and the upper structure was repaired. In addition, after the completion of tracking observation of 60-90 months, the implant surrounding bone health was recorded and analyzed.
		                        		
		                        			RESULTS:
		                        			After 5-7 years of follow-up, 1 of the 53 implants failed to fall out, and the implant retention rate was 98.1%. The amount of bone resorption in the proximal and distal margins 5-7 years after implant restoration was (0.16±0.94) mm and (-0.01±1.29) mm, respectively, and the difference in bone height between the proximal and distal margins of the implant and the immediate post-restoration period was not statistically significant (P>0.05). No statistically significant differences were found in the effects of periodontitis, implant site inflammation, and smoking on peri-implant marginal bone resorption (P>0.05).
		                        		
		                        			CONCLUSIONS
		                        			The single taper-retained implant broadens the indications for immediate implant placement in the posterior region, and its deep sub-osseous placement (≥2 mm below the bone) avoids to a certain extent the disturbance of the implant by external stimuli and the exposure of the cervical abutment of the implant, with the good long-term stability of the marginal bone around the implant.
		                        		
		                        		
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Dental Implantation, Endosseous
		                        			;
		                        		
		                        			Dental Implants
		                        			;
		                        		
		                        			Immediate Dental Implant Loading
		                        			;
		                        		
		                        			Follow-Up Studies
		                        			;
		                        		
		                        			Dental Implants, Single-Tooth
		                        			;
		                        		
		                        			Alveolar Bone Loss/surgery*
		                        			;
		                        		
		                        			Treatment Outcome
		                        			;
		                        		
		                        			Dental Prosthesis, Implant-Supported
		                        			;
		                        		
		                        			Dental Restoration Failure
		                        			
		                        		
		                        	
7.Outcome of surgical repair for aortic coarctation with coexisting descending aortic aneurysm in adult patients.
Yi Fan LU ; Huan Yu QIAO ; Bo YANG ; Hong Lei ZHAO ; Hao ZHANG ; Tao BAI ; Jin Rong XUE ; Yong Min LIU
Chinese Journal of Cardiology 2023;51(5):469-475
		                        		
		                        			
		                        			Objective: To evaluate the efficacy of surgical treatment of aortic coarctation combined with descending aortic aneurysm in adult patients. Methods: This is a retrospective cohort study. Adult patients with aortic coarctation who were hospitalized in Beijing Anzhen Hospital from January 2015 to April 2019 were enrolled. The aortic coarctation was diagnosed by aortic CT angiography, and the included patients were divided into the combined descending aortic aneurysm group and the uncomplicated descending aortic aneurysm group based on descending aortic diameter. General clinical data and surgery-related data were collected from the included patients, and death and complications were recorded at 30 days after surgery, and upper limb systolic blood pressure was measured in all patients at discharge. Patients were followed up after discharge by outpatient visit or telephone call for their survival and the occurrence of repeat interventions and adverse events, which included death, cerebrovascular events, transient ischemic attack, myocardial infarction, hypertension, postoperative restenosis, and other cardiovascular-related interventions. Results: A total of 107 patients with aortic coarctation aged (34.1±15.2) years were included, and 68 (63.6%) were males. There were 16 cases in the combined descending aortic aneurysm group and 91 cases in the uncomplicated descending aortic aneurysm group. In the combined descending aortic aneurysm group, 6 cases (6/16) underwent artificial vessel bypass, 4 cases (4/16) underwent thoracic aortic artificial vessel replacement, 4 cases (4/16) underwent aortic arch replacement+elephant trunk procedure, and 2 cases (2/16) underwent thoracic endovascular aneurysm repair. There was no statistically significant difference between the two groups in the choice of surgical approach (all P>0.05). In the combined descending aortic aneurysm group at 30 days after surgery, one case underwent re-thoracotomy surgery, one case developed incomplete paraplegia of the lower extremity, and one case died; and the differences in the incidence of endpoint events at 30 days after surgery were similar between the two groups (P>0.05). Systolic blood pressure in the upper extremity at discharge was significantly lower in both groups compared with the preoperative period (in the combined descending aortic aneurysm group: (127.3±16.3) mmHg vs. (140.9±16.3) mmHg, P=0.030, 1 mmHg=0.133 kPa; in the uncomplicated descending aortic aneurysm group: (120.7±13.2) mmHg vs. (151.8±26.3) mmHg, P=0.001). The follow-up time was 3.5 (3.1, 4.4) years. There were no new deaths in the combined descending aortic aneurysm group, no transient ischemic attack, myocardial infarction or re-thoracotomy surgery, and one patient (1/15) suffered cerebral infarction and 10 patients (10/15) were diagnosed with hypertension. The differences in the occurrence of endpoint events during postoperative follow-up were similar between the two groups (P>0.05). Conclusion: In experienced centers, long-term prognosis of patients with aortic coarctation combined with descending aortic aneurysm is satisfactory post surgical intervention.
		                        		
		                        		
		                        		
		                        			Male
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Aortic Coarctation/surgery*
		                        			;
		                        		
		                        			Retrospective Studies
		                        			;
		                        		
		                        			Aortic Aneurysm, Abdominal/surgery*
		                        			;
		                        		
		                        			Treatment Outcome
		                        			;
		                        		
		                        			Blood Vessel Prosthesis Implantation/adverse effects*
		                        			;
		                        		
		                        			Endovascular Procedures/adverse effects*
		                        			;
		                        		
		                        			Hypertension/complications*
		                        			;
		                        		
		                        			Myocardial Infarction/complications*
		                        			;
		                        		
		                        			Aortic Aneurysm, Thoracic/surgery*
		                        			
		                        		
		                        	
9.Long-term outcome of transcatheter repair of paravalvular leak post surgical mitral valve replacement.
Chao Fan XING ; Xin PAN ; Cheng WANG ; Lan MA ; Xiao Lei WANG ; Yan Jie LI ; Ben HE
Chinese Journal of Cardiology 2023;51(7):742-749
		                        		
		                        			
		                        			Objective: To explore the long-term clinical efficacy of transcatheter repair of mitral paravalvular leak (PVL) post surgical mitral valve replacement. Methods: This study is a retrospective study. Patients who completed transcatheter repair of paravalvular leak after surgical mitral valve replacement at Shanghai Chest Hospital, Shanghai Jiaotong University School of Medicine from March 2010 to December 2018 were included. Technical success was defined as the occluder being stably implanted in the paravalvular leak site without affecting the function of the mitral valve and surrounding tissues; and there were no intervention-related complications, such as new hemolysis or aggravated hemolysis, and echocardiography confirmed mitral paravalvular regurgitation reduced by more than 1 grade. Patients were followed up at 30 days, 1, and 3 years after the intervention. The main endpoints were all-cause death and re-surgery due to interventional failure or serious complications. The occurrence of occluder-mediated hemolysis and chronic renal insufficiency was recorded, and patients were monitored with echocardiography during follow up. Results: A total of 75 patients were included, aged (54.3±22.9) years old, and 38 patients were males. All patients had decreased cardiac function and/or hemolysis before intervention. Procedural success was achieved in 54 patients (72.0%). Incidence of device-mediated hemolysis was 18.7% (14/75). During the follow-up period, all-cause death occurred in 7 patients (9.3%), and 3 were cardiac deaths.The 3-year event-free survival rate was 81.3% (61/75). The need for cardiac surgery was 9.3% (7/75): 3 cases due to severe device-mediated hemolysis, 2 cases due to prosthetic valve failure and 2 cases due to moderate to severe residual regurgitation. The echocardiography follow-up results showed that the position of the occluder was stable, there was no impact on the artificial valve function and surrounding structures, and the residual regurgitation was stable without progressive increase in event-free patients. Compared with pre-intervention, the left ventricular end systolic diameter ((33.9±7.4)mm vs. (38.3±8.9) mm, P=0.036), end diastolic diameter ((53.7±8.3) mm vs. (58.4±9.1) mm, P=0.045) and left atrial diameter (59.3 (44.5, 90.7) mm vs. 64.3 (44.8, 96.6) mm, P=0.049) were significantly reduced, pulmonary artery systolic pressure was also significantly decreased ((36.5±15.8) mmHg vs. (46.3±14.9) mmHg, P=0.022, 1 mmHg=0.133 kPa). There was no significant difference between 3 years and 1 year after transcatheter repair of mitral paravalvular leak post surgical mitral valve replacement (all P>0.05). Conclusion: Transcatheter repair of mitral paravalvular leak post surgical mitral valve replacement is an effective treatment option in selective patients.
		                        		
		                        		
		                        		
		                        			Male
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Middle Aged
		                        			;
		                        		
		                        			Aged
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Mitral Valve/surgery*
		                        			;
		                        		
		                        			Heart Valve Prosthesis Implantation
		                        			;
		                        		
		                        			Heart Valve Prosthesis
		                        			;
		                        		
		                        			Retrospective Studies
		                        			;
		                        		
		                        			Hemolysis
		                        			;
		                        		
		                        			China
		                        			;
		                        		
		                        			Mitral Valve Insufficiency/surgery*
		                        			;
		                        		
		                        			Treatment Outcome
		                        			;
		                        		
		                        			Cardiac Catheterization
		                        			;
		                        		
		                        			Prosthesis Failure
		                        			
		                        		
		                        	
            
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